Abstract: A reconstitution device having an opening surrounded by a neck, and a cap including a first end, a second end, and an inner bore having a central aperture. A stopper is positioned in the opening of the neck and includes a portion capable of being perforated. A plunger is located at the second end of the cap, is configured to slide along the inner bore of the cap, and includes a shaft extending downwardly in a direction towards the stopper and having a pointed end for piercing the stopper. A locking mechanism is located in the cap and includes an aperture. The locking mechanism is configured such that when the plunger is pushed downwardly the shaft is allowed to pass through the aperture, but when the plunger is pulled upwardly the second aperture changes shape such that the shaft cannot freely pass through the aperture.
Type:
Grant
Filed:
September 19, 2013
Date of Patent:
December 20, 2016
Assignee:
Bayer Healthcare, LLC
Inventors:
Jonathan David Tuckwell, Robert Dyer, Robert Owen Kivlin, John Paul Palmer-Felgate, Matthew Burgess Avery, Kevin George Skinner, Chris Kadamus, Lee Wood, Peter Schwan, Ben Arlett
Abstract: Process for the preparation of triazinyl-substituted oxindoles of formula (3) and salts thereof by reacting an oxindole (1) with a triazine (2) in the presence of a carbonate, a hydroxide, a phosphate or a mixture of two or more of the aforementioned compounds, and also the compounds of formula (3) and salts thereof (3?) and the use of both for producing crop protection agents.
Type:
Grant
Filed:
January 14, 2015
Date of Patent:
December 20, 2016
Assignee:
Bayer Intellectual Property GmbH
Inventors:
Gunter Karig, Mark James Ford, Konrad Siegel
Abstract: The present invention relates to an inserter for an intrauterine system comprising a handle (3), and an insertion tube (6) having a first end and a second end, and being arranged in connection with the handle. The inserter is characterized in that the first end of the insertion tube (6) comprises at least one frame slot for receiving a frame of the intrauterine system. The invention also relates to a kit comprising an inserter according to the present invention and an intrauterine system, wherein the intrauterine system (1) comprises a therapeutic component (1b) and a continuous, closed frame (1a), the therapeutic component (1b) being connected to the frame (1a) at least one point, and therapeutic component (1b) of the intrauterine system (1) is at least mainly arranged inside the first end of the insertion tube (6) and the frame (1a) of the intrauterine system (1) is at least mainly arranged outside the first end of the insertion tube (6).
Type:
Application
Filed:
August 23, 2016
Publication date:
December 15, 2016
Applicant:
Bayer Oy
Inventors:
Heikki LYYTIKÄINEN, Ilkka JUTILA, Ulla Calvo ALONSO, Harri JUKARAINEN, Taina TRÄDER, Andrew MACLEOD, Michael NOBLE, David WHITAKER
Abstract: The present application relates to novel aryl- and hetaryl-substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.
Type:
Application
Filed:
December 1, 2014
Publication date:
December 15, 2016
Applicant:
Bayer Pharma Aktiengesellschaft
Inventors:
Alexandros VAKALOPOULOS, Ingo HARTUNG, Niels LINDNER, Rolf JAUTELAT, Jorma HASSFELD, Dirk SCHNEIDER, Frank WUNDER, Johannes-Peter STASCH, Gorden REDLICH, Volkhart Min-Jian LI, Eva Maria BECKER-PELSTER, Andreas KNORR
Abstract: Contraceptive and/or sterilization methods and devices are disclosed which may improve the speed of tubal occlusion and mechanisms for anchoring for a contraceptive device. In accordance with some embodiments, improvements may be made to the delivery catheter to induce trauma and create faster tubal occlusion, improvements may be made to the occlusion device to prevent migration and induce trauma, and improvements may be made to the occlusion device to reduce the total volume of in-growth required compared to conventional expansive occlusion devices.
Type:
Grant
Filed:
January 15, 2013
Date of Patent:
December 13, 2016
Assignee:
Bayer HealthCare LLC
Inventors:
John R. Frigstad, William S. Tremulis, James R. Mujwid, Betsy Swann
Abstract: The soybean variety GLL0050 is disclosed. The invention relates to seeds, plants, plant cells, plant tissue, harvested products and soybean lint as well as to hybrid soybean plants and seeds obtained by repeatedly crossing plants of variety GLL0050 with other plants. The invention also relates to plants and varieties produced by the method of essential derivation from plants of GLL0050 and to plants of GLL0050 reproduced by vegetative methods, including but not limited to tissue culture of regenerable cells or tissue from GLL0050.
