Patents Assigned to Corixa
  • Processes for the production of aminoalkyl glucosaminide phosphate and disaccharide immunoeffectors, and intermediates therefor
    Publication number: 20050107600
    Abstract: This invention relates to processes for production of alkylamino glucosaminide phosphate compounds, and of disaccharide compounds, including various novel intermediates and intermediate processes. In one aspect, glycosyl halides are produced by reaction of an O-silyl glycoside with a dihalomethyl alkyl ether.
    Type: Application
    Filed: July 21, 2004
    Publication date: May 19, 2005
    Applicant: Corixa Corporation, a corporation of the state of Delaware
    Inventors: David Johnson, Craig Johnson, Helene Bazin-Lee, C. Sowell
  • Compositions and methods for the therapy and diagnosis of prostate cancer
    Patent number: 6894146
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.
    Type: Grant
    Filed: September 6, 2000
    Date of Patent: May 17, 2005
    Assignee: Corixa Corporation
    Inventors: Jiangchun Xu, Davin C. Dillon, Jennifer L. Mitcham, Susan L. Harlocker, Yuqiu Jiang, Michael D. Kalos, Gary R. Fanger, Marc W. Retter, John A. Stolk, Craig H. Day, Thomas S. Vedvick, Darrick Carter, Samuel X. Li, Aijun Wang, Yasir A. W. Skeiky, William T. Hepler, Robert A. Henderson
  • Compounds for immunodiagnosis of prostate cancer and methods for their use
    Patent number: 6887660
    Abstract: Compounds and methods for diagnosing prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate tumor protein. The inventive polypeptides may be used to generate antibodies useful for the diagnosis and monitoring of prostate cancer. Nucleic acid sequences for preparing probes, primers, and polypeptides are also provided.
    Type: Grant
    Filed: February 25, 1998
    Date of Patent: May 3, 2005
    Assignee: Corixa Corporation
    Inventors: Jiangchun Xu, Davin C. Dillon
  • COMPOUNDS AND METHODS FOR TREATMENT AND DIAGNOSIS OF CHLAMYDIAL INFECTION
    Publication number: 20050084499
    Abstract: Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.
    Type: Application
    Filed: July 15, 2002
    Publication date: April 21, 2005
    Applicant: Corixa Corporation
    Inventors: Ajay Bhatia, Jeff Guderian, Yasir Skeiky, Jean-Francois Maisonneuve
  • Leader peptides for enhancing secretion of recombinant protein from a host cell
    Patent number: 6875590
    Abstract: Novel synthetic leader peptides have been identified. The leader peptides have use in a method of enhancing the secretion of a recombinant polypeptide produced in a host cell. Polynucleotides encoding the novel leader peptides and a method of designing the polynucleotides are described.
    Type: Grant
    Filed: June 5, 2001
    Date of Patent: April 5, 2005
    Assignee: Corixa Corporation
    Inventors: Tseng-hui Timothy Chen, Brian Schmidt
  • Compositions and methods for the treatment and diagnosis of breast cancer
    Patent number: 6861506
    Abstract: Compositions and methods for the detection and therapy of breast cancer are disclosed. The compounds provided include nucleotide sequences that are preferentially expressed in breast tumor tissue, as well as polypeptides encoded by such nucleotide sequences. Vaccines and pharmaceutical compositions comprising such compounds are also provided and may be used, for example, for the prevention and treatment of breast cancer. The polypeptides may also be used for the production of antibodies, which are useful for diagnosing and monitoring the progression of breast cancer in a patient.
    Type: Grant
    Filed: March 23, 2000
    Date of Patent: March 1, 2005
    Assignee: Corixa Corporation
    Inventors: Tony N. Frudakis, John M. Smith, Steven G. Reed, Lynda E. Misher, Marc W. Retter, Davin C. Dillon
  • Compositions and methods for the therapy and diagnosis of ovarian cancer
    Patent number: 6858710
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly ovarian cancer.
