Patents Assigned to Abbott Laboratories
  • Patent number: 11022617
    Abstract: Disclosed herein are methods, and kits for use in said methods, that aid in the diagnosis and evaluation of a subject that has sustained an orthopedic injury and sustained or may have sustained an injury to the head, such as mild traumatic brain injury (TBI), using ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), glial fibrillary acidic protein (GFAP), or a combination thereof. Also disclosed herein are methods, and kits for use in said methods, that aid in determining whether a subject that has sustained an orthopedic injury and sustained or may have sustained an injury to the head would benefit from and thus receive an imaging procedure, such as MRI or head computerized tomography (CT) scan based on the levels of GFAP and/or UCH-L1. These methods involve detecting levels and changes in levels of GFAP and/or UCH-L1 in biological samples taken from a subject at time points within 48 hours after the subject has sustained or may have sustained an injury to the head.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: June 1, 2021
    Assignee: Abbott Laboratories
    Inventors: Beth McQuiston, Saul A. Datwyler, Raj Chandran
  • Patent number: 11022598
    Abstract: Methods, devices, and systems for analyte analysis using a nanopore are disclosed. The methods, devices, and systems utilize a first and a second binding member that each specifically bind to an analyte in a biological sample. The method further includes detecting and/or counting a cleavable tag attached to the second binding member and correlating the presence and/or the number of tags to presence and/or concentration of the analyte. Certain aspects of the methods do not involve a tag, rather the second binding member may be directly detected/quantitated. The detecting and/or counting may be performed by translocating the tag/second binding member through a nanopore. Devices and systems that are programmed to carry out the disclosed methods are also provided.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: June 1, 2021
    Assignee: ABBOTT LABORATORIES
    Inventors: Jeffrey B. Huff, Mark A. Hayden, Peter J. Karabatsos, Andrew S. Schapals, Anthony S. Muerhoff, M. Felicia Bogdan, Thomas Leary, Shelley R. Holets-McCormack, Sophie Laurenson, Andrew T. Fischer, Richard Haack, Stefan Hershberger, Dustin House, Lei Qiao, M. Shawn Murphy, Mark R. Pope, Edna M. Prieto-Ballengee, QiaoQiao Ruan, Pathik Soni, Sergey Tetin, Lyle Yarnell
  • Patent number: 11016053
    Abstract: Methods, devices, and systems for analyte analysis using a nanopore are disclosed. The methods, devices, and systems utilize a first and a second binding member that each specifically bind to an analyte in a biological sample. The method further includes detecting and/or counting a cleavable tag attached to the second binding member and correlating the presence and/or the number of tags to presence and/or concentration of the analyte. Certain aspects of the methods do not involve a tag, rather the second binding member may be directly detected/quantitated. The detecting and/or counting may be performed by translocating the tag/second binding member through a nanopore. Devices and systems that are programmed to carry out the disclosed methods are also provided. Also provided herein are instruments that are programmed to operate a cartridge that includes an array of electrodes for actuating a droplet and further includes an electrochemical species sensing region.
    Type: Grant
    Filed: October 5, 2017
    Date of Patent: May 25, 2021
    Assignee: Abbott Laboratories
    Inventors: Jeffrey B. Huff, Mark A. Hayden, Graham Davis, Sergey Gershtein
  • Patent number: 11016092
    Abstract: Disclosed herein are methods that aid in the diagnosis and evaluation of a human subject that has sustained or may have sustained an injury to the head, such as mild or moderate to severe traumatic brain injury (TBI), using an early biomarker, ubiquitin carboxy-terminal hydrolase L1 (UCH-L1). Also disclosed here are methods that aid in determining whether a human subject that has sustained an injury or may have sustained to the head would benefit from and thus receive a head computerized tomography (CT) scan based on the levels of UCH-L1. These methods involve detecting levels and changes in levels of UCH-L1 in one or more samples taken from a human subject at time points within 24 hours after the subject has sustained or may have sustained an injury to the head.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: May 25, 2021
    Assignee: Abbott Laboratories
    Inventors: Beth McQuiston, Justin Rogers, Saul Datwyler, Jaime Marino
  • Patent number: 11016105
    Abstract: Disclosed herein are methods of aiding in the diagnosis and evaluation of a subject that has sustained or may have sustained an injury to the head. For example, the present disclosure provides methods for aiding in the diagnosis and evaluation of a subject to determine whether the subject has sustained a traumatic brain injury (TBI) by detecting or measuring a combination of the levels of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) and glial fibrillary acidic protein (GFAP) in samples taken at various time points within 48 hours after the subject has sustained or may have sustained an injury to the head.
