Patents Assigned to Board of Regents The University of Texas System
  • Patent number: 10656885
    Abstract: The present disclosure is directed to a method of creating an object flow integrity (OFI) library module, capable of redirecting an object-like programmatic call, by initiating a multi-pass, recursive process to analyze a module's interfaces, function parameters, and data types. In another aspect, a method is disclosed to modify the binary code of an untrusted module to enable its usage of the OFI library module. In another aspect, during runtime operations of an untrusted module, the OFI library module can receive an object from a caller module, substitute a proxy object, stored in a secure location, and continue the programmatic call using the proxy object.
    Type: Grant
    Filed: October 29, 2018
    Date of Patent: May 19, 2020
    Assignee: Board of Regents, The University of Texas System
    Inventor: Kevin W. Hamlen
  • Publication number: 20200147161
    Abstract: Provided herein are tumor-antigen VCX/Y specific peptides and engineered VCX/Y specific T cell receptors. Also provided herein are methods of generating VCX/Y-specific immune cells and their use for the treatment of cancer. In addition, the VCX/Y-specific peptides may be used as a vaccine.
    Type: Application
    Filed: December 28, 2017
    Publication date: May 14, 2020
    Applicant: Board of Regents, The University of Texas System
    Inventors: Cassian YEE, Ke PAN
  • Patent number: 10646356
    Abstract: The present disclosure includes a finger exoskeleton including a plurality of joints and a plurality of sensors configured to measure rotation of at least some of the plurality of joints of the finger exoskeleton. The finger exoskeleton also includes a series elastic actuator comprising a spring element, the series elastic actuator configured to rotate at least one of the plurality of joints. The finger exoskeleton also includes a computing device configured to control operation of the series elastic actuator based on a torque of the at least one of the plurality of joints, the torque determined at least based on the spring element and rotation of the at least one of the plurality of joints. The present disclosure also includes associated methods and hand exoskeletons.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: May 12, 2020
    Assignee: Board of Regents, The University of Texas System
    Inventors: Ashish Deshpande, Priyanshu Agarwal
  • Patent number: 10646438
    Abstract: Vaccine compositions that may be administered to a subject via the buccal and/or sublingual mucosa are provided. Methods for administration and preparation of such vaccine compositions are also provided.
    Type: Grant
    Filed: May 10, 2017
    Date of Patent: May 12, 2020
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Maria A. Croyle, Jin Huk Choi, Stephen Clay Schafer
  • Patent number: 10646617
    Abstract: In one aspect, apparatuses for providing chemical gradients are described herein. In some embodiments, an apparatus described herein comprises a conduit having a first end and a second end, one or more microchannels disposed in the conduit and extending from the first end toward the second end, and a fiber coiled around the exterior of at least one microchannel, wherein the fiber comprises an active agent that is operable to diffuse into the interior of the microchannel.
    Type: Grant
    Filed: March 5, 2018
    Date of Patent: May 12, 2020
    Assignee: Board of Regents, The University of Texas System
    Inventors: Mario I. Romero-Ortega, Parisa Lotfi, Benjamin R. Johnston, Swarupnarayan Dash, Joselito Razal, Gordon Wallace
  • Patent number: 10649003
    Abstract: Disclosed herein are devices, systems and methods for in-line, nanoscale metrology. One system comprises monolithic flexure mechanisms with integrated actuators that allow movement and positioning in two axes, with an extremely high degree of accuracy, of a structure comprising one or more scanning probes. This structure is suspended to prevent any destructive interference from a sample, which can be stationary or moving at a nonzero rate, and rigid or flexible in mechanical behavior. This system can be activated at startup and quickly actuate the structure to approach the surface of the sample. Once the system achieves the desired proximity between the one or more probes and the sample, the system maintains that position of the structure to a high degree of accuracy regardless of any disturbances. This array can be moved at varying speeds laterally to match the velocity of any continually moving substrates, thus enabling scanning of moving substrates.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: May 12, 2020
    Assignee: Board of Regents, The University of Texas System
    Inventors: Michael A. Cullinan, Liam Glazer Connolly
  • Patent number: 10651461
    Abstract: A novel lithium battery cathode, a lithium ion battery using the same and processes and preparation thereof are disclosed. The battery cathode is formed by force spinning. Fiber spinning allows for the formation of core-shell materials using material chemistries that would be incompatible with prior spinning techniques. A fiber spinning apparatus for forming a coated fiber and a method of forming a coated fiber are also disclosed.
