Patents Assigned to Abbott Laboratories
  • Patent number: 10345218
    Abstract: The present disclosure provides methods for automated slide assessments made in conjunction with digital image-based microscopy. Automated methods of acquiring patient information and specimen information from prepared slides, and digitally linking such information into patient-tagged specimen data, are provided. Also provided are methods that include automatically identifying an optimal area for morphological assessment of a blood smear on a hematological slide, including methods for triggering the analysis of such an area, e.g., using an automated digital image-based hematology system. The present disclosure also provides devices, systems and computer readable media for use in performing processes of the herein described methods.
    Type: Grant
    Filed: December 5, 2017
    Date of Patent: July 9, 2019
    Assignee: ABBOTT LABORATORIES
    Inventors: Svitlana Y. Berezhna, Rene Nieves Alicea, Kam Lin Wong, Damian John Verdnik, Leigh Whiting, Mahmoud Janbakhsh
  • Patent number: 10345311
    Abstract: The present disclosure provides detection methods employing HCV core lipid binding domain and DNA binding domain monoclonal antibodies. In certain embodiments, the lipid binding domain monoclonal antibody recognizes an epitope in amino acids 141 to 161 of HCV core protein.
    Type: Grant
    Filed: June 22, 2016
    Date of Patent: July 9, 2019
    Assignee: Abbott Laboratories
    Inventors: Robert Ziemann, April Ahlberg, David Hawksworth, Bryan Tieman, A. Scott Muerhoff, Christopher Marohnic, Kathy Otis
  • Patent number: 10342244
    Abstract: Disclosed are infant formulas and corresponding methods of using them to promote retinal health and vision development in infants. The formulas, which are free of egg phospholipids and comprise fat, protein, carbohydrate, vitamins, and minerals, including docosahexaenoic acid and, on a ready-to-feed basis, at least about 50 mcg/liter of lutein, wherein the weight ratio of lutein (mcg) to docosahexaenoic acid (mg) is from about 1:2 to about 10:1. The formulas are also believed to be especially useful in reducing the risk of retinopathy of prematurity in preterm infants.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: July 9, 2019
    Assignee: ABBOTT LABORATORIES
    Inventors: Bridget Barrett-Reis, Pamela T. Price, Amy Mackey
  • Patent number: 10335791
    Abstract: Methods for detecting target analytes utilizing an array of wells are advantageous for detection of low concentrations of target analytes. Use of an array of wells requires sealing of the wells. The methods provided herein utilize digital microfluidics to seal wells of an array with a fluid that is immiscible with the aqueous liquid present in the wells to prevent evaporation and contamination of the aqueous fluid during analysis of signals from the wells. The disclosed method include generating a biphasic droplet composed of the immiscible fluid and an aqueous fluid. The immiscible fluid present in the biphasic droplet is moved over the array of wells to seal the wells by electrically actuating the aqueous fluid present in the biphasic droplet which in turn pulls the immiscible fluid.
    Type: Grant
    Filed: January 17, 2018
    Date of Patent: July 2, 2019
    Assignees: Abbott Laboratories, The Katholieke Universiteit Leuven
    Inventors: Mark A. Hayden, Karen Leirs, Elena Pérez-Ruiz, Jeroen Lammertyn
  • Patent number: 10327760
    Abstract: In accordance with the present invention there is provided apparatuses and methods for using a medical instrument including a sizing and positioning adapter. The apparatus comprises an adapter for a medical instrument, the adapt having a body having a shim portion and an instrument holding portion adjacent the shim portion, wherein the shim portion provides an enlarged peripheral surface adjacent the medical instrument such that when the medical instrument is held in the instrument holding portion and the medical instrument and body are inserted through an opening in a patient tissue, at least a portion of the enlarged peripheral surface is in contact with at least a portion of the periphery of the opening in the patient tissue.
    Type: Grant
    Filed: March 7, 2017
    Date of Patent: June 25, 2019
    Assignee: Abbott Laboratories
    Inventors: Laveille Kao Voss, Erik Kristian Walberg
  • Patent number: 10330691
    Abstract: A diagnostic analyzer includes a track, a light-blocking member, a motor, and an optical testing device. The track moves a reaction vessel held by the track. The light-blocking member is disposed adjacent to the track. The light-blocking member moves from a first position apart from the track to a second position closer to the track. When the light-blocking member is disposed in the first position a sample contained within the reaction vessel held by the track is exposed to light. When the light-blocking member is disposed in the second position the sample contained within the reaction vessel held by the track is blocked from exposure to the light. The motor moves the light-blocking member between the first and the second positions. The optical testing device is disposed adjacent to the track for optically testing the sample contained within the reaction vessel held by the track when the at least one light-blocking member is disposed in the second position.
