Patents Assigned to CorMatrix Cardiovascular, Inc.
  • Patent number: 10624993
    Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.
    Type: Grant
    Filed: July 18, 2017
    Date of Patent: April 21, 2020
    Assignee: CorMatrix Cardiovascular, INC.
    Inventor: Robert G Matheny
  • Patent number: 10512710
    Abstract: Cardiovascular prostheses for treating, reconstructing and replacing damaged or diseased cardiovascular tissue that are formed from acellular extracellular matrix (ECM). The cardiovascular prostheses comprise various compositions, such as ECM based compositions, and structures, such as particulate and sheet structures.
    Type: Grant
    Filed: September 13, 2018
    Date of Patent: December 24, 2019
    Assignee: CorMatrix Cardiovascular Inc.
    Inventor: Robert G Matheny
  • Patent number: 10512711
    Abstract: The invention is to articles made from extracellular matrix sheets that encase biodegradable polymeric material. Methods of healing wounds or regenerating tissue at sites of defect by placing said articles in mammals are claimed. The biodegradable polymer can change quality upon contact with a physiological parameter such as temperature or pH that causes, for example, a liquid polymer to gel or harden. The degradation of the polymer can be controlled to suit a tissue regeneration or wound healing time course. Additional components such as proteins, cells and drugs can be added to the biopolymer composition.
    Type: Grant
    Filed: April 9, 2015
    Date of Patent: December 24, 2019
    Assignee: CORMATRIX CARDIOVASCULAR, INC
    Inventor: Robert G Matheny
  • Patent number: 10383977
    Abstract: Polymeric grafts for treating damaged biological tissue that are formed from poly(glycerol sebacate) (PGS). The PGS grafts preferably comprise a bioactive agent comprising anti-inflammatory corticosteroids, anti-oxidants, anti-thrombotic agents and anti-platelet agents. The PGS grafts can also comprise a HMG-CoA reductase inhibitor.
    Type: Grant
    Filed: January 23, 2018
    Date of Patent: August 20, 2019
    Assignee: CorMatrix Cardiovascular, Inc
    Inventor: Robert G Matheny
  • Patent number: 10201636
    Abstract: Cardiovascular prostheses for treating, reconstructing and replacing damaged or diseased cardiovascular tissue that are formed from acellular extracellular matrix (ECM). The cardiovascular prostheses comprise various compositions, such as ECM based compositions, and structures, such as particulate structures, mesh constructs, encasement structures, coated structures and multi-sheet laminate structures.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: February 12, 2019
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventor: Robert G Matheny
  • Patent number: 10188510
    Abstract: A prosthetic valve comprising a conical shaped sheet member comprising an extracellular matrix (ECM) composition, the sheet member having a plurality of ribbons projecting the sheet member proximal end, the distal ends of the ribbons being positioned proximate each other, wherein the sheet member comprises a conical shape.
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: January 29, 2019
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventors: Robert G Matheny, Minh X Vo, Carlos C Chang, Selvamuthu K Natarajan
  • Patent number: 10188513
    Abstract: A prosthetic valve comprising a conical shaped sheet member comprising an extracellular matrix (ECM) composition and an internal multi-link support stent structure, the sheet member having a plurality of open slit regions that are disposed uniformly on linear planes that are parallel to the sheet member longitudinal axis, and a proximal annulus engagement end diameter and length ratio in the range of 5:1 to 2:1.
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: January 29, 2019
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventors: Robert G Matheny, Minh X Vo, Carlos C Chang, Selvamuthu K Natarajan
  • Patent number: 10188509
    Abstract: A prosthetic valve comprising a conical shaped sheet member comprising an extracellular matrix (ECM) composition, the sheet member having a plurality of open slit regions that are disposed uniformly on linear planes that are parallel to the sheet member longitudinal axis, and a proximal annulus engagement end diameter and length ratio in the range of 5:1 to 2:1.
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: January 29, 2019
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventors: Robert G Matheny, Minh X Vo, Carlos C Chang, Selvamuthu K Natarajan
  • Patent number: 10143778
    Abstract: Cardiovascular prostheses for treating, reconstructing and replacing damaged or diseased cardiovascular tissue that are formed from acellular extracellular matrix (ECM). The cardiovascular prostheses comprise various compositions, such as ECM based compositions, and structures, such as particulate structures, mesh constructs, encasement structures, coated structures and multi-sheet laminate structures.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: December 4, 2018
    Assignee: CORMATRIX CARDIOVASCULAR, INC
    Inventor: Robert G Matheny
  • Patent number: 10052409
    Abstract: A prosthetic valve comprising a plurality of ribbons comprising an extracellular matrix (ECM) composition, the proximal ends of the plurality of ribbons being positioned circumferentially and proximate each other, the distal ends of the plurality of ribbons also being positioned proximate each other, wherein a conical shaped valve member is formed.
