Patents Assigned to CorMatrix Cardiovascular, Inc.
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Patent number: 11903833Abstract: A conical shaped venous valve structure formed from collagenous mammalian tissue.Type: GrantFiled: February 17, 2021Date of Patent: February 20, 2024Assignee: Cormatrix Cardiovascular, Inc.Inventor: Robert G Matheny
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Patent number: 11865226Abstract: Cardiovascular prostheses for treating, reconstructing and replacing damaged or diseased cardiovascular tissue that include particulate structures that are formed from PGS, cerivastatin and everolimus. The particulate structures are configured to modulate inflammation of damaged cardiovascular tissue in vivo by increasing expression of Kruppel like factor 2 (KLF-2), whereby localized expression of monocyte chemoattractant protein 1 (MCP-1) and C-C chemokine receptor type 2 (CCR2) is inhibited at transcriptional and translational levels as a function of the KLF-2 modulation.Type: GrantFiled: November 5, 2020Date of Patent: January 9, 2024Assignee: CorMatrix Cardiovascular, Inc.Inventor: Robert G Matheny
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Patent number: 11160903Abstract: A prosthetic valve comprising a conical shaped ribbon structure comprising an extracellular matrix (ECM) composition. The ribbon structure comprises a plurality of elongated ribbon members that are positioned proximate each other in a joined relationship, wherein the ribbon members are positioned adjacent each other and form a plurality of fluid flow modulating regions that open when fluid flow through the valve exhibits a negative flow pressure and open when fluid flow through the valve exhibits a positive flow pressure.Type: GrantFiled: June 13, 2019Date of Patent: November 2, 2021Assignee: CorMatrix Cardiovascular, Inc.Inventor: Robert G Matheny
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Patent number: 11154395Abstract: A prosthetic valve comprising a conical shaped ribbon structure comprising a polymeric composition. The ribbon structure comprises a plurality of elongated ribbon members that are positioned proximate each other in a joined relationship, wherein the ribbon members are positioned adjacent each other and form a plurality of fluid flow modulating regions that open when fluid flow through the valve exhibits a negative flow pressure and open when fluid flow through the valve exhibits a positive flow pressure.Type: GrantFiled: August 28, 2019Date of Patent: October 26, 2021Assignee: CorMatrix Cardiovascular, Inc.Inventor: Robert G Matheny
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Patent number: 10993802Abstract: A biocompatible and biodegradable construct having a base expandable member and an integral, internal support structure. The support structure is preferably formed from poly(glycerol sebacate) (PGS) or a magnesium alloy. The base member is preferably formed from acellular extracellular matrix (ECM) derived from small intestine submucosa (SIS) tissue that exhibits a flexible, porous, sponge-like structure adapted to expand upon absorption of a bodily fluid, wherein the construct seals a perivalvular leak when disposed proximate thereto.Type: GrantFiled: December 8, 2017Date of Patent: May 4, 2021Assignee: CorMatrix Cardiovascular, Inc.Inventor: Robert G Matheny
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Patent number: 10952843Abstract: A prosthetic valve comprising a conical shaped ribbon structure comprising an extracellular matrix (ECM) composition. The ribbon structure comprises a plurality of elongated ribbon members that are positioned proximate each other in a joined relationship, wherein the ribbon members are positioned adjacent each other and form a plurality of fluid flow modulating regions that open when fluid flow through the valve exhibits a negative flow pressure and open when fluid flow through the valve exhibits a positive flow pressure.Type: GrantFiled: September 13, 2018Date of Patent: March 23, 2021Assignee: CorMatrix Cardiovascular, Inc.Inventor: Robert G Matheny
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Patent number: 10864233Abstract: Methods for treating cardiovascular disorders that include administration of an ECM based composition to damaged cardiovascular tissue in conjunction with a treatment remedy, such as ventricular assistance and transmyocardial revascularization (TMR), which induces enhanced bioremodeling of the damaged cardiovascular tissue and regeneration of new cardiovascular tissue and associated structures with site-specific structural and functional properties.Type: GrantFiled: January 23, 2018Date of Patent: December 15, 2020Assignee: CorMatrix Cardiovascular, Inc.Inventor: Robert G Matheny
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Patent number: 10857263Abstract: A percutaneous transseptal surgical implantation method for replacing a defective atrioventricular (AV) valve with a conical shaped prosthetic valve formed from extracellular matrix (ECM) tissue. When the method is employed to replace a native mitral valve, the method positions the prosthetic tissue valve in the mitral valve region, whereby the valve does not obstruct the outflow tract of the aortic valve and prevents the leaflets of the aortic valve from coapting.Type: GrantFiled: January 3, 2019Date of Patent: December 8, 2020Assignee: CorMatrix Cardiovascular, Inc.Inventor: Robert G Matheny
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Patent number: 10744163Abstract: ECM based compositions including acellular ECM and antibiotics, and methods for employing same to treat damaged cardiovascular tissue and, thereby, disorders.Type: GrantFiled: February 22, 2018Date of Patent: August 18, 2020Assignee: CorMatrix Cardiovascular, Inc.Inventor: Robert G Matheny
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Patent number: 10624993Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.Type: GrantFiled: July 18, 2017Date of Patent: April 21, 2020Assignee: CorMatrix Cardiovascular, INC.Inventor: Robert G Matheny
