Patents Assigned to Corixa
  • Compositions and methods for the therapy and diagnosis of breast cancer
    Publication number: 20040142361
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
    Type: Application
    Filed: November 19, 2003
    Publication date: July 22, 2004
    Applicant: Corixa Corporation
    Inventors: Davin C. Dillon, Yuqiu Jiang
  • Compounds for immunotherapy of prostate cancer and methods for their use
    Publication number: 20040141989
    Abstract: Compounds and methods for treating prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of prostate cancer comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided, together with DNA molecules for preparing the inventive polypeptides.
    Type: Application
    Filed: October 17, 2003
    Publication date: July 22, 2004
    Applicant: Corixa Corporation
    Inventors: Jiangchun Xu, Davin C. Dillon
  • Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors
    Patent number: 6764840
    Abstract: Aminoalkyl glucosaminide phosphate (AGP) compounds that are adjuvants and immunoeffectors are described and claimed. The compounds have a 2-deoxy-2-amino glucose in glycosidic linkage with an aminoalkyl (aglycon) group. Compounds are phosphorylated at the 4 or 6 carbon on the glucosaminide ring and comprise three 3-alkanoyloxyalkanoyl residues. The compounds augment antibody production in immunized animals as well as stimulate cytokine production and activate macrophages. Methods for using the compounds as adjuvants and immunoeffectors are also disclosed.
    Type: Grant
    Filed: July 12, 2001
    Date of Patent: July 20, 2004
    Assignee: Corixa Corporation
    Inventors: David A. Johnson, C. Gregory Sowell
  • Compounds and methods for treatment and diagnosis of chlamydial infection
    Publication number: 20040137007
    Abstract: Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.
    Type: Application
    Filed: January 15, 2004
    Publication date: July 15, 2004
    Applicant: Corixa Corporation
    Inventors: Ajay Bhatia, Peter Probst, Erika Jean Stromberg
  • Compositions and methods for the therapy and diagnosis of lung cancer
    Patent number: 6759508
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
    Type: Grant
    Filed: May 11, 2001
    Date of Patent: July 6, 2004
    Assignee: Corixa Corporation
    Inventors: Michael J. Lodes, Raodoh Mohamath, Robert A. Henderson, Darin R. Benson, Heather Secrist
  • Compositions and methods for the therapy and diagnosis of prostate cancer
    Patent number: 6759515
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.
    Type: Grant
    Filed: October 2, 2000
    Date of Patent: July 6, 2004
    Assignee: Corixa Corporation
    Inventors: Jiangchun Xu, Davin C. Dillon, Jennifer L. Mitcham, Susan L. Harlocker, Yuqiu Jiang, Michael D. Kalos, Gary R. Fanger, Marc W. Retter, John A. Stolk, Craig H. Day, Thomas S. Vedvick, Darrick Carter, Samuel X. Li, Aijun Wang, Yasir A. W. Skeiky, William T. Hepler, Robert A. Henderson
  • Compositions and methods for WT1 specific immunotherapy
    Publication number: 20040126362
    Abstract: Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that specifically binds to a WT1 polypeptide; or a T cell that specifically reacts with a WT1 polypeptide. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases.
    Type: Application
    Filed: August 26, 2003
    Publication date: July 1, 2004
    Applicant: Corixa Corporation
    Inventors: Alexander Gaiger, Molly D. Smithgall, Darrick Carter, Martin A. Cheever, Patricia D. McNeill, R. Alec Sutherland, Sally P. Mossman, Lawrence S. Evans, Ryan M. Swanson
  • Compositions and methods for the therapy and diagnosis of breast cancer
    Patent number: 6756477
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as breast cancer, are disclosed. Compositions may comprise one or more breast tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a breast tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as breast cancer. Diagnostic methods based on detecting a breast tumor protein, or mRNA encoding such a protein, in a sample are also provided.
    Type: Grant
    Filed: June 8, 2000
    Date of Patent: June 29, 2004
    Assignee: Corixa Corporation
    Inventors: Yuqiu Jiang, Davin C. Dillon, Jennifer L. Mitcham, Jiangchun Xu, Susan L. Harlocker
  • Methods for diagnosing lung cancer
    Patent number: 6746846
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as lung cancer, are disclosed. Compositions may comprise one or more lung tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a lung tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as lung cancer. Diagnostic methods based on detecting a lung tumor protein, or mRNA encoding such a protein, in a sample are also provide.
    Type: Grant
    Filed: September 8, 2000
    Date of Patent: June 8, 2004
    Assignee: Corixa Corporation
    Inventors: Tongtong Wang, Chaitanya S. Bangur, Michael J. Lodes, Gary R. Fanger, Thomas S. Vedvick, Darrick Carter, Marc W. Retter, Jane Mannion, Liqun Fan
  • Compositions and methods for the therapy and diagnosis of breast cancer
    Publication number: 20040101899
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
    Type: Application
    Filed: November 13, 2003
    Publication date: May 27, 2004
    Applicant: Corixa Corporation
    Inventors: Davin C. Dillon, Craig H. Day, Yuqiu Jiang, Raymond L. Houghton, Jennifer L. Mitcham, Tongtong Wang, Patricia D. McNeill
  • Compositions and methods for the therapy and diagnosis of lung cancer
    Patent number: 6737514
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as lung cancer, are disclosed. Compositions may comprise one or more lung tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a lung tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as lung cancer. Diagnostic methods based on detecting a lung tumor protein, or mRNA encoding such a protein, in a sample are also provided.
