Abstract: A method and system for patient optical fixation are disclosed. One embodiment of the system comprises: a light source operable to provide a fixation light beam; a filter optically coupled to the light source and operable to attenuate the fixation light beam to provide an apodized light beam, wherein the apodized light beam comprises a more attenuated portion and a less attenuated portion; and a viewer, operable to receive a reflected fine align beam and a reflected coarse align beam from a fixation target. The light source can be, for example, a laser, a light emitting diode or a laser diode. The filter can be a neutral density (“ND”) filter, comprising: an aperture through which a first portion of the fixation light beam can pass unattenuated by the ND filter to form the less attenuated portion of the apodized light beam; and a filter region for attenuating a second portion of the fixation light beam to form the more attenuated portion of the apodized light beam.

Abstract: The present invention relates to development of efficacious pharmaceutical compositions comprising a poorly water soluble active compound in a therapeutically effective amount and a co-solvent in a suitable amount to treat or prevent diseases due to ocular neovascularization and enhanced vascular permeability. In preferred aspects the composition is in the form of a gel.

Abstract: The present invention relates to a re-positioning reminder for personal portable electronic equipment.

Abstract: An ophthalmic surgical cassette for removably receiving in a cassette receiving mechanism of an ophthalmic surgical system. The system includes first and second plunger valves. The cassette includes a body having a rear surface, an irrigation inlet for receiving irrigation fluid from a source, a first irrigation outlet for providing irrigation fluid to a first ophthalmic microsurgical instrument for use in an anterior segment ophthalmic surgical procedure, a first manifold fluidly coupling the irrigation inlet with the first irrigation outlet, a second irrigation outlet for providing irrigation fluid to a second ophthalmic microsurgical instrument for use in a posterior segment ophthalmic surgical procedure, and a second manifold fluidly coupling the irrigation inlet with the second irrigation outlet.

Abstract: Ophthalmic compositions suitable for use as artificial tears or as vehicles for ophthalmic drugs are disclosed. The compositions contain a combination of three polymers that have a synergistic effect on viscosity.

Abstract: A loudspeaker comprising a magnet unit that generates a magnetic field, and a membrane which is mounted in a frame and which is provided with an electrical conductor arranged in a pattern on the membrane, which membrane is positioned in the magnetic field in such a manner that a force is exerted when current is fed through the conductor pattern on the membrane, which force is capable of setting the membrane in motion so as to produce sound, the frame being provided with metallic cooling members that partially cover the conductor pattern, wherein said cooling members are mounted in a metal housing, making contact with said housing over the larger part of their surface area, or are integral with such a metal housing.

Abstract: An apparatus and method for the dissociation of soft proteinaceous tissue using pulsed rapid variable direction energy field flow fractionization is disclosed. The pulsed rapid disruptive energy field is created by the use of a probe which surrounds the soft proteinaceous tissue to be removed. Once the adhesive mechanism between tissue constituents has been compromised, fluidic techniques are used to remove the dissociated tissue.

Abstract: RNA interference, is provided for inhibition of HIF1A mRNA expression for treating patients with ocular angiogenesis, particularly for treating retinal edema, diabetic retinopathy, sequela associated with retinal ischemia, posterior segment neovascularization (PSNV), and neovascular glaucoma, and for treating patients at risk of developing such conditions.

Abstract: A system for controlling a device in ophthalmic refractive surgery includes a processor, a controller, a treatment laser, and a signal receiver. A remote device has a plurality of input elements. At least one input element when activated is configured to emit a discrete signal that is received by the signal receiver and is mapped to an action to be signaled by the controller. A software package is adapted to translate data from the signal receiver into a signal for directing at least the controller. A method for configuring a system for controlling a device in ophthalmic refractive surgery includes providing a remote device as above. A software package resident on a processor receives and translates signal data from the remote device into control data for a hardware element. The software package is also adapted to output a control signal correlated with the control data to the hardware element.

Abstract: Methods for using (indazol-5-yl)-pyrazines and (1,3-dihydro-indol-2-one)-pyrazines are disclosed herein to treat rho kinase-mediated diseases or rho kinase-mediated conditions, including controlling intraocular pressure and treating glaucoma, are disclosed. Ophthalmic pharmaceutical compositions useful in the treatment of eye diseases such as glaucoma, and additionally useful for controlling intraocular pressure, the compositions comprising an effective amount of (indazol-5-yl)-pyrazines and (1,3-dihydro-indol-2-one)-pyrazines, are disclosed herein.

Abstract: The present invention relates to development of efficacious pharmaceutical compositions comprising an active compound in a therapeutically effective amount encapsulated or solubilized in phospholipid vesicles.

Abstract: The present invention relates to development of efficacious intravitreal pharmaceutical compositions comprising a poorly water soluble agent with anti-angiogenic and/or anti vascular leakage properties in a therapeutically effective amount and a co-solvent in a suitable amount to treat or prevent diseases due to ocular neovascularization and enhanced vascular permeability. Other aspects of the invention details the development of efficacious compositions for the treatment of the said diseases via periocular, topical and oral administration.

Abstract: The present invention provides methods for identifying a patient at risk for developing AMD by identifying the presence of the Y402H polymorphism or other at risk variants in the complement factor H gene. The present invention further provides methods for treating persons having AMD or at risk for developing AMD as a result of having the Y402H polymorphism or other at risk variants in the complement factor H gene.

Abstract: The present invention relates to development of efficacious pharmaceutical compositions comprising an anti-angiogenic compound in a therapeutically effective amount complexed with or encapsulated in a cyclodextrin derivative.

Abstract: RNA interference is provided for inhibition of Rho kinase mRNA expression for treating patients with ocular disorders, particularly for treating intraocular pressure, ocular hypertension and glaucoma. Rho kinase mRNA targets include mRNA for ROCK1 and ROCK2.

Abstract: Fused pyridazine derivatives are useful for treating dry eye disorders and other disorders requiring the wetting of the eye.

Abstract: An ophthalmic pharmaceutical composition useful in the treatment of glaucoma and control of intraocular pressure comprising an effective amount of a selective modulator of ALK5 receptor activity is disclosed. Also disclosed is a method of treating glaucoma and controlling intraocular pressure comprising applying a therapeutically effective amount of a pharmaceutical composition comprising a selective modulator of ALK5 receptor activity to an affected eye of a patient.

Abstract: The present invention provides improved dietary supplements and methods for inhibiting the progression of macular degeneration and promoting healthy vision, while at the same time maintaining general health. The dietary supplements of the invention contain vitamin E and carotenoids in the form of Vitamin A, lutein and/or zeaxanthine. The dietary supplements of the invention further contain Vitamin C, copper and zinc and may also contain such ingredients as rosemary, DHA, and other vitamins and minerals.

Abstract: The present invention provides a combination therapy for the treatment of pathologic ocular disorders, such as age-related macular degeneration and choroidal neovascularization. The combination therapy of the invention includes administration of anecortave acetate and bevacizumab or ranibizumab.

Abstract: Ophthalmic compositions suitable for use as artificial tears or as vehicles for ophthalmic drugs are disclosed. The compositions contain a combination of two polymers that have a synergistic effect on viscosity.