Abstract: The present invention provides novel compounds, compositions containing the compounds of the invention in a pharmaceutically acceptable excipient and methods for using the compositions for lowering intraocular pressure.
Abstract: An eye-tracking method includes the step of removably affixing a ring member to an eye in surrounding relation to a cornea of the eye. A plurality of incident light spots are transmitted onto the ring member, and reflections are detected from the ring member of the incident light spots. By analyzing the reflections, eye movement can be determined. A system for tracking eye movement includes a ring member and a device for removably affixing the ring member to an eye in surrounding relation to a cornea of the eye, such as, for example, by applying a vacuum to the ring. A light transmitter transmits a plurality of incident light spots onto the ring member, and a detector for detecting reflections from the ring member of the incident light spots. A processor and software installed thereon are adapted to perform calculations to determine eye movement from an analysis of the reflections.
Abstract: Sustained release suspension formulations for ophthalmic, otic and nasal administration are disclosed. The formulations comprise a basic active, a cation exchange resin, and a combination of a polymeric suspending agents to provide superior resuspendability.
Abstract: Methods of making indazoles are described. The methods involved reacting an aromatic aldehyde with a nitrogen source to form a nitroso aromatic aldehyde. The nitroso aromatic aldehyde is reacted with a reducing agent to form an indazole which ultimately can be used to form desired indazoles which are preferably pharmaceutically active products. The process of the present invention further permits the formation of enantiomerically enriched or pure indazoles such as aminoalkyl indazoles.
Type:
Grant
Filed:
November 26, 2003
Date of Patent:
February 14, 2006
Assignee:
Alcon, Inc.
Inventors:
Raymond E. Conrow, Pete Delgado, William D. Dean, David R. Pierce, Michael S. Gaines
Abstract: Topical formulations of olopatadine for treatment of allergic or inflammatory disorders of the eye and nose are disclosed. The aqueous formulations contain approximately 0.17-0.62% (w/v) of olopatadine and an amount of polyvinylpyrrolidone or polystyrene sulfonic acid sufficient to enhance the physical stability of the formulations.
Type:
Grant
Filed:
June 19, 2002
Date of Patent:
February 7, 2006
Assignee:
Alcon, Inc.
Inventors:
Ernesto J. Castillo, Wesley Wehsin Han, Huixiang Zhang, Haresh G. Bhagat, Onkar N. Singh, Joseph Paul Bullock, Suresh C. Dixit
Abstract: Cleaning compositions for contact lenses are described. The compositions contain multifunctional anionic surfactants that include at least two hydrophilic dissociating head groups. The multifunctional surfactants described (e.g., LED3A) possess both surface active and chelating properties, and have been found to be particularly effective in removing protein deposits from contact lenses.
Type:
Grant
Filed:
December 17, 2003
Date of Patent:
February 7, 2006
Assignee:
Alcon, Inc.
Inventors:
Howard Allen Ketelson, David L. Meadows, Bor-Shyue Hong
Abstract: An ophthalmic drug delivery device having a scleral surface, an orbital surface, an injection port on the orbital surface, and a fluid conducting passageway disposed within the device that is fluidily coupled to the injection port and terminates in an opening for communicating the fluid to an outer surface of the sclera is disclosed. The fluid contains a pharmaceutically active agent useful for the treatment of a disease of the posterior segment of the eye.
Abstract: A two part lens system. The first part is a ring-like supporting component that is implanted in the capsular bag following cataract surgery. The first component is a non-optical component and contains a pair of haptics for fixating the first component within the capsular bag. The second component is an optical component that contains all of the corrective optical power of the lens system. The second component has a pair of tabs for locking the second component within the first component.
Abstract: Apparatus and methods for use in ophthalmic surgery in which a container for fluid is connected to a line through which fluid flows to a surgical handpiece for the irrigation of a patient's eye are provided. A sensor emits a magnetic field and a detector causes another magnetic field to be generated. The interaction of the two magnetic fields causes a pulse to be generated. Based on the timing of the generated pulse, the apparatus or method determines the absolute position of the support coupled to the container and adjusts the height of the support. Circuitry is also provided to prevent changes in height of the support by preventing supply of drive currents and by applying a hold current or by generating an electro motive force.
Abstract: A two-optic accommodative lens system. The first lens has a negative power and is located posteriorly against the posterior capsule. The periphery of the first optic contains a pair of clasps. The second optic is located anteriorly to the first optic and is of a positive power. The peripheral edge of the second optic contains a pair of locking arms that fit into the clasps contained on the periphery of the first optic to lock the second optic onto the first optic, but allow for rotation of the arms within the clasps. Hinge structures on the locking arms allow the second optic to move relative to the first optic along the optical axis of the lens system in reaction to movement of the ciliary muscle.
Abstract: Alkylpolypropyleneoxide amidotriamines having antimicrobial activity are described. The compounds are useful as antimicrobial preservatives in various types of pharmaceutical compositions. Ophthalmic compositions containing these compounds as disinfecting agents or preservatives are also described.
Type:
Grant
Filed:
November 30, 2004
Date of Patent:
November 8, 2005
Assignee:
Alcon, Inc.
Inventors:
Nissanke L. Dassanayake, Ronald L. Schlitzer
Abstract: A cassette having a molded flow channel contained on an elastomeric sheet that is bonded or mechanically attached to a rigid substrate. The flow channel projects outwardly from the exterior of the cassette so that a peristaltic pump having pump head rollers mounted radially from the axis of rotation of the pump motor compress the elastomeric flow channels against the rigid substrate during operation.
Type:
Grant
Filed:
April 4, 2003
Date of Patent:
November 8, 2005
Assignee:
Alcon, Inc.
Inventors:
Sherman G. Davis, Raphael Gordon, Valentine P. Injev, Kurt D. Leukanech, Michael D. Morgan, Mel M. Oliveira, Gary P. Sorensen, Daniel J. Wilson
Abstract: An improved foot controller of a microsurgical system, and a method of operating the foot controller, are disclosed. The method involves using a computer to modulate a detent of the foot controller from the beginning of the detent to the end of the detent.
Abstract: A two part lens system. The first part is a ring-like supporting component that is implanted in the capular bag following cataract surgery. The first component is a non-optical component and contains a pair of haptics for fixating the first component within the capular bag. The second component is an optical component that contains all of the corrective optical power of the lens system. The second component has a pair of tabs for locking the second component within the first component.
Abstract: Compounds with 5HT7 receptor affinity (some of which are novel) useful for lowering IOP, improving blood flow to the optic nerve head and the retina, providing neuroprotection, and treating retinal diseases are disclosed. The Compounds are also useful for treating sleep disorders, depression, and other psychiatric disorders, such as, schizophrenia, anxiety, obsessive compulsive disorder, circadian rhythm disorders, and centrally and peripherally mediated hypertension. Compositions and methods for their use are also disclosed.
Type:
Grant
Filed:
May 10, 1999
Date of Patent:
November 1, 2005
Assignee:
Alcon Manufacturing, Ltd.
Inventors:
Jesse A. May, Thomas R. Dean, Najam A. Sharif, Hwang-Hsing Chen
Abstract: Novel fused indazoles and indoles are disclosed. Also disclosed are methods for the lowering and controlling of normal or elevated intraocular pressure as well as a method for the treatment of glaucoma using compositions containing one or more of the compounds of the present invention.