Patents Assigned to Bayer
  • COMPOUNDS AND METHODS USEFUL FOR TREATING OR PREVENTING HEMATOLOGICAL CANCERS
    Publication number: 20180263970
    Abstract: The present invention includes methods of treating patients with acute myeloid leukemia across a range of genetic subtypes with DHODH inhibitors, such as 6-fluoro-2-(2?-fluoro-[1,1?-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid).
    Type: Application
    Filed: August 29, 2016
    Publication date: September 20, 2018
    Applicants: THE BROAD INSTITUTE, INC., THE GENERAL HOSPITAL CORPORATION, PRESIDENT AND FELLOWS OF HARVARD COLLEGE, BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: David B. Sykes, David Scadden, Timothy A. Lewis, Andreas Janzer, Hanna Meyer, Detlef Stöckigt
  • CHEWABLE GEL PRODUCTS FOR ACTIVE PHARMACEUTICAL INGREDIENTS
    Publication number: 20180263904
    Abstract: The present disclosure relates to chewable gel products containing a gel carrier and an active pharmaceutical ingredient (API), where the chewable gel product has an acceptable taste.
    Type: Application
    Filed: March 16, 2018
    Publication date: September 20, 2018
    Applicant: BAYER HEALTHCARE LLC
    Inventors: Rachan SIRIHORACHAI, Reginald D. BRADLEY, Paul D. ROSAR, Anthony EKPE
  • Substituted oxopyridine derivatives
    Patent number: 10077265
    Abstract: The invention relates to substituted oxopyridine derivatives and to processes for preparation thereof, and also to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
    Type: Grant
    Filed: September 22, 2015
    Date of Patent: September 18, 2018
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Susanne Röhrig, Alexander Hillisch, Julia Straβburger, Stefan Heitmeier, Martina Victoria Schmidt, Karl-Heinz Schlemmer, Adrian Tersteegen, Anja Buchmüller, Christoph Gerdes, Martina Schäfer, Henrik Teller, Eloisa Jiménez Núnez, Hartmut Schirok, Jürgen Klar, Mario Lobell
  • Methods and techniques for collecting, reporting and managing ionizing radiation dose
    Patent number: 10078725
    Abstract: Provided is a method of collecting and managing information relating to medical diagnostic procedures which includes collecting objective information about a plurality of procedures and subjective information about the results of those procedures. The objective information provides information about the parameters of the procedure and the patient who underwent the procedure while the subjective information includes an assessment of the quality of the results of the procedure. This information can be stored in a database. The database can be accessed and the information therein used in connection with understanding the results of past procedures and planning for future procedures.
    Type: Grant
    Filed: November 19, 2012
    Date of Patent: September 18, 2018
    Assignee: BAYER HEALTHCARE LLC
    Inventors: John F. Kalafut, David A. Mishler, Sridhar R. Balasubramanian, John A. Brosovich, Frederick P. Windham
  • N-cycloalkyl-N-(biheterocyclymethylene)-(thio)carboxamide derivatives
    Patent number: 10076116
    Abstract: The present invention relates to fungicidal N-cycloalkyl-N-(biheterocyclylmethylene)carboxamide derivatives and their thiocarbonyl derivatives, their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions.
    Type: Grant
    Filed: October 15, 2014
    Date of Patent: September 18, 2018
    Assignee: BAYER CROPSCIENCE AKTIENGESELLSCHAFT
    Inventors: Philippe Desbordes, Philippe Rinolfi, Tomoki Tsuchiya, Julie Geist, Lionel Nicolas
  • ANTI-MESOTHELIN ANTIBODIES AND USES THEREOF
    Publication number: 20180258181
    Abstract: The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 40 kDa mesothelin polypeptide, which is overexpressed in several tumors, such as pancreatic and ovarian tumors, mesothelioma and lung cancer cells. These antibodies, accordingly, can be used to treat these and other disorders and conditions. Antibodies of the invention also can be used in the diagnostics field, as well as for further investigating the role of mesothelin in the progression of disorders associated with cancer. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.
    Type: Application
    Filed: March 5, 2018
    Publication date: September 13, 2018
    Applicant: Bayer Intellectual Property GmbH
    Inventors: Antje KAHNERT, David LIGHT, Doug SCHNEIDER, Renate PARRY, Noboru SATOZAWA, Tara HEITNER, Stefan STEIDL, Ulrike SCHUBERT
  • BICYCLICALLY SUBSTITUTED URACILS AND THE USE THEREOF
    Publication number: 20180256576
    Abstract: The present application relates to novel bicyclically substituted uracil derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases.
