Patents Assigned to Corixa
  • Immunodominant acetylcholine receptor alpha subunit peptide: MHC complexes
    Publication number: 20030144477
    Abstract: The present invention is directed to the treatment of autoimmune diseases, in particular of myasthenia gravis. This invention provides novel autoimmune dominant peptides derived from the acetylcholine receptor, as well as methods for preparing the peptides. The present invention further provides complexes comprising these peptides associated with an appropriate major histocompatibility complex (MHC) molecule and methods for making these complexes. The complexes of the present invention can be used therapeutically or prophylactically for treating myasthenia gravis.
    Type: Application
    Filed: September 30, 2002
    Publication date: July 31, 2003
    Applicant: Corixa Corporation
    Inventors: Edward Spack, Subhashini Arimilli, Shrikant Deshpande, Nancy Wehner
  • Compositions and methods for the therapy and diagnosis of ovarian cancer
    Publication number: 20030144494
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly ovarian cancer.
    Type: Application
    Filed: October 2, 2002
    Publication date: July 31, 2003
    Applicant: Corixa Corporation
    Inventors: Paul A. Algate, Jane Mannion
  • Compositions and methods for the therapy and diagnosis of lung cancer
    Publication number: 20030138438
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
    Type: Application
    Filed: April 5, 2002
    Publication date: July 24, 2003
    Applicant: Corixa Corporation
    Inventors: Barbara Mericle, Gary R. Fanger, Thomas S. Vedvick, Darrick Carter, Yoshihiro Watanabe, Robert A. Henderson, Michael D. Kalos, A. Gregory Spies, Teresa M. Foy, Liqun Fan, Tongtong Wang
  • Compounds and methods for diagnosis of tuberculosis
    Publication number: 20030135026
    Abstract: Compounds and methods for diagnosing tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of one or more M. tuberculosis proteins, and DNA sequences encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of M. tuberculosis infection in patients and biological samples. Antibodies directed against such polypeptides are also provided.
    Type: Application
    Filed: July 10, 2002
    Publication date: July 17, 2003
    Applicant: Corixa Corporation
    Inventors: Steven G. Reed, Yasir A.W. Skeiky, Davin C. Dillon, Antonio Campos-Neto, Raymond Houghton, Thomas S. Vedvick, Daniel R. Twardzik, Michael J. Lodes, Ronald C. Hendrickson
  • Compounds and methods for immunotherapy and diagnosis of tuberculosis
    Patent number: 6592877
    Abstract: Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more M. tuberculosis proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against M. tuberculosis infection, or may be used for the diagnosis of tuberculosis.
    Type: Grant
    Filed: May 5, 1998
    Date of Patent: July 15, 2003
    Assignee: Corixa Corporation
    Inventors: Steven G. Reed, Yasir A. W. Skeiky, Davin C. Dillon, Antonio Campos-Neto, Raymond Houghton, Thomas S. Vedvick, Daniel R. Twardzik, Michael J. Lodes, Ronald C. Hendrickson
  • Compositions and methods for the therapy and diagnosis of colon cancer
    Publication number: 20030129207
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly colon cancer, are disclosed. Illustrative compositions comprise one or more colon tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly colon cancer.
    Type: Application
    Filed: August 20, 2002
    Publication date: July 10, 2003
    Applicant: Corixa Corporation
    Inventors: Madeleine Joy Meagher, Gordon E. King, Heather Secrist, Yuqiu Jiang, John A. Stolk
  • Compositions and methods for the therapy and diagnosis of ovarian cancer
    Publication number: 20030129192
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly ovarian cancer.
