Patents Assigned to Brown
  • Patent number: 9469816
    Abstract: Disclosed is a process for the upgrading and demetallizing of heavy oils and bitumens. A crude heavy oil and/or bitumen feed is supplied to a solvent extraction process 104 wherein DAO and asphaltenes are separated. The DAO is supplied to an FCC unit 106 having a low conversion activity catalyst for the removal of metals contained therein. The demetallized distillate fraction is supplied to a hydrotreater 110 for upgrading and collected as a synthetic crude product stream. The asphaltene fraction can be supplied to a gasifier 108 for the recovery of power, steam and hydrogen, which can be supplied to the hydrotreater 110 or otherwise within the process or exported. An optional coker unit 234 can be used to convert excess asphaltenes and/or decant oil to naphtha, distillate and gas oil, which can be supplied to the hydrotreater 220.
    Type: Grant
    Filed: May 12, 2008
    Date of Patent: October 18, 2016
    Assignee: Kellogg Brown & Root LLC
    Inventors: Rashid Iqbal, Anshumali, Odette Eng, Phillip Niccum
  • Patent number: 9452794
    Abstract: A cargo containment body with movable wall panels that always remain substantially parallel to a vertical side of the cargo containment body.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: September 27, 2016
    Assignee: BROWN INDUSTRIES, LLC
    Inventors: Dane Jennison, Bryce White
  • Patent number: 9453061
    Abstract: Therapeutic compositions for treatment of protein serine/threonine phosphatase-related diseases are obtained by engineering amino acid sequences that disrupt interaction between the protein serine/threonine phosphatase and a protein inhibitor and are provided herein. Calcineurin and PPI are examples of protein serine/threonine phosphatases. RCAN1 is an inhibitor of calcineurin and is overexpressed in patients with serious diseases, such as Down syndrome and Alzheimer's disease. Molecules that bind RCAN1 at regions that interact with calcineurin selectively modulate functions of calcineurin to treat these diseases. Methods of treating a subject for a protein serine/threonine phosphatase-related disease by administering a molecule having an amino acid sequence selected from the group of SEQ ID NOs: 1-19 are further provided.
    Type: Grant
    Filed: August 6, 2015
    Date of Patent: September 27, 2016
    Assignee: BROWN UNIVERSITY
    Inventors: Wolfgang Peti, Rebecca Page
  • Publication number: 20160274086
    Abstract: Methods, compositions, systems, devices and kits are provided herein for preparing and using a nanoparticle composition and spatial frequency heterodyne imaging for visualizing cells or tissues. In various embodiments, the nanoparticle composition includes at least one of: a nanoparticle, a polymer layer, and a binding agent, such that the polymer layer coats the nanoparticle and is for example a polyethylene glycol, a polyelectrolyte, an anionic polymer, or a cationic polymer, and such that the binding agent that specifically binds the cells or the tissue. Methods, compositions, systems, devices and kits are provided for identifying potential therapeutic agents in a model using the nanoparticle composition and spatial frequency heterodyne imaging.
    Type: Application
    Filed: April 1, 2016
    Publication date: September 22, 2016
    Applicants: Brown University, Rhode Island Hospital
    Inventors: Christoph Rose-Petruck, Jack R. Wands, Danielle Rand, Zoltan Derdak, Vivian Ortiz
  • Patent number: 9446364
    Abstract: Systems and methods for storing and handling slurries are provided. The surge drum system for storing a slurry can include a storage vessel having a first end, a second end, and at least one wall surrounding an internal volume between the first and second ends. The system can also include a slurry inlet and a slurry outlet, both in fluid communication with the internal volume. A recirculation inlet can be in fluid communication with the internal volume at the first end of the storage vessel. The system can also include a pump having a suction line in fluid communication with the outlet. A discharge line of the pump can be in fluid communication with an outlet valve and a recirculation valve that can be in fluid communication with the recirculation inlet.
    Type: Grant
    Filed: February 23, 2012
    Date of Patent: September 20, 2016
    Assignee: KELLOGG BROWN & ROOT LLC
    Inventor: Gary L. Mason
  • Publication number: 20160263183
    Abstract: The methods and assays described herein relate to the diagnosis, prognosis, and treatment of subjects with emphysema, COPD, and/or cigarette-induced lung damage. In some embodiments, the methods and assays relate to subjects with a decreased level of NLRX1 expression. In some embodiments, the methods and assays relate to the administration of an agonist of NLRX1 and/or an inhibitor of MAVS.