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: August 21, 2018
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventors: Robert G Matheny, Minh X Vo, Carlos C Chang, Selvamuthu K Natarajan
  • Patent number: 10052189
    Abstract: Vascular grafts for treating, reconstructing and replacing damaged or diseased cardiovascular vessels that are formed from decellularized extracellular matrix (ECM). The vascular grafts include structural reinforcement means, such as a strand of wound biodegradable polymeric material disposed proximate the outer surface of the graft.
    Type: Grant
    Filed: July 22, 2014
    Date of Patent: August 21, 2018
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventor: Robert G Matheny
  • Patent number: 9919079
    Abstract: Cardiovascular prostheses for treating, reconstructing and replacing damaged or diseased cardiovascular tissue that are formed from acellular extracellular matrix (ECM). The cardiovascular prostheses comprise various compositions, such as ECM based compositions, and structures, such as particulate structures, mesh constructs, encasement structures, coated structures and multi-sheet laminate structures.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: March 20, 2018
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventor: Robert G Matheny
  • Patent number: 9907649
    Abstract: A prosthetic atrioventricular tissue valve comprising a continuous tubular member formed from a first biocompatible material, the tubular member having proximal and distal ends, and at least one valve leaflet formed therein, the distal end of the tubular member including cardiovascular structure engagement means for connecting the tubular member to a cardiovascular structure, the cardiovascular structure engagement means comprising a plurality of elongated members that extend distally from the distal end of the tubular member.
    Type: Grant
    Filed: December 5, 2015
    Date of Patent: March 6, 2018
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventor: Robert Matheny
  • Patent number: 9867906
    Abstract: Cardiovascular prostheses for treating, reconstructing and replacing damaged or diseased cardiovascular tissue that are formed from acellular extracellular matrix (ECM). The cardiovascular prostheses comprise various compositions, such as ECM based compositions, and structures, such as particulate structures, mesh constructs, encasement structures, coated structures and multi-sheet laminate structures.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: January 16, 2018
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventor: Robert G Matheny
  • Patent number: 9867696
    Abstract: An expandable support member comprising an ECM composition that is configured to engage an interior region of a prosthetic valve and capable of transitioning from a pre-deployment configuration, where the support member is capable of being positioned at an interior valve region of the valve when the valve is disposed at a cardiovascular valve structure, to a post-deployment configuration when the support member absorbs a first bodily fluid and expands, where an outer surface region of the valve is placed in intimate contact with host cardiovascular tissue of the cardiovascular structure at a first position and seals perivalvular leaks present at the first cardiovascular structure position.
    Type: Grant
    Filed: July 18, 2017
    Date of Patent: January 16, 2018
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventor: Robert G Matheny
  • Patent number: 9744264
    Abstract: A bioremodelable encasement structure comprising a pouch formed from at least one sheet of bioremodelable material, the pouch including an internal region that is configured to receive a device therein, the bioremodelable material comprising mesothelial tissue.
    Type: Grant
    Filed: December 16, 2014
    Date of Patent: August 29, 2017
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventor: Robert G Matheny
  • Patent number: 9744261
    Abstract: Bioremodelable tissue prostheses having a vasculature that is infused with a biomaterial composition.
    Type: Grant
    Filed: March 23, 2015
    Date of Patent: August 29, 2017
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventors: Robert G Matheny, Craig N Ferrante
  • Patent number: 9737399
    Abstract: An expandable member that is configured to engage an interior region of a prosthetic valve and capable of transitioning from a pre-deployment configuration at a pre-deployment temperature, where the expandable member is capable of being positioned in the valve at an interior valve region when the valve is disposed in a cardiovascular structure, to a post-deployment configuration when the expandable member is subjected to cardiovascular tissue temperature, where an outer surface region of the valve proximate the interior valve region is placed in intimate contact with host cardiovascular tissue of the cardiovascular structure at a first position and seals perivalvular leaks present at the first cardiovascular structure position.
    Type: Grant
    Filed: September 11, 2014
    Date of Patent: August 22, 2017
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventor: Robert G Matheny
  • Patent number: 9737569
    Abstract: ECM based compositions including amniotic membrane and methods for employing same to treat cardiovascular disorders.
    Type: Grant
    Filed: March 11, 2015
    Date of Patent: August 22, 2017
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventor: Robert G Matheny
  • Patent number: 9700654
    Abstract: A multi-sheet extracellular matrix (ECM) structure for tissue regeneration, the ECM structure having joined first and second ECM sheet members and an agent dispersal network disposed between the sheets, the dispersal network being configured to receive and transfer a bioactive agent through the network and, when the ECM structure is attached to tissue, administer the bioactive agent to the tissue.
    Type: Grant
    Filed: August 6, 2014
    Date of Patent: July 11, 2017
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventors: Robert G Matheny, Craig N Ferrante