Patents Assigned to Ben-Gurion University of the Negev Research and Development Authority
  • Patent number: 10716800
    Abstract: Conjugates of drugs suitable for use in the treatment of inflammatory bowel disease and phospholipids, and their use in the treatment of inflammatory bowel disease, are disclosed. The disclosed conjugates serve as targeted prodrugs which are suitable for oral administration, and which are capable of releasing the drug selectively at the diseased tissue upon activation by PLA2.
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: July 21, 2020
    Assignee: Ben-Gurion University of the Negev Research and Development Authority
    Inventor: Arik Dahan
  • Patent number: 10712407
    Abstract: An optical magnetometer comprising: a response frequency measurement unit comprising a vapor cell, a pulsed-mode pump laser and a probe laser; and a computing unit configured to compute a magnetic field change based on a difference between at least two temporally-distinct response frequency values received from the frequency measurement unit. Optionally, the response frequency measurement unit is magnetically non-shielded.
    Type: Grant
    Filed: February 3, 2014
    Date of Patent: July 14, 2020
    Assignee: BEN GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
    Inventors: Andrei Ben Amar Baranga, David Levron, Eugene Paperno, Reuben Shuker
  • Publication number: 20190350878
    Abstract: The present invention is directed to methods and uses of a series of compounds and compositions comprising the same for treating diseases, disorders and/or conditions related to fertility and preserving same and conditions related to same. In some aspects, the compounds and or compositions as herein described promote, improve, recover or restore fertility in a subject in need thereof, including in male and/or female subjects. Such methods/uses include promoting, enhancing or improving fertility-associated cell or tissue yield as part of an in vitro fertilization protocol.
    Type: Application
    Filed: February 12, 2018
    Publication date: November 21, 2019
    Applicant: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
    Inventor: Esther PRIEL
  • Patent number: 10245556
    Abstract: A system and method for switching between flows of water solutions passed in groups of blocks of membrane pressure vessels arranged in parallel in a tapered flow system, wherein the system comprises a system inlet feed line, a system outlet flow line, high pressure booster pumps configured to provide a high pressure feed stream to the system; blocks of membrane pressure vessels arrayed in parallel, and a first and second bypass line each parallel to said blocks.
    Type: Grant
    Filed: April 15, 2013
    Date of Patent: April 2, 2019
    Assignees: BEN GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY, MEKOROT WATER COMPANY LTD.
    Inventors: Jack Gilron, Dan Peled, Yevgeny Goldkine, Sivan Bleich
  • Patent number: 10238113
    Abstract: The present invention relates to regulation of ureide levels for optimal plant survival during nutrient remobilization such as occurs during normal growth, dark stress and senescence. Plants can be genetically engineered or selected using a suitable gene marker to have enhanced ureide accumulation. The present invention further provides methods of protecting plants, or extending the shelf life of fresh plant produce by application of exogenous ureides.
    Type: Grant
    Filed: March 12, 2015
    Date of Patent: March 26, 2019
    Assignees: Yeda Research and Development Co. Ltd. at The Weizmann Institute of Science, Ben-Gurion University of The Negev research and Development Authority
    Inventors: Robert Fluhr, Moshe Sagi
  • Patent number: 10213527
    Abstract: An isolated peptide is disclosed. The peptide comprises a titanium oxide binding amino acid sequence connected to a heterologous biologically active amino acid sequence via a beta sheet breaker linker, wherein: (i) the titanium oxide binding amino acid sequence is selected to bind coordinatively with titanium oxide; (ii) the titanium oxide binding amino acid sequence is selected to induce a beta sheet structure; and (ii) the titanium oxide binding amino acid sequence binds to titanium oxide with a higher affinity than said biologically active amino acid sequence binds to the titanium oxide under physiological conditions. Use of the peptides and titanium devices comprising same are also disclosed.
    Type: Grant
    Filed: August 3, 2017
    Date of Patent: February 26, 2019
    Assignee: Ben-Gurion University of the Negev Research and Development Authority
    Inventors: Hanna Rapaport, Anna Gittelman
  • Patent number: 10167319
    Abstract: The caged cell-penetrating peptide (cCPP) conjugates of this invention are ideal for intracellular delivery of a broad variety of cargoes including various nanoparticulate pharmaceutical carriers (liposomes, micelles, microparticles, nanoparticles, polymer-conjugates). The conjugates comprise a detectable agent or a therapeutic agent, and the conjugates provide a novel strategy for site-specific delivery of the same to appropriate tissues in the subject. Versatile application of the conjugates in diagnostics and imaging is described.
    Type: Grant
    Filed: May 26, 2011
    Date of Patent: January 1, 2019
    Assignee: Ben-Gurion University of Negev Research & Development Authority
    Inventors: Ayelet David, Gonen Ashkenasy, Yosi Shamay
  • Patent number: 10117895
    Abstract: Provided is a method of treating a pathology associated with neural damage, the method comprising administering non-antigen specific polyclonal activated T cells and/or genetically modified T cells into the brain in a manner which prevents meningoencephalitis in the subject, thereby treating the pathology associated with neural damage. Also provided are devices for intrabrain and intrathecal administration of T cells, which comprise the brain-specific or non-antigen specific polyclonal activated T cells and/or genetically modified T cells and a catheter for intrabrain administration in a manner which prevents meningoencephalitis in a subject.