    Type: Grant
    Filed: May 1, 2018
    Date of Patent: May 12, 2020
    Assignees: National Technology & Engineering Solutions of Sandia, LLC, The Board of Regents, The University of Texas System
    Inventors: Nelson S. Bell, Nancy A. Missert, Karen Lozano, Yatinkumar N. Rane
  • Patent number: 10646574
    Abstract: Provided herein are compositions and methods for preparing intraarticular formulations comprising biocompatible pharmaceutical agents and use thereof in the treatment of diseases, such as degenerative bone diseases, including osteoarthritis of the knee, hip, or other joints, and similar chronic or acute destructive arthropathies resulting from autoimmune disorders or infectious disease.
    Type: Grant
    Filed: July 20, 2015
    Date of Patent: May 12, 2020
    Assignee: Board of Regents, The University of Texas System
    Inventors: Jeffrey J. Tarrand, Borje S. Andersson
  • Publication number: 20200140477
    Abstract: Cyclic-GMP-AMP synthase (cGAS) and cyclic-GMP-AMP (cGAMP), including 2?3-cGAMP, 2?2-cGAMP, 3?2?-cGAMP and 3?3?-GAMP, are used in pharmaceutical formulations (including vaccine adjuvants), drug screens, therapies, and diagnostics.
    Type: Application
    Filed: December 13, 2019
    Publication date: May 7, 2020
    Applicant: Board of Regents, The University of Texas System
    Inventors: Zhijian CHEN, Lijun SUN, Jiaxi WU, Heping SHI, Chuo CHEN
  • Publication number: 20200138707
    Abstract: The present invention provides, in some aspects, bilayered and trilayered pharmaceutical implant compositions for the unidirectional delivery of anti-cancer compounds to the brain over a period of time (e.g., several weeks, 1, 2, 3, 4, 5, 6, 7 days, or 1, 2, 3, weeks, or any range derivable therein) following the removal of glioblastoma multiforme or other malignant tumors in the brain.
    Type: Application
    Filed: October 4, 2019
    Publication date: May 7, 2020
    Applicant: Board of Regents, the University of Texas System
    Inventors: Michael J. McGINITY, Feng ZHANG, John R. FLOYD, James W. McGINITY
  • Publication number: 20200140502
    Abstract: The present disclosure describes a new native peptide designated herein as Dwarf Open Reading Frame, or DWORF. This peptide enhances the apparent activity of the SERCA pump, is positively inotropic and lusitropic, and therefore is provided as a therapeutic agent for disorders characterized by cytosolic calcium overload.
    Type: Application
    Filed: January 15, 2020
    Publication date: May 7, 2020
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Eric N. OLSON, Rhonda S. BASSEL-DUBY, Catherine A. MAKAREWICH, Benjamin R. NELSON
  • Publication number: 20200140378
    Abstract: The present disclosure provides one or more amino lipids such as an amino lipids containing a sulfonic acid or sulfonic acid derivative of the formulas: wherein the variables are as defined herein. These amino lipids may be used in compositions with one or more helper lipids and a nucleic acid therapeutic agent. These compositions may be used to treat a disease or disorder such as cancer, cystic fibrosis, or other genetic diseases.
    Type: Application
    Filed: January 15, 2020
    Publication date: May 7, 2020
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Daniel J. SIEGWART, Jason B. MILLER
  • Publication number: 20200139538
    Abstract: In one embodiment, a mechanically over-damped actuator includes an output link comprising a lever and a torsion spring associated with the lever, wherein the lever has an initial equilibrium position and is pivotable about a pivot axis, wherein the spring opposes pivoting of the lever away from its initial equilibrium position such that the spring tends to return the lever to the equilibrium position.
