Patents Assigned to Corixa
  • Compounds and methods for the diagnosis and treatment of B. microti infection
    Patent number: 6451315
    Abstract: Compounds and methods for the diagnosis and treatment of B. microti infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a B. microti antigen, DNA sequences encoding such polypeptides, and fusion proteins comprising such polypeptides. Antigenic epitopes of such antigens are also provided, together with pharmaceutical compositions and vaccines comprising such polypeptides, DNA sequences, fusion proteins or antigenic epitopes. Diagnostic kits containing such polypeptides, DNA sequences, fusion proteins or antigenic epitopes and a suitable detection reagent may be used for the detection of B. microti infection in patients and biological samples. Antibodies directed against such polypeptides and antigenic epitopes are also provided.
    Type: Grant
    Filed: March 17, 2000
    Date of Patent: September 17, 2002
    Assignee: Corixa Corporation
    Inventors: Steven G. Reed, Michael J. Lodes, Raymond L. Houghton, Paul R. Sleath, Patricia D. McNeill
  • Compounds for the diagnosis of Chlamydial infection
    Patent number: 6447779
    Abstract: Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.
    Type: Grant
    Filed: April 8, 1999
    Date of Patent: September 10, 2002
    Assignee: Corixa Corporation
    Inventors: Peter Probst, Ajay Bhatia, Yasir A. W. Skeiky, Steven P. Fling
  • Compounds and methods for treatment and diagnosis of chlamydial infection
    Patent number: 6448234
    Abstract: Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.
    Type: Grant
    Filed: July 20, 2000
    Date of Patent: September 10, 2002
    Assignee: Corixa Corporation
    Inventor: Steven P. Fling
  • Compositions and methods for the therapy and diagnosis of lung cancer
    Publication number: 20020123619
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as lung cancer, are disclosed. Compositions may comprise one or more lung tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a lung tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as lung cancer. Diagnostic methods based on detecting a lung tumor protein, or mRNA encoding such a protein, in a sample are also provided.
    Type: Application
    Filed: September 20, 2001
    Publication date: September 5, 2002
    Applicant: Corixa Corporation
    Inventors: Darin R. Benson, Raodoh Mohamath, Michael J. Lodes
  • Compounds for therapy and diagnosis of lung cancer and methods for their use
    Patent number: 6444425
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as lung cancer, are disclosed. Compositions may comprise one or more lung tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a lung tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as lung cancer. Diagnostic methods based on detecting a lung tumor protein, or mRNA encoding such a protein, in a sample are also provided.
    Type: Grant
    Filed: August 9, 1999
    Date of Patent: September 3, 2002
    Assignee: Corixa Corporation
    Inventors: Steven G. Reed, Michael J. Lodes, Raodoh Mohamath, Heather Secrist
  • Compositions and methods for the therapy and diagnosis of ovarian cancer
    Publication number: 20020119158
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof, polynucleotides that encode such portions or antibodies or immune system cells specific for such proteins. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian cancer. Methods are further provided for identifying tumor antigens that are secreted from ovarian carcinomas and/or other tumors. Polypeptides and polynucleotides as provided herein may further be used for the diagnosis and monitoring of ovarian cancer.
    Type: Application
    Filed: June 18, 2001
    Publication date: August 29, 2002
    Applicant: Corixa Corporation
    Inventors: Paul A. Algate, Darrick Carter
  • Compositions and methods for the therapy and diagnosis of colon cancer
    Publication number: 20020110832
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly colon cancer, are disclosed. Illustrative compositions comprise one or more colon tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly colon cancer.
    Type: Application
    Filed: July 30, 2001
    Publication date: August 15, 2002
    Applicant: Corixa Corporation
    Inventors: Ruth A. Pyle, Jiangchun Xu, Heather Secrist
  • Compounds and methods for treatment and diagnosis of chlamydial infection
    Patent number: 6432916
    Abstract: Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.
