Patents Assigned to Corixa
  • Compositions and methods for the therapy and diagnosis of breast cancer
    Patent number: 6528054
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as breast cancer, are disclosed. Compositions may comprise one or more breast tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a breast tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as breast cancer. Diagnostic methods based on detecting a breast tumor protein, or mRNA encoding such a protein, in a sample are also provided.
    Type: Grant
    Filed: July 20, 2000
    Date of Patent: March 4, 2003
    Assignee: Corixa Corporation
    Inventors: Yuqiu Jiang, Davin C. Dillon, Jennifer L. Mitcham, Jiangchun Xu, Susan L. Harlocker, William T. Hepler
  • Compositions and methods for diagnosis of ovarian cancer
    Patent number: 6528253
    Abstract: Compositions and methods for the diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof or polynucleotides that encode such portions. Such compositions may be used, for example, for the detecting and monitoring diseases such as ovarian cancer.
    Type: Grant
    Filed: December 17, 1998
    Date of Patent: March 4, 2003
    Assignee: Corixa Corporation
    Inventors: Jennifer L. Mitcham, Tony N. Frudakis, Gordon E. King
  • Compositions and methods for WT1 specific immunotherapy
    Publication number: 20030039635
    Abstract: Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that specifically binds to a WT1 polypeptide; or a T cell that specifically reacts with a WT1 polypeptide. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases.
    Type: Application
    Filed: April 16, 2002
    Publication date: February 27, 2003
    Applicant: Corixa Corporation
    Inventors: Alexander Gaiger, Molly D. Smithgall, Darrick Carter, Martin A. Cheever, Patricia D. McNeill, R. Alec Sutherland
  • Immunoeffector compounds
    Patent number: 6525028
    Abstract: This invention provides compounds containing a 2-deoxy-2-amino-&bgr;-D-glucopyranose (glucosamine) glycosidically linked to an cyclic aminoalkyl (aglycon) group. The invention further provides methods for inducing an immune response using the compounds of the present invention in the presence or absence of an antigen. In addition, methods for treating disease with the compounds of the present invention with or without an antigen are also provided in this invention.
    Type: Grant
    Filed: February 4, 2002
    Date of Patent: February 25, 2003
    Assignee: Corixa Corporation
    Inventors: David A. Johnson, Jory R. Baldridge, C. Gregory Sowell, Christopher W. Cluff
  • Methods for the production of 3-O-deactivated-4'-monophosphoryl lipid a (3D-MLA)
    Publication number: 20030031684
    Abstract: Herein is disclosed a method for producing lipopolysaccharide (LPS), comprising: (a) growing a culture of a deep rough mutant bacterial strain in a medium; (b) maintaining the culture in stationary phase for at least about 5 hr; (c) harvesting cells from the culture; and (d) extracting LPS from the cells. The method allows for the production of an LPS which can be used to produce a 3-O-deacylated monophosphoryl lipid A (3D-MLA) having at least about 20 mol % of the hexaacyl congener group.
    Type: Application
    Filed: March 14, 2002
    Publication date: February 13, 2003
    Applicant: Corixa Corporation
    Inventors: Kent R. Myers, D. Scott Snyder
  • Compounds and methods for therapy and diagnosis of lung cancer
    Patent number: 6518256
    Abstract: Compounds and methods for the treatment and diagnosis of lung cancer are provided. The inventive compounds include polypeptides containing at least a portion of a lung tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of lung cancer comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided, together with DNA molecules for preparing the inventive polypeptides.
    Type: Grant
    Filed: April 4, 2000
    Date of Patent: February 11, 2003
    Assignee: Corixa Corporation
    Inventors: Tongtong Wang, Liqun Fan, Michael D. Kalos, Chaitanya S. Bangur, Nancy A. Hosken, Gary R. Fanger
  • Compositions for treatment and diagnosis of breast cancer and methods for their use
    Patent number: 6518237
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as breast cancer, are disclosed. Compositions may comprise one or more breast tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a breast tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as breast cancer. Diagnostic methods based on detecting a breast tumor protein, or mRNA encoding such a protein, in a sample are also provided.
