Patents Assigned to Ben-Gurion University of the Negev Research and Development Authority
  • Patent number: 8932981
    Abstract: A process which comprises providing a porous matrix, mixing said porous matrix with a precursor solution containing manganese and cerium ions dissolved therein, triggering the formation of a non-fluid phase which contains manganese and cerium in the interior of said porous matrix, separating said porous matrix from a liquid phase containing soluble metals, completing the formation of said non-fluid phase which contains manganese and cerium in the interior of said porous matrix, heat treating said porous matrix to convert said non-fluid phase containing manganese and cerium placed therein into a manganese oxide-cerium oxide composite, and isolating said composite from said porous matrix. The resulting composite, and its use as a catalyst, are also provided.
    Type: Grant
    Filed: December 7, 2006
    Date of Patent: January 13, 2015
    Assignee: Ben-Gurion University of the Negev Research and Development Authority
    Inventors: Miron Landau, Mordehai Herskowitz, Meyrav Abecassis-Wolfovich
  • Patent number: 8932581
    Abstract: This invention is directed to coral scaffolds seeded with precursor cells in culture in the presence of a chelator and uses thereof in inducing or enhancing bone and/or cartilage formation in a subject, and kits related thereto. This invention is also directed to use of cadherin-upregulating coral for treating cancer or inhibiting cancer progression. This invention is also directed to use of aragonite or calcite-producing species for in vivo calcium release, and its application to the treatment of skin diseases, disorders or conditions.
    Type: Grant
    Filed: November 18, 2008
    Date of Patent: January 13, 2015
    Assignee: Ben Gurion University of the Negev Research and Development Authority
    Inventor: Razi Vago
  • Patent number: 8901965
    Abstract: A dual-mode logic gate, for selectable operation in either of static and dynamic modes, includes: a static gate which includes at least one logic input and a logic output; a mode selector, configured for outputting a turn-off signal to select static mode operation and for outputting a dynamic clock signal to select dynamic mode operation; and a switching element associated with the mode selector static gate, comprising a first input connected to a constant voltage, a second input for inputting the mode selection signal from the mode selector, and an output connected to a logic output of the static gate. The switching elements switches the logic gate operation from static to dynamic mode, by applying the appropriate signal to the switching element.
    Type: Grant
    Filed: August 2, 2012
    Date of Patent: December 2, 2014
    Assignee: Ben-Gurion University of the Negev Research and Development Authority
    Inventors: Alexander Fish, Asaf Kaizerman, Sagi Fisher, Itamar Levy
  • Patent number: 8895523
    Abstract: Inhibitors of cPLA2? expression are used in the preparation of pharmaceutical compositions for the inhibition of cancer cell proliferation and for the treatment of cancer; the inhibitors are selected from cPLA2?-specific ribozymes, RNA sequences usable for RNA-interference of the cPLA2? gene, and antisense oligonucleotides directed against cPLA2?.
    Type: Grant
    Filed: September 20, 2007
    Date of Patent: November 25, 2014
    Assignees: Mor Research Applications Ltd., Ben-Gurion University of the Negev Research and Development Authority
    Inventor: Rachel Levy
  • Patent number: 8871139
    Abstract: This invention provides a polycrystalline yttrium aluminum garnet (YAG) which is transparent in the visible and near infrared region. The invention also provides a method of manufacturing a transparent sintered YAG, which has nearly no porosity.
    Type: Grant
    Filed: June 22, 2010
    Date of Patent: October 28, 2014
    Assignee: Ben-Gurion University of the Negev Research and Development Authority
    Inventors: Nahum Frage, Moshe Dariel, Sergei Kalabuchov
  • Patent number: 8871808
    Abstract: The present invention is primarily directed to a mutant strain of Parietochloris incisa, characterized in comprising a substantially reduced intracellular concentration of arachidonic acid (AA) together with a substantially increased intracellular concentration of dihomo-gamma-linolenic acid 20:3?6 (DGLA).
    Type: Grant
    Filed: June 21, 2007
    Date of Patent: October 28, 2014
    Assignee: Ben-Gurion University of the Negev Research and Development Authority et al.
    Inventors: Zvi Cohen, Inne Khozin-Goldberg, Sammy Boussiba, Avigad Vonshak
  • Patent number: 8860948
    Abstract: An optical coherence tomography (OCT) imager comprising: a low coherence light source that provides light; a photosensor for imaging light; optics that directs a first portion of the light along a first optical path so that it is imaged on the photosensor and a second portion of the light along a second optical path so that it is reflected by material in the target to the photosensor where it is imaged to interfere with light from the first portion to form an interference pattern; and a mask through which light from at least one of the first and second portions of light passes that generates a relative phase perturbation between portions of light that passes through it.