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Patent number: 10512711Abstract: The invention is to articles made from extracellular matrix sheets that encase biodegradable polymeric material. Methods of healing wounds or regenerating tissue at sites of defect by placing said articles in mammals are claimed. The biodegradable polymer can change quality upon contact with a physiological parameter such as temperature or pH that causes, for example, a liquid polymer to gel or harden. The degradation of the polymer can be controlled to suit a tissue regeneration or wound healing time course. Additional components such as proteins, cells and drugs can be added to the biopolymer composition.Type: GrantFiled: April 9, 2015Date of Patent: December 24, 2019Assignee: CORMATRIX CARDIOVASCULAR, INCInventor: Robert G Matheny
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Patent number: 10512710Abstract: Cardiovascular prostheses for treating, reconstructing and replacing damaged or diseased cardiovascular tissue that are formed from acellular extracellular matrix (ECM). The cardiovascular prostheses comprise various compositions, such as ECM based compositions, and structures, such as particulate and sheet structures.Type: GrantFiled: September 13, 2018Date of Patent: December 24, 2019Assignee: CorMatrix Cardiovascular Inc.Inventor: Robert G Matheny
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Patent number: 10383977Abstract: Polymeric grafts for treating damaged biological tissue that are formed from poly(glycerol sebacate) (PGS). The PGS grafts preferably comprise a bioactive agent comprising anti-inflammatory corticosteroids, anti-oxidants, anti-thrombotic agents and anti-platelet agents. The PGS grafts can also comprise a HMG-CoA reductase inhibitor.Type: GrantFiled: January 23, 2018Date of Patent: August 20, 2019Assignee: CorMatrix Cardiovascular, IncInventor: Robert G Matheny
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Patent number: 10201636Abstract: Cardiovascular prostheses for treating, reconstructing and replacing damaged or diseased cardiovascular tissue that are formed from acellular extracellular matrix (ECM). The cardiovascular prostheses comprise various compositions, such as ECM based compositions, and structures, such as particulate structures, mesh constructs, encasement structures, coated structures and multi-sheet laminate structures.Type: GrantFiled: December 21, 2016Date of Patent: February 12, 2019Assignee: CORMATRIX CARDIOVASCULAR, INC.Inventor: Robert G Matheny
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Patent number: 10188510Abstract: A prosthetic valve comprising a conical shaped sheet member comprising an extracellular matrix (ECM) composition, the sheet member having a plurality of ribbons projecting the sheet member proximal end, the distal ends of the ribbons being positioned proximate each other, wherein the sheet member comprises a conical shape.Type: GrantFiled: July 11, 2016Date of Patent: January 29, 2019Assignee: CorMatrix Cardiovascular, Inc.Inventors: Robert G Matheny, Minh X Vo, Carlos C Chang, Selvamuthu K Natarajan
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Patent number: 10188509Abstract: A prosthetic valve comprising a conical shaped sheet member comprising an extracellular matrix (ECM) composition, the sheet member having a plurality of open slit regions that are disposed uniformly on linear planes that are parallel to the sheet member longitudinal axis, and a proximal annulus engagement end diameter and length ratio in the range of 5:1 to 2:1.Type: GrantFiled: July 11, 2016Date of Patent: January 29, 2019Assignee: CORMATRIX CARDIOVASCULAR, INC.Inventors: Robert G Matheny, Minh X Vo, Carlos C Chang, Selvamuthu K Natarajan
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Patent number: 10188513Abstract: A prosthetic valve comprising a conical shaped sheet member comprising an extracellular matrix (ECM) composition and an internal multi-link support stent structure, the sheet member having a plurality of open slit regions that are disposed uniformly on linear planes that are parallel to the sheet member longitudinal axis, and a proximal annulus engagement end diameter and length ratio in the range of 5:1 to 2:1.Type: GrantFiled: July 11, 2016Date of Patent: January 29, 2019Assignee: CORMATRIX CARDIOVASCULAR, INC.Inventors: Robert G Matheny, Minh X Vo, Carlos C Chang, Selvamuthu K Natarajan
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Patent number: 10143778Abstract: Cardiovascular prostheses for treating, reconstructing and replacing damaged or diseased cardiovascular tissue that are formed from acellular extracellular matrix (ECM). The cardiovascular prostheses comprise various compositions, such as ECM based compositions, and structures, such as particulate structures, mesh constructs, encasement structures, coated structures and multi-sheet laminate structures.Type: GrantFiled: December 21, 2016Date of Patent: December 4, 2018Assignee: CORMATRIX CARDIOVASCULAR, INCInventor: Robert G Matheny
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Patent number: 10052189Abstract: Vascular grafts for treating, reconstructing and replacing damaged or diseased cardiovascular vessels that are formed from decellularized extracellular matrix (ECM). The vascular grafts include structural reinforcement means, such as a strand of wound biodegradable polymeric material disposed proximate the outer surface of the graft.Type: GrantFiled: July 22, 2014Date of Patent: August 21, 2018Assignee: CORMATRIX CARDIOVASCULAR, INC.Inventor: Robert G Matheny
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Patent number: 10052409Abstract: A prosthetic valve comprising a plurality of ribbons comprising an extracellular matrix (ECM) composition, the proximal ends of the plurality of ribbons being positioned circumferentially and proximate each other, the distal ends of the plurality of ribbons also being positioned proximate each other, wherein a conical shaped valve member is formed.Type: GrantFiled: July 11, 2016Date of Patent: August 21, 2018Assignee: CORMATRIX CARDIOVASCULAR, INC.Inventors: Robert G Matheny, Minh X Vo, Carlos C Chang, Selvamuthu K Natarajan