Patents Represented by Attorney Steven F. Stone

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  • Osmotic system with instant drug availability
    Patent number: 4576604
    Abstract: An osmotic device is disclosed for delivering a beneficial agent. The device comprises a wall surrounding a compartment containing an agent, a passageway in the wall connecting the exterior of the device with the compartment, and (a) an agent in the wall or (b) an agent carried on the wall in the wall. The device delivers the agent from the compartment and the wall.
    Type: Grant
    Filed: March 4, 1983
    Date of Patent: March 18, 1986
    Assignee: ALZA Corporation
    Inventors: George V. Guittard, Joseph C. Deters, Felix Theeuwes, Richard Cortese
  • Transdermal therapeutic systems for the administration of naloxone, naltrexone and nalbuphine
    Patent number: 4573995
    Abstract: A method for transdermal delivery of naloxone, naltrexone and nalbuphine base through intact skin is described. Preferred embodiments of transdermal therapeutic systems for delivering these drugs and polyethylene glycol monolaurate employ an ethylene vinylacetate matrix containing drug base at a concentration above saturation and polyethylene glycol monolaurate below unit activity. Polyethylene glycol manolaurate is disclosed as a permeation enhancer for the base form of these drugs and is preferably delivered simultaneously with the drug.
    Type: Grant
    Filed: October 9, 1984
    Date of Patent: March 4, 1986
    Assignee: ALZA Corporation
    Inventors: Yu-Ling Chen, Leslie L. Chun, David J. Enscore
  • Skin permeation enhancer compositions
    Patent number: 4568343
    Abstract: A method for enhancing the transdermal flux of a transdermally deliverable drug through intact skin is described in which the drug is delivered simultaneously with polyethylene glycol monolaurate. Preferred embodiments of transdermal therapeutic systems for delivering drug and polyethylene glycol monolaurate employ matrix containing drug at a concentration above saturation.
    Type: Grant
    Filed: October 9, 1984
    Date of Patent: February 4, 1986
    Assignee: Alza Corporation
    Inventors: Harold M. Leeper, Diane Nedberge, Lina T. Taskovich
  • Active agent dispenser
    Patent number: 4564364
    Abstract: The release pattern of a dispersion type active agent dispenser can be improved by forming the device from a depleted zone containing the agent at a concentration no greater than the saturation and a non-depleted zone containing the agent dispersed in the matrix at a uniform concentration greater than saturation. The depleted zone is disposed between the surface through which the agent is to be dispensed and at least a substantial portion of the non-depleted zone with the interface therebetween disposed at a non-uniform distance from the releasing surface. Certain embodiments are particularly useful for the transdermal administration of drugs.
    Type: Grant
    Filed: May 26, 1983
    Date of Patent: January 14, 1986
    Assignee: ALZA Corporation
    Inventors: Alejandro Zaffaroni, Patrick S. L. Wong
  • Matrix composition for transdermal therapeutic system
    Patent number: 4559222
    Abstract: Mineral oil (MO) polyisobutylene (PIB), colloidal silicon dioxide (CSD) mixtures suitable for use as drug containing matrices in transdermal delivery systems are disclosed. Preferred systems for dispensing moderately mineral oil soluble drugs contain at least about 6% CSD, have a MO/PIB of at least 1.0 and a viscosity of at least 1.5.times.10.sup.7 poises. Preferred systems for dispensing clonidine have a clonidine permeability of at least 1.0.times.10.sup.-4 .mu.g/cm sec and a MO/PIB of at least 1.2.
    Type: Grant
    Filed: May 4, 1983
    Date of Patent: December 17, 1985
    Assignee: ALZA Corporation
    Inventors: David J. Enscore, Robert M. Gale
  • Process for preparing osmotic device
    Patent number: 4553973
    Abstract: An osmotic delivery system is disclosed for dispensing a useful agent. The system comprises a semipermeable wall surrounding a compartment housing the agent. The wall comprises a cellulose ether, an organic solvent soluble polymer, and optionally an aqueous soluble polymer. A passageway in the wall connects the interior of the system with the exterior for dispensing an agent from the system.
    Type: Grant
    Filed: February 1, 1985
    Date of Patent: November 19, 1985
    Assignee: Alza Corporation
    Inventor: David Edgren
  • Body mounted pump housing and pump assembly employing the same
    Patent number: 4552561
    Abstract: A self-contained body mounted pump assembly for continuously administering a therapeutic agent parenterally. The pump has a transparent top through which the contents can be seen and outwardly flaring sides to provide for comfort, stability and other useful features. The pump assembly is driven by a fluid imbibing, preferably osmotic pump and contains its own source of actuating fluid. Means for superimposing a pulse dose on the tonic flow are also described.
