Patents Assigned to Corixa
  • Fusion proteins of mycobacterium tuberculosis antigens and their uses
    Publication number: 20060292169
    Abstract: The present invention relates to fusion proteins containing at least two Mycobacterium tuberculosis antigens. In particular, it relates to bi-fusion proteins which contain two individual M. tuberculosis antigens, tri-fusion proteins which contain three M. tuberculosis antigens, tetra-fusion proteins which contain four M. tuberculosis antigens, and penta-fusion proteins which contain five M. tuberculosis antigens, and methods for their use in the diagnosis, treatment and prevention of tuberculosis infection.
    Type: Application
    Filed: August 28, 2006
    Publication date: December 28, 2006
    Applicant: Corixa Corporation
    Inventors: Steven Reed, Yasir Skeiky, Davin Dillon, Mark Alderson, Antonio Campos-Neto
  • Methods, compositions and kits for the detection and monitoring of lung cancer
    Publication number: 20060292600
    Abstract: Compositions and methods for the diagnosis of lung cancer are disclosed. Such methods are useful to detect early tumors or provide adequate stage/grade information or tumor specificity. Compositions may comprise one or more lung tumor proteins, teins, immunogenic portions thereof, or polynucleotides that encode such portions. Such compositions may be used, for example, to improve lung cancer diagnosis and prognosis and potentially differentiate between NSCLC and SCLC.
    Type: Application
    Filed: March 29, 2006
    Publication date: December 28, 2006
    Applicant: Corixa Corporation
    Inventors: Barbara Zehentner-Wilkinson, Dawn Hayes, Raymond Houghton
  • Compositions and methods for the therapy and diagnosis of breast cancer
    Publication number: 20060287513
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
    Type: Application
    Filed: February 10, 2006
    Publication date: December 21, 2006
    Applicant: Corixa Corporation
    Inventors: Gary Fanger, Shannon Hirst, Davin Dillon, Teresa Foy, Raymond Houghton, David Persing, Michael Kalos
  • Antibodies to treat cancer
    Publication number: 20060275307
    Abstract: Compositions and methods for the treatment of cancer, particularly melanoma, myeloma, small cell lung cancer, thymic lymphoma, T-cell lymphoma, B-cell lymphoma, osteosarcoma, and acute T-cell leukemia, are disclosed. Illustrative compositions include one or more anti-ganglioside antibodies and polynucleotides that encode such anti-ganglioside antibodies. These antibodies may be for example, hamster antibodies, chimeric human/hamster antibodies, or humanized antibodies. The disclosed compositions are useful, for example, in the treatment of cancer and can be used to induce apoptosis in a cancer cell.
    Type: Application
    Filed: August 1, 2006
    Publication date: December 7, 2006
    Applicants: UNIVERSITY OF MASSACHUSETTS, Corixa Corp
    Inventors: Gary Fanger, Neil Fanger, David King, Marc Retter, Kenneth Rock
  • Compositions and methods for WT1 specific immunotherapy
    Patent number: 7144581
    Abstract: Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that specifically binds to a WT1 polypeptide; or a T cell that specifically reacts with a WT1 polypeptide. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases.
    Type: Grant
    Filed: February 15, 2001
    Date of Patent: December 5, 2006
    Assignee: Corixa Corporation
    Inventors: Alexander Gaiger, Martin A. Cheever
  • Compositions and methods for the therapy and diagnosis of prostate cancer
    Publication number: 20060269532
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.
    Type: Application
    Filed: February 1, 2006
    Publication date: November 30, 2006
    Applicant: Corixa Corporation
    Inventors: Jiangchun Xu, Davin Dillon, Jennifer Mitcham, Susan Harlocker, Yuqiu Jiang, Robert Henderson, Michael Kalos, Gary Fanger, Marc Retter, John Stolk, Craig Day, Thomas Vedvick, Darrick Carter, Samuel Li, Aijun Wang, Yasir Skeiky, William Hepler, John Hural, Patricia McNeill, Raymond Houghton, Carlota Vinals y de Bassols, Teresa Foy, Yoshihiro Watanabe, Madeleine Meagher, Ta Deng
  • Antibodies to treat cancer
    Publication number: 20060263374
    Abstract: Compositions and methods for the treatment of cancer, particularly melanoma, myeloma, small cell lung cancer, thymic lymphoma, T-cell lymphoma, B-cell lymphoma, osteosarcoma, and acute T-cell leukemia, are disclosed. Illustrative compositions include one or more anti-ganglioside antibodies and polynucleotides that encode such anti-ganglioside antibodies. These antibodies may be for example, hamster antibodies, chimeric human/hamster antibodies, or humanized antibodies. The disclosed compositions are useful, for example, in the treatment of cancer and can be used to induce apoptosis in a cancer cell.
    Type: Application
    Filed: August 1, 2006
    Publication date: November 23, 2006
    Applicants: UNIVERSITY OF MASSACHUSETTS, Corixa Corp
    Inventors: Gary Fanger, Neil Fanger, David King, Marc Retter, Kenneth Rock
  • Compositions and methods for the therapy and diagnosis of kidney cancer
    Publication number: 20060252066
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly kidney cancer, are disclosed. Illustrative compositions comprise one or more kidney tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly kidney cancer.
    Type: Application
    Filed: March 15, 2006
    Publication date: November 9, 2006
    Applicant: Corixa Corporation
    Inventors: Paul Algate, Brian Gordon, Susan Harlocker
  • Immunoeffector compounds
    Patent number: 7129219
    Abstract: This invention provides compounds containing a 2-deoxy-2-amino-?-D-glucopyranose (glucosamine) glycosidically linked to a cyclic aminoalkyl (aglycon) group. The invention further provides methods for inducing an immune response using the compounds of the present invention in the presence or absence of an antigen. In addition, methods for treating disease with the compounds of the present invention with or without an antigen are also provided in this invention.
