Abstract: A syringe assembly including a syringe barrel having a first end, a second end, and a sidewall extending therebetween defining a chamber is disclosed. The syringe assembly includes a stopper disposed within the chamber of the syringe barrel and a plunger rod having an inner member engaged with the stopper and an outer member adapted for telescopic movement with respect to the inner member. The plunger rod is transitionable from a collapsed position, in which a portion of the inner member is nested within the outer member, to an extended position, in which the same portion of the inner member extends outside the outer member. The syringe assembly also includes a stop member configured for cooperation with a portion of the syringe barrel, upon relative movement of the outer member with respect to the inner member, to limit the outward travel of the plunger rod from the syringe barrel.

Abstract: The invention relates to an adaptor for a distal tip of a drug delivery device. The adaptor includes an inner ring having retaining means capable of exerting a radial inward force on said distal tip and of switching from a free configuration to a locked configuration, in which the radial inward force exerted on said conical distal tip limits the axial movement of the adaptor. The adaptor further includes compressing means movable axially with respect to said retaining means between a proximal position, in which said compressing means does not exert a centripetal pressure on said retaining means, and a distal position, in which centripetal pressure is exerted on said retaining means. The invention further relates to a drug delivery device comprising such an adaptor and to a method for mounting said adaptor on said drug delivery device.

Abstract: Provided is a drug delivery device including: a reservoir for a product, having a distally projecting end-piece defining an axial passageway for the transfer of the product, with a distal portion, an adaptor having a collar engageable around said end-piece said collar being axially movable with respect to said end-piece, securing structure for limiting the axial movement of said collar with respect to said end-piece, between a most distal position and a most proximal position of said collar, and biasing element for urging said collar towards its most distal position. An adaptor for forming a drug delivery device is also provided.

Abstract: This tray includes spaced apart openings arranged in parallel rows, intended to receive the bodies of the elongated objects, and projections making it possible to place the flanges of the elongated objects inserted in these openings in a determined angular position on the tray when the bodies of these elongated objects are engaged in these openings. According to the invention: said projections are arranged so as to place the length of said flanges in a determined angular position with respect to the rows of openings, and the openings of a first row of openings are arranged with respect to a second row of openings adjacent to said first row, such that after installation of the elongated objects on the tray, the flanges of the objects inserted in the openings of said the first row imbricates with the flanges of the objects inserted in the openings of said second row, i.e.

Abstract: A syringe assembly having a flexible and/or slidable flange is provided, wherein in a pre-use or packaged state, the flange is positioned substantially parallel to a barrel of the syringe assembly resulting in the syringe assembly having a smaller packaging footprint. The smaller packaging footprint allows for a reduced storage space of the syringe assembly. Upon removal from a packaging and/or the storage space, the flange can be slid and locked into place such that the flange extends in a perpendicular direction with respect to a longitudinal axis of the barrel of the syringe assembly to allow for a traditional operation of the syringe assembly.

Abstract: A medical injector includes an injector housing defining a reservoir, a plunger rod, and a stopper engaged with a portion of the plunger rod. The stopper being slidably disposed within the reservoir and sized relative to an interior of the injector housing to provide sealing engagement with a sidewall of the injector housing. The medical injector further includes a needle having a sharpened first end and a second end in communication with the reservoir, a first cap covering the sharpened first end of the needle, and a second cap covering at least a part of the first cap. The second cap includes a body having a proximal end, a distal end, and a flange provided adjacent the distal end. The second cap is engaged with the first cap such that removal of the second cap simultaneously removes the first cap from the first end of the needle.

Abstract: A method of making a delivery device for therapeutic agent, drug or vaccine. The method includes providing a flat panel wafer, forming a plurality of reservoirs, with each reservoir defining a cavity, within the flat panel wafer, and attaching a cover layer across the plurality of reservoirs. The method also includes filling the plurality of reservoirs with at least one of a therapeutic agent, drug, and vaccine to form a plurality of filled reservoirs, and providing a housing portion adjacent each of the plurality of filled reservoirs to form a composed layer. The method also includes separating the composed layer into a plurality of delivery devices, wherein each delivery device includes a reservoir. The delivery device may be suitable for self-injection use.

Abstract: An assembly having an adaptor for coupling with a medical container having a septum. The adaptor includes a gripping member for securing the adaptor to the medical container; a pierceable elastomeric piece which, in an inactive state of the adaptor, does not contact the septum outer surface with pressure, and, in an active state of the adaptor, contacts the septum outer surface with pressure; a blister comprising a shell and a removable closing membrane forming a housing receiving the adaptor; a retaining system having a first retaining portion on the adaptor and a second retaining portion on the shell, the first retaining portion adapted, in a locked position of the retaining system, to cooperate with the second retaining portion, when the adaptor is not in the active state; and an unlocking portion adapted to transition the retaining system to an unlocked position, when the adaptor is in the active state.

