Abstract: The present invention describes a novel process for preparing piperidine-4-carbothioamide hydrochloride.

Abstract: The present invention relates to a method for increasing the vigor and/or crop yield of agricultural plants under essentially non-existent pathogen pressure, wherein the plants, the plant propagules, the seed of the plants and/or a locus where the plants are growing or are intended to grow are treated with an effective amount of a composition comprising a Bacillus subtilis strain with Accession No. NRRL B-21661, a mutant of the strain having all the identifying characteristics of the strain, or a cell-free extract thereof; wherein the vigor and/or crop yield of agricultural plants under essentially non-existent pathogen pressure is increased and the increase in vigor is characterized by less fertilizer needed.

Abstract: The invention relates to novel formulation additives of formula 1 and to the production and use thereof, in particular as adjuvants and additives for agrochemical formulations. A novel combination of known ether sulfates and cations allows products with superior characteristics to be obtained, such as pesticides with improved strength.

Abstract: Disclosed is a dsRNA construct that relates to a method to control insect pests of the genus Helicoverpa or Heliothis double-stranded RNA interference of the PBAN/Pyrokinin gene.

Abstract: A liquid herbicidal composition is provided, comprising: a. 20 to 35 percent by weight, based on the total weight of the composition, of a water-soluble herbicidal ingredient; b. a C12-C16 alkyl ether sulfate; c. an organic solvent; and d. an alkyl polyglucoside. The composition is stable; i.e., it occurs in a substantially continuous, single phase at temperatures as low as ?20° C. It also has a viscosity of no more than 2000 cps at temperatures as low as 0° C.

Abstract: The present invention relates to fungicidal benzocycloalkene carboxamides or their thiocarboxamide derivatives of formula (I), their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions.

Abstract: The present invention relates to novel modified macrocyclic compounds of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).

Abstract: The present application relates to novel bicyclic compounds, to compositions comprising these compounds, to their use for controlling animal pests and to processes and intermediates for their preparation.

Abstract: The present application relates to novel bicyclic compounds, to their use for controlling animal pests and to processes and intermediates for their preparation.

Abstract: The present application relates to novel 3-phenylpropionic acid derivatives which carry a branched or cyclic alkyl substituent in the 3-position, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular diseases.

Abstract: A method to generate orthotic product recommendations for users includes receiving interactions from a user including identification of one or more extremity areas of the user's body, the one or more extremity areas relevant to selection of one or more orthotic products. On-screen cues and interactions are provided to assist in positioning of the one or more extremity areas relative to one or more imaging sensors. Scan data is received from the one or more imaging sensors. A model of the one or more extremity areas is generated based on the scan data including estimating one or more complete circumferences of the one or more extremity areas. One or more orthotic products are identified based on a comparison of the model of the one or more extremity areas and one or more factors associated with the user and a plurality of orthotic products. A recommendation is provided that includes the one or more orthotic products.

Abstract: The present invention relates to individual blister packs, methods for production thereof, stack-like arrangements containing individual blister packs of this type, and boxes containing stack-like arrangements of individual blister packs.

Abstract: Antibodies are disclosed that bind to and inhibit the anti-coagulant function of TFPI and have a lower affinity for TFPi at pH 6.0 than at pH 7.4. The lower affinity at pH 6 improves circulating half-life (T1/2) due to reduced target mediated clearance, a process by which an antibody/antigen complex, is endocytased and trafficked to the lysosome where both components are degraded. The lower affinity at pH 6.0 results in disruption of the complex prior to lysosome targeting and allows for re-circulation of the antibody. Specific modifications to antibody binding by histidine residue substitution are disclosed along with methods of use.

Abstract: The present invention relates to a novel method of preparing copanlisib, copanlisib dihydrochloride, or hydrates of copanlisib dihydrochloride, to novel intermediate compounds, and to the use of said novel intermediate compounds for the preparation of said copanlisib, copanlisib dihydrochloride, or hydrates of copanlisib dihydrochloride. The present invention also relates to copanlisib dihydrochloride hydrates as compounds.

Abstract: Methods, kits and compositions of matter are provided which allow amplification of nucleic acid or interest or DNA of interest, comprising the steps of isolating template nucleic acid or DNA from a biological sample using an alkaline extraction solution and directly adding the extract to a reaction mixture, under conditions to amplify the nucleic acids, wherein the isolated template nucleic acid or DNA in the alkaline extraction solution is not diluted or not neutralized prior to the addition to the reaction mixture.

Abstract: The invention relates to novel compounds of the formula (I) in which the R1, R2a, R2b, R3, A1, A2, A3, A4 and n radicals are each as defined above, to their use as acaricides and/or insecticides for controlling animal pests and to processes and intermediates for their preparation.

Abstract: The present invention relates to novel macrocyclic sulfondiimine compounds of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).

Abstract: The present invention provides a nozzle plate and the use of the nozzle plate for producing filaments, preferably silica gel fibers.

Abstract: The invention relates to a method for contraception and for reducing menstrual problems and inducing amcnorrhca, whcrcin an intrauterine delivery device is used for the controlled release of a combination of progestogen or a drug having a progestogenic activity and at least one therapeutically active substance capable of preventing or suppressing abnormal and/or irregular endometrial bleeding over a prolonged period of time.