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: May 25, 2021
    Assignee: Abbott Laboratories
    Inventors: Beth McQuiston, Saul Datwyler, Raj Chandran, Jaime Marino
  • Patent number: 11016109
    Abstract: A diagnostic analyzer includes a rotating device, a first optical reader, and a second optical reader. The rotating device includes a first darkened compartment, a second darkened compartment, and an optical path along which the first darkened compartment and the second darkened compartment travel. The first optical reader is operable to read the first darkened compartment and the second optical reader is operable to read the second darkened compartment.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: May 25, 2021
    Assignee: ABBOTT LABORATORIES
    Inventor: Robert Luoma
  • Patent number: 11007165
    Abstract: Liquid nutritional compositions include functional ingredients such as beta-hydroxy-beta-methylbutyrate, docosahexaenoic acid, and lutein. The nutritional compositions are useful to promote at least one of physical performance (e.g., body composition, muscle mass, muscle strength) and cognitive function (e.g., focus, attention, alertness, executive function) in an individual. The functional ingredients are incorporated into the nutritional composition in such a way that they do not adversely affect the desirable properties of the nutritional composition such as, for example, nutritional value, stability, solubility, taste, and mouthfeel.
    Type: Grant
    Filed: February 7, 2020
    Date of Patent: May 18, 2021
    Assignee: ABBOTT LABORATORIES
    Inventors: Gaurav Patel, Tapas Das, Rockendra Gupta
  • Publication number: 20210142261
    Abstract: In one aspect, a computer readable memory medium comprising program instructions for graphically developing a connectivity driver is provided. The computer readable memory medium is a non-transitory medium. The program instructions are executable by a processor to generate a purchase order for a laboratory item, transmit the purchase order to a remote computer in order to communicate the purchase order to a vendor, receive an advance shipping notice generated in response to the purchase order, receive item information stored in an RFID tag of a tagged item received at the delivery location, and check the item information against the advance shipping notice in order to verify that the tagged item is the same as the ordered laboratory item. The purchase order specifies a delivery location.
    Type: Application
    Filed: November 10, 2020
    Publication date: May 13, 2021
    Applicant: ABBOTT LABORATORIES
    Inventors: John Curtis Jones, Patrick P. Fritchie, Steve Kotlinski, Jay Brian Sailer, Pathik H. Soni, Erich Iwen, Ronald R. Hohs, William B. Williams
  • Publication number: 20210121290
    Abstract: At least a portion of sheet materials for use in medical devices is formed from polymeric materials. The sheet materials may be partially coated or fully coated with one or more additional layers of a polymer. The sheet materials may be used for the leaflets and/or cuffs of prosthetic heart valves and as a component of other medical devices.
    Type: Application
    Filed: June 11, 2020
    Publication date: April 29, 2021
    Applicant: Abbott Laboratories
    Inventors: Yousef F. Alkhatib, Jay Reimer, Paul E. Ashworth, Keith T. High
  • Patent number: 10991185
    Abstract: Digital pass verification systems and methods are disclosed herein. One or more servers are to distribute instructions on a network. The instructions, when executed, cause a first device carried by a person to at least: access a result of a diagnostic test performed on the person, the result provided by a second device; generate a machine-readable code in response to the result being negative; and display the machine-readable code on a display of the first device to enable the person to gain access to a location.
    Type: Grant
    Filed: October 12, 2020
    Date of Patent: April 27, 2021
    Assignee: Abbott Laboratories
    Inventors: Nitesh Luthra, Lev F. Frayman, Terry Finch, John Schullian, Douglas Wager
  • Patent number: 10991190
    Abstract: Digital pass verification systems and methods are disclosed herein. An apparatus disclosed herein includes memory including instructions that, when executed, cause processor circuitry to: access a result of a diagnostic test associated with a test kit identification; associate the result of the diagnostic test with a user identification; and transmit the result of the diagnostic test and the test kit identification to a first device to cause the first device to generate a machine-readable pass on a display of the first device.
    Type: Grant
    Filed: October 12, 2020
    Date of Patent: April 27, 2021
    Assignee: Abbott Laboratories
    Inventors: Nitesh Luthra, Lev F. Frayman, Terry Finch, John Schullian, Douglas Wager
  • Publication number: 20210113630
    Abstract: Disclosed are nutritional compositions including 2?-fucosyllactose (2?-FL) in combination with lutein and RRR-alpha-tocopherol. The nutritional compositions are useful for improving at least one of gut function, health, and development in an individual. In certain embodiments, the nutritional compositions can improve growth or maturation of the gut, as well as promote a healthy balance of beneficial bacteria in the gastrointestinal tract thereby treating and/or preventing formula intolerance or other gastrointestinal diseases and/or disorders resulting from suboptimal gastrointestinal flora population/balance.
