Patents Assigned to Corixa
  • Fusion proteins of mycobacterium tuberculosis antigens and their uses
    Patent number: 7064195
    Abstract: The present invention relates to fusion proteins of Mycobacterium tuberculosis antigens. In particular, it relates to two fusion proteins, each of which contains three individual M. tuberculosis antigens, and a fusion protein of two M. tuberculosis antigens, their coding sequences, and methods for their use in the treatment and prevention of tuberculosis.
    Type: Grant
    Filed: February 5, 2003
    Date of Patent: June 20, 2006
    Assignee: Corixa
    Inventors: Yasir Skeiky, Mark Alderson, Antonio Campos-Neto
  • Compositions and methods for WT1 specific immunotherapy
    Publication number: 20060121046
    Abstract: Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that specifically binds to a WT1 polypeptide; or a T cell that specifically reacts with a WT1 polypeptide. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases.
    Type: Application
    Filed: January 25, 2006
    Publication date: June 8, 2006
    Applicants: Corixa Corporation (c/o GlaxoSmithKline), University of Washington
    Inventors: Alexander Gaiger, Martin Cheever
  • Methods for diagnosis of lung cancer
    Patent number: 7049063
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
    Type: Grant
    Filed: December 12, 2000
    Date of Patent: May 23, 2006
    Assignee: Corixa Corporation
    Inventors: Tongtong Wang, Liqun Fan, Michael D. Kalos, Chaitanya S. Bangur, Nancy A. Hosken, Gary R. Fanger, Samuel X. Li, Aijun Wang, Yasir A. W. Skeiky, Robert A. Henderson, Patricia D. McNeill, Neil Fanger
  • Compositions and methods for the therapy and diagnosis of prostate cancer
    Patent number: 7048931
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.
    Type: Grant
    Filed: November 9, 2000
    Date of Patent: May 23, 2006
    Assignee: Corixa Corporation
    Inventors: Jiangchun Xu, Davin C. Dillon, Jennifer L. Mitcham, Susan L. Harlocker, Yuqiu Jiang, Steven G. Reed, Michael D. Kalos, Marc W. Retter, John A. Stolk, Craig H. Day, Yasir A. W. Skeiky, Aijun Wang
  • Immunologically significant herpes simplex virus antigens and methods for using same
    Patent number: 7037509
    Abstract: The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are epitopes confirmed to be recognized by T-cells derived from herpetic lesions. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.
    Type: Grant
    Filed: June 30, 2004
    Date of Patent: May 2, 2006
    Assignees: University of Washington, Fred Hutchinson Cancer Research Center, Corixa Corporation
    Inventors: David M. Koelle, Nancy A. Hosken, Christine M. Posavad, Hongbo Chen, Patrick McGowan
  • Compositions and methods for the therapy and diagnosis of lung cancer
    Publication number: 20060088527
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
    Type: Application
    Filed: December 13, 2005
    Publication date: April 27, 2006
    Applicant: Corixa Corporation
    Inventors: Robert Henderson, Tongtong Wang, Yoshihiro Watanabe, Michael Kalos, Paul Sleath, Jeffrey Johnson, Marc Retter, Margarita Durham, Darrick Carter, Gary Fanger, Thomas Vedvick, Chaitanya Bangur, Andria McNabb
  • Prostate-specific polynucleotide compositions
    Patent number: 7033827
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.
    Type: Grant
    Filed: May 9, 2002
    Date of Patent: April 25, 2006
    Assignee: Corixa Corporation
    Inventors: Jiangchun Xu, Davin C. Dillon, Jennifer L. Mitcham, Susan L. Harlocker, Yuqiu Jiang, Robert A. Henderson, Michael D. Kalos, Gary R. Fanger, Marc W. Retter, John A. Stolk, Craig H. Day, Thomas S. Vedvick, Darrick Carter, Samuel X. Li, Aijun Wang, Yasir A. W. Skeiky, William T. Hepler, John Hural, Patricia D. McNeill, Raymond L. Houghton, Carlota Vinals y de Bassols, Teresa M. Foy, Yoshihiro Watanabe, Madeleine Joy Meagher, Ta Deng
  • Compositions and methods for the therapy and diagnosis of breast cancer
    Publication number: 20060083749
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
    Type: Application
    Filed: May 25, 2005
    Publication date: April 20, 2006
    Applicant: Corixa Corporation
    Inventors: Gary Fanger, Shannon Hirst, Davin Dillon, Teresa Foy, Raymond Houghton, David Persing
  • Immunostimulant compositions comprising an aminoalkyl glucosaminide phosphate and QS-21
    Patent number: 7030094
    Abstract: The invention provides pharmaceutical compositions, particularly vaccine compositions, employing an adjuvant system comprising RC-529 (an aminoalkyl glucosaminide phosphate compound) and QS-21 (a saponin). Such compositions synergistically enhance the immune response in a mammal to a co-administered antigen. Also provided are methods of using the compositions in the treatment of various human diseases, including cancer, microbial infections and autoimmune disorders.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: April 18, 2006
    Assignees: Corixa Corporation, Antigenics Inc.
    Inventors: Sally Mossman, Lawrence Evans
  • Fusion proteins of
    Patent number: 7026465
    Abstract: The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
    Type: Grant
    Filed: February 18, 2003
    Date of Patent: April 11, 2006
    Assignee: Corixa Corporation
    Inventors: Yasir Skeiky, Jeff Guderian, Steven Reed
  • Compositions and methods for the therapy and diagnosis of breast cancer
    Publication number: 20060069054
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
    Type: Application
    Filed: September 13, 2005
    Publication date: March 30, 2006
    Applicant: Corixa Corpoation
    Inventors: Raymond Houghton, Paul Sleath, David Persing
  • Compositions and methods for the therapy and diagnosis of ovarian cancer
    Publication number: 20060057141
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly ovarian cancer.