    Type: Application
    Filed: March 5, 2018
    Publication date: September 13, 2018
    Applicant: Bayer Pharma Aktiengesellschaft
    Inventors: Chantal FÜRSTNER, Jens ACKERSTAFF, Alexander STRAUB, Heinrich MEIER, Hanna TINEL, Katja ZIMMERMANN, Adrian TERSTEEGEN, Dmitry ZUBOV, Raimund KAST, Jens SCHAMBERGER, Martina SCHÄFER, Kirsten BÖRNGEN
  • Method for producing a holographic optical element
    Patent number: 10073416
    Abstract: The invention relates to a method for producing a holographic optical element by providing a recording stack comprising at least one recording element laminated on at least one supporting element, irradiating at least a part of the recording stack with at least one recording beam in an irradiating step, wherein during the irradiating step, the recording stack bends, providing a bending deviation threshold for the recording stack, and adjusting at least one first process parameter such that an expected maximum bending deviation of the recording stack does not exceed the bending deviation threshold, wherein the at least one first process parameter influences the bending behavior of the recording stack during the irradiating step.
    Type: Grant
    Filed: April 24, 2015
    Date of Patent: September 11, 2018
    Assignees: LG Display Co., Ltd., Bayer MaterialScience AG
    Inventors: Hyungseok Bang, Heejin Im, Guensik Lee, Friedrich-Karl Bruder, Thomas Peter Facke, Marc-Stephan Weiser, Rainer Hagen, Thomas Rolle, Horst Berneth, Dennis Honel, Günther Walze
  • Substituted oxopyridine derivatives
    Patent number: 10071995
    Abstract: The invention relates to substituted oxopyridine derivatives and to processes for preparation thereof, and also to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
    Type: Grant
    Filed: September 22, 2015
    Date of Patent: September 11, 2018
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Susanne Röhrig, Eloisa Jimenez Núnez, Karl-Heinz Schlemmer, Adrian Tersteegen, Henrik Teller, Alexander Hillisch, Stefan Heitmeier, Martina Victoria Schmidt, Jan Stampfuß
  • N-cycloalkyl-N-{[2-(1-substitutedcycloalkyl)phenyl]methylene}-(thio)carboxamide derivatives
    Patent number: 10070645
    Abstract: The present invention relates to fungicidal N-cycloalkyl-N-{[2-(1-substitutedcycloalkyl)phenyl]methylene} carboxamide derivatives and their thiocarbonyl derivatives, their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: September 11, 2018
    Assignee: BAYER CROPSCIENCE AKTIENGESELLSCHAFT
    Inventors: Pierre Cristau, Philippe Desbordes, Julie Geist, Lionel Nicolas, Philippe Rinolfi, Jan-Peter Schmidt, Tomoki Tsuchiya, Jean-Pierre Vors, Ulrike Wachendorff-Neumann
  • Preparation of high-purity gadobutrol
    Patent number: 10072027
    Abstract: What is described is a process for producing high-purity gadobutrol in a purity (according to HPLC) of more than 99.7 or 99.8 or 99.9% and the use for preparing a pharmaceutical formulation for parenteral administration. The process is carried out using specifically controlled crystallization conditions. The more recent developments in the field of the gadolinium-containing MR contrast agents (EP 0448191 B1, CA Patent 1341176, EP 0643705 B1, EP 0986548 B1, EP 0596586 B1) include the MRT contrast agent gadobutrol (Gadovist® 1.0) which has been approved for a relatively long time in Europe and more recently also in the USA under the name Gadavist®.
