Patent number: 5260318
Abstract: Phenylpiperidylamines of the formula I ##STR1## R.sup.1 is H, NO.sub.2, R.sup.4 SO.sub.2 NH, ##STR2## N.dbd.C, CF.sub.3, CF.sub.3 O, F, Cl, Br, C.sub.1 -C.sub.4 -alkyl, R.sup.3 O, CO.sub.2 R.sup.3, CHO, CH.dbd.NOR.sup.3, CH.sub.3 OR.sup.3 andR.sup.2 is H, F, Cl, Br, C.sub.1 -C.sub.4 -alkyl or R.sup.4 O, where R.sup.1 and R.sup.2 are not both H,R.sup.3 is H or R.sup.4,R.sup.4 is C.sub.1 -C.sub.4 -alkyl or phenyl,n is 1, 2, 3 or 4 andAr is ##STR3## and the physiologically tolerated salts thereof, are used as active ingredients in drugs.
Type:
Grant
Filed:
September 16, 1991
Date of Patent:
November 9, 1993
Assignee:
BASF Aktiengesellschaft
Inventors:
Wilfried Lubisch, Sabine Schult, Rudolf Binder, Manfred Raschack, Roland Reinhardt, Dietmar Seemann
Patent number: 5258357
Abstract: Carboxamides of the formulae Ia to Ic ##STR1## where X is oxygen or sulfur;R.sup.1 is hydrogen or substituted or unsubstituted cycloalkyl or alkyl;R.sup.2 is hydroxy, alkoxy, cyanoalkyl, substituted or unsubstituted alkenyl, alkynyl, phenyl or naphthyl, a substituted or unsubstituted 5- to 6-membered heterocyclic structure or one of the groups stated for R.sup.1, orR.sup.1 and R.sup.2 together are a 4- to 7-membered chain which contains, in addition to methylene groups, one of the following groups as ring member: oxygen, sulfur, N-methyl or carbonyl;R.sup.3 and R.sup.4 are each nitro, cyano, halogen, substituted or unsubstituted amino, alkoxy, alkylthio, a substituted or unsubstituted 5- to 6 -membered heterocyclic structure, substituted or unsubstituted alkenyl, alkynyl, phenyl, phenoxy or phenylthio, or one of the groups stated for R.sup.1 ;R.sup.5 is formyl, 4,5-dihydrooxazol-2-yl or COYR.sup.6 (Y=O,S);R.sup.
Type:
Grant
Filed:
September 21, 1992
Date of Patent:
November 2, 1993
Assignee:
BASF Aktiengesellschaft
Inventors:
Peter Muenster, Gerd Steiner, Wolfgang Freund, Bruno Wuerzer, Karl-Otto Westphalen