Patents Assigned to Board of Regents The University of Texas System
  • Patent number: 10703698
    Abstract: Provided are compounds of formulae provided herein. The compounds may include pathway-preferential estrogens (PaPEs) derivatives with tissue-selective activities. Also provided are pharmaceutical compositions comprising the compounds, as well as methods of treating a disease or condition including administering the compounds. The disease or condition may include postmenopausal symptoms, cardiovascular disease, stroke, vascular disease, bone disease, metabolic disease, arthritis, osteoporosis, obesity, vasomotor/hot flush, cognitive decline, cancer including breast cancer.
    Type: Grant
    Filed: January 6, 2017
    Date of Patent: July 7, 2020
    Assignees: The Board of Trustees of the University of Illinois, Board of Regents of the University of Texas System
    Inventors: John A. Katzenellenbogen, Benita Katzenellenbogen, Sung Hoon Kim, Zeynep Madak-Erdogan, Philip Shaul
  • Patent number: 10703805
    Abstract: Methods and devices for molecular imprinting include a molecular imprinting synthesis and matching a physiological pH of a template utilized in the molecular imprinting synthesis to achieve molecular imprinting. Molecular imprinting can be achieved by matching the physiological pH of the template used in a molecular imprinting synthesis. Furthermore, electrostatic charges can be complementary matched to the template, by obtaining crystallographic data of a protein template. Particularly, positively and negatively charged amino acids can be counted and matched by an oppositely charged monomer. For hydrophobic amino acids, isoleucin, leucin, and valine amino acids are counted. Since not all hydrophobic amino acids are exposed, the hydrophobic amino acid and hydrophobic monomer ratio can be determined experimentally by varying ratios from 1:1 to 1:10.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: July 7, 2020
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Julio Rincon, Thomas Boland
  • Patent number: 10703721
    Abstract: In one aspect, the present disclosure provides caffeic acid derivatives of the formula: wherein the variables are as defined herein. In another aspect, the present disclosure provides pharmaceutical compositions and methods of using of the compounds disclosed herein, including for the treatment of cancer.
    Type: Grant
    Filed: November 9, 2018
    Date of Patent: July 7, 2020
    Assignee: Board of Regents, The University of Texas System
    Inventors: Waldemar Priebe, Stanislaw Skora, Izabela Fokt, Rafal Zielinski, Arumugam Jayakumar, Radjendirane Venugopal
  • Publication number: 20200206343
    Abstract: The present disclosure is directed to antibodies that bind to DC-HIL on the surface of myeloid-derived suppressor cells, and thus antagonize the T cell suppressor function of these cells, as well as their use in diagnosing and treating cancers such as melanoma.
    Type: Application
    Filed: December 31, 2019
    Publication date: July 2, 2020
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Kiyoshi ARIIZUMI, Ponciano CRUZ
  • Publication number: 20200208154
    Abstract: Provided herein are compositions and methods for reducing expression of C9orf72 transcripts in cells containing expanded intronic GGGGCC regions, including those in subjects having or at risk of developing amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
    Type: Application
    Filed: January 10, 2020
    Publication date: July 2, 2020
    Applicant: The Board of Regents of the University of Texas System
    Inventors: David COREY, Jiaxin HU
  • Publication number: 20200208614
    Abstract: Yarn energy harvesters containing conducing nanomaterials (such as carbon nanotube (CNT) yarn harvesters) that electrochemically convert tensile or torsional mechanical energy into electrical energy. Stretched coiled yarns can generate 250 W/kg of peak electrical power when cycled up to 24 Hz, and can generate up to 41.2 J/kg of electrical energy per mechanical cycle. Unlike for other harvesters, torsional rotation produces both tensile and torsional energy harvesting and no bias voltage is required, even when electrochemically operating in salt water. Since homochiral and heterochiral coiled harvester yarns provide oppositely directed potential changes when stretched, both contribute to output power in a dual-electrode yarn.
