Abstract: Patient radiation exposure during computerized tomography (CT) scans is estimated. More specifically, efficient approaches for generating a suitable patient model which may be used to make an estimate of a radiation dose received at specific anatomical landmarks or organs of the patient are provided. Further disclosed are approaches for estimating the patient dose by interpolating the results of multiple simulations, and for enabling a service provider to host a dose estimation service made available to multiple CT scan providers.

Abstract: The present invention relates to a process for the preparation of a solid, orally administrable pharmaceutical composition, comprising 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophenecarboxamide in hydrophilized form, and its use for the prophylaxis and/or treatment of diseases.

Abstract: The present invention relates to the field of blood coagulation, more specifically it relates to a method of treating a thromboembolic disorder by administering once daily a direct factor Xa inhibitor in oral dosage form to a patient in need thereof, wherein the factor Xa inhibitor has a plasma concentration half life indicative of a bid or tid administration interval, e.g. of 10 hours or less.

Abstract: The soybean variety GLL0059 is disclosed. The invention relates to seeds, plants, plant cells, plant tissue, harvested products and soybean lint as well as to hybrid soybean plants and seeds obtained by repeatedly crossing plants of variety GLL0059 with other plants. The invention also relates to plants and varieties produced by the method of essential derivation from plants of GLL0059 and to plants of GLL0059 reproduced by vegetative methods, including but not limited to tissue culture of regenerable cells or tissue from GLL0059.

Abstract: The present invention relates to fungicidal N-cycloalkyl-N-[(cycloalkenylphenyl)methylene] carboxamide derivatives and their thiocarbonyl derivatives, their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions.

Abstract: The present invention relates to manufacturing processes for the preparation of a pharmaceutical dosage form comprising nifedipine and candesartan cilexetil and optionally at least one diuretic characterized in that nifedipine is released in the body in a controlled (modified) manner and the candesartan cilexetil is released rapidly (immediate release (IR)) and optionally the diuretic is released rapidly (immediate release (IR)) and the pharmaceutical dosage forms obtainable by these processes.

Abstract: The invention relates to preparations comprising amorphous emodepside in a polyvinylpyrrolidone matrix, pharmaceuticals comprising such preparations, and their use against endoparasites in animals or humans.

Abstract: The present invention relates to substituted thienopyrimidine compounds of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.

Abstract: The present disclosure relates to a method for producing a beam shaping holographic optical element, which is configured to generate diffracted beams configured to reconstruct an image of a diffusor irrespectively of the point of impact of a pencil of light on the beam shaping holographic optical element, comprising providing a recording element, providing a master element comprising a particular pattern, forming a recording stack comprising the recording element and the master element such that the master element is arranged to the recording element in a closed-copy distance, irradiating at least a part of the recording stack with a reconstruction beam, irradiating at least a part of the recording stack with a reference beam, wherein at least one of the reconstruction beam or reference beam penetrates the master element to record the pattern of the master element onto the recording element.

Abstract: The present invention is directed to compounds and methods for inducing ripeness in fruit, increasing the organoleptic properties of fruit, and/or improving desirable characteristics in fruit.

Abstract: The present application relates to sodium 1-[6-(morpholin-4-yl)pyrimidin-4-yl]-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-5-olate, to processes for its preparation, to its use for the treatment and/or prophylaxis of diseases and to its use for the preparation of medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and haematological diseases and kidney diseases, and for promoting wound healing.

Abstract: Provided herein are antibodies, antigen binding portions, and derivatives thereof that are capable of binding tumor necrosis factor alpha (TNF?); nucleic acids encoding the antibodies, antigen binding portions, and derivatives thereof, including complementary nucleic acids; vectors; and host cells containing the nucleic acids.

Abstract: Stress tolerance in plants and plant cells is achieved by using nucleotide sequences encoding enzymes involved in the NAD salvage synthesis pathway and/or the NAD de novo synthesis pathway e.g. for overexpression in plants.

Abstract: Short-acting Factor VII peptides are disclosed. A shortened half-life is desirable for treatment of acute bleeding and similar disorders. Modification of the sialylation and/or glycosylation of Factor VII and variants thereof produced peptides useful in treating conditions of acute bleeding.

Abstract: The invention provides an apparatus and a process for continuous virus inactivation. The apparatus for continuous virus inactivation in a product stream comprises a tube or hose 1 having an inlet 4 and an outlet 5 in each case connected to a product flow line 8 for conveying the product stream, where the tube or the hose 1 is curved and/or helically coiled with a number n of windings around a coil axis h and has one or more changes in direction and/or bends 2 in the coil axis h having an angle ? of from 45° to 180° to alter the direction of action of the normals of the centrifugal force and the apparatus is characterized by a Dean number>0 and a torsion parameter>0.

Abstract: The fluid delivery system includes a pressurizing device for delivering a pressurized injection fluid, a low pressure fluid delivery system, and a pressure isolation mechanism adapted for fluid communication with the pressurizing device and low pressure fluid delivery system. The pressure isolation mechanism includes a housing defining an inlet port, an isolation port, and an internal cavity. The housing defines a seal seat in the internal cavity between the inlet port and isolation port. A valve member is disposed in the internal cavity. The valve member is free floating in the internal cavity and is adapted to engage the seal seat. The valve member has an open position permitting fluid communication between the inlet port and isolation port, and is fluid flow responsive to fluid flow in the inlet port to engage the seal seat and attain a closed position preventing fluid flow between the inlet port and isolation port.

Abstract: Continuous process for preparing ortho-substituted anilines of the formula in a flow reactor in the presence of a nitrogen base not having an NH group, and multistage process for preparing herbicidal N-alkyl-N-[2-(1,3,5-triazin-2-ylcarbonyl)-phenyl]alkansulphonamides of the formula (4-1) wherein the continuous process for preparing ortho-substituted anilines of the formula (4) in a flow reactor constitutes the first process step of the multistage process for preparing the herbicidal active ingredients of the formula (4-1).

Abstract: The cotton variety ST 5445LLB2 is disclosed. The invention relates to seeds, plants, plant cells, plant tissue, harvested products and cotton lint as well as to hybrid cotton plants and seeds obtained by repeatedly crossing plants of variety ST 5445LLB2 with other plants. The invention also relates to plants and varieties produced by the method of essential derivation from plants of ST 5445LLB2 and to plants of ST 5445LLB2 reproduced by vegetative methods, including but not limited to tissue culture of regenerable cells or tissue from ST 5445LLB2.

Abstract: The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.

Abstract: Bin outlet inserts, and systems and methods employing bin outlet inserts for discharging materials are disclosed herein. For example, the bin outlet insert can be a transition device internal to and installed at a bottom of the bin that allows the circular outlet of a bin to be converted to a rectangular outlet (e.g., square outlet). A slide gate arranged at the bin outlet modulates the discharge of material (e.g., grain or seeds) from the bin. The rectangular cross-section of the outlet of the bin insert allows for a linear correspondence between displacement of the slide gate across the outlet to the volume flow of material discharged by the bin. Calculation of sliding gate position for a desired volume discharge, for example, in blending materials from multiple bins, can be simplified over using a circular outlet.