    Type: Application
    Filed: August 2, 2002
    Publication date: July 10, 2003
    Applicant: Corixa Corporation
    Inventors: Ruth A. Chenault, Jiangchun Xu, Gary R. Fanger, Susan L. Harlocker, Patricia D. McNeill
  • Compositions for the treatment and diagnosis of breast cancer and methods for their use
    Patent number: 6590076
    Abstract: Compounds and methods for the treatment and diagnosis of breast cancer are provided. The inventive compounds include polypeptides containing at least a portion of a breast tumor antigen. Vaccines and pharmaceutical compositions for immunotherapy of breast cancer comprising such polypeptides, or polynucleotides encoding such polypeptides, are provided, together with polynucleotides for preparing the inventive polypeptides. The inventive polypeptides may be used to generate antibodies useful for the diagnosis and monitoring of breast cancer.
    Type: Grant
    Filed: April 2, 1999
    Date of Patent: July 8, 2003
    Assignee: Corixa Corporation
    Inventors: Jiang Yuqiu, Davin C. Dillon, Jennifer L. Mitcham, Jiangchun Xu
  • Compositions and methods for the therapy and diagnosis of ovarian cancer
    Publication number: 20030124140
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly ovarian cancer.
    Type: Application
    Filed: July 17, 2002
    Publication date: July 3, 2003
    Applicant: Corixa Corporation
    Inventors: Chaitanya S. Bangur, Marc W. Retter, Gary R. Fanger, Paul Hill
  • Compositions and methods for the therapy and diagnosis of breast cancer
    Publication number: 20030125536
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
    Type: Application
    Filed: August 2, 2002
    Publication date: July 3, 2003
    Applicant: Corixa Corporation
    Inventors: Gary R. Fanger, Shannon Kathleen Hirst, Davin C. Dillon, Teresa M. Foy, Raymond L. Houghton, David H. Persing, Michael D. Kalos
  • Compositions and methods for the therapy and diagnosis of breast cancer
    Patent number: 6586572
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as breast cancer, are disclosed. Compositions may comprise one or more breast tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a breast tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as breast cancer. Diagnostic methods based on detecting a breast tumor protein, or mRNA encoding such a protein, in a sample are also provided.
    Type: Grant
    Filed: June 22, 2000
    Date of Patent: July 1, 2003
    Assignee: Corixa Corporation
    Inventors: Yuqiu Jiang, Davin C. Dillon, Jennifer L. Mitcham, Jiangchun Xu, Susan L. Harlocker, William T. Hepler
  • Compositions and methods for the treatment and diagnosis of breast cancer
    Patent number: 6586570
    Abstract: Compositions and methods for the detection and therapy of breast cancer are disclosed. The compounds provided include nucleotide sequences that are preferentially expressed in breast tumor tissue, as well as polypeptides encoded by such nucleotide sequences. Vaccines and pharmaceutical compositions comprising such compounds are also provided and may be used, for example, for the prevention and treatment of breast cancer. The polypeptides may also be used for the production of antibodies, which are useful for diagnosing and monitoring the progression of breast cancer in a patient.
    Type: Grant
    Filed: April 9, 1999
    Date of Patent: July 1, 2003
    Assignee: Corixa Corporation
    Inventors: Tony N. Frudakis, Steven G. Reed, John M. Smith, Lynda Misher
  • Compositions and methods for the therapy and diagnosis of lung cancer
    Publication number: 20030118599
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
    Type: Application
    Filed: May 10, 2002
    Publication date: June 26, 2003
    Applicant: Corixa Corporation
    Inventors: Paul A. Algate, Michael J. Lodes, Tongtong Wang, Liqun Fan, Patricia D. McNeill
  • Compositions for the treatment and diagnosis of breast cancer and methods for their use
    Patent number: 6579973
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as breast cancer, are disclosed. Compositions may comprise one or more breast tumor proteins, immunogenic portion thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a breast tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as breast cancer. Diagnostic methods based on detecting a breast tumor protein, or mRNA encoding such a protein, in a sample are also provided.
    Type: Grant
    Filed: November 3, 1999
    Date of Patent: June 17, 2003
    Assignee: Corixa Corporation
    Inventors: Jiang Yuqiu, Davin C. Dillon, Jennifer L. Mitcham, Jiangchun Xu, Susan L. Harlocker
  • Compositions and methods for the therapy and diagnosis of kidney cancer
    Publication number: 20030109434
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly kidney cancer, are disclosed. Illustrative compositions comprise one or more kidney tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly kidney cancer.