    Type: Application
    Filed: June 28, 2018
    Publication date: July 2, 2020
    Applicants: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, HANYANG UNIVERSITY
    Inventors: Ray H. Baughman, Shaoli Fang, Carter S. Haines, Na Li, Jiangtao Di, Seon Jeong Kim, Shi Hyeong Kim, Keon Jung Kim, Tae Jin Mun, Changsoon Choi
  • Patent number: 10696710
    Abstract: Cyclic-GMP-AMP synthase (cGAS) and cyclic-GMP-AMP (cGAMP), including 2?3-cGAMP, 2?2-cGAMP, 3?2?-cGAMP and 3?3?-GAMP, are used in pharmaceutical formulations (including vaccine adjuvants), drug screens, therapies, and diagnostics.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: June 30, 2020
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Zhijian Chen, Lijun Sun, Jiaxi Wu, Heping Shi, Chuo Chen
  • Patent number: 10697963
    Abstract: An antibody and/or binding fragment thereof, wherein the antibody and/or binding fragment thereof specifically binds to an epitope of a ?Klotho polypeptide, optionally a folded ?Klotho or optionally with a dissociation constant (KD) of about 2 nM or less, as measured by competitive ELISA assay, methods of making and using to diagnose kidney diseases.
    Type: Grant
    Filed: January 29, 2019
    Date of Patent: June 30, 2020
    Assignees: The Governing Council of the University of Toronto, Board of Regents, The University of Texas System
    Inventors: Sachdev S. Sidhu, Sarah L. Barker, Orson W. Moe, Makoto Kuro-o
  • Patent number: 10696916
    Abstract: Lubricant compositions, core-shell nanoparticles, and related methods are disclosed. In an exemplary embodiment, a lubricant composition includes a plurality of core-shell nanoparticles. The nanoparticles include a core, a first shell disposed on the core, and a second shell disposed on the first shell. The first shell is formed from a siliceous material and the second shell is formed from a hydrophobic material. The first and second shells form functional coatings that reduce wear and friction of parts lubricated with the lubricant composition.
    Type: Grant
    Filed: May 12, 2017
    Date of Patent: June 30, 2020
    Assignee: Board of Regents, The University of Texas System
    Inventors: Pranesh Aswath, Richard B. Timmons, Vinay Sharma, Ali Erdemir
  • Patent number: 10698859
    Abstract: Methods, procedures, apparatuses, computer programs, computer-accessible mediums, processing arrangements and systems generally related to data multi-casting in a distributed processor architecture are described. Various implementations may include identifying a plurality of target instructions that are configured to receive a first message from a source; providing target routing instructions to the first message for each of the target instructions including selected information commonly shared by the target instructions; and, when two of the identified target instructions are located in different directions from one another relative to a router, replicating the first message and routing the replicated messages to each of the identified target instructions in the different directions.
    Type: Grant
    Filed: September 18, 2009
    Date of Patent: June 30, 2020
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Doug Burger, Stephen W. Keckler, Dong Li
  • Patent number: 10697080
    Abstract: Photoactive silicon films may be formed by electrodeposition from a molten salt electrolyte. In an embodiment, SiO2 is electrochemically reduced in a molten salt bath to deposit silicon on a carbonaceous substrate.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: June 30, 2020
    Assignee: Board of Regents of the University of Texas System
    Inventors: Allen J. Bard, Huayi Yin
  • Publication number: 20200197300
    Abstract: The present invention provides a formulation of Coenzyme Q10 that can be re-dispersed from a stable dry powder to formulation to yield a nanodispersion that can be readily aerosolized for inhalation.
    Type: Application
    Filed: January 30, 2020
    Publication date: June 25, 2020
    Applicants: STC.UNM, RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Jason Thomas McConville, Thiago Cardoso Carvalho, Kristina Schönhoff
  • Publication number: 20200204275
    Abstract: Disclosed are various embodiments that enable the identification of the location of a computing device based on radio data. A radio map can be identified for an area. The computing device can measure signal strengths to reference points. The signal strengths can be compared to the radio map. The computing device can determine its location based on the comparison of the signal strengths to the radio map.
    Type: Application
    Filed: November 26, 2019
    Publication date: June 25, 2020
    Applicant: Boards of Regents, The University of Texas System
    Inventors: Ali Khalajmehrabadi, Nikolaos Gatsis, David Akopian
  • Publication number: 20200197306
    Abstract: Provided herein are cationic liquid crystalline nanoparticles (CLCNs). Further provided herein are methods of delivering RNAi using the CLCNs for the treatment of diseases.