    Type: Grant
    Filed: September 2, 1999
    Date of Patent: February 11, 2003
    Assignee: Corixa Corporation
    Inventors: Jiang Yuqiu, Davin C. Dillon, Jennifer L. Mitcham, Jiangchun Xu
  • Compositions and methods for the therapy and diagnosis of breast cancer
    Publication number: 20030023036
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
    Type: Application
    Filed: February 13, 2002
    Publication date: January 30, 2003
    Applicant: Corixa Corporation
    Inventors: Raymond L. Houghton, Paul R. Sleath, David H. Persing
  • Compositions and methods for the therapy and diagnosis of prostate cancer
    Patent number: 6512094
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.
    Type: Grant
    Filed: June 13, 2000
    Date of Patent: January 28, 2003
    Assignee: Corixa Corporation
    Inventors: Jiangchun Xu, Davin C. Dillon, Jennifer L. Mitcham, Susan L. Harlocker, Yuqiu Jiang, Michael D. Kalos, Gary R. Fanger, Marc W. Retter, John A. Stolk, Craig H. Day, Thomas S. Vedvick, Darrick Carter, Samuel X. Li, Aijun Wang, Yasir A. W. Skeiky, William T. Hepler, Robert A. Henderson
  • Compositions and methods for the therapy and diagnosis of colon cancer
    Publication number: 20030017167
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as colon cancer, are disclosed. Compositions may comprise one or more colon tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a colon tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as colon cancer. Diagnostic methods based on detecting a colon tumor protein, or mRNA encoding such a protein, in a sample are also provided.
    Type: Application
    Filed: July 11, 2001
    Publication date: January 23, 2003
    Applicant: Corixa Corporation
    Inventor: Yuqiu Jiang
  • Compositions and methods for the therapy and diagnosis of lung cancer
    Patent number: 6509448
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
    Type: Grant
    Filed: December 13, 2000
    Date of Patent: January 21, 2003
    Assignee: Corixa Corporation
    Inventors: Tongtong Wang, Chaitanya S. Bangur, Michael J. Lodes, Gary R. Fanger, Thomas S. Vedvick, Darrick Carter, Marc W. Retter, Jane Mannion, Liqun Fan, Aijun Wang
  • Compositions and methods for the therapy and diagnosis of ovarian cancer
    Publication number: 20030008299
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses an ovarian tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian cancer. Diagnostic methods based on detecting an ovarian tumor protein, or mRNA encoding such a protein, in a sample are also provided.
    Type: Application
    Filed: December 12, 2001
    Publication date: January 9, 2003
    Applicant: Corixa Corporation
    Inventor: Paul A. Algate
  • Compositions and methods for the therapy and diagnosis of lung cancer
    Patent number: 6504010
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
    Type: Grant
    Filed: October 30, 2000
    Date of Patent: January 7, 2003
    Assignee: Corixa Corporation
    Inventors: Tongtong Wang, Chaitanya S. Bangur, Michael J. Lodes, Gary R. Fanger, Thomas S. Vedvick, Darrick Carter, Marc W. Retter, Jane Mannion, Liqun Fan
  • Leishmania antigens for use in the therapy and diagnosis of leishmaniasis
    Patent number: 6500437
    Abstract: Compositions and methods for preventing, treating and detecting leishmaniasis and stimulating immune responses in patients are disclosed. The compounds provided include polypeptides that contain at least an immunogenic portion of one or more Leishmania antigens, or a variant thereof. Vaccines and pharmaceutical compositions comprising such polypeptides, or polynucleotides encoding such polypeptides, are also provided and may be used, for example, for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmania infection.
    Type: Grant
    Filed: April 14, 2000
    Date of Patent: December 31, 2002
    Assignee: Corixa Corporation
    Inventors: Steven G. Reed, Antonio Campos-Neto, John R. Webb, Davin C. Dillon, Yasir A. W. Skeiky, Ajay Bhatia
  • Compositions and methods for the therapy and diagnosis of Her-2/neu-associated malignancies
    Publication number: 20020193329
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly Her-2/neu-associated cancers, are disclosed. Illustrative compositions comprise one or more Her-2/neu polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of Her-2/neu-associated malignancies.
