Abstract: A method of ?-hydride elimination and subsequent 2,1-insertion from a transient nickel(II) acrylate hydride intermediate (Structure I). Also addressed is treatment of (dppe)Ni(CH(CH3)CO2BArf3) with a nitrogen containing base to produce a diphosphine nickel(0) ?2-acryl borate adduct.

Abstract: The technology described herein is directed to methods of treating, e.g., obesity and/or asthma which relate to the interacting roles of Chi3L1 and Sirt1 in controlling adipose tissue and respiratory health.

Abstract: A system for high-speed molecular diagnostics includes a self-resetting continuous-time integrator configured to integrate an input current on one of a plurality of integration capacitors to generate an integrated voltage. A self-resetting continuous-time differentiator is configured to differentiate the integrated voltage on one of a plurality of differentiating capacitors to generate an output voltage proportional to the input current. A fixed-threshold window comparator is configured to reset one of the plurality of integration capacitors, reset one of the plurality of differentiating capacitors, open a second one of the plurality of integration capacitors and open a second one of the plurality of differentiating capacitors in response to the integrated voltage exceeding a voltage range.

Abstract: A method and system is provided for automatically preparing transmission electron microscopy (TEM) samples for examination by depositing extremely small samples onto a grid without need for a blotting step. A sample liquid droplet is formed at the end of a capillary, wherein a portion of the liquid is transferred to the TEM sample grid by contact. The excess volume in the liquid droplet is then retracted by an adjacent capillary. After a predetermined time interval, the retraction capillary is moved toward the drop of the sample to remove the excess volume. As compared to a conventional machine, where the blotting procedure can deform the structure of the molecule of interest, the present invention utilizes a very low shear rate for removal of the excess sample fluid.

Abstract: Disclosed herein are compositions and methods for detecting nonalcoholic steatohepatitis (NASH) measuring CHI3L1 levels. In some embodiments, the methods described herein can distinguish NASH from nonalcoholic fatty liver disease. CHI3L1 levels can also be used to monitor treatment progress in patients having NASH. Also disclosed herein are compositions and methods for treating NASH by targeting CHI3L1.

Abstract: Compositions are provided for selectively inhibiting bacterial proteasome. Also provided are methods for assaying the compositions, methods for treating bacterial infection, and methods for inducing apoptosis in tumor cells using the compositions.

Abstract: This invention relates in general to a system, apparatus, and method comprises one or more mapping and modeling systems used for power estimation, management, and improved efficiencies for the integrated circuit.

Abstract: Methods, systems, and apparatus for cooling particulates are provided. The apparatus can include one or more coils at least partially disposed within a cylindrical housing. The one or more coils can include a plurality of tubulars connected by return bends disposed at one or more ends thereof. The apparatus can further include a support grid at least partially disposed within the housing and secured to one or more inner surfaces of one or more sidewalls thereof. The support grid can include a plurality of cross members formed of a series of concentric cylinders connected together by a plurality of radially disposed gussets. An outermost concentric cylinder can be disposed proximate the one or more inner surfaces of the one or more sidewalls, and at least one of the one or more coils can be secured to at least one of the cross members, at least one of the gussets, or both.

Abstract: Methods, articles and systems that provide imagewise mapping or display of gene expression of a biosample, by contacting the biosample, such as a tissue slice or metacommunity, to a detector which captures material from the biosample and processes the captured material. In one embodiment the detector has an array of one or more capture sites at defined positions on the detector, each site carrying an immobilized capture oligonucleotide and a site-indexing oligonucleotide. The array captures mRNA from the biosample contacted thereto, and the captured mRNA is processed to form a sequenceable amount of amplified captured material which includes the site-indexing oligonucleotide, so that when sequenced, detection of the site-indexing oligonucleotide indicates the original capture location on the array, thereby mapping the sequenced material to its capture location and imaging display of gene expression distribution in the original biosample.

Abstract: A pump light pulse is generating a strain pulse in a sample that includes quantum wells. A signal is measured using a probe light pulse. The probe light pulse is delayed in relation to the pump light pulse. The signal derives from a change in an optical property of the sample, which optical property responds to the generated strain pulse. One may deduce parameters of interest of the sample, including the quantum wells, from the characteristics of the signal. For discerning between various components of the stress in the quantum wells a lead pump pulse, preceding the pump light, pulse my also be used. A system for the application of such methods is also disclosed.

Abstract: Systems and methods for producing syngas and ammonia are provided. The method can include reforming a hydrocarbon in a first reaction zone in the presence of one or more first catalysts and steam at conditions sufficient to produce an effluent comprising a portion of the hydrocarbon, carbon monoxide, carbon dioxide, and hydrogen. The effluent can be reformed in a second reaction zone in the presence of one or more second catalysts and nitrogen at conditions sufficient to produce a syngas comprising methane, hydrogen, nitrogen, carbon monoxide, and carbon dioxide, or any combination thereof. At least a portion of the nitrogen and hydrogen in the syngas can be converted to ammonia to produce an ammonia effluent. The ammonia effluent can be separated to produce an ammonia product and a purge gas comprising nitrogen. At least a portion of the purge gas can be recycled to the hydrocarbon, the effluent, or a combination thereof.

