Patents Assigned to Board of Regents The University of Texas System
  • Publication number: 20210132076
    Abstract: The present disclosure provides methods for molecular neighborhood detection of molecules, such as by iterative proximity ligation or split-and-pool methods for obtaining positional information.
    Type: Application
    Filed: January 11, 2021
    Publication date: May 6, 2021
    Applicant: Board of Regents, The University of Texas System
    Inventors: Edward MARCOTTE, Jagannath SWAMINATHAN, Andrew ELLINGTON, Alexander BOULGAKOV, Jon LAURENT, Raghav SHROFF, Erhu XIONG, Sanchita BHADRA, Brendan FLOYD, Eric ANSLYN
  • Publication number: 20210130431
    Abstract: Provided are T cell receptors (TCR) and TCR variable regions that can selectively bind the T-cell leukemia/lymphoma 1 (TCL1) oncoprotein. The TCR may be utilized in various therapies, such as autologous TCL1-TCR adoptive T cell therapy, to treat a cancer, such as a B-cell malignancy or a solid tumor expressing TCL1. Methods for expanding a population of T cells that target TCL1 are also provided.
    Type: Application
    Filed: January 9, 2019
    Publication date: May 6, 2021
    Applicant: Board of Regents, The University of Texas System
    Inventors: Jinsheng WENG, Kelsey MORIARTY, Sattva S. NEELAPU
  • Publication number: 20210130906
    Abstract: Methods for increasing immune therapy response and predicting likelihood of cancer metastasis by analyzing the expression of genes associated with replication stress response. In some aspects, cancers are treated with immune checkpoint inhibitors and/or MEK inhibitors. Methods for selecting patients by analyzing the expression of genes associated with a defect in replication stress response are also provided.
    Type: Application
    Filed: March 6, 2019
    Publication date: May 6, 2021
    Applicant: Board of Regents, The University of Texas System
    Inventors: Daniel McGRAIL, Shiaw-Yih LIN, Patrick PILIE, Eric JONASCH, Curtis Chun-Jen LIN
  • Publication number: 20210128536
    Abstract: The present disclosure relates to pharmaceutical formulations including a weakly basic drug and an ionic polymer in an amorphous solid dispersion, as well as methods of forming such pharmaceutical formulations, and methods of administering such pharmaceutical formulations.
    Type: Application
    Filed: October 8, 2020
    Publication date: May 6, 2021
    Applicants: DISPERSOL TECHNOLOGIES, LLC, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Robert O. WILLIAMS, III, Scott V. JERMAIN, Daniel Alan DAVIS, Dave A. MILLER
  • Patent number: 10993983
    Abstract: Disclosed herein are cyclic peptides that induce cellular autophagy and have significant cell penetration activity. Methods for inducing autophagy and thereby treating various diseases and conditions associated with impaired autophagy are provided.
    Type: Grant
    Filed: March 17, 2017
    Date of Patent: May 4, 2021
    Assignees: Trustees of Tufts College, Board of Regents of the University of Texas System
    Inventors: Joshua Kritzer, Beth Levine, Leila Peraro
  • Patent number: 10995056
    Abstract: In some aspects, the present disclosure provides methods of aminating an aromatic compound comprising reacting an aminating agent with an aromatic compound in the presence of a rhodium catalyst. In some embodiments, the methods may comprise aminating an aromatic compound which contains multiple different functional groups. The methods described herein may also be used to create bicyclic system comprising reacting an intramolecular aminating agent with an aromatic ring to obtain a second ring containing a nitrogen atom. In another aspect, the methods described herein may also be used to create a cyclic aliphatic cyclic/poly cyclic amine system comprising a reacting an intramolecular aminating agent by insertion into a C(sp3)-H bond.
    Type: Grant
    Filed: July 11, 2017
    Date of Patent: May 4, 2021
    Assignees: The Board of Regents of the University of Texas System, William Marsh Rice University
    Inventors: John R. Falck, Mahesh P. Paudyal, László Kürti
  • Publication number: 20210120809
    Abstract: Devices and methods for vascular tissue perfusion. In certain examples, the pressurized oxygen is repetitively pulsed between a lower pressure and a higher pressure and a flexible membrane is deflected to control fluid flow.
    Type: Application
    Filed: June 20, 2019
    Publication date: April 29, 2021
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventor: Leonid BUNEGIN
  • Publication number: 20210121411
    Abstract: In some aspects, the present disclosure provides compositions of lipid nanoparticles useful for the delivery of large RNAs including mRNAs. These compositions may include a cationic ionizable lipid, a phospholipid, a PEGylated lipid, and a steroid including using less of a cationic ionizable lipid than compositions with shorter nucleic acids. These compositions may be used to treat a disease or disorder for which the delivery of an mRNA is therapeutically effective.
