Patents Represented by Attorney William H. Edgerton

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  • Certain thiazolyl and isothiazolyl compounds and compositions and methods which employ them
    Patent number: 4038408
    Abstract: The compounds are heterocyclomethylsulphinylethyl derivatives of N-cyanoguanidines, thioureas and 2-amino-1-nitroethylene which are histamine H.sub.2 -antagonists or are converted into histamine H.sub.2 -antagonists in the animal body. Two specific compounds of the present invention are 1-nitro-2-[2-((2-thiazolyl)methylsulphinyl)ethylamino]-2-[2-((2-thiazolyl) methylthio)ethylamino]ethylene and 1-nitro-2,2-bis-[2-((2-thiazolyl)methylsulphinyl)ethylamino]ethylene.
    Type: Grant
    Filed: July 13, 1976
    Date of Patent: July 26, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, Charon Robin Ganellin, Torben Hesselbo, George Raymond White
  • Amidino compounds
    Patent number: 4036971
    Abstract: The compounds are N-(heterocyclomethylthioalkyl)derivatives of alkylguanidines, C-alkyl and C-aryl amidines and S-alkyl-isothioureas. The compounds may also have N'-lower alkyl or N'-(heterocyclomethylthioalkyl)substituents. Three compounds of the invention are S-methyl-N-[2-(5-methyl-4-imidazolylmethylthio)ethyl]isothiourea, N,N'-bis-[2-(5-methyl-4-imidazolylmethylthio)ethyl]acetamidine, N,N'-bis-[2-(5-methyl-4-imidazolylmethylthio)ethyl]N"-methylguanidine. The compounds of this invention are histamine H.sub.2 -antagonists.
    Type: Grant
    Filed: February 19, 1975
    Date of Patent: July 19, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, Charon Robin Ganellin, Rodney Christopher Young
  • Imidazolyl alkylaminopyridone and pyridinethione compounds
    Patent number: 4035374
    Abstract: Heterocyclic compounds which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A specific compound of this invention is 2-[2-(4-methyl-5-imidazolylmethylthio)ethylamino]-4-pyrimidone.
    Type: Grant
    Filed: October 6, 1975
    Date of Patent: July 12, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, John Colin Emmett, Charon Robin Ganellin
  • N-Oxy and N-amino guanidines
    Patent number: 4034101
    Abstract: The compounds are N-oxy and N-amino guanidines which are histamine H.sub.2 -antagonists. A compound of this invention is N-hydroxy-N'methyl-N"-[2-((4-methyl-5-imidazolyl)methylthio)-ethyl]guanidi ne.
    Type: Grant
    Filed: June 11, 1975
    Date of Patent: July 5, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, Charon Robin Ganellin, Geoffrey Robert Owen
  • 7-Acyl-3-(carboxyalkyl and carbamoylalkyl substituted oxadiazolylthiomethyl) cephalosporins
    Patent number: 4034092
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a carboxyalkyl or carbamoylalkyl substituted oxadiazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: May 3, 1976
    Date of Patent: July 5, 1977
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • Substituted 2H-pyran-2,6(3H)-dione derivatives, pharmaceutical compositions comprising such derivatives and methods of inhibiting the antigen-antibody reaction
    Patent number: 4032652
    Abstract: Substituted 2H-pyran-2,6(3H)-dione derivatives, pharmaceutical compositions comprising such derivatives and methods of inhibiting the antigen-antibody reaction by administering said compositions. The active ingredients are the products formed by the reaction of acetonedicarboxylic acid with acetic anhydride followed by reaction with an appropriate amine. Certain of the dione derivatives are novel compounds per se.
    Type: Grant
    Filed: April 30, 1976
    Date of Patent: June 28, 1977
    Assignee: SmithKline Corporation
    Inventors: Lawrence W. Chakrin, Kenneth M. Snader, Chester R. Willis
  • Aromatic prostaglandin derivatives
    Patent number: 4032656
    Abstract: Aromatic prostaglandin derivatives are prepared. These compounds have valuable antiprostaglandin activity specifically inhibiting prostaglandin synthesis and antagonizing diarrhea induced by prostaglandin E.sub.2 (PGE.sub.2).
    Type: Grant
    Filed: November 21, 1975
    Date of Patent: June 28, 1977
    Assignee: SmithKline Corporation
    Inventors: William G. Groves, Bernard Loev, Carl D. Perchonock
  • Feline viral rhinotracheitis vaccine and combination feline viral rhinotracheitis-calicivirus vaccine prepared therefrom
    Patent number: 4031204
    Abstract: A modified live feline viral rhinotracheitis vaccine is prepared by treating with ultraviolet light a feline viral rhinotracheitis virus which has been subjected to chemical treatment with mutagens. A combination feline viral rhinotracheitis-calicivirus vaccine is prepared by combining a modified live feline viral rhinotracheitis virus and naturally-occurring calicivirus.
    Type: Grant
    Filed: March 30, 1976
    Date of Patent: June 21, 1977
    Assignee: Norden Laboratories, Inc.
    Inventor: Eldon Davis
  • Cephalosporin purification process
    Patent number: 4028355
    Abstract: A process for purifying semisynthetic cephalosporins is disclosed which uses alumina and/or a polymeric nonionic resin as adsorbents at a controlled pH. The process is more efficient than previously used methods.
