Patents Assigned to Alcon
  • Pyranoindoles for treating glaucoma
    Patent number: 7012090
    Abstract: Substituted pyranoindoles useful for lowering and controlling IOP and glaucoma are disclosed.
    Type: Grant
    Filed: November 14, 2000
    Date of Patent: March 14, 2006
    Assignee: Alcon, Inc.
    Inventors: Jesse A. May, Hwang-Hsing Chen
  • Use of AP-1 activators to treat glaucoma and ocular hypertension
    Patent number: 7005446
    Abstract: Compositions comprising AP-1 activators and methods of use for treating glaucoma and ocular hypertension are disclosed.
    Type: Grant
    Filed: April 7, 2000
    Date of Patent: February 28, 2006
    Assignee: Alcon Manufacturing, Ltd.
    Inventors: Debra L. Shade, Iok-Hou Pang, Abbot F. Clark
  • Aminoalkyl-benzofuran-5-ol compounds for the treatment of glaucoma
    Patent number: 7005448
    Abstract: The present invention provides novel compounds, compositions containing the compounds of the invention in a pharmaceutically acceptable excipient and methods for using the compositions for lowering intraocular pressure.
    Type: Grant
    Filed: December 5, 2002
    Date of Patent: February 28, 2006
    Assignee: Alcon, Inc.
    Inventor: Jesse A. May
  • 5-Hydroxy indazole derivatives for treating glaucoma
    Patent number: 7005443
    Abstract: 3-(2-aminoethyl)-1H-indazol-5-ols useful for treating elevated intraocular pressure and glaucoma are disclosed.
    Type: Grant
    Filed: November 14, 2000
    Date of Patent: February 28, 2006
    Assignee: Alcon, Inc.
    Inventors: Jesse A. May, Zixia Feng
  • Optical tracking system and associated methods
    Patent number: 7001377
    Abstract: An eye-tracking method includes the step of removably affixing a ring member to an eye in surrounding relation to a cornea of the eye. A plurality of incident light spots are transmitted onto the ring member, and reflections are detected from the ring member of the incident light spots. By analyzing the reflections, eye movement can be determined. A system for tracking eye movement includes a ring member and a device for removably affixing the ring member to an eye in surrounding relation to a cornea of the eye, such as, for example, by applying a vacuum to the ring. A light transmitter transmits a plurality of incident light spots onto the ring member, and a detector for detecting reflections from the ring member of the incident light spots. A processor and software installed thereon are adapted to perform calculations to determine eye movement from an analysis of the reflections.
    Type: Grant
    Filed: December 22, 2003
    Date of Patent: February 21, 2006
    Assignee: Alcon RefractiveHorizons, Inc.
    Inventor: Haizhang Li
  • Sustained release ophthalmic, otic and nasal suspension
    Patent number: 7001615
    Abstract: Sustained release suspension formulations for ophthalmic, otic and nasal administration are disclosed. The formulations comprise a basic active, a cation exchange resin, and a combination of a polymeric suspending agents to provide superior resuspendability.
    Type: Grant
    Filed: November 15, 2002
    Date of Patent: February 21, 2006
    Assignee: Alcon, Inc.
    Inventors: Onkar N. Singh, Ernesto J. Castillo
  • Methods of making indazoles
    Patent number: 6998489
    Abstract: Methods of making indazoles are described. The methods involved reacting an aromatic aldehyde with a nitrogen source to form a nitroso aromatic aldehyde. The nitroso aromatic aldehyde is reacted with a reducing agent to form an indazole which ultimately can be used to form desired indazoles which are preferably pharmaceutically active products. The process of the present invention further permits the formation of enantiomerically enriched or pure indazoles such as aminoalkyl indazoles.
    Type: Grant
    Filed: November 26, 2003
    Date of Patent: February 14, 2006
    Assignee: Alcon, Inc.
    Inventors: Raymond E. Conrow, Pete Delgado, William D. Dean, David R. Pierce, Michael S. Gaines
  • Use of multifunctional surface active agents to clean contact lenses
    Patent number: 6995123
    Abstract: Cleaning compositions for contact lenses are described. The compositions contain multifunctional anionic surfactants that include at least two hydrophilic dissociating head groups. The multifunctional surfactants described (e.g., LED3A) possess both surface active and chelating properties, and have been found to be particularly effective in removing protein deposits from contact lenses.