Abstract: The soybean variety ELL0908 is disclosed. The invention relates to seeds, plants, plant cells, plant tissue, harvested products and soybean lint as well as to hybrid soybean plants and seeds obtained by repeatedly crossing plants of variety ELL0908 with other plants. The invention also relates to plants and varieties produced by the method of essential derivation from plants of ELL0908 and to plants of ELL0908 reproduced by vegetative methods, including but not limited to tissue culture of regenerable cells or tissue from ELL0908.
Abstract: Herbicidally and fungicidally active 5-oxy-substituted 3-phenylisoxazoline-5-carboxamides and 5-oxy-substituted 3-phenylisoxazoline-5-thioamides of the formula (I) are described. In this formula (I), X, X2 to X6, R1 to R4 are radicals such as hydrogen, halogen and organic radicals such as substituted alkyl. A is a bond or a divalent unit. Y is a chalcogen.
Type:
Grant
Filed:
September 23, 2013
Date of Patent:
December 13, 2016
Assignee:
Bayer Cropscience AG
Inventors:
Klaus Bernhard Haaf, Lothar Willms, Hansjoerg Dietrich, Elmar Gatzweiler, Christopher Hugh Rosinger, Dirk Schmutzler, Ulrike Wachendorff-Neumann, Marie-Claire Grosjean-Cournoyer, Helene Lachaise, Philippe Rinolfi, Stephane Brunet
Abstract: The soybean variety ELL0041 is disclosed. The invention relates to seeds, plants, plant cells, plant tissue, harvested products and soybean lint as well as to hybrid soybean plants and seeds obtained by repeatedly crossing plants of variety ELL0041 with other plants. The invention also relates to plants and varieties produced by the method of essential derivation from plants of ELL0041 and to plants of ELL0041 reproduced by vegetative methods, including but not limited to tissue culture of regenerable cells or tissue from ELL0041.
Abstract: The soybean variety ELL0909 is disclosed. The invention relates to seeds, plants, plant cells, plant tissue, harvested products and soybean lint as well as to hybrid soybean plants and seeds obtained by repeatedly crossing plants of variety ELL0909 with other plants. The invention also relates to plants and varieties produced by the method of essential derivation from plants of ELL0909 and to plants of ELL0909 reproduced by vegetative methods, including but not limited to tissue culture of regenerable cells or tissue from ELL0909.
Abstract: The soybean variety DLL1149 is disclosed. The invention relates to seeds, plants, plant cells, plant tissue, harvested products and soybean lint as well as to hybrid soybean plants and seeds obtained by repeatedly crossing plants of variety DLL1149 with other plants. The invention also relates to plants and varieties produced by the method of essential derivation from plants of DLL1149 and to plants of DLL1149 reproduced by vegetative methods, including but not limited to tissue culture of regenerable cells or tissue from DLL1149.
Abstract: The soybean variety ELL0082 is disclosed. The invention relates to seeds, plants, plant cells, plant tissue, harvested products and soybean lint as well as to hybrid soybean plants and seeds obtained by repeatedly crossing plants of variety ELL0082 with other plants. The invention also relates to plants and varieties produced by the method of essential derivation from plants of ELL0082 and to plants of ELL0082 reproduced by vegetative methods, including but not limited to tissue culture of regenerable cells or tissue from ELL0082.
Abstract: Systems and methods for intelligently delivering fluid to a targeted tissue. The systems and methods may include directing a pump to distribute fluid to a targeted tissue and receiving one or more signals from an intracorporeal sensing system, where the one or more signals correspond to one or more sensed feedback parameters at the targeted tissue. The systems and methods may also include determining whether the one or more sensed feedback parameters are within an acceptable range. If the one or more sensed feedback parameters are not within the acceptable range, the systems and methods may include determining an adjusted velocity for the plunger necessary to adjust the pressure of the fluid in the pump so that the one or more sensed feedback parameters move within the acceptable range and directing the pump to distribute the fluid at the adjusted velocity.
