Patents Assigned to Alcon
  • Use of TIMP-3 inducers of TIMP-3 expression, and TIMP-3 mimetics to treat ocular neovascularization
    Patent number: 6534475
    Abstract: Methods and compositions for treating ocular neovascularization with TIMP-3, TIMP-3 inducers, and TIMP-3 mimetics are disclosed.
    Type: Grant
    Filed: October 26, 2000
    Date of Patent: March 18, 2003
    Assignee: Alcon, Inc.
    Inventor: Abbot F. Clark
  • Non-peptide bradykinin receptor antagonists for use in treating ophthalmic diseases and disorders
    Patent number: 6531480
    Abstract: This invention relates to the topical ocular use of non-peptide bradykinin receptor antagonists for the treatment of human ocular pain, neovascularization, corneal haze, allergy and inflammatory diseases.
    Type: Grant
    Filed: October 2, 2000
    Date of Patent: March 11, 2003
    Assignee: Alcon Manufacturing, Ltd.
    Inventor: Najam A. Sharif
  • Method of prostaglandin synthesis
    Patent number: 6531614
    Abstract: Methods of synthesizing 9-Halo-13,14-dihydroprostaglandins useful in the treatment of glaucoma and ocular hypertension are disclosed. Also disclosed are ophthalmic, pharmaceutical compositions comprising such prostaglandins.
    Type: Grant
    Filed: February 4, 2002
    Date of Patent: March 11, 2003
    Assignee: Alcon Manufacturing, Ltd.
    Inventor: Raymond E. Conrow
  • Foldable ophthalmic and otorhinolaryngological device materials
    Patent number: 6528602
    Abstract: Disclosed are soft, high refractive index, acrylic materials having an elongation of at least 150%. These materials, especially useful as intraocular lens materials, contain an aryl acrylic hydrophobic monomer as the single principal device-forming monomer. In addition to their use as intraocular lens materials, the present materials are also suitable for use in other ophthalmic or otorhinolaryngological devices, such as contact lenses, keratoprostheses, corneal inlays or rings; otological ventilation tubes and nasal implants.
    Type: Grant
    Filed: August 23, 2000
    Date of Patent: March 4, 2003
    Assignee: Alcon Universal Ltd.
    Inventors: Charles Freeman, Douglas C. Schlueter
  • Method of operating microsurgical instruments
    Patent number: 6514268
    Abstract: A method of operating a microsurgical instrument, such as a vitrectomy probe, is disclosed. The probe includes a port for receiving tissue and an inner cutting member. A flow of tissue is induced into the port with a vacuum source, and the member is actuated in a cyclic manner to open and close the port over a plurality of cut rates. A duty cycle of the member is varied with the cut rate to vary the flow of the tissue into the port. The method yields the ability to adjust flow rate into the probe and aperture of the probe for a given cut rate so as to effectively perform a wide variety of vitreoretinal surgical objectives.
    Type: Grant
    Filed: August 30, 1999
    Date of Patent: February 4, 2003
    Assignee: Alcon Universal Ltd.
    Inventors: Russell L. Finlay, William W. Furniss, John C. Huculak, Christopher C. Jung
  • Treatment of disorders of the outer retina
    Patent number: 6509355
    Abstract: This invention is directed to the use of glutamate antagonists to treat the disorders of outer retina.
    Type: Grant
    Filed: April 18, 2001
    Date of Patent: January 21, 2003
    Assignee: Alcon Laboratories, Inc.
    Inventors: Robert J. Collier, Jr., Mark R. Hellberg, Michael A. Kapin, George E. Barnes, Michael L. Chandler
  • Compositions and methods for treating otic, ophthalmic and nasal infections
    Patent number: 6509327
    Abstract: Ophthalmic, otic and nasal compositions containing a new class of antibiotics (e.g., moxifloxacin) are disclosed. The compositions preferably also contain one or more anti-inflammatory agents. The compositions may be utilized to treat ophthalmic, otic and nasal conditions by topically applying the compositions to the affected tissues. The compositions and methods of the invention are particularly useful in the treatment of acute otitis externa infections attributable to one or both of two newly identified Microbacterium species, Microbacterium otitidis and Microbacterium alconae.