    Type: Application
    Filed: November 5, 2019
    Publication date: May 7, 2020
    Applicant: Board of Regents, The University of Texas System
    Inventor: Amir Jafari
  • Patent number: 10640873
    Abstract: Disclosed herein are methods comprising: illuminating a first location of an optothermal substrate with electromagnetic radiation; wherein the optothermal substrate converts at least a portion of the electromagnetic radiation into thermal energy; and wherein the optothermal substrate is in thermal contact with a liquid sample comprising a plurality of thermally reducible metal ions; thereby: generating a confinement region at a location in the liquid sample proximate to the first location of the optothermal substrate; trapping at least a portion of the plurality of thermally reducible metal ions within the confinement region; and thermally reducing the trapped portion of the plurality of thermally reducible metal ions; thereby: depositing a metal particle on the optothermal substrate at the first location. Also disclosed herein are systems for performing the methods described herein. Also disclosed herein are patterned substrates made by the methods described herein, and methods of use thereof.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: May 5, 2020
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Yuebing Zheng, Bharath Bangalore Rajeeva
  • Patent number: 10639277
    Abstract: Disclosed are multifunctional-echogenic immunoliposome (MF-ELIP) constructs and compositions, and their methods of use to deliver attached stem cells to a target tissue such as atheroma, to enhance one or more of survival, growth, migration, activity and differentiation of the targeted stem cells, for treating, deterring or preventing mammalian atheroma and coronary artery disease.
    Type: Grant
    Filed: February 2, 2018
    Date of Patent: May 5, 2020
    Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Yong-Jian Geng, David D. McPherson, Melvin E. Klegerman
  • Patent number: 10640816
    Abstract: The present invention relates to, among other things, probes, compositions, methods, and kits for simultaneous, multiplexed detection and quantification of protein and/or nucleic acid expression in a user-defined region of a tissue, user-defined cell, and/or user-defined subcellular structure within a cell.
    Type: Grant
    Filed: July 15, 2016
    Date of Patent: May 5, 2020
    Assignees: NanoString Technologies, Inc., Board of Regents, The University of Texas System
    Inventors: Joseph M. Beechem, Charles Warren, Chris Merritt, Jaemyeong Jung, Dwayne L. Dunaway, Scott Crowder, Kristina Sorg, Gordon B. Mills
  • Patent number: 10640801
    Abstract: Certain embodiments are directed to sensors that enable the use of optimized biocompatible materials such as pre-anodized paper printed electrode transducer to detect binding of a target agent, wherein the surface is modified or functionalized through zero length cross-linker so that it interacts with or specifically binds a target such as sugars (glucose) or glycated proteins (HgbA1c).
    Type: Grant
    Filed: September 26, 2016
    Date of Patent: May 5, 2020
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: XiuJun Li, Gilberto Henao-Pabon
  • Patent number: 10643832
    Abstract: Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for the collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: May 5, 2020
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Livia Schiavinato Eberlin, Thomas Milner, Jialing Zhang, John Lin, John Rector, Nitesh Katta, Aydin Zahedivash
  • Patent number: 10639711
    Abstract: The present invention achieves a high-energy product using Ferromagnetic 3D elements such as nanowires and methods of making the same. The high energy products or magnets of the invention are able to achieve high magnetization and maintain the magnetic properties at a greater range of temperatures than currently known magnets. For example, a high energy product includes at least one material A selected from the group consisting essentially of Fe, Co, and Ni, wherein material A is in the form of nanowires formed by a solvothermal chemical process. A high energy product may also include at least one material A selected from the group consisting essentially of Fe, Co, and Ni, and at least one material B selected from the group consisting essentially of Fe, Co, and Ni, wherein material A and material B are in the form of an alloy of nanowires formed by a solvothermal chemical process.
    Type: Grant
    Filed: June 13, 2016
    Date of Patent: May 5, 2020
    Assignee: Board of Regents, The University of Texas System
    Inventor: J. Ping Liu
  • Patent number: 10641721
    Abstract: The claimed invention is an apparatus and method for performing impedance spectroscopy with a handheld measuring device. Conformal analyte sensor circuits comprising a porous nanotextured substrate and a conductive material situated on the top surface of the solid substrate in a circuit design may be used alone or in combination with a handheld potentiometer. Also disclosed are methods of detecting and/or quantifying target analytes in a sample using a handheld measuring device.
    Type: Grant
    Filed: March 6, 2015
    Date of Patent: May 5, 2020
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Shalini Prasad, Anjan Panneer Selvam