    Type: Application
    Filed: March 9, 2016
    Publication date: September 15, 2016
    Applicants: BROWN UNIVERSITY, YALE UNIVERSITY
    Inventors: Jack A. Elias, Chun Geun Lee, Min-Jong Kang
  • Patent number: 9440167
    Abstract: Systems and methods for two-phase separation are provided. The system can include a vessel having a first end, a second end, an internal volume, an inlet, a first outlet, and a second outlet. At least one separation tray can be disposed within the internal volume. The inlet can be disposed between the separation tray and the second end. At least one impeller can be connected to a shaft and disposed within the internal volume. The shaft can be mechanically linked to a motor. The at least one impeller can be disposed between the at least one separation tray and the first end.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: September 13, 2016
    Assignee: KELLOGG BROWN & ROOT LLC
    Inventors: Robert Hernandez, Michael A. G. Hardy
  • Publication number: 20160250610
    Abstract: A system for processing one or more materials includes a processor having a shell defining a chamber and a plurality of serially stacked pipe assemblies. Each pipe assembly includes a header having at least one substantially straight pipe section receiving a fluid; and a plurality of nozzles in fluid communication with and projecting downwardly from the header. The nozzles direct the fluid into the chamber of the processor.
    Type: Application
    Filed: February 18, 2016
    Publication date: September 1, 2016
    Applicant: KELLOGG BROWN & ROOT LLC
    Inventors: Nan ZHAO, WILLIAM E. PHILLIPS
  • Publication number: 20160230295
    Abstract: Selective electrocatalytic reduction of carbon dioxide (CO2) to carbon monoxide (CO) on gold (Au) nanoparticles (NPs) in 0.5 M KHCO3 at 25° C. Among monodisperse 4-, 6-, 8-, and 10-nm NPs tested, the 8 nm Au NPs show the maximum Faradaic efficiency (FE), up to 90% at ?0.67 V vs. reversible hydrogen electrode. Density functional theory (DFT) calculations suggest that edge sites dominate over corner sites on the Au NP surface facilitating stabilization of the reduction intermediates, such as COOH1*, and the formation of CO. This mechanism is further supported by the fact that Au NPs embedded in a matrix of butyl-3methylimidazolium hexafluorophosphate for more efficient COOH* stabilization exhibit even higher reaction activity (3 A/g mass activity) and selectivity (97% FE) at ?0.52 V (vs. RHE). Use of monodisperse Au NPs to optimize the available reaction intermediate binding sites thus allows efficient and selective electrocatalytic reduction of CO2 to CO.
    Type: Application
    Filed: April 15, 2016
    Publication date: August 11, 2016
    Applicant: Brown University
    Inventors: Shouheng Sun, Andrew Peterson, Wenlei Zhu, Ronald Michalsky
  • Patent number: 9413229
    Abstract: A method and apparatus for low voltage conversion and energy storage uses a charge pump array including a first set of capacitors in parallel with a second set of capacitors and switches for selectively coupling the first and second set of capacitors to a variable input DC voltage. A data processor programmably controls one or more of the switches to couple the first and second set of capacitors to the variable input DC voltage for a variable first time period during which the input DC voltage charges the first and second set of capacitors to a DC voltage level. An energy storage device is switchably coupled to an output of the charge pump array.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: August 9, 2016
    Assignee: MacAulay-Brown, Inc.
    Inventor: Jerry W. Fleming
  • Patent number: 9410721
    Abstract: A heating element that includes a ceramic material doped with various elements is described. The heating element can be heated by forcing a fuel to flow through the ceramic material, where the fuel interacts with the dopants. The interaction can produce energy in the form of heat. Inventive aspects of the present material include apparatus and methods for modulation of the heat energy, physical features providing for an increase in the rate of heat release, optimization of materials and material morphology for quantity and efficiency of heat release and provision for fueling and maintenance.
    Type: Grant
    Filed: June 18, 2013
    Date of Patent: August 9, 2016
    Assignee: Brown Cravens Taylor
    Inventor: Dennis Cravens
  • Patent number: 9413205
    Abstract: A drive arrangement (12) for a wind turbine (10) is disclosed, having a rotor shaft (20) and a gearbox assembly (22) for transferring torque to an electrical power generator (18). The gearbox assembly comprises an input shaft (40), an output shaft (42), a primary gear stage (44) and a secondary gear stage (46). The drive arrangement also comprises a drive transfer mechanism (24) for transferring torque from the rotor shaft into the gearbox assembly via the input shaft, and a primary load carrying member (56) for releasably mounting the gearbox assembly to a housing (34) of the turbine. The rotor shaft is at least partly hollow, having an internal cavity (28) in which at least parts of the gearbox assembly and drive transfer mechanism are located. The gearbox assembly is mountable within the rotor shaft as a single unit by the primary load carrying member.