    Type: Grant
    Filed: November 17, 2011
    Date of Patent: November 6, 2018
    Assignee: Ben-Gurion University of the Negev Research and Development Authority
    Inventor: Alon Monsonego
  • Patent number: 10111880
    Abstract: The present invention is directed to use of a series of tri-aryl compounds and compositions comprising the same for the treatment of diabetes and disease conditions arising as a consequence of the same.
    Type: Grant
    Filed: November 4, 2014
    Date of Patent: October 30, 2018
    Assignee: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
    Inventor: Esther Priel
  • Patent number: 10014823
    Abstract: A power converter, which comprises a resonant Switched Capacitor Converter (SCC) that consists of an input connected to an input voltage source, from which power is delivered to a load; a resonant tank circuit formed by a capacitor connected in series with an inductor and defining a resonant cycle; a first switch connected in series between a first contact of the input voltage source and a first contact of the resonant tank circuit; a second switch connected in series between the first contact of the resonant tank circuit and a first contact of the load; a conducting path connecting between a second contact of the input voltage source, a second contact of the resonant tank circuit and a second contact of the load and a third switch connected in parallel to the resonant tank circuit.
    Type: Grant
    Filed: August 4, 2013
    Date of Patent: July 3, 2018
    Assignee: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH & DEVELOPMENT AUTHORITY
    Inventors: Shmuel Ben-Yaakov, Alon Cervera, Alon Blumenfeld, Mor Mordechai Peretz
  • Patent number: 9977018
    Abstract: An electrochemical lateral flow biosensor (ELFB) includes an ELFB strip and electronic detector unit coupled to the strip. The strip includes a polymeric hydrophobic membrane, conjugation pad, sampling pad, screen-printed electrode (SPE), and wick pad. The membrane provides a solid support and enables capillary flow along the strip. The conjugation pad is placed on the membrane at one end of the strip and contains adsorbed dehydrated labelled conjugate particles that are coated with the biorecognition element and coated or filled with the electrochemically active component. The sampling pad is placed on the conjugation pad and provides adsorption of the liquid sample. The SPE is coated with immobilized capture antibodies. The wick pad is placed on the SPE and provides absorption of excess reagents maintaining a lateral flow along the strip. The ELFB can be used for rapid and early detection and quantity analysis of biological liquids and wastewater.
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: May 22, 2018
    Assignees: NANYANG TECHNOLOGICAL UNIVERSITY, BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
    Inventors: Robert S. Marks, Polina Brangel, Vladislav Papper, Evgeni Eltzov
  • Patent number: 9934388
    Abstract: A method for encrypting a database, according to which a dedicated encryption module is placed inside a Database Management Software above a database cache. Each value of the database is encrypted together with the coordinates of said value using a dedicated encryption method, which assumes the existence of an internal cell identifier that can be queried but not tampered.
    Type: Grant
    Filed: February 16, 2015
    Date of Patent: April 3, 2018
    Assignee: Ben-Gurion University of the Negev Research and Development Authority
    Inventors: Yuval Elovici, Ronen Vaisenberg, Erez Shmueli
  • Patent number: 9906189
    Abstract: A method for increasing the power extraction capability out of Differential Power Processor (DPP) system, which consists of a chain of N serially connected PV elements and an array of N?1 gyrator-type converters which are current sourcing resonant Switched Capacitor Converters (SCCs), each of which being connected in parallel with two adjacent PV elements. Accordingly, local MPPT is continuously performed, by each gyrator-type converter, to one of its two connected PV elements by sinking or sourcing current to/from the neighboring PV element. Whenever a mismatch in the MPPs is detected, the gyrator-type converters are used to provide the difference in current that is required for each of the PV elements to operate at its MPP, such that the amount of power processed by each gyrator-type converter in the chain is linearly proportional to its location in the chain, with respect to the mismatched PV element.
    Type: Grant
    Filed: August 5, 2013
    Date of Patent: February 27, 2018
    Assignee: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH & DEVELOPMENT AUTHORITY
    Inventors: Shmuel Ben-Yaakov, Alon Cervera, Alon Blumenfeld, Mor Mordechai Peretz
  • Patent number: 9867884
    Abstract: The site-specific expression of selectins on endothelial cells of blood vessels during angiogenesis provides an opportunity to target anti-cancer drugs to the vascular endothelium to extend the range of the therapeutic effect. This invention describes an innovative drug targeting strategy for the selective delivery of the anticancer drugs to endothelial cells by means of polymer-drug conjugates modified with a carbohydrate ligand for the vascular selectins. A model chemotherapeutic drug, doxorubicin, and the E-selectin ligand, sLex, are attached to a biocompatible polymer (HPMA). The selective binding, cellular uptake, intracellular fate, and cell cytotoxicity of the polymer-bound drug are investigated in human endothelial cells.
