Patents Assigned to Bayer
  • Patent number: 10131649
    Abstract: The present application relates to novel bicyclic compounds, to compositions comprising these compounds, to their use for controlling animal pests and to processes and intermediates for their preparation.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: November 20, 2018
    Assignee: BAYER CROPSCIENCE AKTIENGESELLSCHAFT
    Inventors: Peter Jeschke, Alexander Arlt, Silvia Cerezo-Galvez, Arnd Voerste, Martin Füßlein, Reiner Fischer, Thomas Bretschneider, Kerstin Ilg, Olga Malsam, Peter Lösel
  • Publication number: 20180327478
    Abstract: A method for the production of freeze-dried pellets comprising factor VIII comprises the steps of: a) freezing droplets of a solution comprising factor VIII to form pellets; b) freeze-drying the pellets; wherein in step a) the droplets are formed by means of droplet formation of the solution comprising factor VIII into a cooling tower which has a temperature-controllable inner wall surface and an interior temperature below the freezing temperature of the solution and wherein in step b) the pellets are freeze-dried in a rotating receptacle which is housed inside a vacuum chamber.
    Type: Application
    Filed: November 4, 2016
    Publication date: November 15, 2018
    Applicant: Bayer Pharma Aktiengesellschaft
    Inventors: Carsten OLBRICH, Matthias PLITZKO, Bernhard LUY, Stefan Christian SCHNEID
  • Publication number: 20180327776
    Abstract: Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a toxin polypeptide are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated toxin nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed, and antibodies specifically binding to those amino acid sequences. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:4-11, or the nucleotide sequence set forth in SEQ ID NO: 1-3, as well as variants and fragments thereof.
    Type: Application
    Filed: October 13, 2016
    Publication date: November 15, 2018
    Applicants: Bayer CropScience LP, Bayer CropScience AG
    Inventors: Elyse Rodgers-Vieira, Kimberly Sampson, Duane Lehtinen, Nanasaheb Chougule, Peter Loesel, Daniela Portz
  • Patent number: 10124110
    Abstract: A fluid injector for use with at least one syringe has at least one injector head with a front end configured to releasably receive the at least one syringe. The fluid injector further includes at least one pressure jacket releasably associated with the front end of the at least one injector head for securing the at least one syringe during an injection procedure. A connection mechanism releasably connects the at least one pressure jacket to the front end of the at least one injector head. The connection mechanism includes at least one magnet. The at least one injector head has the at least one magnet while the at least one pressure jacket has a ferromagnetic material configured for magnetically interacting with the at least one magnet.
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: November 13, 2018
    Assignee: BAYER HEALTHCARE LLC
    Inventors: James A. Dedig, Ralph H. Schriver, Patrick B. Campbell, Herbert M. Grubic
  • Patent number: 10125103
    Abstract: The present invention relates to a novel method for preparing 5-fluoro-1H-pyrazole-4-carbonyl fluorides by halogen exchange reaction of 5-chloro-1H-pyrazole-4-carbonyl chlorides with alkali metal fluorides, using non-polar solvents.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: November 13, 2018
    Assignee: Bayer CropScience Aktiengesellschaft
    Inventors: Sergii Pazenok, Hans Martin Thomas, Frank Volz
  • Patent number: 10127845
    Abstract: A rotating mechanism characterized by a drive arrangement which provides rotating, hoisting and dropping functions with just a single drive.
    Type: Grant
    Filed: April 22, 2014
    Date of Patent: November 13, 2018
    Assignee: BAYER FEINWERK GMBH & CO. KG
    Inventor: Uwe Heiter
  • Patent number: 10125126
    Abstract: The present invention relates to fungicidal N-cycloalkyl-N-[(heterocyclylphenyl)methylene] carboxamide derivatives and their thiocarbonyl derivatives, their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions.