    Type: Grant
    Filed: December 23, 1982
    Date of Patent: November 12, 1985
    Assignee: ALZA Corporation
    Inventors: James B. Eckenhoff, John R. Peery, Felix A. Landrau
  • System for intravenous delivery of a beneficial agent
    Patent number: 4552555
    Abstract: A formulation chamber is disclosed comprising a wall surrounding a space containing a beneficial agent. The formulation chamber has an inlet for admitting a fluid into the chamber and an outlet for letting the fluid containing the agent leave the chamber. The chamber can additionally comprise a film for regulating the rate of release from the chamber, and optionally a filter. The chamber is adapted for use in an intravenous delivery system for delivering the fluid containing the agent to a patient. A method also is disclosed for using the formulation chamber.
    Type: Grant
    Filed: October 19, 1981
    Date of Patent: November 12, 1985
    Assignee: ALZA Corporation
    Inventor: Felix Theeuwes
  • Parenteral controlled therapy
    Patent number: 4552556
    Abstract: A parenteral delivery set is disclosed for administering a beneficial agent to a recipient. The set comprises (a) a primary container of a medical fluid; (b) a primary tubing in fluid communication with the primary container; (c) a secondary container of a medical fluid; (d) a secondary tubing in fluid communication with the secondary container; (e) a formulation chamber connected to the secondary tubing and housing an agent dispensing device or the beneficial agent; and (f) a common tubing in communication with the primary tubing and the secondary tubing for communicating the set to the recipient.
    Type: Grant
    Filed: January 4, 1985
    Date of Patent: November 12, 1985
    Assignee: ALZA Corporation
    Inventors: John Urquhart, Felix Theeuwes
  • Parenteral controlled therapy
    Patent number: 4548599
    Abstract: A parenteral delivery set is disclosed for administering a beneficial agent to a recipient. The set comprises (a) a primary container of a medical fluid; (b) a primary tubing in fluid communication with the primary container; (c) a secondary container of a medical fluid; (d) a secondary tubing in fluid communication with the secondary container; (e) a formulation chamber connected to the secondary tubing and housing an agent dispensing device or the beneficial agent; and (f) a common tubing in communication with the primary tubing and the secondary tubing for communicating the set to the recipient.
    Type: Grant
    Filed: January 5, 1984
    Date of Patent: October 22, 1985
    Assignee: ALZA Corporation
    Inventors: John Urquhart, Felix Theeuwes
  • Parenteral agent dispensing equipment
    Patent number: 4548598
    Abstract: A parenteral delivery system and a formulation chamber are disclosed for administering a beneficial agent. The parenteral delivery system comprises a drip chamber and a formulation chamber. The formulation chamber comprises a wall surrounding an internal space and it has an inlet for admitting a liquid into the formulation chamber and an outlet for letting an agent formulation leave the formulation chamber The chamber houses an agent delivery system for releasing a beneficial agent into a liquid that enters the chamber.
    Type: Grant
    Filed: February 3, 1984
    Date of Patent: October 22, 1985
    Assignee: ALZA Corporation
    Inventor: Felix Theeuwes
  • Parenteral dispensing system with programmable drug administration
    Patent number: 4540403
    Abstract: A parenteral delivery system is disclosed for administering a beneficial agent to an agent-receiving recipient. The parenteral system comprises an electrotransport apparatus that admits an agent at an electrically controlled rate into medical fluid that flows through the parenteral system over delivery time.
    Type: Grant
    Filed: July 2, 1984
    Date of Patent: September 10, 1985
    Assignee: Alza Corporation
    Inventor: Felix Theeuwes
  • Self-driven pump assembly and method of operation
    Patent number: 4539004
    Abstract: A pump assembly particularly useful as an infusor for parenteral administration of a small amount of a therapeutically active substance for a prolonged period of time at a substantially constant rate comprising a fluid imbibing pump mounted within a receptacle into which actuating fluid may be charged. The active agent is dispensed from the pump after the pump is exposed to the fluid. Means to vary or stop the pump by obdurating all or a portion of the exterior surface of the pump can also be provided. Variation in flow rates can also be obtained by changing the composition of the actuating fluid.