    Type: Grant
    Filed: July 17, 2002
    Date of Patent: February 22, 2005
    Assignee: Corixa Corporation
    Inventors: Chaitanya S. Bangur, Marc W. Retter, Gary R. Fanger, Paul Hill
  • Compositions and methods for the therapy and diagnosis of ovarian cancer
    Publication number: 20050031634
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly ovarian cancer.
    Type: Application
    Filed: June 2, 2004
    Publication date: February 10, 2005
    Applicant: Corixa Corporation
    Inventors: Chaitanya Bangur, Marc Retter, Gary Fanger, Paul Hill
  • Compositions for the treatment and diagnosis of breast cancer and methods for their use
    Patent number: 6844325
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as breast cancer, are disclosed. Compositions may comprise one or more breast tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a breast tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as breast cancer. Diagnostic methods based on detecting a breast tumor protein, or mRNA encoding such a protein, in a sample are also provided.
    Type: Grant
    Filed: April 17, 2000
    Date of Patent: January 18, 2005
    Assignee: Corixa Corporation
    Inventors: Yuqiu Jiang, Davin C. Dillon, Jennifer L. Mitcham, Jiangchun Xu, Susan L. Harlocker
  • Compositions and methods for the therapy and diagnosis of breast cancer
    Patent number: 6828431
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
    Type: Grant
    Filed: October 26, 2000
    Date of Patent: December 7, 2004
    Assignee: Corixa Corporation
    Inventors: Tony N. Frudakis, Steven G. Reed, John M. Smith, Lynda E. Misher, Davin C. Dillon, Marc W. Retter, Aijun Wang, Yasir A. W. Skeiky, Susan L. Harlocker
  • Compounds and methods for treatment and diagnosis of chlamydial infection
    Publication number: 20040234536
    Abstract: Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.
    Type: Application
    Filed: June 18, 2004
    Publication date: November 25, 2004
    Applicant: Corixa Corporation
    Inventors: Ajay Bhatia, Yasir A.W. Skeiky, Peter Probst
  • Compositions and methods for the therapy and diagnosis of lung cancer
    Publication number: 20040235072
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
    Type: Application
    Filed: February 10, 2004
    Publication date: November 25, 2004
    Applicant: Corixa Corporation
    Inventors: Robert A. Henderson, Tongtong Wang, Chaitanya S. Bangur
  • Compounds and methods for therapy and diagnosis of lung cancer
    Patent number: 6821518
    Abstract: Compounds and methods for the treatment and diagnosis of lung cancer are provided. The inventive compounds include polypeptides containing at least a portion of a lung tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of lung cancer comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided, together with DNA molecules for preparing the inventive polypeptides.
    Type: Grant
    Filed: April 2, 1999
    Date of Patent: November 23, 2004
    Assignee: Corixa Corporation
    Inventor: Tongtong Wang
  • Compositions and methods for the diagnosis and treatment of herpes simplex virus infection
    Patent number: 6821519
    Abstract: Compounds and methods for the diagnosis and treatment of HSV infection are provided. The compounds comprise polypeptides that contain at least one antigenic portion of an HSV polypeptide and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits are also provided comprising such polypeptides and/or DNA sequences and a suitable detection reagent for the detection of HSV infection in patients and in biological samples.
    Type: Grant
    Filed: September 6, 2002
    Date of Patent: November 23, 2004
    Assignee: Corixa Corporation
    Inventors: Craig H. Day, Nancy A. Hosken, Joseph M. Parsons
  • Compositions and methods for the therapy and diagnosis of prostate cancer
    Patent number: 6818751
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.