    Type: Grant
    Filed: April 17, 2012
    Date of Patent: September 11, 2018
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Johannes Platzek, Wilhelm Trentmann
  • N-cycloalkyl-N-{[2-(1-substitutedcycloalkyl)phenyl]methylene}-(thio)carboxamide derivatives
    Patent number: 10071967
    Abstract: The present invention relates to fungicidal N-cycloalkyl-N-{[2-(1-substitutedcycloalkyl)phenyl]methylene} carboxamide derivatives and their thiocarbonyl derivatives, their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: September 11, 2018
    Assignee: BAYER CROPSCIENCE AKTIENGESELLSCHAFT
    Inventors: Pierre Cristau, Philippe Desbordes, Julie Geist, Lionel Nicolas, Philippe Rinolfi, Jan-Peter Schmidt, Tomoki Tsuchiya, Jean-Pierre Vors, Ulrike Wachendorff-Neumann
  • PROCESS FOR PRODUCING PHOSPHORUS-CONTAINING CYANOHYDRIN ESTERS
    Publication number: 20180251481
    Abstract: The present invention primarily relates to a process for producing certain phosphorus-containing cyanohydrin esters of formula (I) and the use thereof for producing glufosinate/glufosinate salts. The present invention further relates to a process for producing glufosinate/glufosinate salts.
    Type: Application
    Filed: August 29, 2016
    Publication date: September 6, 2018
    Applicant: BAYER CROPSCIENCE AKTIENGESELLSCHAFT
    Inventors: Hans-Joachim RESSEL, Kilian TELLMANN, Mark James FORD, Martin LITTMANN, Günter SCHLEGEL
  • PROTEASE-REGULATED ANTIBODIES
    Publication number: 20180251570
    Abstract: This disclosure provides protease-regulated antibodies which specifically bind to tissue factor pathway inhibitor (TFPI). The antibodies are useful for treating bleeding disorders such as hemophilia.
    Type: Application
    Filed: May 16, 2018
    Publication date: September 6, 2018
    Applicant: BAYER HEALTHCARE LLC
    Inventors: Zhuozhi WANG, Ruth WINTER, John MURPHY
  • SUBSTITUTED OXOPYRIDINE DERIVATIVES
    Publication number: 20180250280
    Abstract: The invention relates to substituted oxopyridine derivatives and to processes for preparation thereof, and also to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
    Type: Application
    Filed: August 30, 2016
    Publication date: September 6, 2018
    Applicant: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Eloisa JIMENEZ NUNEZ, Jens ACKERSTAFF, Pascal ELLERBROCK, Alexander HILLISCH, Katharina MEIER, Stefan HEITMEIER, Adrian TERSTEEGEN, Jan STAMPFUß
  • Use of substituted dihydrooxindolylsulfonamides, or the salts thereof, for increasing the stress tolerance of plants
    Patent number: 10065926
    Abstract: The invention relates to the use of substituted dihydrooxindolylsulfonamides or salts thereof of the formula (I) where the radicals in the general formula (I) correspond to the definitions given in the description, for enhancing stress tolerance in plants to abiotic stress, and/or for increasing plant yield.
    Type: Grant
    Filed: October 2, 2014
    Date of Patent: September 4, 2018
    Assignee: BAYER CROPSCIENCE AKTIENGESELLSCHAFT
    Inventors: Jens Frackenpohl, Guido Bojack, Hendrik Helmke, Stefan Lehr, Thomas Mueller, Lothar Willms, Jan Dittgen, Dirk Schmutzler, Udo Bickers, Harry Strek, Rachel Baltz
  • Catheter with drug coating
    Patent number: 10064981
    Abstract: A composition and methods for improved delivery of a therapeutic agent to a stenosed vessel wall.
    Type: Grant
    Filed: July 10, 2013
    Date of Patent: September 4, 2018
    Assignee: Bayer Pharma Aktiengesellschaft
    Inventors: Edouard A. Koullick, Richard F. Murphy, Jonathan Schmidt
  • Insole
    Patent number: D827272
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: September 4, 2018
    Assignee: Bayer HealthCare LLC
    Inventors: Philip C. Yang, Richard Todd Avent
  • Insole
    Patent number: D827999
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: September 11, 2018
    Assignee: Bayer HealthCare LLC
    Inventors: Philip C. Yang, Richard Todd Avent
  • 5-[(3,3,3-trifluoro-2-hydroxy-1-arylpropyl)amino]-1H-quinolin-2-ones, a process for their production and their use as anti-inflammatory agents
    Patent number: RE47047
    Abstract: The present invention relates to compounds of formula I, processes for their production and their use as anti-inflammatory agents.
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: September 18, 2018
    Assignees: ASTRAZENECA AB, BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Markus Berger, Hartmut Rehwinkel, Thomas Zollner, Ekkehard May, Jorma Hassfeld, Heike Schaecke