Patents Represented by Attorney William H. Edgerton

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  • Substituted glycines and intermediates thereof
    Patent number: 3997584
    Abstract: A new process is disclosed for the preparation of N-acyl-.alpha.-aromatic and N-acyl-.alpha.-heteroaromatic glycines by reaction of an .alpha.-ester or ether of an N-acylglycine ester or acid with an aromatic or heteroaromatic compound. Also disclosed are new intermediates for preparing N-acyl-.alpha.-aromatic and N-acyl-.alpha.-heteroaromatic glycines.
    Type: Grant
    Filed: October 3, 1975
    Date of Patent: December 14, 1976
    Assignee: SmithKline Corporation
    Inventors: John G. Gleason, Kenneth G. Holden, Nelson C. F. Yim
  • 3-Alkylamino-.alpha.-aminomethyl-4-hydroxybenzyl alcohols with .beta.-adrenergic stimulant activity
    Patent number: 3996383
    Abstract: A series of 3-alkylamino-.alpha.-substituted aminomethyl-4-hydroxybenzyl alcohols are prepared. These compounds are .beta.-adrenergic stimulants, in particular as bronchodilators.
    Type: Grant
    Filed: November 12, 1975
    Date of Patent: December 7, 1976
    Assignee: SmithKline Corporation
    Inventors: Donald F. Colella, Carl Kaiser
  • 9-Xanthylamin oalkylpyridine derivatives
    Patent number: 3996364
    Abstract: 9-Xanthylaminoalkylpyridine derivatives are prepared. These compounds are inhibitors of gastric acid secretion.
    Type: Grant
    Filed: August 6, 1975
    Date of Patent: December 7, 1976
    Assignee: SmithKline Corporation
    Inventors: Paul E. Bender, Bernard Loev, Carl David Perchonock
  • Process for preparing substituted glycines
    Patent number: 3994954
    Abstract: A new process is disclosed for the preparation of N-acyl-.alpha.-aromatic and N-acyl-.alpha.-heteroaromatic glycines by reaction of an .alpha.-ester or ether of an N-acylglycine ester or acid with an aromatic or heteroaromatic compound. Also disclosed are new intermediates for preparing N-acyl-.alpha.-aromatic and N-acyl-.alpha.-heteroaromatic glycines.
    Type: Grant
    Filed: June 24, 1975
    Date of Patent: November 30, 1976
    Assignee: SmithKline Corporation
    Inventors: John G. Gleason, Kenneth G. Holden, Nelson C. F. Yim
  • 7-(3-Substituted ureido) cephalosporins
    Patent number: 3994886
    Abstract: Cephalosporin compounds with 3-substituted ureido or -thioureido group at position 7 and hydrogen or heterocyclicthiomethyl groups at position 3 are prepared. These compounds are antibacterial agents.
    Type: Grant
    Filed: June 3, 1975
    Date of Patent: November 30, 1976
    Assignee: Recherche et Industrie Therapeutiques (R.I.T.)
    Inventors: Pierre Crooij, Alain Colinet
  • 7-(3-Substituted ureido) cephalosporins
    Patent number: 3994887
    Abstract: Cephalosporin compounds with 3-substituted ureido or -thioureido group at position 7 and hydrogen or heterocyclicthiomethyl groups at position 3 are prepared. These compounds are antibacterial agents.
    Type: Grant
    Filed: June 4, 1975
    Date of Patent: November 30, 1976
    Assignee: Recherche et Industrie Therapeutiques (R.I.T.)
    Inventors: Pierre Crooij, Alain Colinet
  • Folic acid derivatives and use in radio-assay
    Patent number: 3989812
    Abstract: Novel folic acid derivatives useful for radio-assaying folic acid and its metabolites in biological liquids are prepared from pteroyl-.gamma.-glutamyl-tyrosines by iodination with I.sup.125 or I.sup.131.
    Type: Grant
    Filed: August 9, 1974
    Date of Patent: November 2, 1976
    Assignee: SmithKline Instruments, Inc.
    Inventors: M. James Barrett, Joseph I. De Graw
  • Uricosuric compositions and method of producing uricosuria and hypouricemia
    Patent number: 3989838
    Abstract: Uricosuric compositions containing 2,3-dichloro-4-(.alpha.-hydroxy-2-thenyl)phenoxyacetic acid, its alkali metal salts or pharmaceutically acceptable base addition salts and methods of producing uricosuria and hypouricemia by administering said compounds. Either the racemic mixture or a separated d-or l-optical isomer may be employed as the active ingredient.
    Type: Grant
    Filed: September 22, 1975
    Date of Patent: November 2, 1976
    Assignee: SmithKline Corporation
    Inventor: Alfred R. Maass
  • 7-Acyl-3-(substituted triazolyl thiomethyl)cephalosporins
    Patent number: 3989694
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a substituted triazolyl thiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: December 27, 1974
    Date of Patent: November 2, 1976
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • Pharmaceutical compositions and methods of inhibiting phenylethanolamine N-methyltransferase
    Patent number: 3988339
    Abstract: Pharmaceutical compositions and methods of inhibiting phenylethanolamine N-methyltransferase using 7 and/or 8 substituted 1,2,3,4-tetrahydroisoquinoline compounds.
