Patents Represented by Attorney Steven F. Stone
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Patent number: 4455143Abstract: An osmotic device is disclosed for delivering two beneficial drugs to an environment of use. The device comprises a semipermeable wall surrounding a lumen divided into a first compartment containing a drug that is separated from a second compartment containing a different drug. An orifice through the wall communicates with the first compartment for delivering drug from the first compartment, and another orifice through the wall communicates with the second compartment for delivering drug from the second compartment. In operation, drug is dispensed separately from each compartment by fluid being imbibed through the wall into each compartment at a rate controlled by the permeability of the wall and the osmotic pressure gradient across the wall against the drug in each compartment thereby producing in each compartment a solution containing drug that is dispensed through their orifices at a controlled and continuous rate over a prolonged period of time.Type: GrantFiled: March 22, 1982Date of Patent: June 19, 1984Assignee: ALZA CorporationInventors: Felix Theeuwes, Brian Barclay, Richard Cortese
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Patent number: 4449983Abstract: An osmotic device is disclosed for delivering two beneficial drugs to an environment of use. The device comprises a wall surrounding a lumen divided into a first compartment containing a drug that is separated by a hydrogel partition from a second compartment containing a different drug. An orifice through the wall communicates with the first compartment for delivering drug formulation from the first compartment, and another orifice through the wall communicates with the second compartment for delivering drug formulation from the second compartment.Type: GrantFiled: March 22, 1982Date of Patent: May 22, 1984Assignee: ALZA CorporationInventors: Richard Cortese, Brian Barclay, Felix Theeuwes
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Patent number: 4450198Abstract: A system is disclosed for dispensing an useful agent. The system comprises (1) means for storing an agent, (2) an agent stored in the means, (3) means for releasing agent from the system, (4) means for absorbing fluid into the system surrounding the storing means, and (5) means for admitting fluid into the system. In operation fluid is admitted into the system by the admitting means cooperating with the absorbing means, causing it to increase in dimensions and apply force against the storing means, which force urges the storing means to decrease its dimensions and correspondingly dispense agent through the releasing means from the system. Laminates are disclosed useful for manufacturing the system.Type: GrantFiled: August 17, 1981Date of Patent: May 22, 1984Assignee: Alza CorporationInventor: Alan S. Michaels
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Patent number: 4445889Abstract: A method for preventing an infection in a patient introduced through a indwelling catheter, the method comprising, connecting the patient to the catheter, connecting the catheter to a fluid receiving container, admitting into the container a biocidal dispensing device, and releasing a biocide into fluid in the container for inhibiting the growth of infectious bacteria in the container and concomitantly their introduction into the catheter and the patient.Type: GrantFiled: July 12, 1982Date of Patent: May 1, 1984Assignee: ALZA CorporationInventors: Patrick S. Wong, Jimmy B. Langston, Harold M. Leeper
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Patent number: 4439195Abstract: An osmotic device is disclosed that provides a means for improving the delivery properties of a beneficial agent in situ.Type: GrantFiled: February 1, 1982Date of Patent: March 27, 1984Assignee: Alza CorporationInventors: David Swanson, David Edgren
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Patent number: 4436741Abstract: Method and therapeutic system in the form of a bandage that administer scopolamine base transdermally in an initial pulse of 10 to 200 .mu.g/cm.sup.2 of skin that quickly brings the concentration of scopolamine in the plasma to a level at which emesis and nausea are inhibited without intolerable side effects, followed by a substantially constant dosage in the range of 0.3 to 15 .mu.g/hr that holds said level. The bandage is a four-layer laminate of, from the top: a protective backing; a gelled, mineral oil-polyisobutene-scopolamine reservoir lamina that is the source of the constant dosage; a microporous membrane that controls the constant dosage rate; and a gelled, mineral oil-polyisobutene-scopolamine adhesive layer that is the source of the pulse dose and the means by which the bandage is attached to the skin.Type: GrantFiled: March 14, 1983Date of Patent: March 13, 1984Assignee: ALZA CorporationInventors: John Urquhart, Santosh K. Chandrasekaran, Jane E. Shaw
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Patent number: 4435180Abstract: A transdermal therapeutic system is formed from a body member surrounding means at least a portion of which is an active agent loaded elastomer which is in a stretched condition during use. The tension created by the stretching of the elastomer is preferably from 20 to 35 psi and maintains the agent transferring contact between the skin and the transdermal therapeutic system. The transdermal therapeutic system may be in the form of a glove, sock, sleeve, cuff or band, for example.Type: GrantFiled: May 25, 1982Date of Patent: March 6, 1984Assignee: ALZA CorporationInventor: Harold M. Leeper