    Type: Application
    Filed: December 16, 2020
    Publication date: April 29, 2021
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Daniel J. SIEGWART, Qiang CHENG
  • Patent number: 10989718
    Abstract: Methods and kits are provided for amplifying and detecting ?S proteins from samples, for example, from patients having Parkinson's Disease. For example, a method for determining a presence of a soluble, misfolded ?S protein may include: contacting the sample with a monomeric, folded ?S protein to form an incubation mixture; conducting an incubation cycle two or more times on the incubation mixture effective to form an amplified portion of misfolded ?S protein; incubating the incubation mixture effective to cause misfolding and/or aggregation of at least a portion of the monomeric, folded ?S protein in the presence of the soluble, misfolded ?S protein; physically disrupting the incubation mixture effective to at least partly de-aggregate at least a portion of a misfolded ?S aggregate present; and determining the presence of the soluble, misfolded ?S protein in the sample by detecting at least a portion of the soluble, misfolded ?S protein.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: April 27, 2021
    Assignees: Amprion, Inc., The Board of Regents of the University of Texas System
    Inventors: Claudio Soto Jara, Mohammad Shahnawaz, Russell M. Lebovitz, Benedikt K. Vollrath
  • Patent number: 10987500
    Abstract: A nanochannel delivery device and method of manufacturing and use. The nanochannel delivery device comprises an inlet, an outlet, electrodes and a nanochannel. The nanochannel may be oriented parallel to the primary plane of the nanochannel delivery device. The inlet and outlet may be in direct fluid communication with the nanochannel.
    Type: Grant
    Filed: August 1, 2014
    Date of Patent: April 27, 2021
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Daniel Fine, Alessandro Grattoni, Mauro Ferrari, Xuewu Liu, Randal Goodall, Sharath Hosali
  • Patent number: 10989661
    Abstract: Light-sheet fluorescence microscopy (LSFM) affords highly parallelized 3D imaging with optical sectioning capability and minimal light exposure. However, using Gaussian beams for light-sheet generation results in a trade-off between beam waist thickness and the area over which the beam can approximate a light-sheet. Novel techniques for LSFM are disclosed that uses extended focusing and/or laser line focuses to produce divergence free light-sheets with near diffraction-limited resolution and uniform intensity distribution.
    Type: Grant
    Filed: April 26, 2016
    Date of Patent: April 27, 2021
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Reto P. Fiolka, Kevin M. Dean
  • Patent number: 10989680
    Abstract: In one embodiment, assessing the quality of an adhesive bond of a composite material includes passing a vector electric field through a thickness of the composite material, measuring dielectric properties of the composite material, determining one or more dielectric parameters of the composite material, and comparing the one or more dielectric parameters with one or more reference dielectric parameters.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: April 27, 2021
    Assignee: Board or Regents, The University of Texas Systems
    Inventors: Kenneth L. Reifsnider, Md Rassel Raihan, Muthu Ram Prabhu Elenchezhian, Priyanshu Kumar Banerjee, Chaitanya Dave, Vamsee Vadlamudi
  • Patent number: 10990580
    Abstract: An exemplary system, method and computer-accessible medium for modifying a design of an integrated circuit(s) (ICs), which can include, for example, modifying a logic gate(s) in the design for a protected input pattern(s), and providing a restoration unit(s) into the design, where the restoration unit(s) can be configured to (i) produce an error-free output(s) when a correct secret key can be applied to the restoration unit(s), and (ii) produce an erroneous output(s) when an incorrect key can be applied to the restoration unit(s); and ensure that the modified design along with the restoration unit produces at least one erroneous output with respect to the original design for only a pre-determined constant number of incorrect keys based on at least one input pattern.
    Type: Grant
    Filed: October 25, 2018
    Date of Patent: April 27, 2021
    Assignees: NEW YORK UNIVERSITY, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Ozgur Sinanoglu, Jeyavijayan Rajendran, Muhammad Yasin
  • Publication number: 20210113602
    Abstract: Targeting RAS is one of the greatest challenges in cancer therapy. Oncogenic mutations in NRAS are present in over 25% of melanomas and patients whose tumors harbor NRAS mutations have limited therapeutic options and poor prognosis. Thus far, there are no clinical agents available to effectively target NRAS or any other RAS oncogene. An alternative approach is to identify and target critical tumor vulnerabilities or non-oncogene addictions that are essential for tumor survival. The inventors investigated the consequences of NRAS blockade in NRAS-mutant melanoma and show that decreased expression of the telomerase catalytic subunit, TERT, is a major consequence. TERT silencing or treatment of NRAS-mutant melanoma with the telomerase-dependent telomere uncapping agent 6-thio-2?-deoxy-guanosine (6-thio-dG), led to rapid cell death, along with evidence of both telomeric and non-telomeric DNA damage, increased ROS levels, and upregulation of a mitochondrial anti-oxidant adaptive response.
