Abstract: Human antibodies, preferably recombinant human antibodies, both humanized and chimeric, which specifically bind to human OX40 are disclosed. Preferred antibodies have high affinity for OX40 receptor and activate the receptor in vitro and in vivo. The antibody can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, are useful for modulating receptor activity, e.g., in a human subject suffering from a disorder in which OX40 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies are provided, and methods of synthesizing the recombinant human antibodies, are also provided.

Abstract: The present disclosure provides compounds that are useful for inhibiting the STAT6 pathway. Also provided are related pharmaceutical compositions and methods of using the compounds. In some embodiments, the compounds may be used to treat a disease such as, e.g., an allergic lung disease, allergic rhinitis, chronic pulmonary obstructive disease, or a cancer.

Abstract: Embodiments of the invention are directed to a device having one or more electromagnetic components embedded in an anisotropic metamaterial (AM) comprising an array of asymmetric unit cells comprising a substrate forming a plurality of channels or spaces having at least one material with different electromagnetic properties included in the channels or spaces in the first material forming an anisotropic metamaterial.

Abstract: Apparatus and methods are provided for applying negative pressure to tissues of a patient that are transmitted to the vertebral venous system of the patient and thereby lowering intracranial pressure. Intracranial pressure is thus lowered easily without increasing the work of breathing, without needing to be intubated, and without breathing through a valve in patients with elevated increased intracranial pressure.

Abstract: Provided is a method of inhibiting heterodimerization of HIF-2? to HIF1? (ARNT) comprising binding certain small molecules to the HIF-2? PAS-B domain cavity but not to HIF1? and inhibiting HIF-2? heterodimerization to HIF1? (ARNT) but not inhibiting HIF1? heterodimerization to HIF1? (ARNT). Those certain small molecules are also referenced synonymously as HIF2-HDI and HIF2? heterodimerization inhibitors and also simply as certain small molecules.

Abstract: A novel method of fabricating carbon nanotube sheet scrolled fiber and fiber tows (carbon, graphite, glass, natural polymer, synthetic polymer, metallic, silicon carbide, Kevlar, etc.) in composites with improved interfacial shear strength, compressive strength, yield strength, stiffness and toughness has been reported. Single or multiple layers of carbon nanotube sheet, with a bias/wrapping angle of 0° and 90°, has been scrolled around single fiber and fibers tows to improve the above mentioned mechanical properties of the matrix surrounding the fiber. Other common methods of growing CNTs directly on the fibers actually damage the fiber surface during the required precursor deposition and CNTs growth process. This demonstrated solid-state method overcomes such known problems. The CNTs sheet scrolled fiber is embedded into the polymer matrix exhibits significant (80%) increase in interfacial shear strength, compressive strength and toughness.

Abstract: Certain embodiments include materials that carry oxygen and emit molecular oxygen upon heating. The approach reported here uses thermal decomposition of organic endoperoxide compounds to produce singlet oxygen. In certain aspects the oxygen carrier comprises an organic compound either alone or contained in a polymeric carrier or other carrier material that is used to form a coating, layer, or bulk substance that can be a solid, a gel or a fluid. The oxygen-carrier is most conveniently prepared by oxidation of a precursor compound, the structure of which determines its thermal stability and thus how rapidly oxygen is released at any given temperature.

Abstract: An apparatus for determining blood clotting capacity comprises an actuator to cyclically move a member within a sample of blood received in a well in a tray and one of a deflection sensor and a position sensor to determine the position of the wetted member upon being acted upon by the actuator. The theoretical position of the wetted member, as determined using a known actuator force and wetted member physical data, is compared to the sensed deflection or position of the wetted member, and the resistance to movement of the wetted member caused by the blood is determined and correlated to a clotting capacity.

Abstract: Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R? is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.

Abstract: In one embodiment, a flexible strain sensor includes a flexible substrate having a top surface and a layer of piezoresistive amorphous carbon formed on the top surface of the substrate.