    Type: Application
    Filed: June 21, 2018
    Publication date: April 22, 2021
    Applicant: ABBOTT LABORATORIES
    Inventors: Alejandro Perez BARRANCO, Maria Gonzalez RAMIREZ, Rachael BUCK, Enrique Hernandez VAZQUEZ
  • Patent number: 10983305
    Abstract: Methods, systems and devices for automatically focusing a microscope on a specimen and collecting a focused image of the specimen are provided. Aspects of the methods include detecting the presence of a substrate in a microscope, determining whether the substrate is in a correct orientation for imaging, focusing the microscope on a specimen that is placed on the substrate, and collecting one or more images of the specimen. Systems and devices for carrying out the subject methods are also provided.
    Type: Grant
    Filed: July 16, 2019
    Date of Patent: April 20, 2021
    Assignee: Abbott Laboratories
    Inventors: Trevor David Shields, Robert John Fahey, Damian J. Verdnik, Svitlana Y. Berezhna, Mahmoud Janbakhsh, Koshy T. Chacko
  • Patent number: 10973837
    Abstract: Disclosed are nutritional compositions including human milk oligosaccharides in combination with long chain polyunsaturated fatty acids and/or carotenoids that can be administered to preterm infants, term infants, toddlers, and children for reducing inflammation and the incidence of inflammatory diseases.
    Type: Grant
    Filed: August 5, 2019
    Date of Patent: April 13, 2021
    Assignee: ABBOTT LABORATORIES
    Inventors: Rachael Buck, Geralyn O. Duska-McEwen, Joseph P. Schaller
  • Publication number: 20210077512
    Abstract: Disclosed are nutritional compositions including human milk oligosaccharides in combination with long chain polyunsaturated fatty acids and/or carotenoids that can be administered to preterm infants, term infants, toddlers, and children for reducing inflammation and the incidence of inflammatory diseases.
    Type: Application
    Filed: November 16, 2020
    Publication date: March 18, 2021
    Applicant: ABBOTT LABORATORIES
    Inventors: RACHAEL BUCK, GERALYN O. DUSKA-MCEWEN, JOSEPH P. SCHALLER
  • Patent number: 10942179
    Abstract: Provided herein are assays and kits useful for avoiding “prozone phenomenon” or “hook effect” and which expand the range of accurately measurable analyte concentrations.
    Type: Grant
    Filed: August 8, 2018
    Date of Patent: March 9, 2021
    Assignee: Abbott Laboratories
    Inventors: Barry L. Dowell, Susan Gayda, Qiaoqiao Ruan, Joseph P. Skinner, Sergey Y. Tetin
  • Patent number: 10926263
    Abstract: Methods and apparatus to mitigate bubble formation in a liquid are disclosed. An example apparatus disclosed herein includes a bottom wall, a first baffle cantilevered from the bottom wall, and a second baffle cantilevered from the bottom wall. The first baffle is spaced apart from the second baffle, and the first baffle and the second baffle are positioned radially relative to an axis of rotation of the apparatus.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: February 23, 2021
    Assignee: Abbott Laboratories
    Inventors: Robert Paul Luoma, II, Brian Ochranek, Cheryl L. Davidson, Bradley C. Weston
  • Publication number: 20210045868
    Abstract: A stabilized fabric composed of a mesh or a woven fabric is disclosed as are methods of their manufacture, the manufacture of medical devices made using a stabilized fibers and stabilized medical devices are all disclosed. Fabrics can be stabilized by several techniques including: using mechanical, chemical and/or energetic fasteners at warp and weft intersections in the weave; by using various weaving techniques and fibers. Meshes can be stabilized when properly dimensioned and arranged junctions and struts of the necessary properties are used. All of these stabilized fabrics can be made of synthetic polymer materials such as ultrahigh molecular weight PE or PP and expanded PTFE.
    Type: Application
    Filed: September 30, 2020
    Publication date: February 18, 2021
    Applicant: Abbott Laboratories
    Inventors: Jay Reimer, Paul E. Ashworth
  • Publication number: 20210038620
    Abstract: Disclosed are nutritional compositions including human milk oligosaccharides and nucleotides that can be administered to preterm infants, term infants, toddlers, and children for reducing inflammation and the incidence of inflammatory diseases.
    Type: Application
    Filed: October 23, 2020
    Publication date: February 11, 2021
    Applicant: ABBOTT LABORATORIES
    Inventors: Rachael Buck, Debra Thomas, Joseph Schaller
  • Patent number: D910448
    Type: Grant
    Filed: September 24, 2019
    Date of Patent: February 16, 2021
    Assignee: ABBOTT LABORATORIES
    Inventors: Timothy J. Boyd, Jeremy McBroom, Xinzhong Zhang, Jay Yuan