    Type: Grant
    Filed: April 18, 2013
    Date of Patent: November 13, 2018
    Assignee: BAYER CROPSCIENCE AG
    Inventors: Christoph Braun, Pierre Cristau, Peter Dahmen, Philippe Desbordes, Mazen Es-Sayed, Helene Lachaise, Philippe Rinolfi, Jan-Peter Schmidt, Tomoki Tsuchyia, Jean-Pierre Vors, Ulrike Wachendorff-Neumann
  • Patent number: 10123536
    Abstract: A composition comprising at least a pyridylethylbenzamide derivative of general formula (I) (a) and a compound capable of inhibiting the ergosterol biosynthesis (b) in a (a)/(b) weight ratio of from 0.01 to 20. A composition further comprising an additional fungicidal compound.
    Type: Grant
    Filed: August 9, 2016
    Date of Patent: November 13, 2018
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Marie-Claire Grosjean-Cournoyer, Jean-Marie Gouot
  • Patent number: 10124007
    Abstract: The present invention relates to combinations of at least two components, component A and component B, component A being an inhibitor of PI3K kinase, and component B being a pharmaceutically acceptable salt of radium 223. Another aspect of the present invention relates to the use of such combinations as described supra for the preparation of a medicament for the treatment or prophylaxis of a disease, particularly for the treatment of cancer with bone metastases.
    Type: Grant
    Filed: December 1, 2014
    Date of Patent: November 13, 2018
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Ningshu Liu, Arne Scholz, Andrea Hägebarth
  • Publication number: 20180318438
    Abstract: The present application relates to novel binder drug conjugates (ADCs), to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for the treatment and/or prophylaxis of diseases and to the use of these ADCs for preparing medicaments for treatment and/or prophylaxis of diseases, in particular hyperproliferative and/or angiogenic disorders such as, for example, cancer diseases. Such treatments can be effected as monotherapy or else in combination with other medicaments or further therapeutic measures.
    Type: Application
    Filed: June 20, 2016
    Publication date: November 8, 2018
    Applicant: Bayer Pharma Aktiengesellschaft
    Inventors: Hans-Georg LERCHEN, Anne-Sophie REBSTOCK, Yolanda CANCHO GRANDE, Sven WITTROCK, Beatrix STELTE-LUDWIG, Stephan MÄRSCH, Uwe GRITZAN, Christoph MAHLERT, Simone GREVEN, Anette SOMMER, Sandra BERNDT, Lisa DIETZ
  • Publication number: 20180319519
    Abstract: The invention relates to a macroblister comprising a flat body, in which are introduced cavities for receiving individual medicament portions, wherein the cavities are filled with individual medicament portions and are sealed with a foil. According to the invention, said macroblister contains a number T of medicament portions, characterized in that T is at least 60 and the flat body has a dimension in the range of 200 mm×200 mm to 1200 mm×1200 mm.
    Type: Application
    Filed: August 18, 2016
    Publication date: November 8, 2018
    Applicant: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Olaf STANGE, Johannes-Walter HÖHL, Reiner DIEDERICH, Klaus DRÖDER, Christoph HERRMANN, Franz DIETRICH, Philipp BLUMENTHAL, Kai STÜHM, Paul BOBKA, Christopher SCHMIDT, Sebastian THIEDE
  • Publication number: 20180318437
    Abstract: The present application relates to novel binder drug conjugates (ADCs), to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for the treatment and/or prophylaxis of diseases and to the use of these ADCs for preparing medicaments for treatment and/or prophylaxis of diseases, in particular hyperproliferative and/or angiogenic disorders such as, for example, cancer diseases. Such treatments can be effected as monotherapy or else in combination with other medicaments or further therapeutic measures.