    Type: Grant
    Filed: January 24, 2011
    Date of Patent: October 14, 2014
    Assignee: Ben Gurion University of the Negev Research and Development Authority Ltd.; Bar Ilan University
    Inventors: Ibrahim Abdulhalim, Zeev Zalevsky
  • Publication number: 20140303233
    Abstract: Antisense oligonucleotides against cPLA2 are provided, which are capable of inhibiting cPLA2 expression as well as superoxide production, especially in phagocytes. These antisense oligonucleotides are powerful agents for the treatment of inflammatory conditions, in particular arthritis, as well as in neurodegenerative diseases. The antisense oligonucleotides or compositions comprising the same may be used in methods of treatment of such diseases.
    Type: Application
    Filed: March 10, 2014
    Publication date: October 9, 2014
    Applicants: Ben-Gurion University of the Negev Research and Development Authority, Mor Research Applications Ltd.
    Inventor: Rachel LEVY
  • Patent number: 8840874
    Abstract: The site-specific expression of selectins on endothelial cells of blood vessels during angiogenesis provides an opportunity to target anti-cancer drugs to the vascular endothelium to extend the range of the therapeutic effect. This invention describes an innovative drug targeting strategy for the selective delivery of the anticancer drugs to endothelial cells by means of polymer-drug conjugates modified with a carbohydrate ligand for the vascular selectins. A model chemotherapeutic drug, doxorubicin, and the E-selectin ligand, sLex, are attached to a biocompatible polymer (HPMA). The selective binding, cellular uptake, intracellular fate, and cell cytotoxicity of the polymer-bound drug are investigated in human endothelial cells.
    Type: Grant
    Filed: November 24, 2010
    Date of Patent: September 23, 2014
    Assignee: Ben-Gurion University of the Negev Research and Development Authority
    Inventors: Ayelet David, Gonen Ashkensy, Yosi Shamay
  • Publication number: 20140248243
    Abstract: The invention provides virus-like particles for treatment of viral infections based on the virus causing the infection. The virus-like particles comprise the virus recombinant proteins that form a capsid, recombinant virus membrane proteins attached to the capsid and vRNA packaged within said capsid. The vRNA is generated from a DNA sequence encoding a polypeptide capable of specifically binding to a constant region of a nonstructural protein of the virus that is essential for propagation of the virus.
    Type: Application
    Filed: April 5, 2012
    Publication date: September 4, 2014
    Applicant: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
    Inventors: Leslie Lobel, Guy Gubi
  • Publication number: 20140234976
    Abstract: The present invention provides a protein, specifically Parietochloris incisa acetohydroxyacid synthase, and methods for producing branched-chain amino acid in a cell. The present invention further provides polypeptides and polynucleotides useful for conferring herbicide resistance in a cell or an organism. In particular, the present invention discloses a mutated acetohydroxyacid synthase which is resistant to herbicides.
    Type: Application
    Filed: October 4, 2012
    Publication date: August 21, 2014
    Applicant: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
    Inventors: Omer Grundman, Inna Khozin-Goldberg, Zvi Hacohen, Michal Shapira, Dina Raveh, Sammy Boussiba, Boris Zorin
  • Patent number: 8807350
    Abstract: There is provided a composite membrane, which may include an electronically conductive asymmetric porous support and an electro-polymerized selective layer. There is also provided a composite membrane for water application(s), which may include an electronically conductive porous support and an electro-polymerized selective layer. Moreover, there is provided a composite membrane for gas application(s), which may include an electronically conductive asymmetric porous support and an electro-polymerized selective layer. There is also provided a membrane system which may include at least one composite membrane which may include an electronically conductive asymmetric porous support and an electro-polymerized selective layer. In addition there is provided a method for the preparation of a composite membrane.
    Type: Grant
    Filed: July 16, 2006
    Date of Patent: August 19, 2014
    Assignee: Ben-Gurion University of The Negev Research & Development Authority
    Inventors: Charles Linder, Viatcheslav Freger, Yoram Oren
  • Patent number: 8802924
    Abstract: An isolated protein which is at least partially encoded by a polynucleotide sequence encoding a novel elongase is provided together with a composition which includes the isolated protein. A transgenic plant or a transgenic seed transformed by a polynucleotide encoding a protein which is at least partially encoded by a novel elongase is also provided. The invention also includes a process for making a very long-chain polyunsaturated fatty acid in a transformed cell or plant expressing the isolated protein which is at least partially encoded by a polynucleotide sequence encoding a novel elongase.
    Type: Grant
    Filed: November 26, 2009
    Date of Patent: August 12, 2014
    Assignee: Ben Gurion University of the Negev Research and Development Authority
    Inventors: Zvi Hacohen, Inna Khozin Goldberg, Rivka Ofir, Iskandarov Umidjon
  • Publication number: 20140219981
    Abstract: The present invention relates in general to the field of tissue engineering and more specifically to amphiphilic peptides and peptide matrices thereof useful in vitro and in situ biomineralization and inducing bone repair. The present invention provides peptides, which are useful in hydrogels and other pharmaceutical compositions, and methods and kits of use for bone repair and promotion of biomineralization. Certain hydrogels according to the invention comprise cells within or adhered to the peptide matrix.