    Type: Grant
    Filed: August 2, 2000
    Date of Patent: May 18, 2004
    Assignee: Corixa Corporation
    Inventors: Tongtong Wang, Liqun Fan, Michael D. Kalos, Chaitanya S. Bangur, Nancy A. Hosken, Gary R. Fanger, Samuel X. Li, Aijun Wang, Yasir A. W. Skeiky, Robert A. Henderson, Patricia D. McNeill
  • Compositions and methods for the therapy and diagnosis of breast cancer
    Publication number: 20040073016
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
    Type: Application
    Filed: February 20, 2002
    Publication date: April 15, 2004
    Applicant: Corixa Corporation
    Inventors: Tony N. Frudakis, Steven G. Reed, John M. Smith, Lynda E. Misher, Davin C. Dillon, Marc W. Retter, Aijun Wang, Yasir A.W. Skeiky, Susan L. Harlocker, Craig H. Day, Samuel X. Li, Ta Deng
  • Compositions and methods for the therapy and diagnosis of ovarian cancer
    Patent number: 6720146
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly ovarian cancer.
    Type: Grant
    Filed: October 2, 2001
    Date of Patent: April 13, 2004
    Assignee: Corixa Corporation
    Inventors: John A. Stolk, David Alan Molesh, Steven P. Fling, Jiangchun Xu
  • Novel amphipathic aldehydes and their use as adjuvants and immunoeffectors
    Publication number: 20040063647
    Abstract: This invention relates to novel aldehyde containing compounds and their uses as adjuvants and immunoeffectors.
    Type: Application
    Filed: August 28, 2003
    Publication date: April 1, 2004
    Applicant: Corixa Corporation
    Inventor: David A. Johnson
  • Compositions and methods for the therapy and diagnosis of ovarian cancer
    Patent number: 6710170
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly ovarian cancer.
    Type: Grant
    Filed: April 3, 2001
    Date of Patent: March 23, 2004
    Assignee: Corixa Corporation
    Inventors: Jiangchun Xu, John A. Stolk, Paul A. Algate, Steven P. Fling
  • Leishmania antigens for use in the therapy and diagnosis of leishmaniasis
    Patent number: 6709661
    Abstract: Compositions and methods for preventing, treating and detecting leishmaniasis and stimulating immune responses in patients are disclosed. The compounds provided include polypeptides that contain at least an immunogenic portion of one or more Leishmania antigens, or a variant thereof. Vaccines and pharmaceutical compositions comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided and may be used, for example, for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmania infection.
    Type: Grant
    Filed: February 12, 1997
    Date of Patent: March 23, 2004
    Assignee: Corixa Corporation
    Inventors: Steven G. Reed, Antonio Campos-Neto, John R. Webb, Davin C. Dillon, Yasir A. W. Skeiky
  • Compounds and methods for therapy and diagnosis of lung cancer
    Patent number: 6706262
    Abstract: Compounds and methods for the treatment and diagnosis of lung cancer are provided. The inventive compounds include polypeptides containing at least a portion of a lung tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of lung cancer comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided, together with DNA molecules for preparing the inventive polypeptides.
    Type: Grant
    Filed: December 30, 1999
    Date of Patent: March 16, 2004
    Assignee: Corixa Corporation
    Inventors: Tongtong Wang, Nancy A. Hosken, Michael D. Kalos, Gary R. Fanger
  • Compositions and methods for the therapy and diagnosis of ovarian cancer
    Patent number: 6699664
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof, polynucleotides that encode such portions or antibodies or immune system cells specific for such proteins. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian cancer. Methods are further provided for identifying tumor antigens that are secreted from ovarian carcinomas and/or other tumors. Polypeptides and polynucleotides as provided herein may further be used for the diagnosis and monitoring of ovarian cancer.
    Type: Grant
    Filed: September 20, 2000
    Date of Patent: March 2, 2004
    Assignee: Corixa Corporation
    Inventors: Jennifer L. Mitcham, Gordon E. King, Paul A. Algate, Steven P. Fling, Marc W. Retter, Gary R. Fanger, Steven G. Reed, Thomas S. Vedvick, Darrick Carter
  • Mono- and disaccharides for the treatment of nitric oxide related disorders
    Patent number: 6699846
    Abstract: Methods for treating diseases or conditions modulated or ameliorated by nitric oxide, particularly ischemia and reperfusion injury, are provided, using glycolipids structurally related to monophosphoryl lipid A but with notable reduction in proinflammatory and pyrogenic activity.
    Type: Grant
    Filed: March 14, 2001
    Date of Patent: March 2, 2004
    Assignee: Corixa Corporation
    Inventors: Gary T. Elliott, David Johnson, Patricia Weber, Greg Sowell
  • Compositions and methods for the therapy and diagnosis of colon cancer
    Publication number: 20040037842
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly colon cancer, are disclosed. Illustrative compositions comprise one or more colon tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly colon cancer.
    Type: Application
    Filed: March 13, 2002
    Publication date: February 26, 2004
    Applicant: Corixa Corporation
    Inventors: Madeleine Joy Meagher, Gordon E. King, Heather Secrist, Susan L. Harlocker, Jiangchun Xu