Patents Assigned to Alcon
  • Method of making high refractive index ophthalmic device materials
    Patent number: 6541572
    Abstract: Disclosed is a two-step method of making soft, high refractive index, acrylic ophthalmic device materials. In the first step, a copolymer containing pendant oxirane groups is formed by copolymerizing one or more aryl acrylic hydrophobic monomers with one or more compounds of the formula wherein X is H or CH3; and n is 1-4. In the second step, the copolymer containing pendant oxirane groups formed in the first step is reacted with a compound of the formula W—T—H wherein W is H, CH3(CH2)a, or Z(OCH2CH2)b; a is 0-3; b is 1-5; Z is H, or CH3(CH2)p; p is 0-3; and T is O, NH, S; provided that if T≠O, then W≠H.
    Type: Grant
    Filed: September 17, 2001
    Date of Patent: April 1, 2003
    Assignee: Alcon Manufacturing, Ltd.
    Inventor: Albert R. LeBoeuf
  • Intraocular lens shipping case and injection cartridge
    Patent number: 6537283
    Abstract: An intraocular lens cartridge having a distal injector portion and a proximal shipping portion. The injector portion and the shipping portion are join be a hinge that allows the shipping portion to be rotated so that the lens, when held in the shipping portion, aligns with the bore of the injector portion. The shipping portion may also be flexible so as to provide a prefold to the lens.
    Type: Grant
    Filed: August 17, 2001
    Date of Patent: March 25, 2003
    Assignee: Alcon, Inc.
    Inventor: Stephen J. Van Noy
  • Olopatadine formulations for topical administration
    Publication number: 20030055102
    Abstract: Topical formulations of olopatadine for treatment of allergic or inflammatory disorders of the eye and nose are disclosed. The aqueous formulations contain approximately 0.17-0.62% (w/v) of olopatadine and an amount of polyvinylpyrrolidone or polystyrene sulfonic acid sufficient to enhance the physical stability of the formulations.
    Type: Application
    Filed: June 19, 2002
    Publication date: March 20, 2003
    Applicant: Alcon, Inc.
    Inventors: Ernesto J. Castillo, Wesley Wehsin Han, Huixiang Zhang, Haresh G. Bhagat, Onkar N. Singh, Joseph Paul Bullock, Suresh C. Dixit
  • Use of TIMP-3 inducers of TIMP-3 expression, and TIMP-3 mimetics to treat ocular neovascularization
    Patent number: 6534475
    Abstract: Methods and compositions for treating ocular neovascularization with TIMP-3, TIMP-3 inducers, and TIMP-3 mimetics are disclosed.
    Type: Grant
    Filed: October 26, 2000
    Date of Patent: March 18, 2003
    Assignee: Alcon, Inc.
    Inventor: Abbot F. Clark
  • Non-peptide bradykinin receptor antagonists for use in treating ophthalmic diseases and disorders
    Patent number: 6531480
    Abstract: This invention relates to the topical ocular use of non-peptide bradykinin receptor antagonists for the treatment of human ocular pain, neovascularization, corneal haze, allergy and inflammatory diseases.
    Type: Grant
    Filed: October 2, 2000
    Date of Patent: March 11, 2003
    Assignee: Alcon Manufacturing, Ltd.
    Inventor: Najam A. Sharif
  • Method of prostaglandin synthesis
    Patent number: 6531614
    Abstract: Methods of synthesizing 9-Halo-13,14-dihydroprostaglandins useful in the treatment of glaucoma and ocular hypertension are disclosed. Also disclosed are ophthalmic, pharmaceutical compositions comprising such prostaglandins.
    Type: Grant
    Filed: February 4, 2002
    Date of Patent: March 11, 2003
    Assignee: Alcon Manufacturing, Ltd.
    Inventor: Raymond E. Conrow
  • Foldable ophthalmic and otorhinolaryngological device materials
    Patent number: 6528602
    Abstract: Disclosed are soft, high refractive index, acrylic materials having an elongation of at least 150%. These materials, especially useful as intraocular lens materials, contain an aryl acrylic hydrophobic monomer as the single principal device-forming monomer. In addition to their use as intraocular lens materials, the present materials are also suitable for use in other ophthalmic or otorhinolaryngological devices, such as contact lenses, keratoprostheses, corneal inlays or rings; otological ventilation tubes and nasal implants.