    Type: Application
    Filed: June 7, 2018
    Publication date: June 25, 2020
    Applicant: Board of Regents, The University of Texas System
    Inventors: Emanuela GENTILE, Ji LIN, Jack A. ROTH
  • Publication number: 20200200755
    Abstract: The present invention provides that exosomes from human body fluid samples contain double stranded genomic DNA that spans all chromosomes and may be used to determine the mutation status of genes of interest in diseases, such as cancer. Furthermore, the present invention provides the use of exosomes to produce therapeutic proteins and for their use in therapy as well as the detection of cancer cell-derived exosomes to diagnose cancer and monitor therapeutic response.
    Type: Application
    Filed: March 4, 2020
    Publication date: June 25, 2020
    Applicant: Board of Regents, The University of Texas System
    Inventors: Raghu KALLURI, Sónia MELO
  • Publication number: 20200201997
    Abstract: Memory allocation techniques may provide improved security and performance. A method may comprise mapping a block of memory, dividing the block of memory into a plurality of heaps, dividing each heap into a plurality of sub-heaps, wherein each sub-heap is associated with one thread of software executing in the computer system, dividing each sub-heap into a plurality of bags, wherein each bag is associated with one size class of objects, creating an allocation buffer and a deallocation buffer for each bag, storing a plurality of objects in at least some of the bags, wherein each object is stored in a bag having size class corresponding to a size of the object, storing in the allocation buffer of each bag information relating to available objects stored in that bag, and storing in the deallocation buffer of each bag information relating to freed objects that were stored in that bag.
    Type: Application
    Filed: October 18, 2019
    Publication date: June 25, 2020
    Applicant: The Board of Regents of The University of Texas System
    Inventors: Tongping Liu, Sam Albert Silvestro, Hongyu Liu, Tianyi Liu
  • Publication number: 20200200929
    Abstract: Systems and methods for simulating subterranean regions having multi-scale fracture geometries. Non-intrusive embedded discrete fracture modeling formulations are applied in conjunction with commercial simulators to efficiently and accurately model subsurface transient flow characteristics in regions having complex hydraulic fractures, complex natural fractures, or a combination of both, and geometries including corner point grids.
    Type: Application
    Filed: December 2, 2019
    Publication date: June 25, 2020
    Applicants: Sim Tech LLC, Board of Regents, The University of Texas System
    Inventors: Kamy Sepehrnoori, Yifei Xu, Wei Yu, Jijun Miao
  • Patent number: 10689526
    Abstract: The present invention is a composition and method for making and using a rechargeable multifunctional additive that reduce the formation of biofilms on a surface, the additive can also remain photo and thermally stable by synthesizing one or more N-halamine compounds and adding one or more N-halamine biocidal compounds to a target material prior, during or after the target material is made. The resultant material can be used directly to provide antimicrobial functions and control biofilm formation, or the material can be further processed into an article.
    Type: Grant
    Filed: October 22, 2018
    Date of Patent: June 23, 2020
    Assignee: Board of Regents, The University of Texas System
    Inventors: Yuyu Sun, Zhaobin Chen
  • Patent number: 10687953
    Abstract: In one embodiment, an anterior cervical transarticular fixation implant including a cervical plate including a central body, lateral wings that extend laterally outward from the central body, each lateral wing including a fastener opening configured to receive a fastener configured to thread into vertebrae, and locking mechanisms configured to selectively lock the fasteners in place.
    Type: Grant
    Filed: February 19, 2018
    Date of Patent: June 23, 2020
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Kenrick Chur-wei Lam, Sohum Desai, Daniel Williams Branch
  • Patent number: 10688203
    Abstract: In one aspect, radioactive nanoparticles are described herein. In some embodiments, a radioactive nanoparticle described herein comprises a metal nanoparticle core, an outer metal shell disposed over the metal nanoparticle core, and a metallic radioisotope disposed within the metal nanoparticle core or within the outer metal shell. In some cases, the radioactive nanoparticle has a size of about 30-500 nm in three dimensions. In addition, in some embodiments, the radioactive nanoparticle further comprises an inner metal shell disposed between the metal nanoparticle core and the outer metal shell. The metal nanoparticle core, outer metal shell, and inner metal shell of the radioactive nanoparticle can have various metallic compositions.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: June 23, 2020
    Assignee: Board of Regents, The University of Texas System
    Inventors: Xiankai Sun, Yaowu Hao, Sina Moeendarbari