Patents Represented by Attorney William H. Edgerton

Find this attorney in the Justia Lawyer Directory

  • Pharmaceutical compositions and methods involving benzazepine derivatives
    Patent number: 4011319
    Abstract: Pharmaceutical compositions and a method of stimulating peripheral dopamine receptors by administering internally a nontoxic effective quantity of a benzazepine derivative to an animal. Renal vasodilator and diuretic methods are also disclosed.
    Type: Grant
    Filed: July 2, 1975
    Date of Patent: March 8, 1977
    Assignee: SmithKline Corporation
    Inventors: Carl Kaiser, Robert G. Pendleton
  • Pharmaceutical compositions and methods of inhibiting .beta.-adrenergic receptors
    Patent number: 4011321
    Abstract: The compounds are 6-(3-substituted amino-2-hydroxypropoxyaryl)-4,5-dihydro-3(2H)-pyridazinones which are .beta.-adrenergic blocking agents.
    Type: Grant
    Filed: September 15, 1975
    Date of Patent: March 8, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: William John Coates, Anthony Maitland Roe, Robert Antony Slater
  • Varicella-zoster virus vaccine and preparation thereof
    Patent number: 4008317
    Abstract: Non-pathogenic varicella-zoster virus mutants are obtained by induction and isolation of temperature-sensitive mutant strains. N-methyl-N'-nitro-N-nitrosoguanidine is employed as mutagenic agent. The obtained mutants are useful for vaccine production.
    Type: Grant
    Filed: December 29, 1975
    Date of Patent: February 15, 1977
    Assignee: Recherche et Industrie Therapeutiques (R.I.T.)
    Inventor: Jacqueline Gits
  • .alpha.-amino-.alpha.-(ureidophenyl)acetamidocephalosporins
    Patent number: 4007173
    Abstract: Cephalosporins with a .alpha.-amino-(ureidophenyl)acetamido substituent at position 7 are prepared by acylation of a 7-aminocephalosporin with a derivative of .alpha.-amino-p(or m)-ureidophenylacetic acid. These compounds are antibacterial agents.
    Type: Grant
    Filed: May 7, 1973
    Date of Patent: February 8, 1977
    Assignee: SmithKline Corporation
    Inventors: John Russel Eugene Hoover, Jerry Arnold Weisbach
  • O-acyl-7-acylaminocephalosporadesic acids
    Patent number: 4007178
    Abstract: A method for O-acylating the 3-hydroxymethyl group of 7-acylaminocephalosporadesic acids by reaction with an azolide and new O-acyl-7-acylaminocephalosporadesic acids in which the O-acyl group is derived from an alkoxyalkanoic acid or an amino acid.
    Type: Grant
    Filed: May 15, 1975
    Date of Patent: February 8, 1977
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • Epoxidation of .alpha.,.beta.-ethylenic ketones
    Patent number: 4006169
    Abstract: A method of preparing .alpha.,.beta.-epoxy ketones by reacting water-soluble .alpha.,.beta.-ethylenic ketones with sodium hypochlorite. Especially useful for preparing 3,4-epoxy-butanone.
    Type: Grant
    Filed: February 26, 1976
    Date of Patent: February 1, 1977
    Assignee: SmithKline Corporation
    Inventors: Elvin L. Anderson, Bing L. Lam, George R. Wellman
  • Compositions and methods for inhibiting H.sub.2 histamine receptors
    Patent number: 4005205
    Abstract: Heterocyclic compounds which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A specific compound of this invention is 2-[2-(4-methyl-5-imidazolylmethylthio)ethylamino]-4-pyrimidone.
    Type: Grant
    Filed: October 6, 1975
    Date of Patent: January 25, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, John Colin Emmett, Charon Robin Ganellin
  • N-Heterocyclic-9-xanthenylamines
    Patent number: 4005208
    Abstract: The compounds are N-piperidinyl and pyrrolidinyl-9-xanthenylamines which are inhibitors of gastric acid secretion.
    Type: Grant
    Filed: May 16, 1975
    Date of Patent: January 25, 1977
    Assignee: SmithKline Corporation
    Inventors: Paul E. Bender, Bernard Loev
  • Phenoxypropanolamines
    Patent number: 4004028
    Abstract: Phenoxypropanolamine derivatives are prepared. These compounds have .beta.-adrenergic stimulant activity particularly as selective bronchodilators.
    Type: Grant
    Filed: August 6, 1975
    Date of Patent: January 18, 1977
    Assignee: SmithKline Corporation
    Inventor: Carl Kaiser
  • 6-Aminopenicillanic acid derivative
    Patent number: 4002530
    Abstract: Penicillin derivative substituted at the 6 position with a (D)-[(2-amino-2-carboxy)-ethylthio]-acetamido group is obtained from Acremonium Chrysogenum new strain ATCC 20 389 or by semi-synthetic route. The product is an antibacterial agent.
    Type: Grant
    Filed: January 9, 1975
    Date of Patent: January 11, 1977
    Assignee: Recherche et Industrie Therapeutiques (R.I.T.)
