Patents Assigned to Corixa
  • Compositions and methods for WT1 specific immunotherapy
    Publication number: 20030095971
    Abstract: Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that specifically binds to a WT1 polypeptide; or a T cell that specifically reacts with a WT1 polypeptide. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases.
    Type: Application
    Filed: October 30, 2001
    Publication date: May 22, 2003
    Applicant: Corixa Corporation
    Inventors: Alexander Gaiger, Patricia D. McNeill, Molly Smithgall, Gus Moulton, Thomas S. Vedvick, Paul R. Sleath, Sally P. Mossman, Lawrence S. Evans, A. Gregory Spies, Jeremy Boydston
  • Compounds and methods for treatment and diagnosis of chlamydial infection
    Patent number: 6565856
    Abstract: Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.
    Type: Grant
    Filed: June 20, 2000
    Date of Patent: May 20, 2003
    Assignee: Corixa Corporation
    Inventors: Yasir A. W. Skeiky, John Scholler
  • Compounds and methods for the diagnosis and treatment of Babesia infection
    Publication number: 20030091598
    Abstract: Compounds and methods for the diagnosis and treatment of Babesia sp. WA1 infection are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of a Babesia sp. WA1 antigen and polynucleotides encoding such polypeptides. Pharmaceutical compositions and immunogenic compositions comprising such polypeptides or polynucleotides are also provided. Diagnostic kits containing such polypeptides or polynucleotides and a suitable detection reagent may be used for the detection of Babesia sp. WA1 infection in patients and biological samples. Antibodies directed against such polypeptides are also provided.
    Type: Application
    Filed: August 30, 2002
    Publication date: May 15, 2003
    Applicant: Corixa Corporation
    Inventors: Mary J. Homer, Michael J. Lodes, Raymond L. Houghton, David H. Persing, Patricia D. McNeill
  • Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors
    Publication number: 20030092643
    Abstract: Aminoalkyl glucosaminide phosphate (AGP) compounds that are adjuvants and immunoeffectors are described and claimed. The compounds have a 2-deoxy-2-amino glucose in glycosidic linkage with an aminoalkyl (aglycon) group. Compounds are phosphorylated at the 4 or 6 carbon on the glucosaminide ring and comprise three 3- alkanoyloxyalkanoyl residues. The compounds augment antibody production in immunized animals as well as stimulate cytokine production and activate macrophages. Compositions and methods for using the compounds as adjuvants and immunoeffectors are also disclosed.
    Type: Application
    Filed: January 8, 2002
    Publication date: May 15, 2003
    Applicant: Corixa Corporation
    Inventors: David A. Johnson, C. Gregory Sowell
  • Compositions and methods for therapy and diagnosis of prostate cancer
    Publication number: 20030088062
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.
    Type: Application
    Filed: December 5, 2001
    Publication date: May 8, 2003
    Applicant: Corixa Corporation
    Inventors: Jiangchun Xu, Davin C. Dillon, Jennifer L. Mitcham, Susan L. Harlocker, Jiang Yuqiu, Steven G. Reed, Michael D. Kalos, Gary R. Fanger, Marc W. Retter, John A. Stolk, Craig H. Day
  • Compositions and methods for the therapy and diagnosis of colon cancer
    Publication number: 20030087818
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly colon cancer, are disclosed. Illustrative compositions comprise one or more colon tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly colon cancer.
    Type: Application
    Filed: February 1, 2002
    Publication date: May 8, 2003
    Applicant: Corixa Corporation
    Inventors: Yuqiu Jiang, Ruth A. Chenault, Jiangchun Xu, Carol Yoseph Indirias, Michael J. Lodes, Heather Secrist, Darrick Carter, Gary R. Fanger, Carole L. Smith, Margarita Durham, John A. Stolk
  • Compounds for diagnosis of tuberculosis and methods for their use
    Patent number: 6555653
    Abstract: Compounds and methods for diagnosing tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of one or more M. tuberculosis proteins, and DNA sequences encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of M. tuberculosis infection in patients and biological samples. Antibodies directed against such polypeptides are also provided.
    Type: Grant
    Filed: May 5, 1998
    Date of Patent: April 29, 2003
    Assignee: Corixa Corporation
    Inventors: Mark Raymond Alderson, Davin C. Dillon, Yasir A. W. Skeiky, Antonio Campos-Neto
  • Compounds and methods for treatment and diagnosis of chlamydial infection
    Patent number: 6555115
    Abstract: Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.