    Type: Grant
    Filed: October 31, 2016
    Date of Patent: June 25, 2019
    Assignee: ABBOTT LABORATORIES
    Inventors: Joseph P. Donohue, Ryan Patrick Johnson
  • Patent number: 10328049
    Abstract: This invention relates to a method of improving CNS maturation in an infant by administering a mixture of natural tocopherols, wherein the composition contains an optimum tocopherol profile similar to that found in human breast milk, and can encompass a tocopherol profile from early stage to transitional to mature human breast milk. For ease of administration and maximized efficacy, the optimized mixture of natural tocopherols are typically delivered in an oral dosage form with a limited level of non-RRR alpha-tocopherols to maximize efficacy of the RRR alpha-tocopherol on stimulating post-natal CNS development.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: June 25, 2019
    Assignee: ABBOTT LABORATORIES
    Inventors: Chron-Si Lai, Matthew Kuchan, Gary Katz
  • Patent number: 10316353
    Abstract: Disclosed are methods for detecting a target nucleic acid in a sample. The methods include contacting said sample, in the presence of a polymerase and an endonuclease, with a sequence conversion oligonucleotide. Also disclosed are methods for detecting a target nucleic acid in a sample in which said sample is contacted, in the presence of a polymerase and an endonuclease, with a sequence conversion oligonucleotide and a signal amplifier oligonucleotide. The disclosure also provides compositions and kits comprising such sequence conversion and signal amplifier oligonucleotides.
    Type: Grant
    Filed: October 13, 2015
    Date of Patent: June 11, 2019
    Assignees: Abbott Laboratories, Tokyo Institute of Technology
    Inventors: Ken Komiya, Makoto Komori, Toru Yoshimura
  • Patent number: 10308709
    Abstract: Disclosed herein are antibodies and methods of using said antibodies to detect Golgi protein 73 (GP73) and fucosylated GP73 in a sample.
    Type: Grant
    Filed: October 11, 2016
    Date of Patent: June 4, 2019
    Assignee: Abbott Laboratories
    Inventors: Bailin Tu, Robert N. Ziemann, Bryan C. Tieman, Philip M. Hemken, Carol S. Ramsay, Carolyn J. Strobel, David J. Hawksworth, Larry G. Birkenmeyer, Cheng Zhao, Susan E. Brophy, Barry L. Dowell, Anthony S. Muerhoff
  • Patent number: 10288633
    Abstract: A diagnostic analyzer includes a rotating device, a first optical reader, and a second optical reader. The rotating device includes a first darkened compartment, a second darkened compartment, and an optical path along which the first darkened compartment and the second darkened compartment travel. The first optical reader is operable to read the first darkened compartment and the second optical reader is operable to read the second darkened compartment.
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: May 14, 2019
    Assignee: ABBOTT LABORATORIES
    Inventors: Robert Luoma, Ryan Patrick Johnson
  • Patent number: 10288557
    Abstract: The instant disclosure provides spectrophotometric methods for assessing histological stains used in a histology analyzer. The methods find use in various assessments including determinations of the identity of a histological stain, determinations of the quality of a histological stain, etc. Also included are devices and systems for practicing the described methods. The instant disclosure also provides computer readable media containing libraries of reference spectrophotometric characteristics of histological stains useful in assessing a histological stain used in a histology analyzer. Also provided is computer readable media containing instructions that cause a computing device to perform steps for making an assessment of a histological stain.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: May 14, 2019
    Assignee: Abbott Laboratories
    Inventors: Svitlana Y. Berezhna, Rene Nieves Alicea, Ema C. Olah
  • Patent number: 10273065
    Abstract: In some aspects, a keyed cap for a container is provided. Furthermore, in some aspects, a keyed container device including a container and the keyed cap for the container is also provided. Still further, in some aspects, a keyed containing system including a container, keyed cap for the container, and an electronic device having a keying element that is adapted to mate or otherwise fit with a specific keying element on the keyed cap. If a keyed cap has a keying element that does not correctly correspond to a specific keying element on an electronic device, then the keyed cap will not properly mate with the keying element on the electronic device. For example, the two keying elements that do not match may not fit sufficiently far enough within each other to permit the piercing member on the electronic device to reach a septum on the cap.
