Patents Represented by Attorney William H. Edgerton

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  • Coronary vasodilator and anti-anginal compositions comprising substituted benzofurans and benzothiophenes and methods of producing coronary vasodilation and anti-anginal activity
    Patent number: 4024273
    Abstract: The compounds of this invention are substituted benzofurans and benzothiophenes having pharmacological activity. In particular, these compounds have coronary vasodilator activity and are useful in the treatment of angina pectoris.
    Type: Grant
    Filed: November 17, 1975
    Date of Patent: May 17, 1977
    Assignee: SmithKline Corporation
    Inventors: L. Martin Brenner, John M. Petta, Stephen T. Ross
  • Certain thiazole, isothiazole, oxazole, and isoxazole compounds
    Patent number: 4022797
    Abstract: The compounds are substituted thioalkyl-, aminoalkyl- and oxyalkyl-guanidines which are inhibitors of histamine activity.
    Type: Grant
    Filed: December 4, 1975
    Date of Patent: May 10, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, John Colin Emmett, Charon Robin Ganellin
  • Substituted phenylglycylcephalosporins
    Patent number: 4022895
    Abstract: Cephalosporin compounds having a substituted phenylglycyl substituent at the 7-position and any of a variety of groups at the 3-position are prepared by acylation of a 7-aminocephalosporanic acid. The compounds have antibacterial activity.
    Type: Grant
    Filed: December 15, 1975
    Date of Patent: May 10, 1977
    Assignee: SmithKline Corporation
    Inventor: John Gerald Gleason
  • 7.beta.-Acyloxy cephalosporins
    Patent number: 4020057
    Abstract: The compounds of this invention are cephalosporins having a 7.beta.-acyloxy group and 7.beta.-hydroxy intermediates for the preparation thereof. The compounds have antibacterial activity.
    Type: Grant
    Filed: June 18, 1975
    Date of Patent: April 26, 1977
    Assignee: SmithKline Corporation
    Inventor: John G. Gleason
  • Process for O-acylating thallus salts of 2-pyridone
    Patent number: 4020073
    Abstract: Thallous salts of .beta.-dicarbonyl compounds, prepared by reaction of the .beta.-dicarbonyl compounds with a thallous alkoxide, are treated with alkyl halides to give C-alkyl products in high yield, with acyl halides at room temperature to give C-acyl products, and with acyl halides at low temperatures to give O-acyl products. Thallous phenolates are esterified with acyl or aroyl halides. Anhydrides are also prepared, as are biaryls and bi-sec-alkyls. N-heterocyclics, including purines and pyrimidines, are N-alkylated. Lactams are O-acylated or N-alkylated.
    Type: Grant
    Filed: May 21, 1974
    Date of Patent: April 26, 1977
    Inventors: Edward C. Taylor, Alexander McKillop
  • 3-Heterocyclicthiomethylcephalosporins
    Patent number: 4018759
    Abstract: Cephalosporins containing a heterocyclicthiomethyl group at position 3 are prepared. The heterocyclic group is 5-oxo-.DELTA..sup.2 -1,2,4-triazolinyl, 5-thiono-.DELTA..sup.2 -1,2,4-triazolinyl, 5-oxo-.DELTA..sup.2 -1,2,4-thiadiazolinyl or 5-thiono-.DELTA..sup.2 -1,3,4-thiadiazolinyl. The compounds have antibacterial activity.
    Type: Grant
    Filed: December 29, 1975
    Date of Patent: April 19, 1977
    Assignee: SmithKline Corporation
    Inventor: David Alan Berges
  • Substituted phenylglycylcephalosporins
    Patent number: 4018921
    Abstract: Cephalosporin compounds having a substituted phenylglycyl substituent at the 7-position and any of a variety of groups at the 3-position are prepared by acylation of a 7-aminocephalosporanic acid. The compounds have antibacterial activity.
    Type: Grant
    Filed: December 15, 1975
    Date of Patent: April 19, 1977
    Assignee: SmithKline Corporation
    Inventor: John Gerald Gleason
  • Pharmacologically active thiourea and urea compounds
    Patent number: 4018931
    Abstract: The compounds are substituted thioalkyl-, aminoalkyl- and oxyalkyl-thioureas and ureas which are inhibitors of histamine activity.
    Type: Grant
    Filed: December 4, 1975
    Date of Patent: April 19, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, John Colin Emmett, Charon Robin Ganellin
  • Pyridyl substituted aminoalkyl-thioureas and ureas
    Patent number: 4018928
    Abstract: The compounds are pyridyl substituted aminoalkylthioureas and ureas which are inhibitors of H-2 histamine receptors. A compound of this invention is N-methyl-N'-[2-(2-pyridylmethylamino)ethyl]thiourea.
    Type: Grant
    Filed: October 29, 1975
    Date of Patent: April 19, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, John Colin Emmett, Charon Robin Ganellin
  • Stable oxidase reagent solutions
    Patent number: 4017420
    Abstract: Stable oxidase reagent solutions containing N,N,N',N'-tetramethyl-p-phenylenediamine or N,N-dimethyl-p-phenylenediamine for determining the presence of oxidase in microbial colonies.
    Type: Grant
    Filed: December 22, 1975
    Date of Patent: April 12, 1977
    Assignee: SmithKline Corporation
    Inventors: Betty Anne Bowie, Joseph F. Pagano
  • Substituted 3-(1-aminoethylidene)-5-cinnamoyl-2H-pyran-2,6(3H)-diones
    Patent number: 4017633
    Abstract: Substituted 3-(1-aminoethylidene)-5-cinnamoyl-2H-pyran-2,6(3H)-diones useful as inhibitors of certain antigen-antibody reactions, particularly in alleviating allergic manifestations such as asthma, are prepared by reaction of a 3-(1-aminoethylidene)-5-acetyl-2H-pyran-2,6(3H)-dione with an appropriately substituted benzaldehyde.
