Abstract: The disclosure relates to benzoimidazole derivatives, acting as anticancer drugs, as well as pharmaceutical composition containing said compounds. These compounds are able to firstly inhibit the protein/protein interactions of the MAP Kinase Erk, leading to inhibition of proliferation and secondly to induce apoptosis in human cancer cell lines.
Type:
Grant
Filed:
September 20, 2017
Date of Patent:
July 12, 2022
Assignees:
CENTRE LEON BERARD, HOSPICES CIVILS DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
Abstract: A sequence layer in a machine-learning engine configured to learn from the observations of a computer vision engine. In one embodiment, the machine-learning engine uses the voting experts to segment adaptive resonance theory (ART) network label sequences for different objects observed in a scene. The sequence layer may be configured to observe the ART label sequences and incrementally build, update, and trim, and reorganize an ngram trie for those label sequences. The sequence layer computes the entropies for the nodes in the ngram trie and determines a sliding window length and vote count parameters. Once determined, the sequence layer may segment newly observed sequences to estimate the primitive events observed in the scene as well as issue alerts for inter-sequence and intra-sequence anomalies.
Type:
Grant
Filed:
September 28, 2018
Date of Patent:
July 12, 2022
Assignee:
AVIGILON PATENT HOLDING 1 CORPORATION
Inventors:
Wesley Kenneth Cobb, David Samuel Friedlander, Kishor Adinath Saitwal
Abstract: The invention relates to a device for olfactory stimulation of a patient with a plurality of scents, said device comprising: —a source (2) of a carrier gas (G); —a plurality of scent odorization circuits, each odorization circuit (4) comprising: —a container (18) containing an odorous volatile substance (V), —a container inlet line (26), provided with a container inlet valve (28), connecting an inlet (30) of said container with said source of carrier gas, and —a container outlet line (36), provided with a container outlet valve (38), connecting an outlet (40) of said container with an exit line (12); —a control unit (8), configured to control said container inlet valve and container outlet valve according to a medical protocol.
Type:
Grant
Filed:
February 2, 2017
Date of Patent:
July 12, 2022
Assignees:
INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE CLAUDE BERNARD LYON 1, UNIVERSITE JEAN MONNET SAINT ETIENNE
Abstract: Many people who suffer from anal rectal discomfort and disorders need fibrous sheet materials which are pre-moistened with a solution for improved cleansing without excessive skin irritation. The invention particularly concerns wet wipes, such as anal-rectal wipes, which comprises a solution comprising hamamelis water or witch hazel, to effectively treat anal-rectal disorders.
Type:
Grant
Filed:
September 12, 2018
Date of Patent:
July 5, 2022
Assignee:
PF CONSUMER HEALTHCARE 1 LLC
Inventors:
Gary Robert Agisim, Robert Alan Friedline, Richard John Kenny
Abstract: An office chair has an armrest. In order to provide an armrest which is of particularly simple construction, the armrest contains an armrest column and an arm support which is mounted on the armrest column and is rotatable about a rotation axis and which is linearly displaceable relative to the armrest column. A rotary mechanism for the rotation of the arm support is arranged substantially fully within the armrest column.
Abstract: Methods, systems, and apparatuses are disclosed for generating a spatial audio format. An input audio source may include one or more individual channels. The one or more individual channels may be designated to be played by a corresponding one or more speakers. The one or more individual channels of the audio source may be separated. The one or more individual tracks may be input into a modeling space representing a multi-dimensional space. The modeling space may include a plurality of emitters at various locations in a vector space. Each of the one or more individual channels may be panned to one or more of the plurality of emitters. The panning may be based on a normalized proximity of the one or more individual channels in the modeling space to the plurality of emitters. The one or more of the plurality of emitters may be encoded into a single multichannel file.
Abstract: Hydrogen generation assemblies, hydrogen purification devices, and their components, and methods of manufacturing those assemblies, devices, and components are disclosed. In some embodiments, the devices may include an insulation base having insulating material and at least one passage that extends through the insulating material. In some embodiments, the at least one passage may be in fluid communication with a combustion region.
Abstract: A method of prognosis of patient outcome and of the resistance to a chemotherapy treatment of an individual afflicted by a tumor. The method involves determining the amount of the product of each of at least 21 genes belonging to the group of 160 genes as set forth in SEQ ID NO: 1 to SEQ ID NO: 160.
Type:
Application
Filed:
March 27, 2020
Publication date:
June 16, 2022
Applicants:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CENTRE LÉON BERARD, INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, UNIVERSITÉ CLAUDE BERNARD LYON 1
Inventors:
Véronique MAGUER-SATTA, Boris GUYOT, Flora CLÉMENT, Pierre SAINTIGNY, Jean-Philippe FOY, Emmanuel DELAY
Abstract: A support for a piece of seating furniture provides an additional degree of freedom of movement. The support has a connecting unit fitted on a main body that connects to a supporting element of an underframe. The connecting unit has a mounting device for the supporting element, in particular a mount for the upper end of the supporting element. The connecting unit is fitted on the main body such that it is possible to alter the inclination of the main body relative to the supporting element. For that purpose the main body has a preferably convex contact base, which in the fitted state is contacted by a contact head of the connecting unit, with the abutment forming a non-planar contact rather than a contact over a surface area, in particular a punctiform contact.