    Type: Grant
    Filed: August 3, 2012
    Date of Patent: August 9, 2016
    Assignee: David Brown Wind UK Limited
    Inventors: Alan Bradley Dewar, Scott Douglas Edmondson, Scott Tran
  • Publication number: 20160221977
    Abstract: An antibacterial therapeutic wherein R1 is selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, alkoxy, substituted alkoxy, alkoxyalkyl, substituted alkoxyalkyl, NH2, NHR, NR2, mono- or polyhydroxy-substituted alkyl, aryl, substituted aryl, heteroaryl, and substituted heteroaryl and the like; and wherein, R2 is contemplated as a single substitution of a hydrogen at any position on the benzene ring where the substituted moiety is selected from the group consisting of alkyl, substituted alkyl, alkynyl, substituted alkyl, vinyl, nitro, halo (e.g., includes bromine, chlorine, fluorine and iodine), cyano, aryl, hetero aryl, alkoxy and Cn is carbon and n is a number of from 1 to 5. The invention further encompasses a method of making Structure A, a pharmaceutical preparation of Structure A and method of therapeutically treating a subject by administering Structure A, with particular reference to treating an infection.
    Type: Application
    Filed: August 26, 2014
    Publication date: August 4, 2016
    Applicant: Brown University
    Inventors: Jason K. Sello, Corey L. Compton
  • Patent number: 9403876
    Abstract: A composition which is reversible inhibitor of at least one neuron-specific PDZ domain comprising wherein R is a molecular transporter with or without a linker amino acid; R1 is at least about one amino acid covalently bound; and, R2 is isoleucine, leucine, alanine, phenylalanine, or valine, and methods of use.
    Type: Grant
    Filed: May 18, 2010
    Date of Patent: August 2, 2016
    Assignee: Brown University
    Inventors: Mark Spaller, John Marshall, Dennis J. Goebel
  • Publication number: 20160216234
    Abstract: The present invention generally relates to devices and methods for containing molecules. In some embodiments, the device comprises a nanopore, a pore, and a cavity capable of entropically containing (e.g., trapping) a molecule (e.g., a biomolecule), e.g., for minutes, hours, or days. In certain embodiments, the method comprises urging a molecule into a cavity of a device by application of an electric field, and/or by deposition of fluids having different ionic strengths. The molecule may comprise, in some cases, nucleic acids (e.g., DNA). The molecule, when present in the cavity and/or the nanopore, may be capable of being analyzed, determined, or chemically modified. In some instances, a second molecule (e.g., a second molecule which interacts the first molecule) may also be urged into the cavity. In some embodiments, the interaction of the second molecule with the first molecule (e.g.
    Type: Application
    Filed: January 26, 2015
    Publication date: July 28, 2016
    Applicant: Brown University
    Inventors: Derek M. Stein, Xu Liu, Mirna Mihovilovic Skanata
  • Patent number: 9388980
    Abstract: Systems and methods for gasifying a hydrocarbon feedstock are provided. The hydrocarbon feedstock can be gasified in the presence of one or more particulates to produce a syngas and one or more carbon-containing particulates. At least a portion of the carbon of the one or more carbon-containing particulates can be combusted in a combustion process external to the gasifying of the hydrocarbon feedstock to produce a combustion gas. The combustion gas can be utilized in one or more processes external to the gasifying of the hydrocarbon feedstock.
    Type: Grant
    Filed: December 15, 2011
    Date of Patent: July 12, 2016
    Assignee: Kellogg Brown + Root LLC
    Inventor: John Abughazaleh
  • Publication number: 20160182006
    Abstract: A high-selectivity low-loss duplexing system includes a first duplexer having a first port, a second port, a transmit port and a receive port. A second duplexer has a third port, a fourth port, an inverted transmit port and the receive port. The first port and the third port are connected to an antenna by a balun. The transmit port and the inverted transmit port are connected to at least one power amplifier. The receive port is connected to a low noise amplifier. A phase shifter includes a lattice filter configured to short the second port to the third port and the fourth port to the first port at a receive frequency, and short the second port to the first port and the fourth port to the third port at a transmit frequency.
    Type: Application
    Filed: December 11, 2015
    Publication date: June 23, 2016
    Applicant: Brown University
    Inventor: Lawrence Larson
  • Patent number: 9373931
    Abstract: The methods and materials described herein contemplate the use films of colloidal quantum dots as a gain medium in a vertical-cavity surface-emitting laser. The present disclosure demonstrates a laser with single-exciton gain in the red, green, and blue wavelengths. Leveraging this nanocomposite gain, the results realize a significant step toward full-color single-material lasers.
    Type: Grant
    Filed: April 11, 2013
    Date of Patent: June 21, 2016
    Assignee: BROWN UNIVERSITY
    Inventors: Arto V. Nurmikko, Cuong Dang
  • Patent number: D763087
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: August 9, 2016
    Assignee: BROWN-FORMAN FINLAND LTD.
    Inventor: Kenneth Hirst
  • Patent number: D766445
    Type: Grant
    Filed: November 25, 2015
    Date of Patent: September 13, 2016
    Assignee: Dennis E. Brown, DDS, Inc
    Inventor: Dennis E. Brown