Abstract: A staircase avalanche photodiode with a staircase multiplication region composed of an AlInAsSb alloy. The photodiode includes a buffer layer adjacent to a substrate and an avalanche multiplication region adjacent to the buffer layer, where the avalanche multiplication region includes a graded AlInAsSb alloy grown lattice-matched or psuedomorphically strained on either InAs or GaSb. The photodiode further includes a photoabsorption layer adjacent to the avalanche multiplication region, where the photoabsorption layer is utilized for absorbing photons. By utilizing AlInAsSb in the multiplication region, the photodiode exhibits a direct bandgap over a wide range of compositions as well as exhibits large conduction band offsets much larger than the smallest achievable bandgap and small valance band offsets. Furthermore, the photodiode is able to detect extremely weak light with a high signal-to-noise ratio.

Abstract: The present invention provides methods for treating inflammation or a wound in a subject in need of such wound treatment or inflammation treatment by delivering a volatile anesthetic to the wound or the inflammation site.

Abstract: A remote laboratory gateway enables a plurality of students to access and control a laboratory experiment remotely. Access is provided by an experimentation gateway, which is configured to provide secure access to the experiment via a network-centric, web-enabled interface graphical user interface. Experimental hardware is directly controlled by an experiment controller, which is communicatively coupled to the experimentation gateway and which may be a software application, a standalone computing device, or a virtual machine hosted on the experimentation gateway. The remote laboratory of the present specification may be configured for a software-as-a-service business model.

Abstract: Memory devices based on gate controlled ferromagnetism and spin-polarized current injection are provided. The device structure can include a two dimensional (2D) topological insulator (TI) having an active area body. One or a pair of ferromagnetic storage units are provided on top of the 2D TI with a dielectric and a gate thereon. A first contact can be at one end of the 2D TI and a second contact can be at the other end of the 2D TI, with the one or pair of ferromagnetic storage units on the 2D TI between the two contacts to facilitate 2D TI transport along a one-dimensional edge of the first and/or second lateral side. Application of biases via the gate and the first and second contacts enable read and write operations.

Abstract: Certain embodiments are directed to methods of treating pain, e.g., chronic or neuropathic pain, comprising administering an effective amount of an EPAC inhibitor.

Abstract: A method of poling an organic polymeric electro-optic material. The method includes doping the organic polymeric electro-optic material with nanoparticles. The method also includes heating the organic polymeric electro-optic material to a poling temperature. The method also includes poling the organic polymeric electro-optic material by applying an electric field across the organic polymeric electro-optic material.

Abstract: The disclosure relates to lanthanum-yttrium oxide scintillators used for detecting radiation, such as X-rays, gamma rays and thermal neutron radiation and charged particles, in security, medical imaging, particle physics and other applications.

Abstract: A variety of nanostructures are provided having a metal nanowire having a plurality of faces extending along a length of the nanowire, and a plurality of semiconductor nanorods forming two or more nanorod arrays, wherein each of the nanorod arrays is attached to a different surface of the nanowire. For example, in some embodiments, the nanostructure is a silver nanowire having a pentagonal cross section and five faces extending along the length of the nanowire, and metal oxide nanorods forming five nanorod arrays extending along each of the five faces of the silver nanowire. The nanostructures can demonstrate high temperature coefficients of resistance, and can be used in a variety of bolometric materials. In some embodiments, bolometric materials are provided including a plurality of the nanostructures deposited onto a surface of a substrate. Methods of making the nanostructures and bolometers are also provided.

Abstract: A novel fixation method is presented that will circumvent both biological and safety concerns with current fixation methods.

Abstract: A nonlinear metasurface structure including a multi-quantum-well layer designed for a nonlinear response for a desired nonlinear optical process and an array of nanoantennas coupled to the intersubband transitions of the multi-quantum-well layer. Each nanoantenna in the array is designed to have electromagnetic resonances at or close to all input and output frequencies of a given nonlinear optical process. Nanoantennas allow efficient coupling of any incident and outgoing light polarizations to intersubband transitions. Nanoantennas may further provide significant field enhancement in the multi-quantum-well layer. As a result, the nonlinear metasurface structure can be designed to produce a highly nonlinear response for any polarization and angle of incidence of incoming and outgoing waves in a nonlinear optical process. Due to their very larger nonlinear response, efficient frequency conversion can be produced in these metasurfaces without the stringent phase-matching constraints of bulk nonlinear crystals.