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Patent number: 4432756Abstract: A parenteral delivery set is disclosed for administering a beneficial agent to a recipient. The set comprises (a) a primary container of a medical fluid; (b) a primary tubing in fluid communication with the primary container; (c) a secondary container of a medical fluid; (d) a secondary tubing in fluid communication with the secondary container; (e) a formulation chamber connected to the secondary tubing and housing an agent dispensing device or the beneficial agent; and (f) a common tubing in communication with the primary tubing and the secondary tubing for communicating the set to the recipient.Type: GrantFiled: November 27, 1981Date of Patent: February 21, 1984Assignee: Alza CorporationInventors: John Urquhart, Felix Theeuwes
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Patent number: 4424056Abstract: A parenteral delivery system is disclosed for administering a beneficial agent to a recipient. The system comprises (a) a container of a medical fluid; (b) a primary tubing in communication with the container; (c) a parallel tubing connected to the primary tubing having a formulation chamber connected thereto, the formulation chamber housing a beneficial agent, or a device for deliverying a beneficial agent; and (d) a common tubing connected to the primary tubing and the parallel tubing for administering the fluid and the agent to a recipient.Type: GrantFiled: November 27, 1981Date of Patent: January 3, 1984Assignee: Alza CorporationInventors: John Urquhart, Felix Theeuwes
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Patent number: 4419096Abstract: Elastomeric bladder assemblies designed for operation at constant pressure to maintain a constant dispensing rate for the contents exhibit a pressure spike shortly before the end of the duty cycle. This pressure spike may be prevented by including within the lumen of the bladder a bolus forming means which prevents the bladder from collapsing to a cylindrical configuration.Type: GrantFiled: February 22, 1982Date of Patent: December 6, 1983Assignee: ALZA CorporationInventors: Harold M. Leeper, Nikki Baumrind, John R. Peery
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Patent number: 4418038Abstract: Devices for dispensing a chlorine biocide. The devices disclosed are (a) a device comprising a polymer containing a chlorine donating reagent and chlorine accepting reagent that on their release react to produce a chlorinous biocide, and (b) a device comprising a polymer containing a biocide containing chlorine. A process for using the devices for controlling micro-organisms.Type: GrantFiled: November 2, 1981Date of Patent: November 29, 1983Assignee: Alza CorporationInventor: Felix Theeuwes
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Patent number: 4410328Abstract: A device is disclosed for delivering a beneficial agent. The device comprises (1) a housing defining an internal space (2) a piston in the housing separating the space into an agent compartment and a power compartment, or a flexible container in the space, (3) an opening in the housing connecting the agent compartment or the container with the exterior of the housng, and (4) an osmotic device in the power compartment or beneath the container.Type: GrantFiled: July 10, 1981Date of Patent: October 18, 1983Assignee: Alza CorporationInventor: Felix Theeuwes
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Patent number: 4386929Abstract: The bladder assembly of this invention has spaced apart inlet and outlet means and the bladder is capable of expanding and contracting radially and axially upon inflation and deflation. When deflated the lumen of the bladder is substantially completely filled by lumen filling means, which in a preferred embodiment, protect the bladder from being punctured by the hypodermic needle used to fill and inflate the bladder. The lumen filling means resists the compressive load applied during insertion of the needle and maintains the inlet and outlet means in spaced apart relationship while providing substantially no resistance to the axial expansion of the bladder. By having the lumen of the bladder filled with the lumen filling means when the bladder is deflated, before its subsequent inflation and deflation, substantially complete expulsion of the fluid contents of the bladder can be obtained.Type: GrantFiled: October 19, 1981Date of Patent: June 7, 1983Assignee: ALZA CorporationInventors: John R. Peery, William K. Griesinger, Peter F. Carpenter
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Patent number: 4379454Abstract: A dosage form that coadministers a drug and a percutaneous absorption enhancer to a defined area of the skin. The dosage form comprises a body that contains supplies of drug and enhancer and has a basal surface that contacts the area of skin and transmits the drug and enhancer to the area for absorption thereby. The drug is provided to the basal surface at a rate at least as great as the rate at which the skin is able to absorb the drug whereas the enhancer is via a rate controlling means at a substantially constant rate that increases the permeability of the treated area of skin to the drug to a level at which the drug is absorbed at a therapeutically effective rate.Type: GrantFiled: February 17, 1981Date of Patent: April 12, 1983Assignee: ALZA CorporationInventors: Patricia S. Campbell, Santosh K. Chandrasekaran