    Inventors: Hugo Troonen, Piet Roelants, Bernard Boon
  • 2,3-Bis-(3-lower alkanoyl-2-thioureido)-pyridines
    Patent number: 4002761
    Abstract: New 2,3-bis-(3-acyl-2-thioureido)-pyridines having anthelmintic activity are prepared by reacting a diaminopyridine with acylthiocyanates.
    Type: Grant
    Filed: February 10, 1976
    Date of Patent: January 11, 1977
    Assignee: SmithKline Corporation
    Inventor: Roger C. Parish
  • Pyridylbutylamino ethylene compounds
    Patent number: 4002759
    Abstract: The compounds are ethylene derivatives which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A compound of this invention is 1-nitro-2-methylamino-2-[4-(3-chloro-pyridyl)butylamino]ethylene.
    Type: Grant
    Filed: November 5, 1975
    Date of Patent: January 11, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, John Colin Emmett, Charon Robin Ganellin, Hunter Douglas Prain
  • 2-Alkoxy(and 2-alkoxyalkyl)-2-quinolyl-thioacetamides
    Patent number: 4001241
    Abstract: The compounds are 2-alkoxy(and 2-alkoxyalkyl)-2-heterocyclic-thioacetamides which are inhibitors of gastric acid secretion.
    Type: Grant
    Filed: June 12, 1975
    Date of Patent: January 4, 1977
    Assignee: SmithKline Corporation
    Inventors: Helene E. Bowman Van Hoeven, L. Martin Brenner, Bernard Loev
  • Substituted benzofurans and benzothiophenes
    Patent number: 4001426
    Abstract: The compounds are benzoyl benzofurans and benzothiophenes having pharmacological activity, in particular, coronary vasodilator activity useful for the treatment of angina pectoris and intermediates for the preparation thereof.
    Type: Grant
    Filed: May 9, 1975
    Date of Patent: January 4, 1977
    Assignee: SmithKline Corporation
    Inventors: L. Martin Brenner, Charles K. Brush
  • Pharmaceutical compositions and methods of inhibiting H-1 and H-2 histamine receptors
    Patent number: 4000302
    Abstract: Pharmaceutical compositions and methods of inhibiting H-1 and H-2 histamine receptors by administering an antihistamine and an H-2 histamine receptor inhibitor. Exemplary of the antihistamine in the compositions and methods of this invention is mepyramine and exemplary of the H-2 histamine receptor inhibitor is N-cyano-N'-methyl-N"-[2-((4-methyl-5-imidazolyl)-methylthio)ethyl]guanidin e.
    Type: Grant
    Filed: April 16, 1975
    Date of Patent: December 28, 1976
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: James Whyte Black, Michael Edward Parsons
  • Imidazole alkylguanidine compounds
    Patent number: 4000296
    Abstract: The compounds are guanidines, for example N-benzenesulphonyl-N'-[2-((4-methyl-5-imidazolyl)-methylthio)ethyl]guanidi ne, which are inhibitors of histamine activity.
    Type: Grant
    Filed: March 21, 1975
    Date of Patent: December 28, 1976
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, John Colin Emmett, Charon Robin Ganellin
  • 2,3-Bis-(3-acyl-2-thioureido)-pyridines
    Patent number: 4000285
    Abstract: New 2,3-bis-(3-acyl-2-thioureido)-pyridines having anthelmintic activity are prepared by reacting a diaminopyridine with acylthiocyanates.
    Type: Grant
    Filed: February 10, 1976
    Date of Patent: December 28, 1976
    Assignee: SmithKline Corporation
    Inventor: Roger C. Parish
  • 3-Substituted-6.beta.-(amino- and acylamino)-7-oxo-1,3-diazabicyclo[3.2.0]- h
    Patent number: 4000154
    Abstract: Novel bicyclic .beta.-lactam penicillin analogs which have antibacterial activity and intermediates for the synthesis thereof are disclosed. In particular, 3-acetyl-7-oxo-6.beta.-phenoxyacetylamino-1,3-diazabicyclo[3.2.0]heptane-2 -carboxylic acid and derivatives thereof are prepared.
    Type: Grant
    Filed: September 3, 1975
    Date of Patent: December 28, 1976
    Assignee: SmithKline Corporation
    Inventors: John G. Gleason, Kenneth G. Holden, William F. Huffman
  • Trifluoroethylmercapto, -sulfinyl or -sulfonyl acetamidocephalosporins
    Patent number: 3998818
    Abstract: Novel cephalosporins with the trifluoroethylmercaptoacetamido, trifluoroethylsulfinylacetamido, and trifluoroethylsulfonylacetamido groups at position 7 are prepared. These compounds have antibacterial activity.
    Type: Grant
    Filed: December 29, 1975
    Date of Patent: December 21, 1976
    Assignee: SmithKline Corporation
    Inventor: Robert M. DeMarinis
  • Trifluoroethyl-mercapto, -sulfinyl or -sulfonyl acetamidocephalosporins
    Patent number: 3998819
    Abstract: Novel cephalosporins with the trifluoroethylmercaptoacetamido, trifluoroethylsulfinylacetamido, and trifluoroethylsulfonylacetamido groups at position 7 are prepared. These compounds have antibacterial activity.
    Type: Grant
    Filed: December 29, 1975
    Date of Patent: December 21, 1976
    Assignee: SmithKline Corporation
    Inventor: Robert M. DeMarinis