    Type: Grant
    Filed: July 12, 2016
    Date of Patent: April 30, 2019
    Assignee: Abbott Laboratories
    Inventor: Roger W. Accurso
  • Patent number: 10274413
    Abstract: In some aspects, a flow cytometer system is provided that includes beam shaping optics positioned to manipulate a light beam and produce a resulting light beam that irradiates the core stream at the interrogation zone of the flow cell. The beam shaping optics include an acylindrical lens positioned to receive and focus light in a direction of a first axis orthogonal to a direction of light travel, and a cylindrical lens positioned to receive the light output from the acylindrical lens and to focus the light output from the acylindrical lens in a direction of a second axis orthogonal to the first axis and to the direction of light travel. The resulting light beam output has a flat-top shaped intensity profile along the first axis, and a Gaussian-shaped intensity profile along the second axis. Related methods of shaping a light beam at an interrogation zone of a flow cell are also provided.
    Type: Grant
    Filed: November 10, 2016
    Date of Patent: April 30, 2019
    Assignee: Abbott Laboratories
    Inventors: John F. Heanue, Stuart L. Friedman
  • Patent number: 10274406
    Abstract: The present disclosure provides methods for carrying out Romanowsky-type stains, specifically Wright-Giemsa and May-Grünwald stains, quickly and efficiently. The methods greatly reduce the overall amount of time required to complete a Wright-Giemsa stain or a May-Grünwald stain of sufficient quality on a biological sample. The subject methods can be applied to both manual and automated staining procedures.
    Type: Grant
    Filed: February 26, 2018
    Date of Patent: April 30, 2019
    Assignee: Abbott Laboratories
    Inventors: Abe S. Mamaghani, Koshy T. Chacko, Rupa Rao, Rene Nieves Alicea
  • Patent number: 10267818
    Abstract: Example apparatus and methods related to automated diagnostic analyzers having rear accessible track systems. An example apparatus disclosed herein includes an analyzer to perform a diagnostic test, the analyzer having a first side and a second side opposite the first side. The example apparatus includes a loading bay disposed on the first side of the analyzer to receive a first carrier and a pipetting mechanism coupled to the analyzer adjacent the second side. The example apparatus also includes a first carrier shuttle to transport the first carrier from a first location adjacent the loading bay to a second location adjacent the pipetting mechanism and a track disposed adjacent the second side of the analyzer to transfer a second carrier to a third location adjacent the pipetting mechanism.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: April 23, 2019
    Assignees: Abbott Laboratories, Toshiba Medical Systems Corporation
    Inventors: Brian L. Ochranek, David C. Arnquist, Takehiko Oonuma, Hirotoshi Tahara, Naoto Sato, Bradley P. Smith
  • Patent number: D847651
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: May 7, 2019
    Assignee: ABBOTT LABORATORIES
    Inventors: Timothy LaPlante, James Perry, Emily Untener Brudos, Damien Vizcarra, Elizabeth Kneen Winter
  • Patent number: D848019
    Type: Grant
    Filed: August 3, 2017
    Date of Patent: May 7, 2019
    Assignee: Abbott Laboratories
    Inventors: Christina A. Barton, Rachel Elizabeth Wallace, Ami Marie Verhalen, Daniel Roger Nett
  • Patent number: D850955
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: June 11, 2019
    Assignee: Abbott Laboratories
    Inventors: Christina A. Barton, Vladlena Belozerova, Ami Marie Verhalen, Jesse Charles Darley, Sherry Sue Eckholm
  • Patent number: D850956
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: June 11, 2019
    Assignee: Abbott Laboratories
    Inventors: Christina A. Barton, Vladlena Belozerova, Ami Marie Verhalen, Jesse Charles Darley, Sherry Sue Eckholm
  • Patent number: D851519
    Type: Grant
    Filed: January 17, 2018
    Date of Patent: June 18, 2019
    Assignee: Abbott Laboratories
    Inventors: Christina A. Barton, Rachel Elizabeth Wallace, Ami Marie Verhalen, Christopher Alan Harris, Daniel Roger Nett