    Type: Grant
    Filed: October 1, 1999
    Date of Patent: April 29, 2003
    Assignee: Corixa Corporation
    Inventors: Peter Probst, Ajay Bhatia, Yasir A. W. Skeiky, Shyian Jen, Erika Jean Stromberg
  • Compositions and methods for the detection, diagnosis and therapy of hematological malignancies
    Publication number: 20030078396
    Abstract: Disclosed are methods and compositions for the detection, diagnosis, prognosis, and therapy of hematological malignancies, and in particular, B cell leukemias, lymphomas and multiple myelomas. Disclosed are compositions, methods and kits for eliciting immune and T cell responses to specific malignancy-related antigenic polypeptides and antigenic polypeptide fragments thereof in an animal. Also disclosed are compositions and methods for use in the identification of cells and biological samples containing one or more hematological malignancy-related compositions, and methods for the detection and diagnosis of such diseases and affected cell types. Also disclosed are diagnostic and therapeutic kits, as well as methods for the diagnosis, therapy and/or prevention of a variety of leukemias and lymphomas.
    Type: Application
    Filed: November 6, 2001
    Publication date: April 24, 2003
    Applicant: Corixa Corporation
    Inventors: Alexander Gaiger, Paul A. Algate, Jane Mannion, Marc Retter
  • Compositions and methods for the therapy and diagnosis of pancreatic cancer
    Publication number: 20030073144
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly pancreatic cancer, are disclosed. Illustrative compositions comprise one or more pancreatic tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly pancreatic cancer.
    Type: Application
    Filed: January 30, 2002
    Publication date: April 17, 2003
    Applicant: Corixa Corporation
    Inventors: Darin R. Benson, Michael D. Kalos, Michael J. Lodes, David H. Persing, William T. Hepler, Yuqiu Jiang
  • Compositions and methods for the therapy and diagnosis of colon cancer
    Publication number: 20030069180
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as colon cancer, are disclosed. Compositions may comprise one or more colon tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a colon tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as colon cancer. Diagnostic methods based on detecting a colon tumor protein, or mRNA encoding such a protein, in a sample are also provided.
    Type: Application
    Filed: May 14, 2002
    Publication date: April 10, 2003
    Applicant: Corixa Corporation
    Inventors: Yuqiu Jiang, Susan L. Harlocker, Heather Secrist, Aijun Wang, John A. Stolk
  • Compositions and methods for the diagnosis and threatment of herpes simplex virus infection
    Publication number: 20030068327
    Abstract: Compounds and methods for the diagnosis and treatment of HSV infection are provided. The compounds comprise polypeptides that contain at least one antigenic portion of an HSV polypeptide and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits are also provided comprising such polypeptides and/or DNA sequences and a suitable detection reagent for the detection of HSV infection in patients and in biological samples.
    Type: Application
    Filed: April 11, 2002
    Publication date: April 10, 2003
    Applicant: Corixa Corporation
    Inventors: Nancy Ann Hosken, Patrick McGowan, Paul R. Sleath, Sally P. Mossman, Lawrence S. Evans, Ryan M. Swanson, Patricia D. McNeill
  • MHC conjugates useful in ameliorating autoimmunity
    Publication number: 20030068363
    Abstract: The present invention is directed to complexes consisting essentially of an isolated MHC component and an autoantigenic peptide associated with the antigen binding site of the MHC component. These complexes are useful in treating autoimmune disease.
    Type: Application
    Filed: July 19, 2002
    Publication date: April 10, 2003
    Applicant: Anergen, Inc. a wholly-owned subsidiary of Corixa Corporation
    Inventors: Brian R. Clark, Somesh D. Sharma, Bernard L. Lerch
  • Fusion proteins of mycobacterium tuberculosis antigens and their uses
    Patent number: 6544522
    Abstract: The present invention relates to fusion proteins of Mycobacterium tuberclosis antigens. In particular, it relates to two fusion proteins, each of which contains three individual M. tuberculosis antigens, and a fusion protein of two M. tuberculosis antigens, their coding sequences, and methods for their use in the treatment and prevention of tuberculosis.