    Type: Grant
    Filed: April 19, 2000
    Date of Patent: August 13, 2002
    Assignee: Corixa Corporation
    Inventors: Peter Probst, Ajay Bhatia, Yasir A. W. Skeiky, Steven P. Fling
  • Compositions and methods for the therapy and diagnosis of breast cancer
    Patent number: 6432707
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as breast cancer, are disclosed. Compositions may comprise one or more breast tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a breast tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as breast cancer. Diagnostic methods based on detecting a breast tumor protein, or mRNA encoding such a protein, in a sample are also provided.
    Type: Grant
    Filed: June 22, 2000
    Date of Patent: August 13, 2002
    Assignee: Corixa Corporation
    Inventors: Steven G. Reed, Jiangchun Xu, Davin C. Dillon
  • Compositions and methods for the therapy and diagnosis of lung cancer
    Patent number: 6426072
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as lung cancer, are disclosed. Compositions may comprise one or more lung tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a lung tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as lung cancer. Diagnostic methods based on detecting a lung tumor protein, or mRNA encoding such a protein, in a sample are also provided.
    Type: Grant
    Filed: August 21, 2000
    Date of Patent: July 30, 2002
    Assignee: Corixa Corporation
    Inventors: Tongtong Wang, Liqun Fan, Michael D. Kalos, Chaitanya S. Bangur, Nancy A. Hosken, Gary R. Fanger, Samuel X. Li, Aijun Wang, Yasir A. W. Skeiky, Robert A. Henderson, Patricia D. McNeill
  • Compositions and methods for the treatment and diagnosis of breast cancer
    Patent number: 6423496
    Abstract: Compositions and methods for the detection and therapy of breast cancer are disclosed. The compounds provided include nucleotide sequences that are preferentially expressed in breast tumor tissue, as well as polypeptides encoded by such nucleotide sequences. Vaccines and pharmaceutical compositions comprising such compounds are also provided and may be used, for example, for the prevention and treatment of breast cancer. The polypeptides may also be used for the production of antibodies, which are useful for diagnosing and monitoring the progression of breast cancer in a patient.
    Type: Grant
    Filed: June 20, 2000
    Date of Patent: July 23, 2002
    Assignee: Corixa Corporation
    Inventors: Tony N. Frudakis, John M. Smith, Steven G. Reed
  • Compounds and methods for the detection and prevention of T.cruzi infection
    Patent number: 6419933
    Abstract: Compounds and methods are provided for diagnosing Trypanosoma cruzi infection. The disclosed compounds are polypeptides, or antibodies thereto, that contain one or more epitopes of T. cruzi antigens. The compounds are useful in a variety of immunoassays for detecting T. cruzi infection. The polypeptide compounds are further useful in vaccines and pharmaceutical compositions for inducing protective immunity against Chagas' disease in individuals exposed to T. cruzi.
    Type: Grant
    Filed: February 24, 1999
    Date of Patent: July 16, 2002
    Assignee: Corixa Corporation
    Inventors: Steven G. Reed, Yasir A. W. Skeiky, Michael J. Lodes, Raymond L. Houghton, John M. Smith, Patricia D. McNeill
  • Compounds and methods for the diagnosis and treatment of Ehrlichia infection
    Publication number: 20020086984
    Abstract: Compounds and methods for the diagnosis and treatment of Ehrlichia infection, in particular human granulocytic ehrlichiosis, are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of an Ehrlichia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Ehrlichia infection in patients and biological samples. Antibodies directed against such polypeptides are also provided.