Abstract: Embodiments generally relate to a motor driven compressor (MDC) power network electrically isolated and independent from a balance of plant (BOP) power network within an electrical power system and methods for operating the same. In one embodiment, the MDC power network can include one or more MDC trains, and each of the MDC trains can include an MDC distribution bus, one or more MDC turbine generators, one or more electric motors, and one or more compressors. The BOP power network can include a BOP distribution bus, one or more BOP turbine generators, and one or more plant circuits comprising the balance of the plant.

Abstract: Methods, compositions, systems, devices and kits are provided herein for preparing and using a nanoparticle composition and spatial frequency heterodyne imaging for visualizing cells or tissues. In various embodiments, the nanoparticle composition includes at least one of: a nanoparticle, a polymer layer, and a binding agent, such that the polymer layer coats the nanoparticle and is for example a polyethylene glycol, a polyelectrolyte, an anionic polymer, or a cationic polymer, and such that the binding agent that specifically binds the cells or the tissue. Methods, compositions, systems, devices and kits are provided for identifying potential therapeutic agents in a model using the nanoparticle composition and spatial frequency heterodyne imaging.

Abstract: In one aspect, a method and apparatus for detecting subject matter of interest in view data obtained by scanning an object including generating a filter adapted to respond to the subject matter of interest, splatting the filter onto a portion of the view data to provide a filter splat, and performing at least one operation on the portion of the view data using the filter splat to facilitate determining whether the subject matter of interest is present in the portion of the view data.

Abstract: A method and system is provided for automatically preparing transmission electron microscopy (TEM) samples for examination by depositing extremely small samples onto a grid without need for a blotting step. A sample liquid droplet is formed at the end of a capillary, wherein a portion of the liquid is transferred to the TEM sample grid by contact. The excess volume in the liquid droplet is then retracted by an adjacent capillary. After a predetermined time interval, the retraction capillary is moved toward the drop of the sample to remove the excess volume. As compared to a conventional machine, where the blotting procedure can deform the structure of the molecule of interest, the present invention utilizes a very low shear rate for removal of the excess sample fluid.

Abstract: A novel “contour person” (CP) model of the human body is proposed that has the expressive power of a detailed 3D model and the computational benefits of a simple 20 part-based model. The CP model is learned from a 3D model of the human body that captures natural shape and pose variations. The CP model factors deformations of the body into three components: shape variation, viewpoint change and pose variation. The CP model can be “dressed” with a low-dimensional clothing model. The clothing is represented as a deformation from the underlying CP representation. This deformation is learned from training examples using principal component analysis to produce so-called eigen-clothing. The coefficients of the eigen-clothing can be used to recognize different categories of clothing on dressed people. The parameters of the estimated 20 body can be used to discriminatively predict 3D body shape using a learned mapping approach.

Abstract: Systems, apparatus and methods for a neural implant are provided. In one embodiment, a neural implant that can both optically stimulate neurons and record electrical signals from neurons is provided, including a wide band gap semiconductor opto electronic microarray, such optoelectronic microarray including a plurality of needles, each providing both optical transparency and electrical conductivity; a flexible optical conduit from the optoelectronic microarray to an optical signal source; a flexible electrical conduit from the optoelectronic microarray to an electrical signal sensor; integration of the optical and electrical conduits to a single monolithic optical cable; a circuit assembly coupled to the electrical signal source and the optical signal source; and a processor for providing control of at least one of the electrical signal sensor and the optical signal source. Further embodiments are described herein.

Abstract: System and methods for detecting analytes are provided. The system includes a plasmonic interferometer with a first surface having a first and second scattering element and an aperture disposed between the first scattering element and the second scattering element. A first distance between the aperture and the first scattering element and a second distance between the aperture and the second scattering element are selected to provide interference of light at the slit. The system also includes a light source for illuminating the first surface of the plasmonic interferometer, a detector positioned for detecting light transmitted through the aperture, and a sample holder for disposing a sample to be analyzed onto the first surface of the plasmonic interferometer.

Abstract: An adjustably attenuating ear plug adapted for use in an ear canal, includes a flexible body, and a valve assembly further comprising a disk and knob translatable relative to the disk, wherein the knob defines at least one inlet, the disk alternately defines at least one shield and hole, and the inlet is alternatively aligned with the hole and shield to varying degrees, so as to selectively and variably expose the canal to the environment.

Abstract: A method and apparatus for low voltage conversion and energy storage uses a charge pump array including a first set of capacitors in parallel with a second set of capacitors and switches for selectively coupling the first and second set of capacitors to a variable input DC voltage. A data processor programmably controls one or more of the switches to couple the first and second set of capacitors to the variable input DC voltage for a variable first time period during which the input DC voltage charges the first and second set of capacitors to a DC voltage level. An energy storage device is switchably coupled to an output of the charge pump array.