    Type: Grant
    Filed: August 23, 2000
    Date of Patent: March 4, 2003
    Assignee: Alcon Universal Ltd.
    Inventors: Charles Freeman, Douglas C. Schlueter
  • Method of operating microsurgical instruments
    Patent number: 6514268
    Abstract: A method of operating a microsurgical instrument, such as a vitrectomy probe, is disclosed. The probe includes a port for receiving tissue and an inner cutting member. A flow of tissue is induced into the port with a vacuum source, and the member is actuated in a cyclic manner to open and close the port over a plurality of cut rates. A duty cycle of the member is varied with the cut rate to vary the flow of the tissue into the port. The method yields the ability to adjust flow rate into the probe and aperture of the probe for a given cut rate so as to effectively perform a wide variety of vitreoretinal surgical objectives.
    Type: Grant
    Filed: August 30, 1999
    Date of Patent: February 4, 2003
    Assignee: Alcon Universal Ltd.
    Inventors: Russell L. Finlay, William W. Furniss, John C. Huculak, Christopher C. Jung
  • Treatment of disorders of the outer retina
    Patent number: 6509355
    Abstract: This invention is directed to the use of glutamate antagonists to treat the disorders of outer retina.
    Type: Grant
    Filed: April 18, 2001
    Date of Patent: January 21, 2003
    Assignee: Alcon Laboratories, Inc.
    Inventors: Robert J. Collier, Jr., Mark R. Hellberg, Michael A. Kapin, George E. Barnes, Michael L. Chandler
  • Compositions and methods for treating otic, ophthalmic and nasal infections
    Patent number: 6509327
    Abstract: Ophthalmic, otic and nasal compositions containing a new class of antibiotics (e.g., moxifloxacin) are disclosed. The compositions preferably also contain one or more anti-inflammatory agents. The compositions may be utilized to treat ophthalmic, otic and nasal conditions by topically applying the compositions to the affected tissues. The compositions and methods of the invention are particularly useful in the treatment of acute otitis externa infections attributable to one or both of two newly identified Microbacterium species, Microbacterium otitidis and Microbacterium alconae.
    Type: Grant
    Filed: May 19, 2000
    Date of Patent: January 21, 2003
    Assignee: Alcon Manufacturing, Ltd.
    Inventors: Gerald Cagle, Robert L. Abshire, David W. Stroman, Celeste H. McLean, Linda L. Clark, John M. Yanni
  • Disulfide derivatives useful for treating allergic diseases
    Patent number: 6506802
    Abstract: Novel disulfide derivatives useful for preventing or treating allergic diseases of the eye, nose, skin, ear, gastrointestinal tract, airways or lung and preventing or treating manifestations of systemic mastocytosis are disclosed. The disulfide derivatives act as mast cell stabilizers.
    Type: Grant
    Filed: May 22, 2002
    Date of Patent: January 14, 2003
    Assignee: Alcon Universal Ltd.
    Inventors: Zixia Feng, Mark R. Hellberg, Steven T. Miller
  • Use of NF-kappabeta inhibitors to treat dry eye disorders
    Publication number: 20030008854
    Abstract: NF-&kgr;B inhibitors are useful for treating dry eye disorders and other disorders requiring the wetting of the eye.
    Type: Application
    Filed: May 17, 2002
    Publication date: January 9, 2003
    Applicant: Alcon, Inc.
    Inventors: Daniel A. Gamache, John M. Yanni
  • Method for treating dry eye disorders
    Publication number: 20030008853
    Abstract: 22,29-epoxy-3,4,6,7,29-pentahydroxy-,(3&agr;,4&bgr;,5&agr;,6&agr;,7&bgr;,14&bgr;,22S)-stigmastan-15-one is useful for treating dry eye disorders and other disorders requiring the wetting of the eye.
    Type: Application
    Filed: May 17, 2002
    Publication date: January 9, 2003
    Applicant: Alcon, Inc.
    Inventors: John M. Yanni, Daniel A. Gamache
  • Use of proteasome inhibitors to treat dry eye disorders
    Publication number: 20030008910
    Abstract: Proteasome inhibitors are useful for treating dry eye disorders and other disorders requiring the wetting of the eye.
    Type: Application
    Filed: May 17, 2002
    Publication date: January 9, 2003
    Applicant: Alcon, Inc.