    Type: Grant
    Filed: February 18, 1976
    Date of Patent: April 12, 1977
    Assignee: SmithKline Corporation
    Inventor: Chester Rhodes Willis
  • Pharmaceutical compositions comprising substituted 3-cinnamoyl-2H-pyran-2,6(3H)-diones
    Patent number: 4015009
    Abstract: Pharmaceutical compositions comprising a substituted 3-cinnamoyl-2H-pyran-2,6(3H)-dione and methods of inhibiting the antigen-antibody reaction by administering said compositions. Certain of the 3-cinnamoyl-2H-pyran-2,6(3H)-diones are novel compounds per se.
    Type: Grant
    Filed: February 19, 1976
    Date of Patent: March 29, 1977
    Assignee: SmithKline Corporation
    Inventors: Lawrence William Chakrin, Kenneth Means Snader, Chester Rhodes Willis
  • Certain N,N'-disubstituted guanidine compounds and their use
    Patent number: 4013659
    Abstract: N-(4-Imidazolyl)propyl-N'-heterocyclomethylthioethyl guanidines which are selective histamine H.sub.2 -receptor agonists.
    Type: Grant
    Filed: December 15, 1975
    Date of Patent: March 22, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, Charon Robin Ganellin, Michael Edward Parsons
  • Bis-phenoxypropanolamines
    Patent number: 4013777
    Abstract: Bis-phenoxypropanolamine derivatives are prepared. These compounds have .beta.-adrenergic stimulant activity particularly as selective bronchodilators.
    Type: Grant
    Filed: August 22, 1975
    Date of Patent: March 22, 1977
    Assignee: SmithKline Corporation
    Inventors: Donald F. Colella, Carl Kaiser
  • Pharmaceutical compositions comprising substituted phenylglycylcephalosporins and methods of treating bacterial infections
    Patent number: 4013764
    Abstract: Cephalosporin compounds having a substituted phenylglycyl substituent at the 7-position and any of a variety of groups at the 3-position are prepared by acylation of a 7-aminocephalosporinic acid. The compounds have antibacterial activity.
    Type: Grant
    Filed: December 15, 1975
    Date of Patent: March 22, 1977
    Assignee: SmithKline Corporation
    Inventor: John Gerald Gleason
  • Compositions and methods for treating bacterial infections with substituted acetamidocephalosporins
    Patent number: 4013765
    Abstract: Novel cephalosporins with the trifluoroethyl-mercaptoacetamido, trifluoroethylsulfinylacetamido, and trifluoroethylsulfonylacetamido groups at position 7 are prepared. These compounds have antibacterial activity.
    Type: Grant
    Filed: December 29, 1975
    Date of Patent: March 22, 1977
    Assignee: SmithKline Corporation
    Inventor: Robert M. DeMarinis
  • Pyridyl-alkylaminoethylene compounds
    Patent number: 4013769
    Abstract: The compounds are ethylene derivatives which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A compound of this invention is 1-nitro-2-[2-((4-methyl-5-imidazolyl)methylthio)ethylamino]-2-[2-((3-chlor o-2-pyridyl)methylthio)ethylamino]ethylene.
    Type: Grant
    Filed: November 5, 1975
    Date of Patent: March 22, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, John Colin Emmett, Charon Robin Ganellin, Hunter Douglas Prain
  • Process for preparing heterocyclicalkylthioalkyl-N-cyanoguanidines
    Patent number: 4013678
    Abstract: Process for preparing heterocyclicalkylthioalkyl-N-cyanoguanidines and thioureas by treating a heterocyclicalkyl derivative with a mercaptoalkyl-N-cyanoguanidine or thiourea. Two specific products are N-cyano-N'-methyl-N"-[2-((5-methyl-4-imidazolyl)methylthio)ethyl]guanidine and N-methyl-N'-[2-((5-methyl-4-imidazolyl)methylthio)ethyl]thiourea, both useful as histamine H.sub.2 -antagonists.
    Type: Grant
    Filed: August 20, 1975
    Date of Patent: March 22, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Thomas Henry Brown, Graham John Durant, John Colin Emmett, Charon Robin Ganellin
  • .alpha.-AMINOALKYL-3-(1,2-DIHYDROXYETHYL)-4-HYDROXY-BENZYL ALCOHOLS HAVING .beta.-ADRENERGIC STIMULANT ACTIVITY
    Patent number: 4012528
    Abstract: .alpha.-Aminoalkyl-3-(1,2-dihydroxyethyl)-4-hydroxy-benzyl alcohols having .beta.-adrenergic stimulant activity, particularly as selective bronchodilators, are disclosed.
    Type: Grant
    Filed: June 13, 1975
    Date of Patent: March 15, 1977
    Assignee: SmithKline Corporation
    Inventors: Timothy Yu-Wen Jen, Carl Kaiser, Joe R. Wardell
  • 4-Sulfanilamidothiazole
    Patent number: 4011210
    Abstract: 4-Sulfanilamidothiazole having antibacterial activity is prepared from the previously unknown 4-aminothiazole.
    Type: Grant
    Filed: November 7, 1975
    Date of Patent: March 8, 1977
    Assignee: SmithKline Corporation
    Inventors: Gregory Gallagher, Jr., William D. Kingsbury