    Type: Grant
    Filed: July 18, 1975
    Date of Patent: June 7, 1977
    Assignee: SmithKline Corporation
    Inventor: Dale W. Blackburn
  • Process for preparing 2-amino-2-alkylthio-1-nitroethylene compounds
    Patent number: 4028379
    Abstract: A process for preparing 2-amino-2-alkylthio-1-nitroethylene compounds by reacting a 1-lower alkylsulfinyl-1-lower alkylthio-2-nitroethylene with an amine. The products of the process are intermediates for the production of histamine H.sub.2 -antagonists.
    Type: Grant
    Filed: May 5, 1976
    Date of Patent: June 7, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: George Raymond White
  • Novel preparation of trifluoromethylthioacetic acid
    Patent number: 4028408
    Abstract: Methods and intermediates are disclosed for the preparation of trifluoromethylthioacetic acid using the reaction of trifluoromethylsulfenyl halides with certain orthoesters.
    Type: Grant
    Filed: April 15, 1976
    Date of Patent: June 7, 1977
    Assignee: SmithKline Corporation
    Inventors: Sidney Harry Levinson, Wilford Lee Mendelson
  • Pharmaceutical compositions and methods of inhibiting H-2 histamine receptors with pyridyl substituted thioalkyl- and oxyalkyl-thioureas and ureas
    Patent number: 4027026
    Abstract: Pharmaceutical compositions and methods of inhibiting H-2 histamine receptors with pyridyl substituted thioalkyl- and oxyalkyl-thioureas and ureas.
    Type: Grant
    Filed: June 13, 1975
    Date of Patent: May 31, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, John Colin Emmett, Charon Robin Ganellin
  • Methods and compositions using 5-cycloalkylthio- and oxy-2-carbalkoxy-aminobenzimidazole
    Patent number: 4025638
    Abstract: New anthelmintic compositions and methods of use are described utilizing 5-cycloalkylthio and oxy-2-carbalkoxyaminobenzimidazoles as active ingredients.
    Type: Grant
    Filed: February 2, 1976
    Date of Patent: May 24, 1977
    Assignee: SmithKline Corporation
    Inventors: Robert J. Gyurik, William D. Kingsbury
  • Certain thiazoles and oxazoles
    Patent number: 4025527
    Abstract: The compounds are N,N'-substituted thioureas, ureas and guanidines which are H-2 histamine receptor inhibitors. Two compounds of this invention are N,N'-bis[2-((4-methyl-5-imidazolyl)methylthio)ethyl]thiourea and N,N'-bis[2-((4-methyl-5-imidazolyl)methylthio)ethyl]-N"-cyanoguanidine.
    Type: Grant
    Filed: December 15, 1975
    Date of Patent: May 24, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, Charon Robin Ganellin
  • Substituted 2H-pyran-2,6 (3H)-dione derivatives useful in treatment of allergic reactions
    Patent number: 4025614
    Abstract: Substituted 2H-pyran-2,6(3H)-dione derivatives useful in the treatment of allergic conditions are prepared by reaction of 3,5-diacetyl-4,6-dihydroxy-2H-pyran-2-one with an appropriate aniline.
    Type: Grant
    Filed: April 30, 1976
    Date of Patent: May 24, 1977
    Assignee: SmithKline Corporation
    Inventors: Kenneth M. Snader, Chester R. Willis
  • 7-Acyl-3-(ureidoalkyl substituted tetrazolylthiomethyl)-cephalosporins
    Patent number: 4025626
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and an ureidoalkyl substituted tetrazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: December 9, 1975
    Date of Patent: May 24, 1977
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • Substituted 2H-pyran-2, 6(3H)-dione derivatives
    Patent number: 4025642
    Abstract: Substituted 2H-pyran-2,6(3H)-dione derivatives useful in the treatment of allergic conditions are prepared by reaction of 3,5-diacetyl-4,6-dihydroxy-2H-pyran-2-one with an appropriate aniline.
    Type: Grant
    Filed: December 3, 1975
    Date of Patent: May 24, 1977
    Assignee: SmithKline Corporation
    Inventors: Kenneth M. Snader, Chester R. Willis
  • Pharmacologically active guanidine compounds
    Patent number: 4024271
    Abstract: The compounds are substituted thioalkyl-, aminoalkyl- and oxyalkyl-guanidines which are inhibitors of histamine activity.
    Type: Grant
    Filed: December 4, 1975
    Date of Patent: May 17, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, John Colin Emmett, Charon Robin Ganellin
  • N,N-bis[2-(3-substituted-4-hydroxyphenyl)-ethyl or -2-hydroxyethyl]-polymethylenediamines
    Patent number: 4024281
    Abstract: N,N'-Bis[2-(3-substituted-4-hydroxyphenyl)-ethyl or -2-hydroxyethyl]-polymethylenediamines having .beta.-adrenergic stimulant activity particularly as selective bronchodilators, are prepared generally by condensation of an N-benzylphenethylamine with a polymethylene dihalide or by reaction of an .beta.-bromoacetophenone with an N,N'-dibenzyl-polymethylenediamine, with further operations depending on the nature of the 3-substituent, and subsequently hydrogenating catalytically with for example palladium-on-carbon. The key intermediates are also part of the invention.
    Type: Grant
    Filed: October 16, 1975
    Date of Patent: May 17, 1977
    Assignee: SmithKline Corporation
    Inventors: Donald F. Colella, Carl Kaiser
  • Ethylene derivatives
    Patent number: 4024260
    Abstract: The compounds are ethylene derivatives which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A compound of this invention is 1-nitro-2-methylamino-2-[2-((4-methyl-5-imidazolyl)methylthio)-ethylamino[ ethylene.
    Type: Grant
    Filed: November 11, 1975
    Date of Patent: May 17, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, John Colin Emmett, Charon Robin Ganellin, Hunter Douglas Prain