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Patent number: 4350271Abstract: A fluid dispenser that operates by absorbing water is disclosed. The dispenser includes a rigid water permeable housing; a water insoluble, water swellable composition that fills a segment of the space within the housing, a lipophilic fluid charge that fills the remainder of the space within the housing and that is immiscible in the water-swellable composition, and an outlet through the housing that communicates with the fluid charge. In operation the water swellable composition absorbs water, expands, and in piston-like fashion displaces the fluid charge from the dispenser via the outlet.Type: GrantFiled: August 22, 1980Date of Patent: September 21, 1982Assignee: Alza CorporationInventor: James B. Eckenhoff
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Patent number: 4320758Abstract: An improved version of an osmotically driven mini-osmotic pump that is used to administer drug solutions. The basic components of the improved pump are: an inner flexible bag that holds the drug solution; a plug having a recessed inner end that seals the bag opening; a solution filling/discharge port through the plug; a cup-shaped, thermo-formed sleeve that fits partly about the bag and is made from a dispersion of an osmotically effective solute in a water soluble, theroplastic polymer vehicle; a shape-retaining, semipermeable membrane that encapulates the bag-sleeve subassembly; and a flow moderator that is received through the filling/discharge port in the plug.Type: GrantFiled: December 8, 1980Date of Patent: March 23, 1982Assignee: Alza CorporationInventors: James B. Eckenhoff, Johan H. Geerke, Felix A. Landrau
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Patent number: 4318400Abstract: A portable elastomeric bladder-powered infusor for dispensing drug in liquid form under pressure at a predetermined flow rate is disclosed. The main elements of the infusor are a tubular housing, a plug/flow control assembly fixed in one end of the bladder, an axially slidable piston/filling port assembly within the housing, and a tubular bladder. The plug and piston assemblies each has an axial post about which the bladder ends are attached. When the bladder is not charged with drug, the posts fill the bladder's lumen and their ends abut. Drug is charged to the infusor by inserting a drug-filled syringe into the open end of the housing with the syringe's needle entering an axial bore in the piston, penetrating a septum that blocks the bore, and extending into the axial post. The force exerted on the piston by the syringe is transmitted to the fixed plug assembly via the axial posts. Drug is plunged from the syringe causing the posts to separate and the bladder to expand axially and radially.Type: GrantFiled: January 18, 1980Date of Patent: March 9, 1982Assignee: Alza CorporationInventors: John R. Peery, Peter F. Carpenter, William K. Griesinger
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Patent number: 4264018Abstract: Collapsing bladder positive expulsion devices are provided in which the bladder itself is configured to have areas of longitudinal stiffening such that upon the application of external pressure the bladder can be caused to collapse inwardly upon itself in a predetermined fashion without the requirement for a separate internal support structure.Type: GrantFiled: December 18, 1978Date of Patent: April 28, 1981Assignee: United Technologies CorporationInventor: Thomas C. Warren
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Patent number: 4263071Abstract: The addition of copper phthalocyanine to composite solid propellant compositions has been found to substantially reduce the tendency toward combustion instability of the propellant. The invention is particularly useful in connection with smokeless composite propellants employing hydroxy-terminated polybutadiene as a binder.Type: GrantFiled: July 19, 1974Date of Patent: April 21, 1981Assignee: United Technologies CorporationInventors: Leland S. Bain, Thomas P. Rudy
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Patent number: 4260437Abstract: Metals such as copper and the transition elements may give rise to serious problems in conventional rubber based solid propellant binders. These metals may accelerate the curing action to such a degree that the pot life of the freshly mixed propellant is reduced. Also the metals may promote oxidative degradation of cured and uncured binder systems. These undesirable effects can be prevented by adding to the uncured binder certain binder soluble agents which are capable of forming stable complexes with the undesirable metals in which the valence of the metal ion is fixed. A wide variety of chelating agents can be used and include, particularly, the condensation products of salicylaldehyde with aliphatic di- and polyamines and with o-aminophenols.Type: GrantFiled: May 4, 1979Date of Patent: April 7, 1981Assignee: United Technologies CorporationInventors: Toshio W. Nakagawa, Thomas P. Rudy