Abstract: Disclosed are various embodiments that enable the identification of the location of a computing device based on radio data. A radio map can be identified for an area. The computing device can measure signal strengths to reference points. The signal strengths can be compared to the radio map. The computing device can determine its location based on the comparison of the signal strengths to the radio map.

Abstract: Memory allocation techniques may provide improved security and performance. A method may comprise mapping a block of memory, dividing the block of memory into a plurality of heaps, dividing each heap into a plurality of sub-heaps, wherein each sub-heap is associated with one thread of software executing in the computer system, dividing each sub-heap into a plurality of bags, wherein each bag is associated with one size class of objects, creating an allocation buffer and a deallocation buffer for each bag, storing a plurality of objects in at least some of the bags, wherein each object is stored in a bag having size class corresponding to a size of the object, storing in the allocation buffer of each bag information relating to available objects stored in that bag, and storing in the deallocation buffer of each bag information relating to freed objects that were stored in that bag.

Abstract: Provided herein are cationic liquid crystalline nanoparticles (CLCNs). Further provided herein are methods of delivering RNAi using the CLCNs for the treatment of diseases.

Abstract: The present invention provides that exosomes from human body fluid samples contain double stranded genomic DNA that spans all chromosomes and may be used to determine the mutation status of genes of interest in diseases, such as cancer. Furthermore, the present invention provides the use of exosomes to produce therapeutic proteins and for their use in therapy as well as the detection of cancer cell-derived exosomes to diagnose cancer and monitor therapeutic response.

Abstract: The present invention provides a formulation of Coenzyme Q10 that can be re-dispersed from a stable dry powder to formulation to yield a nanodispersion that can be readily aerosolized for inhalation.

Abstract: Systems and methods for simulating subterranean regions having multi-scale fracture geometries. Non-intrusive embedded discrete fracture modeling formulations are applied in conjunction with commercial simulators to efficiently and accurately model subsurface transient flow characteristics in regions having complex hydraulic fractures, complex natural fractures, or a combination of both, and geometries including corner point grids.

Abstract: The present invention is a composition and method for making and using a rechargeable multifunctional additive that reduce the formation of biofilms on a surface, the additive can also remain photo and thermally stable by synthesizing one or more N-halamine compounds and adding one or more N-halamine biocidal compounds to a target material prior, during or after the target material is made. The resultant material can be used directly to provide antimicrobial functions and control biofilm formation, or the material can be further processed into an article.

Abstract: In one embodiment, an anterior cervical transarticular fixation implant including a cervical plate including a central body, lateral wings that extend laterally outward from the central body, each lateral wing including a fastener opening configured to receive a fastener configured to thread into vertebrae, and locking mechanisms configured to selectively lock the fasteners in place.

Abstract: Methods and systems for diagnosing and controlling material deposition during a material extrusion 3D printing process. A current sensor can measure a current signal consumed by a material feed motor. The current signal can be analyzed in the time domain and frequency domain to detect material deposition characteristics and prescribe process parameter changes.

Abstract: Duchenne muscular dystrophy (DMD), which affects 1 in 5,000 male births, is one of the most common genetic disorders of children. This disease is caused by an absence or deficiency of dystrophin protein in striated muscle. The major DMD deletion “hot spots” are found between exon 6 to 8, and exons 45 to 53. Here, a “humanized” mouse model is provided that can be used to test a variety of DMD exon skipping strategies. Among these are, CRISPR/Cas9 oligonucleotides, small molecules or other therapeutic modalities that promote exon skipping or micro dystrophin mini genes or cell based therapies. Methods for restoring the reading frame of exon 44 deletion via CRISPR-mediated exon skipping in the humanized mouse model, in patient-derived iPS cells and ultimately, in patients using various delivery systems are also contemplated. The impact of CRISPR technology on DMD is that gene editing can permanently correct mutations.

Abstract: In one aspect, radioactive nanoparticles are described herein. In some embodiments, a radioactive nanoparticle described herein comprises a metal nanoparticle core, an outer metal shell disposed over the metal nanoparticle core, and a metallic radioisotope disposed within the metal nanoparticle core or within the outer metal shell. In some cases, the radioactive nanoparticle has a size of about 30-500 nm in three dimensions. In addition, in some embodiments, the radioactive nanoparticle further comprises an inner metal shell disposed between the metal nanoparticle core and the outer metal shell. The metal nanoparticle core, outer metal shell, and inner metal shell of the radioactive nanoparticle can have various metallic compositions.

Abstract: Provided herein are BAFF-R antibodies as well as compositions and methods of making and using the same. The antibodies provided herein are, inter alia, useful for the treatment of cancer and autoimmune diseases.

Abstract: Certain embodiments are directed to methods of treating or preventing an addictive behavior in a subject by administering to the subject an effective amount of a 5-HT2C receptor agonist in combination with a DA D3/D4 receptor antagonist.

Abstract: Disclosed are a desalination device and processes of desalination using the device. The device is directly ocean-situated and fully nature-powered with on intake, no brine production, and no electricity consumption. The device contains a heating unit, configured to receive a dry air stream and heat the dry air stream with one or more renewable energy sources to produce a heated air stream; a humidifier, configured to receive the heated air stream, evaporate at least portion of water present in the humidifier and humidify the heated air stream to produce a wet air stream, a cooling unit, configured to receive the wet stream and cool the wet air stream resulting in condensation of at least a portion of the moisture to produce fresh water and a dehumidified air stream; and a fresh water collection tank, configured to collect at least a portion of the fresh water.

Abstract: Actuators (artificial muscles) comprising twist-spun nanofiber yarn or twist-inserted polymer fibers generate torsional actuation when powered electrically, photonically, chemically, thermally, by absorption, or by other means. These artificial muscles utilize coiled yarns/polymer fibers and can be either neat or comprising a guest. In some embodiments, the actuator system includes a twisted and coiled polymer fiber actuator, and at least one of (i) wire connections that enable electrical heating of the twisted and coiled polymer fiber actuator, (ii) a radiation source and radiation pathway that enables photothermal heating of the twisted and coiled polymer fiber actuator, and (iii) a delivery system for delivering chemicals whose reaction produces heating of the twisted and coiled polymer fiber actuator.

Abstract: Devices and methods for detecting joint motion of a user. In particular embodiments, devices may comprise a deflectable beam coupled to a user via adhesive pads located between the neck and shoulder of the use. Audio and haptic feedback can be provided to the user when the deflectable beam deflects due to motion of the joint.

Abstract: The disclosure describes PELP1 binding peptides and peptoids and their use the interaction of PELP1 with molecules that lead to oncogenic signaling in cancers.

Abstract: In some embodiments, an anti-corrosive composite ceramic coating includes an inner metal layer formed on the surface of a metal object to be protected and an outer composite ceramic layer formed on the inner metal layer.

Abstract: Various examples are provided for coherence diversity. In one example, a method includes receiving a product signal transmitted over a plurality of subcarriers, the product signal including a product superposition of a first baseband signal and a second baseband signal; estimating equivalent channel responses for the plurality of subcarriers based upon the pilot symbol in the number of time slots of the plurality of subcarriers; and decoding the second encoded message based at least in part upon the first baseband signal and the equivalent channel responses. The first baseband signal can include a pilot symbol in a number of time slots of at least a portion of the plurality of subcarriers and a first encoded message in a remaining number of time slots of the plurality of subcarriers, and the second baseband signal can include a second encoded message.

Abstract: Embodiments of the current invention include methods and compositions for regulating the activity of hormone receptors.