    Inventors: Peter G. Klimko, Mark R. Hellberg
  • Use of borate-polyol complexes in ophthalmic compositions
    Patent number: 6503497
    Abstract: Water-soluble borate-polyol complexes are useful as buffers and/or antimicrobials in aqueous ophthalmic compositions, including those containing polyvinyl alcohol. These compositions have greater antimicrobial activity than comparable compositions containing typical borate buffers and unexpectedly increase the antimicrobial efficacy of other antimicrobial agents when used in combination. In addition, use of the boratepolyol complexes avoids the incompatibility problem typically associated with the combination of borate buffer and polyvinyl alcohol; therefore, the compositions disclosed herein may also contain polyvinyl alcohol.
    Type: Grant
    Filed: December 19, 2001
    Date of Patent: January 7, 2003
    Assignee: Alcon Manufacturing, Ltd.
    Inventors: Masood Chowhan, Nissanke L. Dassanayake
  • Non-peptide bradykinin receptor antagonists for use in controlling intraocular pressure and treating glaucoma
    Patent number: 6500831
    Abstract: This invention relates to the topical ocular use of non-peptide bradykinin receptor antagonists to treat glaucoma and ocular hypertension.
    Type: Grant
    Filed: October 2, 2000
    Date of Patent: December 31, 2002
    Assignee: Alcon Manufacturing, Ltd.
    Inventor: Najam A. Sharif
  • Disulfide derivatives useful for treating allergic diseases
    Patent number: 6500864
    Abstract: Novel disulfide derivatives useful for preventing or treating allergic diseases of the eye, nose, skin, ear, gastrointestinal tract, airways or lung and preventing or treating manifestations of systemic mastocytosis are disclosed. The disulfide derivatives act as mast cell stabilizers.
    Type: Grant
    Filed: May 22, 2002
    Date of Patent: December 31, 2002
    Assignee: Alcon Universal Ltd.
    Inventors: Zixia Feng, Mark R. Hellberg, Steven T. Miller
  • Apparatus and method for objective measurement of optical systems using wavefront analysis
    Patent number: 6497483
    Abstract: An apparatus for determining aberrations of an eye includes a patient head rest allowing for positioning adjustment. The patient head rest is operable with an optical table having a base. The base includes a probe beam generating apparatus, probe beam directing optics which itself comprises a beam splitter; a mirror; and a lens. The probe beam directing optics is capable of directing a probe beam toward an eye of a patient positioned on the patient head rest. Video image components are provided and comprise a light source, a mirror; and a video camera. The video image components are capable of generating an image of an eye of a patient positioned on the patient head rest. Eye fixation components generate a target that the eye of a patient positioned on the patient head rest can view. The eye fixation components comprise a fixation target, a light source, a lens, and a mirror.
    Type: Grant
    Filed: March 6, 2002
    Date of Patent: December 24, 2002
    Assignee: Alcon, Inc.
    Inventors: Rudolph W. Frey, James H. Burkhalter, Neil Zepkin, Edward Poppeliers, John Alfred Campin
  • Methods of performing surgery with galactomannan polymers and borate
    Patent number: 6495608
    Abstract: The present invention is directed to viscoelastic systems comprising a combination of a galactomannan polysaccharide containing composition and borate containing composition. The two compositions gel or partially gel upon combination. The present invention also discloses methods of using the systems during surgery and, in particular, eye surgery.
    Type: Grant
    Filed: January 26, 2000
    Date of Patent: December 17, 2002
    Assignee: Alcon Manufacturing, Ltd.
    Inventor: Bahram Asgharian
  • Infusion control system
    Patent number: 6491661
    Abstract: An infusion control system having a flexible, collapsible infusion container. The container can be compressed between rollers or plate so at to pressurize the container. Such a system allows for rapid pressure response rates without the need of venting devices or air filtering. The may also include an irrigation flow sensor. The sensor may be placed in the control console or in the infusion handpiece. Irrigation flow measurements provided by the sensor allows the control system to vary irrigation pressure and/or flow, aspiration pressure and/or flow and power supplied to the handpiece more accurately than sensors that monitor aspiration flow.
    Type: Grant
    Filed: November 10, 1999
    Date of Patent: December 10, 2002
    Assignee: Alcon Manufacturing, Ltd.
    Inventors: Mikhail Boukhny, Michael D. Morgan, Gary P. Sorensen