    Type: Application
    Filed: February 28, 2019
    Publication date: April 22, 2021
    Applicants: The Board of Regents of the University of Texas System, The Wistar Institute of Anatomy and Biology
    Inventors: Jerry SHAY, Gao ZHANG
  • Publication number: 20210116152
    Abstract: Cooling by a twist-untwist process, by a stretch-release process for twisted, coiled, or supercoiled yarns or fibers, and methods and systems thereof. High mechanocaloric cooling results from release of inserted twist or from stretch release for twisted, coiled, or supercoiled fibers, including natural rubber fibers, NiTi wires, and polyethylene fishing line. Twist utilization can increase cooling and cooling efficiencies. A cooler using twist insertion and release can be shorter and smaller in volume than a cooler that requires a large elastomeric elongation. The cooler system can be utilized in mechanochromic textiles and remotely readable tensile and torsional sensors.
    Type: Application
    Filed: September 29, 2020
    Publication date: April 22, 2021
    Applicant: Board of Regents, The University of Texas System
    Inventors: Zunfeng Liu, Run Wang, Jiuke Mu, Zhong Wang, Shaoli Fang, Marcio Dias Lima, Ali E. Aliev, Na Li, Carter S. Haines, Ray H. Baughman
  • Publication number: 20210115024
    Abstract: Small molecule disruptors of Beclin-1/Bcl-2 protein-protein interactions induce autophagy and hence are useful for treating a variety of indications where stimulation of autophagy is therapeutically useful, including cancer, infection immunity, neurodegeneration, longevity.
    Type: Application
    Filed: December 4, 2020
    Publication date: April 22, 2021
    Applicant: Board of Regents, The University of Texas System
    Inventors: Jef De Brabander, Qiren Liang, Beth Levine, Wei-Chung Chiang
  • Patent number: 10980841
    Abstract: Embodiments of the invention stimulate three levels of beta cell physiology: (i) glucose metabolism, (ii) membrane receptor function, and (iii) transcriptional factors that result in the in vivo formation of beta cells in the pancreas for the purpose of treating diabetes.
    Type: Grant
    Filed: April 25, 2019
    Date of Patent: April 20, 2021
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Bruno Doiron, Ralph A Defronzo
  • Patent number: 10980847
    Abstract: The present invention includes composition, methods and kits for detecting and treating brain injury associated fatigue or altered cognition (BIAFAC) in a human patient comprising: identifying a human patient in need of treatment for brain injury associated fatigue or altered cognition associated with an altered intestinal flora; and providing the human patient with a composition comprising at least one of: a Prevotella spp or a Bacteroidies spp bacteria, or one or more agents that increase the amount of the Prevotella spp or the Bacteroidies spp bacteria in an intestinal flora of the human patient to reduce or eliminate the brain injury associated fatigue or altered cognition.
    Type: Grant
    Filed: June 21, 2019
    Date of Patent: April 20, 2021
    Assignee: Board of Regents, The University of Texas System
    Inventors: Randall J. Urban, Melinda Sheffield-Moore, Richard Pyles, Brent Masel
  • Patent number: 10984964
    Abstract: Disclosed herein are stretchable strain sensors that include a graphite network embedded within an elastomeric material. The sensors are wearable and can be used to detect mechanical movements in three dimensions in a wide variety of contexts.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: April 20, 2021
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Donglei Fan, Weigu Li, Jianhe Guo
  • Patent number: 10982068
    Abstract: The present invention includes a hydrogel and a method of making a porous hydrogel by preparing an aqueous mixture of an uncrosslinked polymer and a crystallizable molecule; casting the mixture into a vessel; allowing the cast mixture to dry to form an amorphous hydrogel film; seeding the cast mixture with a seed crystal of the crystallizable molecule; growing the crystallizable molecule into a crystal structure within the uncrosslinked polymer; crosslinking the polymer around the crystal structure under conditions in which the crystal structure within the crosslinked polymer is maintained; and dissolving the crystals within the crosslinked polymer to form the porous hydrogel.
    Type: Grant
    Filed: October 9, 2019
    Date of Patent: April 20, 2021
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Scott Zawko, Christine Schmidt