    Type: Grant
    Filed: May 19, 2000
    Date of Patent: January 21, 2003
    Assignee: Alcon Manufacturing, Ltd.
    Inventors: Gerald Cagle, Robert L. Abshire, David W. Stroman, Celeste H. McLean, Linda L. Clark, John M. Yanni
  • Disulfide derivatives useful for treating allergic diseases
    Patent number: 6506802
    Abstract: Novel disulfide derivatives useful for preventing or treating allergic diseases of the eye, nose, skin, ear, gastrointestinal tract, airways or lung and preventing or treating manifestations of systemic mastocytosis are disclosed. The disulfide derivatives act as mast cell stabilizers.
    Type: Grant
    Filed: May 22, 2002
    Date of Patent: January 14, 2003
    Assignee: Alcon Universal Ltd.
    Inventors: Zixia Feng, Mark R. Hellberg, Steven T. Miller
  • Method for treating dry eye disorders
    Publication number: 20030008853
    Abstract: 22,29-epoxy-3,4,6,7,29-pentahydroxy-,(3&agr;,4&bgr;,5&agr;,6&agr;,7&bgr;,14&bgr;,22S)-stigmastan-15-one is useful for treating dry eye disorders and other disorders requiring the wetting of the eye.
    Type: Application
    Filed: May 17, 2002
    Publication date: January 9, 2003
    Applicant: Alcon, Inc.
    Inventors: John M. Yanni, Daniel A. Gamache
  • Use of proteasome inhibitors to treat dry eye disorders
    Publication number: 20030008910
    Abstract: Proteasome inhibitors are useful for treating dry eye disorders and other disorders requiring the wetting of the eye.
    Type: Application
    Filed: May 17, 2002
    Publication date: January 9, 2003
    Applicant: Alcon, Inc.
    Inventors: Peter G. Klimko, Mark R. Hellberg
  • Use of NF-kappabeta inhibitors to treat dry eye disorders
    Publication number: 20030008854
    Abstract: NF-&kgr;B inhibitors are useful for treating dry eye disorders and other disorders requiring the wetting of the eye.
    Type: Application
    Filed: May 17, 2002
    Publication date: January 9, 2003
    Applicant: Alcon, Inc.
    Inventors: Daniel A. Gamache, John M. Yanni
  • Use of borate-polyol complexes in ophthalmic compositions
    Patent number: 6503497
    Abstract: Water-soluble borate-polyol complexes are useful as buffers and/or antimicrobials in aqueous ophthalmic compositions, including those containing polyvinyl alcohol. These compositions have greater antimicrobial activity than comparable compositions containing typical borate buffers and unexpectedly increase the antimicrobial efficacy of other antimicrobial agents when used in combination. In addition, use of the boratepolyol complexes avoids the incompatibility problem typically associated with the combination of borate buffer and polyvinyl alcohol; therefore, the compositions disclosed herein may also contain polyvinyl alcohol.
    Type: Grant
    Filed: December 19, 2001
    Date of Patent: January 7, 2003
    Assignee: Alcon Manufacturing, Ltd.
    Inventors: Masood Chowhan, Nissanke L. Dassanayake
  • Non-peptide bradykinin receptor antagonists for use in controlling intraocular pressure and treating glaucoma
    Patent number: 6500831
    Abstract: This invention relates to the topical ocular use of non-peptide bradykinin receptor antagonists to treat glaucoma and ocular hypertension.
    Type: Grant
    Filed: October 2, 2000
    Date of Patent: December 31, 2002
    Assignee: Alcon Manufacturing, Ltd.