    Type: Application
    Filed: September 10, 2001
    Publication date: July 4, 2002
    Applicant: Corixa Corporation
    Inventors: Steven G. Reed, Michael J. Lodes, Patricia D. McNeill, Raymond L. Houghton
  • Compositions and methods for the therapy and diagnosis of breast cancer
    Publication number: 20020085998
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
    Type: Application
    Filed: April 13, 2001
    Publication date: July 4, 2002
    Applicant: Corixa Corporation
    Inventors: Yuqiu Jiang, Davin C. Dillon, Jennifer L. Mitcham, Jiangchun Xu, Susan L. Harlocker, William T. Hepler, Robert A. Henderson
  • Immunologically significant herpes simplex virus antigens and methods for identifying and using same
    Patent number: 6413518
    Abstract: The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are epitopes confirmed to be recognized by T-cells derived from herpetic lesions. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: July 2, 2002
    Assignees: University of Washington, Fred Hutchinson Cancer Research Center, Corixa Corporation
    Inventors: David M. Koelle, Hongbo Chen, Lawrence Corey, Nancy Ann Hosken, Patrick McGowan, Steven P. Fling, Christine M. Posavad
  • Methods for indentifying anti-cancer agents
    Patent number: 6413717
    Abstract: Methods are provided for identifying agents that modulate the expression of genes, such as genes encoding tumor suppressor or tumor-promoting proteins. The methods generally comprise screening candidate agents for the ability to enhance expression of a tumor suppressor gene, such as mda-7, or for the ability to inhibit expression of a tumor-promoting gene within a cell. Modulating agents may be used, for example, within anti-cancer therapies.
    Type: Grant
    Filed: March 18, 1998
    Date of Patent: July 2, 2002
    Assignee: Corixa Corporation
    Inventors: Yilong Sun, Paul B. Fisher, Neil I. Goldstein
  • Compounds for immunotherapy and diagnosis of breast cancer and methods for their use
    Patent number: 6410507
    Abstract: Compounds and methods for the treatment and diagnosis of breast cancer are provided. The inventive compounds include polypeptides containing at least a portion of a breast tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of breast cancer comprising such polypeptides, or polynucleotides encoding such polypeptides, are also provided, together with polynucleotides for preparing the inventive polypeptides.
    Type: Grant
    Filed: July 2, 1999
    Date of Patent: June 25, 2002
    Assignee: Corixa Corporation
    Inventors: Steven G. Reed, Jiangchun Xu, Davin C. Dillon
  • Compositions and methods for the therapy and diagnosis of pancreatic cancer
    Publication number: 20020076721
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly pancreatic cancer, are disclosed. Illustrative compositions comprise one or more pancreatic tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly pancreatic cancer.
    Type: Application
    Filed: August 6, 2001
    Publication date: June 20, 2002
    Applicant: Corixa Corporation
    Inventors: Ruth A. Pyle, Jiangchun Xu, Michael D. Kalos
  • Compounds for immunotherapy and diagnosis of colon cancer and methods for their use
    Publication number: 20020076414
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as colon cancer, are disclosed. Compositions may comprise one or more colon tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a colon tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as colon cancer. Diagnostic methods based on detecting a colon tumor protein, or mRNA encoding such a protein, in a sample are also provided.
    Type: Application
    Filed: August 3, 2001
    Publication date: June 20, 2002
    Applicant: Corixa Corporation
    Inventors: Jiangchun Xu, Michael J. Lodes, Heather Secrist, Darin R. Benson, Madeleine Joy Meagher, John A. Stolk, Tongtong Wang, Yuqiu Jiang, Carole L. Smith, Gordon E. King, Aijun Wang, Jonathan D. Clapper
  • Phosphoglycolipid and methods for its use
    Patent number: 6399590
    Abstract: The invention concerns a novel phosphoglycolipid compound. The compound of the subject invention is 2-Deoxy-6-O-[2-deoxy-4-O-phosphono-3-O-[(R)-3-tetradecanoyloxytetradecanoyl]-2-[(R)-3-octadecanoyloxytetradecanoylamino]-&bgr;-D-glucopyranosyl]-2-[(R)-3-hexadecanoyloxytetradecanoylamino]-D-glucopyranose and pharmaceutically acceptable salts thereof. The compound is not immunoreactive, not pyrogenic, not toxic but is active in ameliorating tissue damage due to ischemia/reperfusion injury. Methods for using the subject compound to protect against reversible and irreversible damage due to ischemia/reperfusion injury are also disclosed.
    Type: Grant
    Filed: August 10, 2001
    Date of Patent: June 4, 2002
    Assignee: Corixa Corporation
    Inventors: Gary T. Elliott, Patricia A. Weber, C. Gregory Sowell