    Type: Grant
    Filed: December 17, 2003
    Date of Patent: February 7, 2006
    Assignee: Alcon, Inc.
    Inventors: Howard Allen Ketelson, David L. Meadows, Bor-Shyue Hong
  • Olopatadine formulations for topical administration
    Patent number: 6995186
    Abstract: Topical formulations of olopatadine for treatment of allergic or inflammatory disorders of the eye and nose are disclosed. The aqueous formulations contain approximately 0.17-0.62% (w/v) of olopatadine and an amount of polyvinylpyrrolidone or polystyrene sulfonic acid sufficient to enhance the physical stability of the formulations.
    Type: Grant
    Filed: June 19, 2002
    Date of Patent: February 7, 2006
    Assignee: Alcon, Inc.
    Inventors: Ernesto J. Castillo, Wesley Wehsin Han, Huixiang Zhang, Haresh G. Bhagat, Onkar N. Singh, Joseph Paul Bullock, Suresh C. Dixit
  • Substituted [1,4]oxazino[2,3-g]indazoles for the treatment of glaucoma
    Patent number: 6989445
    Abstract: Substituted [1,4]oxazino[2,3-g]indazols for lowering intraocular pressure and treating glaucoma are disclosed.
    Type: Grant
    Filed: December 14, 2004
    Date of Patent: January 24, 2006
    Assignee: Alcon, Inc.
    Inventors: Anura P. Dantanarayana, Jesse Albert May
  • Ophthalmic drug delivery device
    Patent number: 6986900
    Abstract: An ophthalmic drug delivery device having a scleral surface, an orbital surface, an injection port on the orbital surface, and a fluid conducting passageway disposed within the device that is fluidily coupled to the injection port and terminates in an opening for communicating the fluid to an outer surface of the sclera is disclosed. The fluid contains a pharmaceutically active agent useful for the treatment of a disease of the posterior segment of the eye.
    Type: Grant
    Filed: November 5, 2003
    Date of Patent: January 17, 2006
    Assignee: Alcon, Inc.
    Inventor: Yoseph Yaacobi
  • Intraocular lens system
    Patent number: 6972034
    Abstract: A two part lens system. The first part is a ring-like supporting component that is implanted in the capsular bag following cataract surgery. The first component is a non-optical component and contains a pair of haptics for fixating the first component within the capsular bag. The second component is an optical component that contains all of the corrective optical power of the lens system. The second component has a pair of tabs for locking the second component within the first component.
    Type: Grant
    Filed: January 8, 2004
    Date of Patent: December 6, 2005
    Assignee: Alcon, Inc.
    Inventors: Son Trung Tran, David L. Jinkerson
  • Accommodative intraocular lens
    Patent number: 6969403
    Abstract: A two-optic accommodative lens system. The first lens has a negative power and is located posteriorly against the posterior capsule. The periphery of the first optic contains a pair of clasps. The second optic is located anteriorly to the first optic and is of a positive power. The peripheral edge of the second optic contains a pair of locking arms that fit into the clasps contained on the periphery of the first optic to lock the second optic onto the first optic, but allow for rotation of the arms within the clasps. Hinge structures on the locking arms allow the second optic to move relative to the first optic along the optical axis of the lens system in reaction to movement of the ciliary muscle.
    Type: Grant
    Filed: June 4, 2003
    Date of Patent: November 29, 2005
    Assignee: Alcon, Inc.
    Inventors: Qun Peng, Yin Yang, Xiaoxiao Zhang
  • Infusion fluid container support
    Patent number: 6969032
    Abstract: Apparatus and methods for use in ophthalmic surgery in which a container for fluid is connected to a line through which fluid flows to a surgical handpiece for the irrigation of a patient's eye are provided. A sensor emits a magnetic field and a detector causes another magnetic field to be generated. The interaction of the two magnetic fields causes a pulse to be generated. Based on the timing of the generated pulse, the apparatus or method determines the absolute position of the support coupled to the container and adjusts the height of the support. Circuitry is also provided to prevent changes in height of the support by preventing supply of drive currents and by applying a hold current or by generating an electro motive force.