    Type: Application
    Filed: January 14, 2014
    Publication date: August 7, 2014
    Applicant: Ben-Gurion University of the Negev Research and Development Authority
    Inventor: Hanna RAPAPORT
  • Publication number: 20140212450
    Abstract: Vaccine compositions and methods for protecting a mammalian subject against infection with S. pneumoniae are disclosed. These vaccine compositions include as the active ingredient a purified preparation of the cell wall protein ABC transporter substrate-binding protein having the Accession No. NP_344690 and the amino acid sequence set forth in SEQ ID NO: 32, optionally together with one or more pharmaceutically acceptable adjuvants.
    Type: Application
    Filed: February 19, 2014
    Publication date: July 31, 2014
    Applicant: Ben-Gurion University of the Negev Research and Development Authority
    Inventor: Yaffa MIZRACHI NEBENZAHL
  • Publication number: 20140213640
    Abstract: The invention provides virus-like particles for treatment of viral infections based on the virus causing the infection. The virus-like particles comprise the virus recombinant proteins that form a capsid, recombinant virus membrane proteins attached to the capsid and vRNA packaged within said capsid. The vRNA is generated from a DNA sequence encoding a polypeptide capable of specifically binding to a constant region of a nonstructural protein of the virus that is essential for propagation of the virus.
    Type: Application
    Filed: April 10, 2014
    Publication date: July 31, 2014
    Applicant: Ben Gurion University of The Negev Research and Development Authority
    Inventors: Leslie Lobel, Guy Gubi
  • Publication number: 20140205623
    Abstract: Vaccine compositions and methods for protecting a mammalian subject against infection with S. pneumoniae are disclosed. These vaccine compositions include as the active ingredient a purified preparation of the cell wall protein NADH oxidase (NOX) having the Accession No. NP_345923 and the amino acid sequence set forth in SEQ ID NO: 8, optionally together with one or more pharmaceutically acceptable adjuvants.
    Type: Application
    Filed: February 19, 2014
    Publication date: July 24, 2014
    Applicant: Ben-Gurion University of the Negev Research and Development Authority
    Inventor: Yaffa MIZRACHI NEBENZAHL
  • Publication number: 20140196177
    Abstract: An isolated protein which is at least partially encoded by a polynucleotide sequence encoding a novel acyl-CoA: diacylglycerol acyltransferase 1—like gene (PtDGAT1) from the diatom Phaeodactylum tricomutum is provided together with a composition which includes the isolated protein and a transgenic organism transformed by a polynucleotide encoding same. The invention also provides a method for producing or enhancing the production of oil or triacylglycerols with high saturated fatty acids content.
    Type: Application
    Filed: November 3, 2011
    Publication date: July 10, 2014
    Applicant: Ben Gurion University of the Negev Research and Development Authority
    Inventors: Freddy Guiheneuf, Stefan Leu, Aliza Zarka, Inna Khozin-Goldberg, Sammy Boussiba
  • Publication number: 20140192942
    Abstract: The present invention provides a method for producing molybdenum-99 comprising: i) providing an electron accelerator; ii) providing a molybdenum converter/target unit (Mo-CTU) comprising one or more metallic components, wherein each one of said metallic components is made of a material selected from the group consisting of natural molybdenum, molybdenum-100, molybdenum-98, and mixtures thereof; iii) directing an electron beam generated via said electron accelerator onto said Mo-CTU to produce a braking radiation (bremsstrahlung); iv) employing said bremsstrahlung onto said Mo-CTU to produce molybdenum-99 and neutrons via a photo-neutron reaction; v) slowing down the neutrons produced in step iv) with a low atomic liquid, e.g. distilled water; and optionally vi) employing the neutrons produced in step iv) to produce a complementary amount of molybdenum-99 via a neutron capture reaction on said Mo-CTU. The invention further provides an apparatus for producing molybdenum-99.
    Type: Application
    Filed: August 22, 2012
    Publication date: July 10, 2014
    Applicant: Ben-Gurion University of the Negev, Research and Development Authority
    Inventor: Alexander Tsechanski
  • Patent number: 8772756
    Abstract: A method of forming a nanowire structure is disclosed. The method comprises applying on a surface of carrier liquid a layer of a liquid composition which comprises a surfactant and a plurality of nanostructures each having a core and a shell, and heating at least one of the carrier liquid and the liquid composition to a temperature selected such that the nanostructures are segregated from the surfactant and assemble into a nanowire structure on the surface.
    Type: Grant
    Filed: June 24, 2013
    Date of Patent: July 8, 2014
    Assignee: Ben-Gurion University of the Negev Research and Development Authority
    Inventors: Roman Volinsky, Raz Jelinek