    Type: Application
    Filed: October 14, 2005
    Publication date: March 16, 2006
    Applicant: Corixa Corporation
    Inventors: Gary Fanger, Steven Fling
  • Compounds for immunodiagnosis of prostate cancer and methods for their use
    Patent number: 7008772
    Abstract: Compounds and methods for diagnosing prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate tumor protein. The inventive polypeptides may be used to generate antibodies useful for the diagnosis and monitoring of prostate cancer. Nucleic acid sequences for preparing probes, primers, and polypeptides are also provided.
    Type: Grant
    Filed: July 14, 1998
    Date of Patent: March 7, 2006
    Assignee: Corixa Corporation
    Inventors: Jiangchun Xu, Davin C. Dillon
  • Methods of using a coding sequence to facilitate stable and high yield expression of the heterologous proteins
    Patent number: 7009042
    Abstract: The present invention relates generally to nucleic acid and amino acid sequences of a fusion polypeptide comprising a Mycobacterium tuberculosis polypeptide, and a heterologous polypeptide of interest, expression vectors and host cells comprising such nucleic acids, and methods for producing such fusion polypeptides. In particular, the invention relates to materials and methods of using such M. tuberculosis sequence as a fusion partner to facilitate the stable and high yield expression of recombinant heterologous polypeptides of both eukaryotic and prokaryotic origin.
    Type: Grant
    Filed: October 6, 2000
    Date of Patent: March 7, 2006
    Assignee: Corixa Corporation
    Inventors: Yasir Skeiky, Jeffrey Guderian
  • Methods of using a Mycobacterium tuberculosis coding sequence to facilitate stable and high yield expression of the heterologous proteins
    Publication number: 20060040356
    Abstract: The present invention relates generally to nucleic acid and amino acid sequences of a fusion polypeptide comprising a Mycobacterium tuberculosis polypeptide, and a heterologous polypeptide of interest, expression vectors and host cells comprising such nucleic acids, and methods for producing such fusion polypeptides. In particular, the invention relates to materials and methods of using such M. tuberculosis sequence as a fusion partner to facilitate the stable and high yield expression of recombinant heterologous polypeptides of both eukaryotic and prokaryotic origin.
    Type: Application
    Filed: September 7, 2005
    Publication date: February 23, 2006
    Applicant: Corixa Corporation
    Inventors: Yasir Skeiky, Jeffrey Guderian
  • Fusion proteins of mycobacterium tuberculosis antigens and their uses
    Publication number: 20060034764
    Abstract: The present invention relates to fusion proteins containing at least two Mycobacterium tuberculosis antigens. In particular, it relates to bi-fusion proteins which contain two individual M. tuberculosis antigens, tri-fusion proteins which contain three M. tuberculosis antigens, tetra-fusion proteins which contain four M. tuberculosis antigens, and penta-fusion proteins which contain five M. tuberculosis antigens, and methods for their use in the diagnosis, treatment and prevention of tuberculosis infection.
    Type: Application
    Filed: August 10, 2005
    Publication date: February 16, 2006
    Applicant: Corixa Corporation
    Inventors: Steven Reed, Yasir Skeiky, Davin Dillon, Mark Alderson, Antonio Campos-Neto
  • Prostate-specific polypeptides and fusion polypeptides thereof
    Publication number: 20060024301
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.
    Type: Application
    Filed: September 23, 2005
    Publication date: February 2, 2006
    Applicant: Corixa Corporation
    Inventors: Jiangchun Xu, Davin Dillon, Jennifer Mitcham, Susan Harlocker, Yuqiu Jiang, Steven Reed, Michael Kalos, Gary Fanger, Marc Retter, John Stolk, Craig Day, Thomas Vedvick, Darrick Carter, Samuel Li, Aijun Wang, Yasir Skeiky
  • Fusion proteins of Mycobacterium tuberculosis antigens and their uses
    Patent number: 6977069
    Abstract: The present invention relates to fusion proteins containing at least two Mycobacterium tuberculosis antigens. In particular, it relates to bi-fusion proteins which contain two individual M. tuberculosis antigens, tri-fusion proteins which contain three M. tuberculosis antigens, tetra-fusion proteins which contain four M. tuberculosis antigens, and penta-fusion proteins which contain five M. tuberculosis antigens, and methods for their use in the diagnosis, treatment and prevention of tuberculosis infection.
    Type: Grant
    Filed: February 5, 2003
    Date of Patent: December 20, 2005
    Assignee: Corixa Corporation
    Inventors: Steven G. Reed, Yasir A. Skeiky, Davin C. Dillon, Mark Alderson, Antonio Campos-Neto
  • Prophylactic and therapeutic treatment of infectious and other diseases with mono-and disaccharide-based compounds
    Publication number: 20050272693
    Abstract: Methods and compositions for treating or ameliorating diseases and other conditions, such as infectious diseases, autoimmune diseases and allergies are provided. The methods employ mono- and disaccharide-based compounds for selectively stimulating immune responses in animals and plants.
    Type: Application
    Filed: June 30, 2005
    Publication date: December 8, 2005
    Applicant: Corixa Corporation
    Inventors: David Persing, Richard Crane, Gary Elliott, J. Ulrich, Michael Lacy, David Johnson, Jory Baldridge, Ron Wang
  • Compositions and methods for the therapy and diagnosis of breast cancer
    Patent number: 6969518
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
    Type: Grant
    Filed: April 15, 2002
    Date of Patent: November 29, 2005
    Assignee: Corixa Corporation
    Inventors: Raymond L. Houghton, Paul R. Sleath, David H. Persing