    Type: Grant
    Filed: June 26, 1975
    Date of Patent: October 26, 1976
    Assignee: SmithKline Corporation
    Inventors: Carl Kaiser, Robert G. Pendleton
  • .alpha.-Amino-.alpha.-(acylamidophenyl)acetamidocephalosporins
    Patent number: 3988451
    Abstract: 7-[.alpha.-Amino-.alpha. -(acylamidophenyl)acetamido]-cephalosporins are prepared. They show improved antibacterial activity especially when they are administered orally.
    Type: Grant
    Filed: October 20, 1975
    Date of Patent: October 26, 1976
    Assignee: SmithKline Corporation
    Inventor: George L. Dunn
  • Novel compounds and compositions for treating Parkinson's disease
    Patent number: 3988457
    Abstract: .beta.-Naphthylmethyl piperazinyl derivates having anti-Parkinsonism activity prepared by condensation of .beta.-chloromethylnaphthalene with the appropriate substituted piperazine.
    Type: Grant
    Filed: July 17, 1975
    Date of Patent: October 26, 1976
    Assignee: SmithKline Corporation
    Inventors: Harlan F. Hill, John J. Lafferty
  • P-Hydroxymethylphenylacetamidocephalosporins
    Patent number: 3987041
    Abstract: 7-(p-Hydroxymethylphenylglycylamido)cephalosporins are prepared by acylating a 7-aminocephalosporin compound. The products have antibacterial activity.
    Type: Grant
    Filed: February 25, 1975
    Date of Patent: October 19, 1976
    Assignee: SmithKline Corporation
    Inventors: George L. Dunn, John R. E. Hoover
  • 3-Heterocyclic thiomethylcephalosporins
    Patent number: 3985739
    Abstract: Cephalosporin compounds substituted at the 7-position with free or substituted .alpha.-amino or hydroxy phenylacetamido and at the 3-position with a heterocyclic thiomethyl group are prepared by displacement of a 3-acetoxymethyl compound with a mercaptoheterocycle or by 7-acylation. The products are antibacterial agents.
    Type: Grant
    Filed: October 1, 1974
    Date of Patent: October 12, 1976
    Assignee: SmithKline Corporation
    Inventors: George L. Dunn, John R. E. Hoover
  • Benzophenalenofurans
    Patent number: 3985896
    Abstract: The compounds are benzophenalenofurans having pharmacological activity, in particular, coronary vasodilator activity.
    Type: Grant
    Filed: July 15, 1975
    Date of Patent: October 12, 1976
    Assignee: SmithKline Corporation
    Inventors: L. Martin Brenner, Charles K. Brush
  • 3-Substituted-4-hydroxyphenyl-2-piperidylcarbinols as .beta.-adrenergic stimulants
    Patent number: 3985887
    Abstract: 3-Substituted-3-hydroxyphenyl-2-piperidylcarbinols are prepared. These compounds are .beta.-adrenergic stimulants and are useful in particular as bronchodilators.
    Type: Grant
    Filed: June 11, 1975
    Date of Patent: October 12, 1976
    Assignee: SmithKline Corporation
    Inventors: Carl Kaiser, Joe R. Wardell, Jr.
  • Process of reduction
    Patent number: 3984293
    Abstract: An electrochemical process for preparing 4-(hydroxymethyl)-imidazoles, which are useful as chemical intermediates.
    Type: Grant
    Filed: August 6, 1975
    Date of Patent: October 5, 1976
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Ronald Joseph King, George Raymond White
  • Compositions comprising tetramic acid analogs of pulvinic acid and methods of combating arthritis
    Patent number: 3984559
    Abstract: Pharmaceutical compositions comprising tetramic acid analogs of pulvinic acid and methods of combating arthritis by administration of these compositions are disclosed.
    Type: Grant
    Filed: October 17, 1975
    Date of Patent: October 5, 1976
    Assignee: SmithKline Corporation
    Inventor: Joseph Weinstock
  • Certain 4-(3-azacycloalkoxy or azacycloalkylmethoxy)benzoylbenzofurans or benzothiophenes
    Patent number: 3983245
    Abstract: The compounds of this invention are substituted benzofurans and benzothiophenes having pharmacological activity. In particular, these compounds have coronary vasodilator activity and are useful in the treatment of angina pectoris.
    Type: Grant
    Filed: February 6, 1975
    Date of Patent: September 28, 1976
    Assignee: SmithKline Corporation
    Inventors: David L. Ladd, Stephen T. Ross
  • Pharmaceutical compositions and methods of inhibiting gastric acid secretion
    Patent number: 3980788
    Abstract: Pharmaceutical compositions and methods of inhibiting gastric acid secretion by administering 1-(9-xanthenyl) amino-substituted-piperidines and pyrrolidines and new 1-(9-xanthenyl) amino-piperidine compounds.
    Type: Grant
    Filed: September 15, 1975
    Date of Patent: September 14, 1976
    Assignee: SmithKline Corporation
    Inventors: Paul E. Bender, Bernard Loev