    Type: Grant
    Filed: December 13, 2002
    Date of Patent: November 29, 2005
    Assignee: Alcon, Inc.
    Inventors: Argelio M. Olivera, Stanley C. Polski
  • Alkylpolypropyleneoxide amidotriamines and method of using same
    Patent number: 6962693
    Abstract: Alkylpolypropyleneoxide amidotriamines having antimicrobial activity are described. The compounds are useful as antimicrobial preservatives in various types of pharmaceutical compositions. Ophthalmic compositions containing these compounds as disinfecting agents or preservatives are also described.
    Type: Grant
    Filed: November 30, 2004
    Date of Patent: November 8, 2005
    Assignee: Alcon, Inc.
    Inventors: Nissanke L. Dassanayake, Ronald L. Schlitzer
  • Surgical cassette having an aspiration pressure sensor
    Patent number: 6962488
    Abstract: A cassette having a molded flow channel contained on an elastomeric sheet that is bonded or mechanically attached to a rigid substrate. The flow channel projects outwardly from the exterior of the cassette so that a peristaltic pump having pump head rollers mounted radially from the axis of rotation of the pump motor compress the elastomeric flow channels against the rigid substrate during operation.
    Type: Grant
    Filed: April 4, 2003
    Date of Patent: November 8, 2005
    Assignee: Alcon, Inc.
    Inventors: Sherman G. Davis, Raphael Gordon, Valentine P. Injev, Kurt D. Leukanech, Michael D. Morgan, Mel M. Oliveira, Gary P. Sorensen, Daniel J. Wilson
  • Foot controller for microsurgical system
    Patent number: 6962581
    Abstract: An improved foot controller of a microsurgical system, and a method of operating the foot controller, are disclosed. The method involves using a computer to modulate a detent of the foot controller from the beginning of the detent to the end of the detent.
    Type: Grant
    Filed: December 3, 2002
    Date of Patent: November 8, 2005
    Assignee: Alcon, Inc.
    Inventor: David A. Thoe
  • Intraocular lens system
    Patent number: 6960231
    Abstract: A two part lens system. The first part is a ring-like supporting component that is implanted in the capular bag following cataract surgery. The first component is a non-optical component and contains a pair of haptics for fixating the first component within the capular bag. The second component is an optical component that contains all of the corrective optical power of the lens system. The second component has a pair of tabs for locking the second component within the first component.
    Type: Grant
    Filed: July 14, 2003
    Date of Patent: November 1, 2005
    Assignee: ALcon, Inc.
    Inventor: Son Trung Tran
  • Fused indazoles and indoles and their use for the treatment of glaucoma
    Patent number: 6960608
    Abstract: Novel fused indazoles and indoles are disclosed. Also disclosed are methods for the lowering and controlling of normal or elevated intraocular pressure as well as a method for the treatment of glaucoma using compositions containing one or more of the compounds of the present invention.
    Type: Grant
    Filed: November 25, 2003
    Date of Patent: November 1, 2005
    Assignee: Alcon, Inc.
    Inventors: Jesse A. May, Anura P. Dantanarayana
  • Serotonergic 5HTreceptor compounds for treating ocular and CNS disorders
    Patent number: 6960579
    Abstract: Compounds with 5HT7 receptor affinity (some of which are novel) useful for lowering IOP, improving blood flow to the optic nerve head and the retina, providing neuroprotection, and treating retinal diseases are disclosed. The Compounds are also useful for treating sleep disorders, depression, and other psychiatric disorders, such as, schizophrenia, anxiety, obsessive compulsive disorder, circadian rhythm disorders, and centrally and peripherally mediated hypertension. Compositions and methods for their use are also disclosed.
    Type: Grant
    Filed: May 10, 1999
    Date of Patent: November 1, 2005
    Assignee: Alcon Manufacturing, Ltd.
    Inventors: Jesse A. May, Thomas R. Dean, Najam A. Sharif, Hwang-Hsing Chen