Patents Assigned to Board of Regents The University of Texas System
  • Publication number: 20220143024
    Abstract: Provided herein are methods of using ClpP levels and mutation status as a marker for the selection and treatment of cancer patients who will respond to the administration of imipridones. Also provided are methods of treating patients having Perrault syndrome. Also provided are methods of killing bacterial cells and treating bacterial infections using imipridones.
    Type: Application
    Filed: February 21, 2020
    Publication date: May 12, 2022
    Applicants: Board of Regents, The University of Texas System, University Health Network
    Inventors: Michael ANDREEFF, Jo ISHIZAWA, David SCHIMMER, Sara ZARABI
  • Publication number: 20220143023
    Abstract: The present disclosure provides methods of treating cancer in a patient determined to have an EGFR and/or HER2 exon 20 mutation, such as an insertion mutation, by administering a third-generation tyrosine kinase inhibitor, such as poziotinib or afatinib.
    Type: Application
    Filed: March 27, 2020
    Publication date: May 12, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventors: Jacqulyne ROBICHAUX, Monique NILSSON, John V. HEYMACH
  • Publication number: 20220143030
    Abstract: Provided herein are RNA-dependent protein kinase (PKR)-associated compounds for the treatment of PKR-associated disorders including cancer, neurodegenerative diseases, and inflammatory conditions.
    Type: Application
    Filed: February 7, 2020
    Publication date: May 12, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventors: Apar PATAER, Bulent OZPOLAT, Stephen G. SWISHER, Ruping SHAO
  • Publication number: 20220144944
    Abstract: Provided herein are LILRB4-binding antibodies and methods of treating cancer by administering the LILRB4-binding antibodies alone or in combination with other therapies. Recombinant polypeptides comprising the CDRs of LILRB4-binding antibodies are also provided.
    Type: Application
    Filed: March 2, 2020
    Publication date: May 12, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventors: Naveen SHARMA, James P. ALLISON
  • Patent number: 11327448
    Abstract: The present disclosure provides a method and system for optimizing a control process. The method and system comprise using a sensor to generate a feedback signal that represents a measured performance index for an extremum seeking control (ESC) method and sending the feedback signal to an ESC conditioning circuit that applies a logarithmic transformation to the feedback signal to obtain a modified feedback signal. An ESC controller applies the modified feedback signal to the ESC method to generate an output value that is used to control an actuator to maximize the performance of a machine or process.
    Type: Grant
    Filed: May 30, 2018
    Date of Patent: May 10, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventor: Mario A. Rotea
  • Patent number: 11329389
    Abstract: A method for fabricating a hyperbolic metamaterial coating having a near-zero refractive index is disclosed. The direction of propagating light changes by means of generating subwavelength structures that alter the coatings permittivity and permeability. The coating can be deposited on lenses or incorporated into optical devices. This type of metamaterial can be utilized to direct light towards sensors or to collect light efficiently.
    Type: Grant
    Filed: July 24, 2019
    Date of Patent: May 10, 2022
    Assignee: Board Of Regents, The University of Texas System
    Inventors: Nantakan Wongkasem, Andres Ochoa
  • Patent number: 11326263
    Abstract: The present disclosure relates to nanocomposites of CuO/Cu2O and continuous flow solar reactors. The nanocomposites can be utilized as a photocatalyst and can be incorporated into photoelectrochemical devices. The described devices, systems, and methods can be used for converting CO2 into one or more alcohols and other small organics with the use of solar energy and electricity. Other embodiments are described.
    Type: Grant
    Filed: March 14, 2019
    Date of Patent: May 10, 2022
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Brian Dennis, Krishnan Rajeshwar, Norma Tacconi, Wilaiwan Chanmanee, Homayon Homayoni, Ghazaleh Ghadimkhani
  • Patent number: 11325898
    Abstract: Small molecule disruptors of Beclin-1/Bcl-2 protein-protein interactions induce autophagy and hence are useful for treating a variety of indications where stimulation of autophagy is therapeutically useful, including cancer, infection immunity, neurodegeneration, longevity.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: May 10, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: Jef De Brabander, Qiren Liang, Beth Levine, Wei-Chung Chiang
  • Patent number: 11326327
    Abstract: Disclosed herein are water harvesting networks. The harvesters allow extraction and collection of moisture from the atmosphere without requiring electrical energy inputs.
    Type: Grant
    Filed: February 9, 2018
    Date of Patent: May 10, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: Guihua Yu, Fei Zhao, Xingyi Zhou
  • Publication number: 20220136011
    Abstract: Provided herein are compositions of lipid-based nanoparticles, such as exosomes, that comprise a therapeutic anti-aging agent. Also provided are methods of using such compositions to treat a patient having an age-associated disorder. In particular, exosomes comprising a telomerase-encoding RNA are provided along with methods of their use in treating age-associated disorders.
    Type: Application
    Filed: February 7, 2020
    Publication date: May 5, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventor: Raghu KALLURI
  • Publication number: 20220137056
    Abstract: The present invention provides methods of predicting, diagnosing, and prognosing disease in a patient by analyzing the microbiome signature present in isolated exosomes. In one embodiment, provided herein are methods of detecting a microbiome in a patient, the method comprising: (a) obtaining a body fluid sample from a patient; (b) isolating an exosomes fraction of the body fluid sample; and (c) detecting a microbial macromolecule present in the exosomes fraction.