    Type: Application
    Filed: August 14, 2001
    Publication date: December 19, 2002
    Applicant: Corixa Corporation
    Inventors: Susan Hand-Zimmermann, Martin A. Cheever, Teresa M. Foy, Michael J. Lodes, Michael D. Kalos, Patricia D. McNeill, Thomas S. Vedvick
  • Aqueous immunologic adjuvant compostions of monophosphoryl lipid A
    Patent number: 6491919
    Abstract: An aqueous adjuvant composition comprising an attenuated lipid A derivative and a non-immunostimulatory surfactant or surfactants enhances the immunological response in a warm blooded animal to a protein antigen. Attenuated lipid A derivatives useful according to the subject invention include monophosphoryl lipid A and 3-O-deacylated monophosphoryl lipid A. A surfactant or mixtures of surfactants are dissolved in a solvent. 1,2 Dipalmitoyl-sn-glycero-3-phosphocholine is a preferred surfactant. The dissolved surfactant is added to an attenuated lipid A derivative to obtain a mixture. The molar ratio of attenuated lipid A derivative to surfactant in the mixture is about 4:1. The solvent is evaporated and water is added to the resulting film. The suspension is sonicated in a 60° C. water bath until it becomes clear.
    Type: Grant
    Filed: June 22, 1999
    Date of Patent: December 10, 2002
    Assignee: Corixa Corporation
    Inventor: R. Thomas Crane
  • Compositions and methods for the therapy and diagnosis of lung cancer
    Publication number: 20020183499
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
    Type: Application
    Filed: May 11, 2001
    Publication date: December 5, 2002
    Applicant: Corixa Corporation
    Inventors: Michael J. Lodes, Raodoh Mohamath, Robert A. Henderson, Darin R. Benson, Heather Secrist
  • Compounds for immunotherapy and diagnosis of colon cancer and methods for their use
    Publication number: 20020182191
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as colon cancer, are disclosed. Compositions may comprise one or more colon tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a colon tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as colon cancer. Diagnostic methods based on detecting a colon tumor protein, or mRNA encoding such a protein, in a sample are also provided.
    Type: Application
    Filed: December 19, 2001
    Publication date: December 5, 2002
    Applicant: Corixa Corporation
    Inventors: Jiangchun Xu, Michael J. Lodes, Heather Secrist, Darin R. Benson, Madeleine Joy Meagher, John A. Stolk, Tongtong Wang, Yuqiu Jiang, Carole L. Smith, Gordon E. King, Aijun Wang, Jonathan D. Clapper, Yasir A.W. Skeiky, Gary R. Fanger, Thomas S. Vedvick, Darrick Carter
  • Compositions and methods for the therapy and diagnosis of prostate cancer
    Publication number: 20020183251
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.
    Type: Application
    Filed: December 10, 2001
    Publication date: December 5, 2002
    Applicant: Corixa Corporation
    Inventors: Jiangchun Xu, Davin C. Dillon, Jennifer L. Mitcham, Susan L. Harlocker, Yuqiu Jiang, Michael D. Kalos, Gary R. Fanger, Marc W. Retter, John A. Stolk, Craig H. Day, Thomas S. Vedvick, Darrick Carter, Samuel X. Li, Aijun Wang, Yasir A.W. Skeiky, William T. Hepler, Robert A. Henderson, John Hural, Patricia D. McNeill, Raymond L. Houghton, Carlota Vinals y de Bassols, Teresa M. Foy, Yoshihiro Watanabe, Madeleine Joy Meagher
  • Compositions and methods for therapy and diagnosis of breast cancer
    Patent number: 6489101
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as breast cancer, are disclosed. Compositions may comprise one or more breast tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a breast tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as breast cancer. Diagnostic methods based on detecting a breast tumor protein, or mRNA encoding such a protein, in a sample are also provided.
    Type: Grant
    Filed: November 30, 1999
    Date of Patent: December 3, 2002
    Assignee: Corixa Corporation
    Inventor: Davin C. Dillon