Abstract: An assembly including a connecting member to be mounted on a first medical container, an adaptor including a gripping member to be mounted on a second medical container, a pierceable elastomeric piece, fixed with respect to the gripping member, a protecting envelope comprising a rigid shell substantially surrounding the connecting member and the adaptor in a storage position of the assembly, in which the connecting member is separate from the adaptor. The rigid shell is closed by a removable film. The assembly further comprises a first engagement portion for preventing the connecting member from escaping from the rigid shell when the film is removed. Also, a kit including such an assembly and first and second medical containers.

Abstract: The invention relates to a lubricant coating for a medical container comprising a cross-linked lubricant composition comprising a mixture of non-reactive silicone with reactive silicone, characterized in that the reactive silicone comprises a mixture of vinyl-based silicone and acrylate-based silicone. The invention further relates to a lubricant composition usable as an intermediate product in the fabrication of a lubricant coating. The invention further relates to a medical container comprising a barrel and a stopper in gliding engagement within the barrel, comprising such a lubricant coating. The invention also relates to a process of manufacturing a medical container comprising a barrel and a stopper in gliding engagement within the barrel including depositing a lubricant composition on the inner surface of the barrel and/or on the stopper, and irradiating the coated barrel and/or stopper so as to cross-link the lubricant composition to form a lubricant coating.

Abstract: This packaging is for containers having each a cylindrical body and an upper surface located at or near an extremity of the body, said packaging comprising a nest, a tub and a sealing cover; the nest having a nesting structure to receive the containers and comprising at least one first supporting surface, to be received on at least one corresponding supporting surface of the tub, the tub having a bottom wall, lateral walls forming an upper opening, and a peripheral flange leveled with said upper opening, for the sealing of said sealing cover thereon; said nest includes at least one second supporting surface rigidly connected to said at least one first supporting surface and so positioned with respect to this at least one first supporting surface that this second supporting surface is located, when the nest is placed in the tub, at the level of said peripheral flange.

Abstract: A method of making a delivery device (10) for therapeutic agent, drug or vaccine is disclosed. The method includes providing a flat panel wafer, forming a plurality of reservoirs, with each reservoir defining a cavity, within the flat panel wafer, and attaching a cover layer (20) across the plurality of reservoirs. The method also includes filling the plurality of reservoirs with at least one of a therapeutic agent, drug, and vaccine to form a plurality of filled reservoirs, and providing a housing portion adjacent each of the plurality of filled reservoirs to form a composed layer. The method also includes separating the composed layer into a plurality of delivery devices, wherein each delivery device includes a reservoir. The delivery device may be suitable for self-injection use.

Abstract: The invention relates to a lubricant coating (5) for a medical injection device (1), comprising successively: —a bottom layer (50) in contact with the medical device surface (21) of the container to be lubricated, comprising a mixture of cross-linked and non-cross-linked poly-(dimethylsiloxane), —an intermediate layer (51) consisting essentially of oxidized poly-(dimethylsiloxane) and having a thickness comprised between 10 and 30 nm and, —a top layer (52) consisting essentially of non-cross-linked poly-(dimethylsiloxane) and having a thickness of at most 2 nm. The invention also relates to a medical injection device comprising such a lubricant coating, and a manufacturing process for said coating.

Abstract: The application relates to needle protection assembly (1)) comprising:—a support (2) of the needle (3),—a needle shield (8) having a longitudinal axis A,—urging means (13) for displacing said needle shield (8) from a “in, use” position to a “after use” position,—a locking element (10) intended to prevent said needle shield (8) from moving back from its “after use” position to its “in use” position, characterized in that said locking element (10) has a longitudinal axis B and is radially movable with respect to said needle shield (8) between a “free” position, in which the longitudinal axis A of the needle shield (8) and the longitudinal axis B of the locking element (10) are merged and in which said needle shield (8) is movable from its “in use” position to its “after use” position, and a “locking position”, in which the longitudinal axis B is radially spaced apart from the longitudinal axis A and in which movement of the needle shield (8) from its “after use” position to its “in use” position is prevented.

Abstract: A drug storage and dispensing system that includes a packaging unit and an injection device for pre-filled containers having a needle shield and containing a medication is disclosed. The drug storage and dispensing system of the present disclosure provides for drug administration while minimizing the space occupied by such containers in the cold chain. The packaging unit minimizes the risk of a needle-stick injury, as a healthcare worker does not have to manually remove the needle shield. The injection device provides a novel way of auto-disabling a container, such as a syringe, as a plunger rod is not engaged with the container until the container is actually used. The drug storage and dispensing system provides for a reduction in the number of steps required to perform an injection, and thus a productivity and efficiency gain in mass immunization campaigns.

Abstract: The present invention relates to an automatic injection device (1) comprising: a container aligned on a longitudinal axis A and movable between a first position and a second position, in which the needle is inserted, biasing means, laterally spaced with respect to said longitudinal axis A, and coupled to the container for moving it to its second position, via linking means, retaining means (70) for maintaining said biasing means in a first stressed state, deactivating means (80) capable of moving along a transversal direction for releasing said retaining means, triggering means (90) for releasing said deactivating means.