Abstract: A method of manufacturing a drug-eluting coating for a stent is disclosed. A method for increasing blood flow to ischemic tissues by implanting the stent is also disclosed.
Type:
Grant
Filed:
October 2, 2003
Date of Patent:
December 1, 2009
Assignee:
Advanced Cardiovascular Systems, Inc.
Inventors:
Evgenia Mandrusov, Paul Consigny, Syed Faiyaz Ahmed Hossainy, Dary Mirzaee
Abstract: The apparatus and method use an optical feedback system to align a brush assembly with a stent strut. Once alignment is achieved, a coating is dispensed onto the stent strut via the brush assembly and the brush assembly is moved along the stent strut to coat the stent strut.
Type:
Application
Filed:
July 27, 2009
Publication date:
November 26, 2009
Applicant:
Advanced Cardiovascular Systems, Inc.
Inventors:
Grayson Morris, Svava Maria Atladottir, Carla Pienknagura
Abstract: A polymeric tube is positioned on a polymeric mandrel and then laser cut to form an implantable medical device, such as a stent. The method reduces contamination of the inner surface of the stent, which would be caused if conventional glass or metal mandrels are used, while simultaneously reducing damage to the inner surface of the stent due to the shielding effect of the polymeric mandrel.
Type:
Grant
Filed:
June 20, 2005
Date of Patent:
November 24, 2009
Assignee:
Advanced Cardiovascular Systems, Inc.
Inventors:
Svava Maria Atladottir, David C. Gale, Klaus Kleine
Abstract: A method of coating an implantable medical device, such as a stent, is disclosed. The method includes applying a formulation on a first polymer layer containing a therapeutic substance to form a second layer. The formulation can contain a highly hydrophobic polymer or a solvent which is a poor solvent for the drug or the polymer of the first layer. The formulation can have a low surface tension value or a high Weber number value.
Type:
Grant
Filed:
November 2, 2006
Date of Patent:
November 24, 2009
Assignee:
Advanced Cardiovascular Systems, Inc.
Inventors:
Wouter E. Roorda, Syed F. A. Hossainy, Ni Ding, Fuh-Wei Tang, Stephen D. Pacetti
Abstract: Implantable devices (e.g., stent) having a protein patterning or bioactive patterning for accelerated healing and method of forming and using the same are provided.
Type:
Application
Filed:
July 24, 2009
Publication date:
November 19, 2009
Applicant:
Advanced Cardiovascular systems, Inc.
Inventors:
Syed Faiyaz Ahmed Hossainy, Florian Niklas Ludwig, David Gale
Abstract: A polymer of fluorinated monomers and hydrocarbon monomers is provided. It is also provided a polymer blend that contains a polymer formed of fluorinated monomers and hydrocarbon monomers and another biocompatible polymer. The polymer or polymer blend described herein and optionally a bioactive agent can form an implantable device such as a stent or a coating on an implantable device such as a drug-delivery stent, which can be used for treating or preventing a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.
Abstract: A stent mandrel fixture for supporting a stent during the application of a coating substance is provided. A method supporting a stent during the application of a coating substance is also provided.
Type:
Grant
Filed:
January 16, 2007
Date of Patent:
October 20, 2009
Assignee:
Advanced Cardiovascular Systems, Inc.
Inventors:
Jason Fox, Nathan Harold, Barry Templin, Andrew Tochterman
Abstract: A method is disclosed for spin coating a stent. The method comprises applying a coating substance to the stent; rotating the stent about an axis of rotation, the axis of rotation being perpendicular to a longitudinal axis of the stent; and rotating the stent about the longitudinal axis of the stent contemporaneously with rotating the stent about the axis of rotation. The axis of rotation can intersect a center of the mass of the stent.
Abstract: A method of coating a medical device, such as a stent is provided. The method can include forming a polymer layer containing a drug on the device, applying a polymer melt free from any solvents to the polymer layer to form a topcoat layer, wherein the during the application of the polymer melt the migration of the drug from the polymer layer is prevented or significantly minimized.
Abstract: Implantable devices (e.g., stent) having a protein patterning or bioactive patterning for accelerated healing and method of forming and using the same are provided.
Type:
Grant
Filed:
December 16, 2005
Date of Patent:
September 22, 2009
Assignee:
Advanced Cardiovascular Systems, Inc.
Inventors:
Syed Faiyaz Ahmed Hossainy, Florian Niklas Ludwig, David Gale
Abstract: The apparatus and method use an optical feedback system to align a brush assembly with a stent strut. Once alignment is achieved, a coating is dispensed onto the stent strut via the brush assembly and the brush assembly is moved along the stent strut to coat the stent strut.
Type:
Grant
Filed:
November 29, 2004
Date of Patent:
September 15, 2009
Assignee:
Advanced Cardiovascular Systems, Inc.
Inventors:
Grayson Morris, Svava Maria Atladottir, Carla Pienknagura
Abstract: A polymer coating for implantable medical devices based on polyorthoesters and methods for fabricating the coating are disclosed. The implantable medical devices made of polyorthoesters and methods for fabricating thereof are also disclosed.
Abstract: A polymer coating for medical devices based on a polyolefin derivative. A variety of polymers are described to make coatings for medical devices, particularly, for drug delivery stents. The polymers include homo-, co-, and terpolymers having at least one olefin-derived unit and at least one unit derived from vinyl alcohol, allyl alcohol and derivatives thereof.
Abstract: An embolic filtering device for use in a bifurcated vessel includes delivery device having a first guide wire and a second guide wire. The second guide wire diverges from the distal-end region of the first guide wire. The filter device also includes a filter support having a first deployment member and a second deployment member. These deployment members can be formed as a first loop and a second loop. A bifurcated filter element is coupled to the filter support. The distal-end region of the first guide wire extends through a first leg of the filter element and the second guide wire extends through a second leg of the filter element. During use, the first leg of the filter element is deployed within a first branch of the bifurcated vessel and the second leg of the filter element is deployed within a second branch of the bifurcated vessel.