    Type: Application
    Filed: February 7, 2020
    Publication date: May 5, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventor: Raghu KALLURI
  • Publication number: 20220133637
    Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.
    Type: Application
    Filed: January 10, 2022
    Publication date: May 5, 2022
    Applicant: The Board of Regents of The University of Texas System
    Inventors: Qiang CHENG, Tuo WEI, Daniel J. SIEGWART
  • Publication number: 20220135973
    Abstract: Provided are antisense oligomers targeted against bacterial mRNAs and other macromolecules associated with a biochemical pathway and/or cellular process, and related compositions and methods of using the oligomers and compositions to treat an infected mammalian subject, for example, as primary antimicrobials or as adjunctive therapies with classic antimicrobials.
    Type: Application
    Filed: October 12, 2021
    Publication date: May 5, 2022
    Applicants: Board of Regents, The University of Texas System, Oregon State University
    Inventors: David GREENBERG, Bruce L. GELLER
  • Publication number: 20220137073
    Abstract: Methods and kits are provided for amplifying and detecting misfolded tau protein from samples, for example, from patients having tauopathies such as Alzheimer's Disease, Progressive Supranuclear Palsy, and the like.
    Type: Application
    Filed: January 19, 2022
    Publication date: May 5, 2022
    Applicants: Amprion, Inc., Board of Regents of the University of Texas System
    Inventors: Claudio Soto-Jara, Russell M. Lebovitz, Benedikt K. Vollrath, Mohammad Shahnawaz, Nicolas Mendez Dinamarca
  • Patent number: 11318186
    Abstract: The present invention relates to the treatment of secretory disorders, and provides novel methods of treatment of these disorders comprising the administration of fibroblast growth factor 21 (FGF21) or derivatives thereof. The methods of the invention are useful in conditions including exocrine pancreatic insufficiency (EPI), for example EPI resulting from cystic fibrosis, alcoholism, pancreatitis, pancreatic cancer, gallstones, celiac disease, high triglycerides, or lupus. The methods of the present invention find further utility in the treatment of salivary flow disorders, for example Sjorgen's syndrome, and the treatment of EPI or pancreatitis resulting from surgical procedures.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: May 3, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: David J. Mangelsdorf, Steven A. Kliewer, Katie C. Coate, Genaro Hernandez
  • Publication number: 20220127340
    Abstract: Provided herein is an antibody as well as chimeric antigen receptor (CAR) to the Aspergillus antigen p60-binding domain. Further provided herein are immune cells expressing the CARs as well as methods of their use in the treatment of fungal infections and cancer.
    Type: Application
    Filed: February 7, 2020
    Publication date: April 28, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventors: Pappanaicken KUMAR, Thiago APARECIDO DA SILVA, Paul J. HAUSER
  • Patent number: 11313868
    Abstract: The invention relates to devices and methods for detecting the presence of antibodies to folic acid in a sample.
    Type: Grant
    Filed: June 14, 2017
    Date of Patent: April 26, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: Robert M. Cabrera, Richard H. Finnell
  • Patent number: 11311223
    Abstract: Epidermal electronics are sensors with mechanical properties matching human epidermis. Their manufacturing process includes photolithography and dry and wet etching within cleanroom facilities. The high cost of manpower, materials, photo masks, and facilities greatly hinders the commercialization potential of disposable epidermal electronics. In contrast, an embodiment of the invention includes a low cost, high throughput, bench top “cut-and-paste” method to complete the freeform manufacture of epidermal sensor system (ESS) in minutes. This versatile method works for many types of thin metal and polymeric sheets and is compatible with many tattoo adhesives or medical tapes. The resultant ESS is highly multimaterial and multifunctional and may measure ECG, EMG, skin temperature, skin hydration, as well as respiratory rate. Also, a stretchable planar coil made of serpentine ribbons can be used as a wireless strain gauge and/or a near field communication (NFC) antenna. Other embodiments are described herein.
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: April 26, 2022
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Nanshu Lu, Shixuan Yang, Pulin Wang
  • Patent number: 11311720
    Abstract: The present disclosure provides methods of making and applying metallized graphene fibers in bioelectronics applications. For example, platinized graphene fibers may be used as an implantable conductive suture for neural and neuro-muscular interfaces in chronic applications. In some embodiments, an implantable electrode includes a multi-layer graphene-fiber core, an insulative coating surrounding the multi-layer graphene-fiber core, and a metal layer disposed between the multi-layer graphene-fiber core and the insulative coating.
    Type: Grant
    Filed: November 21, 2019
    Date of Patent: April 26, 2022
    Assignees: University of Wollongong, Board of Regents, The University of Texas System
    Inventors: Mario Romero-Ortega, Gordon Wallace, Maria Gonzalez Gonzalez, Rouhollah Ali Jalili
  • Patent number: 11317515
    Abstract: A method for embedding a line in a substrate. A line embedding head in positioned relative to a surface of the substrate. The line from an output port in the line embedding head is output at an angle relative to the embedding head such that the line is embedded in the substrate.
    Type: Grant
    Filed: September 5, 2017
    Date of Patent: April 26, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: David Espalin, Ryan Wicker, Alfonso Fernandez, Jorge Ramirez, Jose Motta