    Inventor: Najam A. Sharif
  • Disulfide derivatives useful for treating allergic diseases
    Patent number: 6500864
    Abstract: Novel disulfide derivatives useful for preventing or treating allergic diseases of the eye, nose, skin, ear, gastrointestinal tract, airways or lung and preventing or treating manifestations of systemic mastocytosis are disclosed. The disulfide derivatives act as mast cell stabilizers.
    Type: Grant
    Filed: May 22, 2002
    Date of Patent: December 31, 2002
    Assignee: Alcon Universal Ltd.
    Inventors: Zixia Feng, Mark R. Hellberg, Steven T. Miller
  • Apparatus and method for objective measurement of optical systems using wavefront analysis
    Patent number: 6497483
    Abstract: An apparatus for determining aberrations of an eye includes a patient head rest allowing for positioning adjustment. The patient head rest is operable with an optical table having a base. The base includes a probe beam generating apparatus, probe beam directing optics which itself comprises a beam splitter; a mirror; and a lens. The probe beam directing optics is capable of directing a probe beam toward an eye of a patient positioned on the patient head rest. Video image components are provided and comprise a light source, a mirror; and a video camera. The video image components are capable of generating an image of an eye of a patient positioned on the patient head rest. Eye fixation components generate a target that the eye of a patient positioned on the patient head rest can view. The eye fixation components comprise a fixation target, a light source, a lens, and a mirror.
    Type: Grant
    Filed: March 6, 2002
    Date of Patent: December 24, 2002
    Assignee: Alcon, Inc.
    Inventors: Rudolph W. Frey, James H. Burkhalter, Neil Zepkin, Edward Poppeliers, John Alfred Campin
  • Methods of performing surgery with galactomannan polymers and borate
    Patent number: 6495608
    Abstract: The present invention is directed to viscoelastic systems comprising a combination of a galactomannan polysaccharide containing composition and borate containing composition. The two compositions gel or partially gel upon combination. The present invention also discloses methods of using the systems during surgery and, in particular, eye surgery.
    Type: Grant
    Filed: January 26, 2000
    Date of Patent: December 17, 2002
    Assignee: Alcon Manufacturing, Ltd.
    Inventor: Bahram Asgharian
  • Toric intraocular lens material
    Patent number: 6491721
    Abstract: A method of selecting an intraocular lens material for toric lenses is disclosed. The method comprises determining the tack of the material.
    Type: Grant
    Filed: January 16, 2001
    Date of Patent: December 10, 2002
    Assignee: Alcon Manufacturing, Ltd.
    Inventors: Charles Freeman, Mutlu Karakelle, Michael J. Simpson
  • Disulfide derivatives useful for treating allergic diseases
    Patent number: 6492552
    Abstract: Novel disulfide derivatives useful for preventing or treating allergic diseases of the eye, nose, skin, ear, gastrointestinal tract, airways or lung and preventing or treating manifestations of systemic mastocytosis are disclosed. The disulfide derivatives act as mast cell stabilizers.
    Type: Grant
    Filed: April 25, 2001
    Date of Patent: December 10, 2002
    Assignee: Alcon Universal Ltd.
    Inventors: Zixia Feng, Mark R. Hellberg, Steven T. Miller
  • 11-deoxy-16-fluoro-PGF2&agr; analogs as FP receptor antagonists
    Patent number: 6492417
    Abstract: Methods and compositions for the antagonism of FP receptor-mediated biological responses are disclosed.
    Type: Grant
    Filed: December 14, 1998
    Date of Patent: December 10, 2002
    Assignee: Alcon Manufacturing, Ltd.
    Inventors: Najam A. Sharif, Brenda W. Griffin
  • Surgical console
    Patent number: D467001
    Type: Grant
    Filed: March 25, 2002
    Date of Patent: December 10, 2002
    Assignee: Alcon, Inc.
    Inventors: Mark J. Buczek, Kevin M. Creed, David A. Eister, Douglas M. Fanney, Michael D. Morgan, Argelio M. Olivera, Robert H. Peterson, David M. Weston