    Type: Grant
    Filed: April 23, 1984
    Date of Patent: September 3, 1985
    Assignee: ALZA Corporation
    Inventors: James B. Eckenhoff, Virgil A. Place, John R. Peery
  • In-line drug dispenser for use in intravenous therapy
    Patent number: 4533348
    Abstract: A formulation dispenser is disclosed for use in a parenteral delivery system. The dispenser comprises an inlet for admitting fluid into the dispenser and an outlet for letting fluid leave the dispenser. A beneficial agent is housed in a formulation chamber in the dispenser and a membrane permeable to fluid and agent defines one boundary of the formulation chamber. A piston is slideably disposed in the dispenser for governing the flow of fluid through the dispenser, or for permitting fluid to contact the membrane and enter the formulation chamber for forming a solution containing agent that flows through the outlet into the parenteral system.
    Type: Grant
    Filed: September 12, 1984
    Date of Patent: August 6, 1985
    Assignee: ALZA Corporation
    Inventors: Allan M. Wolfe, James M. Davenport, Felix Theeuwes, Su I. Yum
  • Vaginal diaphragm
    Patent number: 4526578
    Abstract: A vaginal diaphragm is disclosed comprising an annular reservoir housing a beneficial agent, and in a preferred embodiment the diaphragm film embraces a means for containing and releasing a beneficial agent.
    Type: Grant
    Filed: May 16, 1983
    Date of Patent: July 2, 1985
    Assignee: ALZA Corporation
    Inventor: Patrick S. L. Wong
  • Parenteral controlled delivery
    Patent number: 4525162
    Abstract: A parenteral delivery set is disclosed for administering a beneficial agent to a recipient. The set comprises (a) a primary container of a medical fluid; (b) a primary tubing in fluid communication with the primary container; (c) a secondary container of a medical fluid; (d) a secondary tubing in fluid communication with the secondary container; (e) a formulation chamber connected to the secondary tubing and housing an agent dispensing device or the beneficial agent; and (f) a common tubing in communication with the primary tubing and the secondary tubing for communicating the set to the recipient.
    Type: Grant
    Filed: March 9, 1984
    Date of Patent: June 25, 1985
    Assignee: ALZA Corporation
    Inventors: John Urquhart, Felix Theeuwes
  • Multiple fluid pulse dispenser
    Patent number: 4522622
    Abstract: A multiple fluid pulse dispenser comprising a plurality of interconnected fluid reservoirs defined by mating, oppositely directed concavities at least one of which mating concavity is formed from an invertable, preferrably permanently deformable blister. The reservoirs are in fluid communication with an outlet through which the contents of the reservoirs may be dispensed. A preferred embodiment permits fluid to flow through a reservoir after it has been discharged to allow random activation of the individual reservoirs.
    Type: Grant
    Filed: December 23, 1982
    Date of Patent: June 11, 1985
    Assignee: ALZA Corporation
    Inventors: John R. Peery, James B. Eckenhoff
  • Drug dispenser comprising wall formed of semipermeable member and enteric member
    Patent number: 4522625
    Abstract: An osmotic dispenser is disclosed for releasing drug formulation in the gastrointestinal tract. The dispenser comprises a semipermeable-enteric wall surrounding a compartment housing drug formulation. A passageway in the wall communicates with the compartment for dispensing drug formulation.
    Type: Grant
    Filed: September 29, 1982
    Date of Patent: June 11, 1985
    Assignee: Alza Corporation
    Inventor: David Edgren
  • Parenteral agent dispensing equipment
    Patent number: 4521211
    Abstract: A parenteral delivery system and a formulation chamber are disclosed for administering a beneficial agent. The parenteral delivery system comprises a drip chamber and a formulation chamber. The formulation chamber comprises a wall surrounding an internal space and it has an inlet for admitting a liquid into the formulation chamber and an outlet for letting an agent formulation leave the formulation chamber. The chamber houses an agent delivery system for releasing a beneficial agent into a liquid that enters the chamber.
    Type: Grant
    Filed: February 3, 1984
    Date of Patent: June 4, 1985
    Assignee: ALZA Corporation
    Inventor: Felix Theeuwes
  • Body mounted pump for dispensing medication
    Patent number: D281528
    Type: Grant
    Filed: December 23, 1982
    Date of Patent: November 26, 1985
    Assignee: ALZA Corporation
    Inventors: John R. Peery, James B. Eckenhoff