    Type: Grant
    Filed: August 3, 2001
    Date of Patent: October 31, 2006
    Assignee: Corixa Corporation
    Inventors: David A. Johnson, C. Gregory Sowell
  • Compounds and methods for diagnosis of tuberculosis
    Patent number: 7122196
    Abstract: Compounds and methods for diagnosing tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of one or more M. tuberculosis proteins, and DNA sequences encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of M. tuberculosis infection in patients and biological samples. Antibodies directed against such polypeptides are also provided.
    Type: Grant
    Filed: March 15, 2005
    Date of Patent: October 17, 2006
    Assignee: Corixa Corporation
    Inventors: Steven G. Reed, Yasir A. W. Skeiky, Davin C. Dillon, Antonio Campos-Neto, Raymond Houghton, Thomas S. Vedvick, Daniel R. Twardzik, Michael J. Lodes, Ronald C. Hendrickson
  • Compounds for immunodiagnosis of prostate cancer and methods for their use
    Publication number: 20060223129
    Abstract: Compounds and methods for diagnosing prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate tumor protein. The inventive polypeptides may be used to generate antibodies useful for the diagnosis and monitoring of prostate cancer. Nucleic acid sequences for preparing probes, primers, and polypeptides are also provided.
    Type: Application
    Filed: February 6, 2006
    Publication date: October 5, 2006
    Applicant: Corixa Corporation
    Inventors: Jiangchun Xu, Davin Dillon
  • Compositions and methods for WT1 specific immunotherapy
    Patent number: 7115272
    Abstract: Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise a WT1 polypeptide comprising an immunogenic portion of WT1, wherein said WT1 polypeptide comprises the polypeptide of SEQ ID NO:144. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases.
    Type: Grant
    Filed: October 6, 2000
    Date of Patent: October 3, 2006
    Assignees: Corixa Corporation, University of Washington
    Inventors: Alexander Gaiger, Martin A. Cheever
  • Fusion proteins of Mycobacterium tuberculosis
    Publication number: 20060193876
    Abstract: The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
    Type: Application
    Filed: May 5, 2006
    Publication date: August 31, 2006
    Applicant: Corixa Corporation
    Inventors: Yasir Skeiky, Steven Reed, Mark Alderson
  • Compositions and methods for the therapy and diagnosis of colon cancer
    Publication number: 20060193870
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly colon cancer, are disclosed. Illustrative compositions comprise one or more colon tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly colon cancer.
    Type: Application
    Filed: March 13, 2006
    Publication date: August 31, 2006
    Applicant: Corixa Corporation
    Inventors: Gordon King, Madeleine Meagher, Jiangchun Xu, Heather Secrist, Yuqui Jiang
  • Compounds and methods for diagnosis and immunotherapy of tuberculosis
    Patent number: 7087713
    Abstract: Compounds and methods for diagnosing tuberculosis or for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more Mycobacterium proteins and DNA molecules encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Mycobacterium infection in patients and biological samples. Antibodies directed against such polypeptides are also provided. In addition, such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against Mycobacterium infection.
    Type: Grant
    Filed: February 26, 2001
    Date of Patent: August 8, 2006
    Assignee: Corixa Corporation
    Inventors: Antonio Campos-Neto, Yasir Skeiky, Pamela Ovendale, Shyian Jen, Michael Lodes
  • Fusion proteins of mycobacterium tuberculosis
    Publication number: 20060171965
    Abstract: The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
    Type: Application
    Filed: March 30, 2006
    Publication date: August 3, 2006
    Applicant: Corixa Corporation
    Inventors: Yasir Skeiky, Steven Reed, Mark Alderson
  • Fusion proteins of
    Patent number: 7083796
    Abstract: The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
    Type: Grant
    Filed: June 20, 2001
    Date of Patent: August 1, 2006
    Assignee: Corixa Corporation
    Inventors: Yasir Skeiky, Steven Reed, Mark Alderson
  • Compositions and methods for therapy and diagnosis of prostate cancer
    Patent number: 7074898
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.
    Type: Grant
    Filed: December 5, 2001
    Date of Patent: July 11, 2006
    Assignee: Corixa Corporation
    Inventors: Jiangchun Xu, Davin C. Dillon, Jennifer L. Mitcham, Susan L. Harlocker, Yuqiu Jiang, Steven G. Reed, Michael D. Kalos, Gary R. Fanger, Marc W. Retter, John A. Stolk, Craig H. Day
  • Composition and methods for WTI specific immunotherapy
    Patent number: 7063854
    Abstract: Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that specifically binds to a WT1 polypeptide; or a T cell that specifically reacts with a WT1 polypeptide. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases.
    Type: Grant
    Filed: September 30, 1998
    Date of Patent: June 20, 2006
    Assignees: Corixa Corporation, University of Washington
    Inventors: Alexander Gaiger, Martin A. Cheever
  • Fusion proteins of mycobacterium tuberculosis antigens and their uses
    Patent number: 7064195
    Abstract: The present invention relates to fusion proteins of Mycobacterium tuberculosis antigens. In particular, it relates to two fusion proteins, each of which contains three individual M. tuberculosis antigens, and a fusion protein of two M. tuberculosis antigens, their coding sequences, and methods for their use in the treatment and prevention of tuberculosis.
    Type: Grant
    Filed: February 5, 2003
    Date of Patent: June 20, 2006
    Assignee: Corixa
    Inventors: Yasir Skeiky, Mark Alderson, Antonio Campos-Neto