    Type: Application
    Filed: March 19, 2002
    Publication date: June 12, 2003
    Applicant: Corixa Corporation
    Inventors: Paul A. Algate, Jane Mannion, Alexander Gaiger, Brian Gordon, Susan L. Harlocker
  • HLA-DR2 binding peptides
    Publication number: 20030103993
    Abstract: The invention provides a polypeptide sequence, GHIKSSISFMGM, that disrupts binding of the amino acid sequence peptides of myelin basic protein (MBP) to HLA-DR2 class II MHC molecules and acts as an antagonist in DR2-restricted antigen presentation to human T cell clones. In particular, the invention provides the polypeptide sequence itself and variants, compositions comprising the polypeptide, polynucleotides encoding the polypeptide, and methods for using the polypeptides and polynucleotides for treating autoimmune disorders.
    Type: Application
    Filed: December 12, 2001
    Publication date: June 5, 2003
    Applicant: Corixa Corporation
    Inventors: Shrikant Deshpande, Subhashini Arimilli, Kalidip Choudhury
  • Compositions and methods for the therapy and diagnosis of lung cancer
    Publication number: 20030103994
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
    Type: Application
    Filed: April 1, 2002
    Publication date: June 5, 2003
    Applicant: Corixa Corporation
    Inventors: Yoshihiro Watanabe, Robert A. Henderson, Michael D. Kalos
  • Vaccines for the treatment of autoimmune disease
    Publication number: 20030104012
    Abstract: The present invention provides pharmaceutical compositions comprising M. vaccae cells for treatment of autoimmune diseases such as diabetes, multiple sclerosis, rheumatoid arthritis, and scleroderma. The compositions may comprise either killed cells or delipidated and deglycolipidated cells.
    Type: Application
    Filed: May 13, 2002
    Publication date: June 5, 2003
    Applicant: Corixa Corporation
    Inventors: Nannette Solvason, Simonetta Mocci
  • Compositions for the treatment and diagnosis of breast cancer and methods for their use
    Patent number: 6573368
    Abstract: Compounds and methods for the treatment and diagnosis of breast cancer are provided. The inventive compounds include polypeptides containing at least a portion of breast tumor antigen. Vaccines and pharmaceutical compositions for immunotherapy of breast cancer comprising such polypeptides, or polynucleotides encoding such polypeptides, are provided, together with polynucleotides for preparing the inventive polypeptides. The inventive polypeptides may be used to generate antibodies useful for the diagnosis and monitoring of breast cancer.
    Type: Grant
    Filed: June 23, 1999
    Date of Patent: June 3, 2003
    Assignee: Corixa Corporation
    Inventors: Jiang Yuqiu, Davin C. Dillon, Jennifer L. Mitcham, Jiangchun Xu
  • Compounds and methods for the diagnosis and treatment of B. microti infection
    Patent number: 6569433
    Abstract: Compounds and methods for the diagnosis and treatment of B. microti infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a B. microti antigen and DNA sequences encoding such polypeptides. Antigenic epitopes of such antigens are also provided, together with pharmaceutical compositions and vaccines comprising such polypeptides, DNA sequences or antigenic epitopes. Diagnostic kits containing such polypeptides, DNA sequences or antigenic epitopes and a suitable detection reagent may be used for the detection of B. microti infection in patients and biological samples. Antibodies directed against such polypeptides and antigenic epitopes are also provided.
    Type: Grant
    Filed: May 10, 2000
    Date of Patent: May 27, 2003
    Assignee: Corixa Corporation
    Inventors: Steven G. Reed, Michael J. Lodes, Raymond L. Houghton, Paul R. Sleath, Patricia D. McNeill, Mary J. Homer, Heather Secrist