    Type: Grant
    Filed: December 30, 1998
    Date of Patent: April 8, 2003
    Assignee: Corixa Corporation
    Inventors: Yasir Skeiky, Mark Alderson, Antonio Campos-Neto
  • Compositions and methods for the therapy and diagnosis of lung cancer
    Publication number: 20030064947
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
    Type: Application
    Filed: November 30, 2001
    Publication date: April 3, 2003
    Applicant: Corixa Corporation
    Inventors: Tongtong Wang, Aijun Wang, Yasir A. W. Skeiky, Samuel X. Li, Michael D. Kalos, Robert A. Henderson, Patricia D. McNeill, Neil Fanger, Marc W. Retter, Margarita Durham, Gary R. Fanger, Thomas S. Vedvick, Darrick Carter, Yoshihiro Watanabe, David W. Peckham, Feng Cai, Teresa M. Foy
  • Compositions and methods for the therapy and diagnosis of ovarian and endometrial cancer
    Publication number: 20030059781
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as ovarian or endometrial cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses such an antigen, or a T cell that is specific for cells expressing such an antigen. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian and endometrial cancer. Diagnostic methods based on detecting an ovarian carcinoma protein, or mRNA encoding such an antigen, in a sample are also provided.
    Type: Application
    Filed: November 28, 2001
    Publication date: March 27, 2003
    Applicant: Corixa Corporation
    Inventors: Ruth A. Chenault, Jiangchun Xu
  • Compositions and methods for the diagnosis and treatment of herpes simplex virus infection
    Patent number: 6537555
    Abstract: Compounds and methods for the diagnosis and treatment of HSV infection are provided. The compounds comprise polypeptides that contain at least one antigenic portion of an HSV polypeptide and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits are also provided comprising such polypeptides and/or DNA sequences and a suitable detection reagent for the detection of HSV infection in patients and in biological samples.
    Type: Grant
    Filed: June 28, 2001
    Date of Patent: March 25, 2003
    Assignee: Corixa Corporation
    Inventors: Nancy A. Hosken, Craig H. Day, Davin C. Dillon, Patrick McGowan, Paul R. Sleath
  • Compositions and methods for the therapy and diagnosis of lung cancer
    Publication number: 20030054363
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
    Type: Application
    Filed: October 29, 2001
    Publication date: March 20, 2003
    Applicant: Corixa Corporation
    Inventors: Robert A. Henderson, Tongtong Wang, Yoshihiro Watanabe, Jeffrey C. Johnson, Marc W. Retter, Margarita Durham, Darrick Carter, Gary R. Fanger, Thomas S. Vedvick, Chaitanya S. Bangur, Andria McNabb
  • Compositions and methods for the therapy and diagnosis of lung cancer
    Patent number: 6531315
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as lung cancer, are disclosed. Compositions may comprise one or more lung tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a lung tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as lung cancer. Diagnostic methods based on detecting a lung tumor protein, or mRNA encoding such a protein, in a sample are also provided.
    Type: Grant
    Filed: June 28, 2000
    Date of Patent: March 11, 2003
    Assignee: Corixa Corporation
    Inventors: Tongtong Wang, Liqun Fan, Michael D. Kalos, Chaitanya S. Bangur, Nancy A. Hosken, Gary R. Fanger, Samuel X. Li, Aijun Wang, Yasir A. W. Skeiky
  • Compositions and methods for the therapy, diagnosis and monitoring of breast cancer
    Publication number: 20030045468
    Abstract: Compositions and methods for the therapy, diagnosis and monitoring of breast cancer are disclosed. Compositions may comprise one or more mammaglobin epitopes, or antibodies or T cells thereto, and may be used, for example, for the prevention and treatment of breast cancer. Diagnostic methods based on detecting the presence of mammaglobin epitopes, or antibodies or T cells thereto, in a sample are also provided. Also provided are methods for detecting RNA encoding mammaglobin in patient blood or fractions thereof. These methods may be used to detect and/or monitor the progression of breast cancer.
    Type: Application
    Filed: January 8, 2002
    Publication date: March 6, 2003
    Applicant: Corixa Corporation
    Inventors: Steven P. Fling, Teresa M. Foy, Jonathan D. Clapper, Aijun Wang, Jeffrey C. Johnson, Patricia D. McNeill, R. Alec Sutherland