Type:
Grant
Filed:
March 15, 2013
Date of Patent:
December 13, 2016
Assignee:
BAYER HEALTHCARE LLC
Inventors:
Martin J. Uram, Michael J. Yanniello, Barry L. Tucker, David A. Mishler, Edward J. Rhinehart, Mark Trocki, Arthur E. Uber, III, Kevin P. Cowan, John A. Brosovich
Abstract: The present invention relates to novel isoxazoline carboxamide derivatives, to processes for preparing these compounds, to compositions comprising these compounds, and to the use thereof as biologically active compounds, especially for control of harmful microorganisms in crop protection and in the protection of materials.
Type:
Grant
Filed:
September 25, 2013
Date of Patent:
December 6, 2016
Assignee:
BAYER CROPSCIENCE AG
Inventors:
Lothar Willms, Monika H. Schmitt, Thomas Frenzel, Klaus Bernhard Haaf, Isolde Haeuser-Hahn, Ines Heinemann, Elmar Gatzweiler, Christopher Hugh Rosinger, Heinz Kehne, Jan Dittgen, Dieter Feucht, Martin Hills, Jan Peter Schmidt, Mazen Es-Sayed, Philippe Rinolfi, Stephane Brunet, Marie-Claire Grosjean-Cournoyer, Helene Lachaise, Jacky Vidal, Pierre-Yves Coqueron, Arounarith Tuch
Abstract: N-(Tetrazol-5-yl)- and N-(triazol-5-yl)arylcarboxylic acid thioamides of the general formula (I) are described as herbicides. In this formula (I), R, W, X and Z represent radicals such as hydrogen, organic radicals such as alkyl, and other radicals such as halogen. A and B each represent carbon or nitrogen.
Type:
Grant
Filed:
May 22, 2013
Date of Patent:
December 6, 2016
Assignee:
Bayer Cropscience AG
Inventors:
Ralf Braun, Simon Doerner-Rieping, Hartmut Ahrens, Arnim Koehn, Christian Waldraff, Hansjoerg Dietrich, Dirk Schmutzler, Elmar Gatzweiler, Christopher Hugh Rosinger
Abstract: Heteroarylpiperidine and -piperazine derivatives of the formula (I) in which the symbols A, X, Y, L1, L2, G, Q, p, R1, R2 and R10 are each as defined in the description, and salts, metal complexes and N-oxides of the compounds of the formula (I), and the use thereof for controlling phytopathogenic harmful fungi and processes for preparing compounds of the formula (I).
Type:
Grant
Filed:
January 16, 2015
Date of Patent:
December 6, 2016
Assignee:
BAYER INTELLECTUAL PROPERTY GMBH
Inventors:
Stefan Hillebrand, Pierre Cristau, Sebastian Hoffmann, Joachim Kluth, Pierre Wasnaire, Tomoki Tsuchiya, Juergen Benting, Ulrike Wachendorff-Neumann, Thomas Seitz
Abstract: The present invention relates to substituted imidazopyridazine compounds of general formula I in which R3, R5 and A are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
Type:
Grant
Filed:
March 11, 2013
Date of Patent:
December 6, 2016
Assignee:
Bayer Intellectual Property GmbH
Inventors:
Marcus Koppitz, Ulrich Klar, Antje Margret Wengner, Roland Neuhaus, Gerhard Siemeister
Abstract: The invention relates to AKR1C3 inhibitors and to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular bleeding disorders and endometriosis.
Type:
Grant
Filed:
July 5, 2013
Date of Patent:
December 6, 2016
Assignee:
BAYER PHARMA AKTIENGESELLSCHAFT
Inventors:
Ulrich Bothe, Matthias Busemann, Oliver Martin Fischer, Naomi Barak, Andrea Rotgeri, Tobias Marquardt, Christian Stegmann
Abstract: Disclosed are compounds of formula (I) which possess nematicidal properties wherein the structural elements have the meaning as indicated in the description.
Type:
Grant
Filed:
July 21, 2014
Date of Patent:
December 6, 2016
Assignee:
BAYER CROPSCIENCE AKTIENGESELLSCHAFT
Inventors:
Klaus-Helmut Mueller, Hans-Georg Schwarz, Kerstin Ilg, Arnd Voerste, Olga Malsam, Daniela Portz, Peter Jeschke