    Type: Grant
    Filed: August 19, 2014
    Date of Patent: January 16, 2018
    Assignee: Ben-Gurion University of Negev Research & Development Authority
    Inventors: Ayelet David, Gonen Ashkenasy, Yosi Shamay
  • Patent number: 9861686
    Abstract: The present invention provides a method of treating, delaying the onset, delaying progression of, reducing the incidence of or reducing the severity of amyotrophic lateral sclerosis in a subject, the method comprising administering to a subject an agent, which interferes with IgG-A2BG2 expression, IgG-A2BG2 function or IgG-A2BG2 interaction with CD16 in said subject.
    Type: Grant
    Filed: December 4, 2012
    Date of Patent: January 9, 2018
    Assignee: Ben-Gurion University of the Negev Research & Development Authority
    Inventors: Angel Porgador, Rachel Lichtenstein
  • Patent number: 9844336
    Abstract: An embodiment of the invention provides a method of diagnosing obstructive sleep apnea, the method comprising: acquiring a sleep sound signal comprising sounds made by a person during sleep; detecting a plurality of snore sounds in the sleep sound signal; determining a set of mel-frequency cepstral coefficients for each of the snore sounds; determining a characterizing feature for the sleep sound signal responsive to a sum of the variances of the cepstral coefficients; and using the characterizing feature to diagnose obstructive sleep apnea in the person.
    Type: Grant
    Filed: August 24, 2011
    Date of Patent: December 19, 2017
    Assignees: Ben Gurion University of the Negev Research and Development Authority, Mor Research Applications Ltd.
    Inventors: Yaniv Zigel, Ariel Tarasiuk, Nir Ben Israel
  • Publication number: 20170328895
    Abstract: An isolated peptide is disclosed. The peptide comprises a titanium oxide binding amino acid sequence connected to a heterologous biologically active amino acid sequence via a beta sheet breaker linker, wherein: (i) the titanium oxide binding amino acid sequence is selected to bind coordinatively with titanium oxide; (ii) the titanium oxide binding amino acid sequence is selected to induce a beta sheet structure; and (ii) the titanium oxide binding amino acid sequence binds to titanium oxide with a higher affinity than said biologically active amino acid sequence binds to the titanium oxide under physiological conditions. Use of the peptides and titanium devices comprising same are also disclosed.
    Type: Application
    Filed: August 3, 2017
    Publication date: November 16, 2017
    Applicant: Ben-Gurion University of the Negev Research and Development Authority
    Inventors: Hanna RAPAPORT, Anna GITTELMAN
  • Patent number: 9802989
    Abstract: An isolated novel oil globule protein encoded by a polynucleotide sequence is provided together with a composition which includes the isolated protein. A transgenic organism transformed by a polynucleotide encoding a protein which at least partially comprises the amino acid sequence of the novel oil globule protein is also provided. The invention also provides a method for producing or enhancing the production of a carotenoid such as astaxanthin, which is an oil globule constituent.
    Type: Grant
    Filed: August 30, 2011
    Date of Patent: October 31, 2017
    Assignees: Ben Gurion University of the Negev Research and Development Authority, Yeda Research and Development Co. Ltd. at the Weizmann Institute of Science
    Inventors: Sammy Boussiba, Ehud Peled, Uri Pick, Aliza Zarka, Stefan Lou, Meira Weiss
  • Patent number: 9731048
    Abstract: An isolated peptide is disclosed. The peptide comprises a titanium oxide binding amino acid sequence connected to a heterologous biologically active amino acid sequence via a beta sheet breaker linker, wherein: (i) the titanium oxide binding amino acid sequence is selected to bind coordinatively with titanium oxide; (ii) the titanium oxide binding amino acid sequence is selected to induce a beta sheet structure; and (ii) the titanium oxide binding amino acid sequence binds to titanium oxide with a higher affinity than said biologically active amino acid sequence binds to the titanium oxide under physiological conditions. Use of the peptides and titanium devices comprising same are also disclosed.
    Type: Grant
    Filed: June 3, 2013
    Date of Patent: August 15, 2017
    Assignee: Ben-Gurion University of the Negev Research and Development Authority
    Inventors: Hanna Rapaport, Anna Gittelman
  • Patent number: 9731046
    Abstract: The present invention provides a multi-compartment hydrogel, and a sulfated polysaccharide and at least two bioactive polypeptides capable of binding said sulfated polysaccharide, for use in repair or regeneration of a damaged tissue in a mammal. Also provided is a method for constructing the multi-compartment hydrogel. The present invention also provides a method for the repair or regeneration of a damaged tissue in a mammal, and a kit for constructing a multi-compartment hydrogel.
    Type: Grant
    Filed: February 21, 2013
    Date of Patent: August 15, 2017
    Assignee: Ben Gurion University of the Negev Research and Development Authority
    Inventors: Smadar Cohen, Tali Re'Em, Emil Ruvinov