Abstract: A wireless peripheral mode is provided by a host system that communicates to a WiFi infrastructure and, utilizing the same WiFi RF subsystem, also communicates to peripherals. The host system may employ additional RF channels for communicating with high bandwidth peripherals, such as display devices, where high levels of QoS may be managed locally. The host system may be a conventional desktop computer system, a notebook computer system, a multi-media access point, a cell phone, a game machine, a portable game machine, a Personal Digital Assistant (PDA), a smart phone or any other type of device that benefits from accessing both a WiFi infrastructure and local peripherals.
Abstract: The invention relates to a process in vitro for diagnosing a paraneoplastic neurological syndrome (PNS) associated with a tumor in an individual, comprising the detection of at least one antibody chosen among antibodies against TRIM9 and antibodies against TRIM67, in a biological fluid of said individual.
Type:
Application
Filed:
May 2, 2019
Publication date:
June 9, 2022
Applicants:
HOSPICES CIVILS DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
Inventors:
Le Duy DO, Jérôme HONNORAT, Véronique ROGEMOND
Abstract: The present invention relates to a pharmaceutical or veterinary composition for the use thereof in preventing and/or treating infection by the influenza viruses. Said composition is characterized in that it contains, in an appropriate pharmaceutical carrier, at least one compound selected from among Etilefrine and Diltiazem.
Type:
Grant
Filed:
March 18, 2016
Date of Patent:
June 7, 2022
Assignees:
UNIVERSITE CLAUDE BERNARD LYON 1, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), HOSPICES CIVILS DE LYON, UNIVERSITE LAVAL
Inventors:
Manuel Rosa-Calatrava, Olivier Terrier, Julien Textoris, Guy Boivin, Mario Pizzorno
Abstract: A method for displaying graphical content in a playback device (DISP), the graphical content being displayed and erased periodically on the display device according to successive cycles that take place at a predetermined frequency (Fd) and in that the successive display periods each have a duration (T1) comprised in an interval of values ranging from 15 to 30% of the duration (T) of the cycles that have taken place.
Abstract: The present invention relates to use of an isobaric label in mass spectrometry (MS) analysis using data-independent acquisition (DIA), wherein said isobaric label comprises or consists of a group which fragments in the mass spectrometer (i) at an energy below the energy required for fragmenting analyte-derived precursor ions and/or a higher conversion rate than said precursor ions; and (ii) at said energy according to (i) and when coupled to a precursor ion, at a single site within said group, to yield a first moiety and a second moiety, said second moiety being coupled to said precursor ion.
Type:
Grant
Filed:
November 14, 2018
Date of Patent:
June 7, 2022
Assignee:
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAF 1 EN E.V.
Inventors:
Felix Meissner, Matthias Mann, Florian Meier, Sebastian Virreira Winter, Arturo Zychlinsky
Abstract: A drug delivery system is provided that has an adjustable dose mechanism allowing setting and locking the dose then administration of the set dose. A method for administering a medicament using the drug delivery system is also provided.
Abstract: A solvent transfer printing method for applying a pattern made of a non-soluble material and non-dispersible on the surface of an object. The method includes the steps of: m1/forming a pattern on a surface of a solvent-soluble substrate, m2/depositing the solvent-soluble substrate on the surface of a solvent bath, on the side of the substrate opposed to the side on which the pattern is applied, in order to dissolve partially the substrate, m3/dipping the object in the bath, so that the surface of the object comes into contact with the pattern, m4/getting the object, on which the pattern is applied, out of the bath, and b 5/drying the object.
Type:
Grant
Filed:
January 26, 2018
Date of Patent:
May 31, 2022
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, UNIVERSITE DE RENNES 1
Inventors:
Maxime Harnois, Jacques Emmanuel, Brice Le Borgne
Abstract: An asset management and tracking system for use in a facility having a product designation RFID tag having product information is attached to a product and at least one location designation RFID tag having location information. The system includes a RFID reader and a portable communication device. The RFID reader reads at least one of the product designation RFID tag and the at least one location designation RFID tag and the portable communication device receives product information from and transmits product information to an asset tracking and management device. The RFID reader transmits product information read from the product designation RFID tag and the location information read from the location designation RFID tags to the portable communication device. The portable communication device, in turn, transmits the received product information and location information to the asset tracking device and queries the asset tracking device for additional product and location information.
Abstract: Performance issues in a service function chain having a plurality of resources and a plurality of network functions each having a network function queue are diagnosed. Each network function queue is monitored and queueing information for input packets for each of the plurality of network functions is dumped to a data store. Each resource that is under contention is identified as well as which of the network functions is a contender for the resources. A diagnosing algorithm is used to diagnose performance problems and an impact graph for each victim packet is generated. A summary of results as a list of rules is then provided.
Type:
Grant
Filed:
December 13, 2019
Date of Patent:
May 31, 2022
Assignees:
AT&T Intellectual Property 1, L.P., President and Fellows of Harvard College
Inventors:
Muhammad Bilal Anwer, Aman Shaikh, Junzhi Gong, Minlan Yu, Yuliang Li