    Type: Grant
    Filed: August 29, 2000
    Date of Patent: November 16, 2004
    Assignee: Corixa Corporation
    Inventors: Jiangchun Xu, Davin C. Dillon, Jennifer L. Mitcham, Susan L. Harlocker, Yuqiu Jiang, Michael D. Kalos, Gary R. Fanger, Marc W. Retter, John A. Stolk, Craig H. Day, Thomas S. Vedvick, Darrick Carter, Samuel X. Li, Aijun Wang, Yasir A. W. Skeiky, William T. Hepler, Robert A. Henderson
  • Prophylactic and therapeutic treatment of infectious and other diseases with mono- and disaccharide-based compounds
    Patent number: 6800613
    Abstract: Methods and compositions for treating or ameliorating diseases and other conditions, such as infectious diseases, autoimmune diseases and allergies are provided. The methods employ mono- and disaccharide-based compounds for selectively stimulating immune responses in animals and plants.
    Type: Grant
    Filed: May 18, 2001
    Date of Patent: October 5, 2004
    Assignee: Corixa Corporation
    Inventors: David H. Persing, Richard Thomas Crane, Gary T. Elliott, J. Terry Ulrich, Michael J. Lacy, David A. Johnson, Jory R. Baldridge, Rong Wang
  • Compositions and methods for the therapy and diagnosis of prostate cancer
    Patent number: 6800746
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.
    Type: Grant
    Filed: January 12, 2001
    Date of Patent: October 5, 2004
    Assignee: Corixa Corporation
    Inventors: Jiangchun Xu, Davin C. Dillon, Jennifer L. Mitcham, Susan L. Harlocker, Yuqiu Jiang, Michael D. Kalos, Gary R. Fanger, Marc W. Retter, John A. Stolk, Craig H. Day, Thomas S. Vedvick, Darrick Carter, Samuel X. Li, Aijun Wang, Yasir A. W. Skeiky, William T. Hepler, Robert A. Henderson
  • Compositions and methods for the detection, diagnosis and therapy of hematological malignancies
    Publication number: 20040175739
    Abstract: Disclosed are methods and compositions for the detection, diagnosis, prognosis, and therapy of hematological malignancies, and in particular, B cell leukemias, lymphomas and multiple myelomas. Disclosed are compositions, methods and kits for eliciting immune and T cell responses to specific malignancy-related antigenic polypeptides and antigenic polypeptide fragments thereof in an animal. Also disclosed are compositions and methods for use in the identification of cells and biological samples containing one or more hematological malignancy-related compositions, and methods for the detection and diagnosis of such diseases and affected cell types. Also disclosed are diagnostic and therapeutic kits, as well as methods for the diagnosis, therapy and/or prevention of a variety of leukemias and lymphomas.
    Type: Application
    Filed: January 23, 2004
    Publication date: September 9, 2004
    Applicant: Corixa Corporation
    Inventors: Alexander Gaiger, Paul A. Algate, Jane Mannion, Marc Retter
  • Compositions and methods for high-level, large-scale production of recombinant proteins
    Publication number: 20040161817
    Abstract: Compositions and methods for the high-level, large-scale production of recombinant proteins are disclosed. Illustrative compositions comprise one or more expression vectors capable of high-level protein and/or polypeptide expression in combination with an immortalized host cell-line capable of growth in serum-free, suspension culture. Bi-directional UCOE vectors that permit the simultaneous, high-level expression of two or more recombinant proteins and/or polypeptides from a single UCOE based plasmid vector.
    Type: Application
    Filed: June 4, 2002
    Publication date: August 19, 2004
    Applicant: Corixa Corporation
    Inventors: Trish Benton, Christopher Robert Bebbington, Karla Ann Henning, David J. King, Robert Crombie, Xiang Shao
  • Prophylactic and therapeutic treatment of infectious and other diseases with mono-and disaccharide-based compounds
    Publication number: 20040147480
    Abstract: Methods and compositions for treating or ameliorating diseases and other conditions, such as infectious diseases, autoimmune diseases and allergies are provided. The methods employ mono- and disaccharide-based compounds for selectively stimulating immune responses in animals and plants.
    Type: Application
    Filed: January 13, 2004
    Publication date: July 29, 2004
    Applicant: Corixa Corporation
    Inventors: David H. Persing, Richard T. Crane, Gary T. Elliott, J. Terry Ulrich, Michael J. Lacy, David A. Johnson, Jory R. Baldridge, Rong Wang