Abstract: An osmotic delivery system is disclosed for dispensing a useful agent. The system comprises a semipermeable wall surrounding a compartment housing the agent. The wall comprises a cellulose ether, an organic solvent soluble polymer, and optionally an aqueous soluble polymer. A passageway in the wall connects the interior of the system with the exterior for dispensing an agent from the system.
Abstract: A parenteral delivery system is disclosed for administering a beneficial agent to a recipient. The system comprises (a) a primary container of a medical fluid; (b) a primary drip chamber in fluid communication with the primary container; (c) a primary formulation chamber in fluid communication with the primary drip chamber and housing an agent dispensing device or a beneficial agent; (d) a secondary container of a medical fluid; (e) a secondary drip chamber in fluid communication with the secondary container; (f) a secondary formulation chamber in fluid communication with the secondary drip chamber and housing an agent dispensing device or a beneficial agent; and (g) a common tubing in communication with the primary formulation chamber and the secondary formulation chamber for communicating the system with the recipient.
Abstract: A formulation chamber is disclosed comprising a wall surrounding a lumen containing a device for delivering a beneficial agent. The chamber has an inlet for admitting a fluid into the chamber and an outlet for letting an agent formulation leave the chamber. The chamber is adapted for use in an intravenous delivery system for delivering an agent formulation to a patient.
Abstract: A parenteral delivery system is disclosed for delivering a beneficial agent to an agent recipient. The delivery system comprises a reservoir, a drip chamber and a flexible container that collapses as agent formulation leaves the system.
Abstract: A formulation cell consisting essentially of a hollow fiber surrounded by a beneficial agent is disclosed for use in an intravenous delivery system. An intravenous system is disclosed that uses the formulation cell.
Abstract: A patient-care apparatus is disclosed for providing a biocide for controlling the presence of unwanted pathogens in a liquid. The patient-care apparatus comprises a container having means for maintaining a biocide dispensing device in a position in the container such that it dispenses an amount of biocide relative to the amount of liquid present in the container.
Abstract: A manually operated rotary syringe comprises a fixed base member and a relatively rotable cap member, one of which has an arcuate recess and the other of which carries a mating plug which is received in the arcuate recess in fluid tight relationship with the walls of the recess. Outlet means extend through the stationary base from one end of the arcuate recess such that on rotation of the cap the plug will be caused to traverse the recess towards the outlet to expel the contents of the recess through the outlet means in the base. Means are provided to permit rotation of the cap with respect to the base in only in the direction of operation.
Abstract: An osmotic device is disclosed for delivering a beneficial agent to a first environment having a pH of 1.0 to 3.5 inclusive and to a second environment having a pH of greater than 3.5 to 8.0. The device maintains its integrity in the first environment and loses its integrity in the second environment.
Type:
Grant
Filed:
June 6, 1983
Date of Patent:
March 5, 1985
Assignee:
ALZA Corporation
Inventors:
David Edgren, Patrick S. L. Wong, Felix Theeuwes
Abstract: A parenteral delivery set is disclosed for administering a beneficial agent to a recipient. The set comprises (a) a primary container of a medical fluid; (b) a primary tubing in fluid communication with the primary container; (c) a secondary container of a medical fluid; (d) a secondary tubing in fluid communication with the secondary container; (e) a formulation chamber connected to the secondary tubing and housing an agent dispensing device or the beneficial agent; and (f) a common tubing in communication with the primary tubing and the secondary tubing for communicating the set to the recipient.
Abstract: A method is disclosed for treating an ischemic condition. The method comprises coadministering topically and internally a vasodilator to a patient having the condition for treating said condition.
Abstract: The invention pertains to the administration of an immunopotentiator to activate an immune response. The administration comprises the controlled and continuous administration of the immunopotentiator leading to a high immune response with adequate persistancy, while simultaneously and substantially reducing or eliminating inflammatory reactions usually accompanying depot-type administration.
Abstract: A parenteral delivery set is disclosed for administering a beneficial agent to a recipient. The set comprises (a) a primary container of a medical fluid; (b) a primary tubing in fluid communication with the primary container; (c) a secondary container of a medical fluid; (d) a secondary tubing in fluid communication with the secondary container; (e) a formulation chamber connected to the secondary tubing and housing an agent dispensing device or the beneficial agent; and (f) a common tubing in communication with the primary tubing and the secondary tubing for communicating the set to the recipient.
Abstract: A parenteral delivery system is disclosed for administering a beneficial agent to a recipient. The system comprises (a) a container of a medical fluid; (b) a primary tubing in communication with the container; (c) a parallel tubing connected to the primary tubing having a formulation chamber connected thereto, the formulation chamber housing a beneficial agent, or a device for delivering a beneficial agent; and (d) a common tubing connected to the primary tubing and the parallel tubing for administering the fluid and the agent to a recipient.
Abstract: A parenteral delivery system is disclosed for administering a beneficial agent to a recipient. The system comprises (a) a container of a medical fluid; (b) a primary tubing in communication with the container; (c) a parallel tubing connected to the primary tubing having a formulation chamber connected thereto, the formulation chamber housing a beneficial agent, or a device for delivering a beneficial agent; and (d) a common tubing connected to the primary tubing and the parallel tubing for administering the fluid and the agent to a recipient.
Abstract: A formulation dispenser is disclosed for use in a parenteral delivery system. The dispenser comprises an inlet for admitting fluid into the dispenser and an outlet for letting fluid leave the dispenser. A beneficial agent is housed in a formulation chamber in the dispenser and a membrane permeable to fluid and agent defines one boundary of the formulation chamber. A piston is slideably disposed in the dispenser for governing the flow of fluid through the dispenser, or for permitting fluid to contact the membrane and enter the formulation chamber for forming a solution containing agent that flows through the outlet into the parenteral system.
Type:
Grant
Filed:
July 29, 1983
Date of Patent:
October 2, 1984
Assignee:
ALZA Corporation
Inventors:
Allan M. Wolfe, James M. Davenport, Felix Theeuwes, Su I. Yum
Abstract: A pump assembly particularly useful as an infusor for parenteral administration of a small amount of a therapeutically active substance for a prolonged period of time at a substantially constant rate comprising a fluid imbibing pump mounted within a receptacle into which actuating fluid may be charged. The active agent is dispensed from the pump after the pump is exposed to the fluid. Means to vary or stop the pump by obdurating all or a portion of the exterior surface of the pump can also be provided. Variation in flow rates can also be obtained by changing the composition of the actuating fluid.
Type:
Grant
Filed:
September 22, 1982
Date of Patent:
October 2, 1984
Assignee:
Alza Corporation
Inventors:
James B. Eckenhoff, Virgil A. Place, John R. Peery
Abstract: A dosage form that coadministers a drug and a percutaneous absorption enhancer to a defined area of the skin. The dosage form comprises a body that contains supplies of drug and enhancer and has a basal surface that contacts the area of skin and transmits the drug and enhancer to the area for absorption thereby. The drug is provided to the basal surface at a rate at least as great as the rate at which the skin is able to absorb the drug whereas the enhancer is via a rate controlling means at a substantially constant rate that increases the permeability of the treated area of skin to the drug to a level at which the drug is absorbed a therapeutically effective rate.
Type:
Grant
Filed:
April 1, 1983
Date of Patent:
July 17, 1984
Assignee:
ALZA Corporation
Inventors:
Patricia S. Campbell, Santosh K. Chandrasekaran