    Type: Application
    Filed: June 20, 2016
    Publication date: November 8, 2018
    Applicant: Bayer Pharma Aktiengesellschaft
    Inventors: Hans-Georg LERCHEN, Anne-Sophie REBSTOCK, Yolanda CANCHO-GRANDE, Sven WITTROCK, Beatrix STELTE-LUDWIG, Christoph MAHLERT, Simone GREVEN, Stephan MÄRSCH, Dennis KIRCHHOFF
  • Publication number: 20180319794
    Abstract: The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
    Type: Application
    Filed: July 2, 2018
    Publication date: November 8, 2018
    Applicant: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Alexandros VAKALOPOULOS, Markus FOLLMAN, Ingo HARTUNG, Philipp BUCHGRABER, Rolf JAUTELAT, Jorma HAßFELD, Niels LINDNER, Alexey GROMOV, Frank WUNDER, Johannes-Peter STASCH, Gorden REDLICH, Volkhart Min-Jian LI, Eva Maria BECKER-PELSTER, Andreas KNORR
  • Patent number: 10118930
    Abstract: The present application relates to novel substituted piperidinylpyrazolopyrimidinones, to processes for their preparation, the compounds for use alone or in combinations in a method for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of acute and recurrent bleeding in patients with or without underlying hereditary or acquired hemostatic disorders, wherein the bleeding is associated with a disease or medical intervention selected from the group consisting of heavy menstrual bleeding, postpartum hemorrhage, hemorrhagic shock, hemorrhagic cystitis, gastrointestinal hemorrhage, trauma, surgery, transplantation, stroke, liver diseases, hereditary angioedema, nosebleed, and synovitis and cartilage damage following hemarthrosis.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: November 6, 2018
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Manuel Ellermann, Gaelle Valot, Yolanda Cancho Grande, Jorma Haßfeld, Tom Kinzel, Johannes Köbberling, Kristin Beyer, Susanne Röhrig, Michael Sperzel, Jan Stampfuß, Imke Meyer, Maria Köllnberger, Nils Burkhardt, Karl-Heinz Schlemmer, Christian Stegmann, Joachim Schuhmacher, Matthias Werner, Jörg Heiermann, Willem Jan Hengeveld
  • Patent number: 10117864
    Abstract: The present application relates to novel substituted N-bicyclo-2-arylquinoline-4-carboxamide derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of fibrotic and inflammatory disorders.
    Type: Grant
    Filed: March 15, 2016
    Date of Patent: November 6, 2018
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Hartmut Beck, Tobias Thaler, Raimund Kast, Mark Meininghaus, Carsten Terjung, Uwe Muenster, Britta Olenik
  • Patent number: 10117874
    Abstract: The present invention relates to combinations of at least two components, component A and component B, component A being an inhibitor of PI3K kinase, and component B being radium 223, particularly a pharmaceutically acceptable salt of radium-223. Another aspect of the present invention relates to the use of such combinations as described herein for the preparation of a medicament for the treatment or prophylaxis of a disease, particularly for the treatment of breast and prostate cancer as well as their bone metatases.
    Type: Grant
    Filed: November 28, 2014
    Date of Patent: November 6, 2018
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventor: Ningshu Liu
  • Patent number: 10119147
    Abstract: The present invention relates to Brassica plants comprising mutant phosphatidylcholine:diacylglycerol cholinephosphotransferase encoding (ROD1) genes, ROD1 nucleic acid sequences and proteins, as well as methods for generating and identifying said plants and alleles, which can be used to plants with increased levels of C18:1 in the seeds.
    Type: Grant
    Filed: July 4, 2013
    Date of Patent: November 6, 2018
    Assignees: Washington State University, Bayer CropScience NV
    Inventors: Peter Denolf, Shuangyi Bai, John Browse
  • Patent number: 10118145
    Abstract: A method of reacting phosgene with a second compound containing one or more of hydroxyl, thil, amino and/or formamide groups, wherein phosgene has a GHS hazard identification of GHS06 and is obtainable from the reaction of carbon monoxide and chlorine and wherein the second compound is capable of a chemical reaction with phosgene is provided.
    Type: Grant
    Filed: August 18, 2015
    Date of Patent: November 6, 2018
    Assignee: BAYER AKTIENGESELLSCHAFT
    Inventors: Jens Stefan Roggan, Leslaw Mleczko, Konstantinos Metaxas, Michael Gottfried, Ilja Peckermann, Stephan Schubert, Ekkehard Barth
  • Publication number: 20180311220
    Abstract: The present invention provides compositions and methods for treating cancers which have acquired resistance to a KIT inhibitor by administering effective amounts of DAST.
    Type: Application
    Filed: July 10, 2018
    Publication date: November 1, 2018
    Applicant: Bayer HealthCare LLC
    Inventors: Scott Wilhelm, Richard Gedrich
  • Patent number: D833132
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: November 13, 2018
    Assignee: Bayer HealthCare LLC
    Inventors: Philip C. Yang, Richard Todd Avent