Patents Assigned to CorMatrix Cardiovascular, Inc.
  • Patent number: 9694105
    Abstract: Bioremodelable tissue prostheses having a vasculature that is infused with a biomaterial composition.
    Type: Grant
    Filed: March 23, 2015
    Date of Patent: July 4, 2017
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventors: Robert G Matheny, Craig N Ferrante
  • Patent number: 9694104
    Abstract: Methods of treating biological tissue with bioremodelable tissue prostheses having a vasculature that is infused with a biomaterial composition.
    Type: Grant
    Filed: March 23, 2015
    Date of Patent: July 4, 2017
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventors: Robert G Matheny, Craig N Ferrante
  • Patent number: 9682171
    Abstract: A bioremodelable encasement structure comprising a pouch formed from at least one sheet of bioremodelable material, the pouch including an internal region that is configured to receive a device therein, the bioremodelable material comprising mesothelial tissue.
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: June 20, 2017
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventor: Robert G Matheny
  • Patent number: 9681937
    Abstract: Extracellular matrix (ECM) constructs having a biodegradable support scaffold and an anchoring mechanism, which includes a plurality of biodegradable microneedles that are capable of piercing tissue and anchoring therein. In a preferred embodiment, the support scaffold and anchoring mechanism comprise an ECM material. In some embodiments, the microneedles are also capable of administering a biologically active agent and/or a pharmacological composition to the engaged tissue.
    Type: Grant
    Filed: August 21, 2015
    Date of Patent: June 20, 2017
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventor: Robert G Matheny
  • Patent number: 9669133
    Abstract: A pouch structure formed from extracellular matrix (ECM) derived from small intestine submucosa (SIS) that includes an internal region configured to receive a medical device therein. The pouch structure is configured to modulate inflammation of damaged biological tissue and induce cell and tissue proliferation, bioremodeling of the damaged biological tissue, and regeneration of tissue structures with site-specific structural and functional properties, when implanted in a subject.
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: June 6, 2017
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventor: Robert G Matheny
  • Patent number: 9662418
    Abstract: A bioremodelable encasement structure comprising a pouch formed from at least one sheet of bioremodelable material, the pouch including an internal region that is configured to receive a device therein, the bioremodelable material comprising mesothelial tissue.
    Type: Grant
    Filed: April 14, 2015
    Date of Patent: May 30, 2017
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventor: Robert G Matheny
  • Patent number: 9662419
    Abstract: A bioremodelable encasement structure comprising a pouch formed from at least one sheet of bioremodelable material, the pouch including an internal region that is configured to receive a device therein, the bioremodelable material comprising mesothelial tissue.
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: May 30, 2017
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventor: Robert G Matheny
  • Patent number: 9642692
    Abstract: Extracellular matrix (ECM) constructs having a biodegradable support scaffold and an anchoring mechanism, which includes a plurality of biodegradable microneedles that are capable of piercing tissue and anchoring therein. In a preferred embodiment, the support scaffold and anchoring mechanism comprise an ECM material. In some embodiments, the microneedles are also capable of administering a biologically active agent and/or a pharmacological composition to the engaged tissue.
    Type: Grant
    Filed: August 21, 2015
    Date of Patent: May 9, 2017
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventor: Robert G Matheny
  • Patent number: 9636437
    Abstract: A bioremodelable encasement structure comprising a pouch formed from at least one sheet of bioremodelable material, the pouch including an internal region that is configured to receive a device therein, the bioremodelable material comprising mesothelial tissue.
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: May 2, 2017
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventor: Robert G Matheny
  • Patent number: 9532943
    Abstract: A polymeric matrix for delivery of an HMG CoA reductase inhibitor such as a statin to tissue such as cardiac tissue in need thereof for the treatment or prevention of a disease or defect such as atrial fibrillation has been developed. In the preferred embodiment, a statin is delivered by means of a patch sutured to cardiac tissue at the time of cardiothoracic surgery. In the most preferred embodiment, the patch is a biodegradable material providing controlled or sustained release over a prolonged period of time, such as a week. Suitable materials include extracellular matrix, or other biodegradable hydrogels or polymeric materials providing sustained or controlled release of statin at the site of application.
    Type: Grant
    Filed: December 16, 2011
    Date of Patent: January 3, 2017
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventor: Robert Matheny
  • Patent number: 9533072
    Abstract: Vascular grafts for treating, reconstructing and replacing damaged or diseased cardiovascular vessels that are formed from decellularized extracellular matrix (ECM). The vascular grafts include outer or outer and inner coatings that provide structural reinforcement.
    Type: Grant
    Filed: December 10, 2014
    Date of Patent: January 3, 2017
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventor: Robert G Matheny
  • Patent number: 9498559
    Abstract: Vascular grafts for treating, reconstructing and replacing damaged or diseased cardiovascular vessels that are formed from decellularized extracellular matrix (ECM). The vascular grafts include outer or outer and inner coatings that provide structural reinforcement.
    Type: Grant
    Filed: December 10, 2014
    Date of Patent: November 22, 2016
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventor: Robert G Matheny
  • Patent number: 9446078
    Abstract: Disclosed herein are compositions and methods for treating or preventing a cardiac arrhythmia in a subject.
    Type: Grant
    Filed: June 25, 2013
    Date of Patent: September 20, 2016
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventor: Robert G Matheny
  • Patent number: 9433491
    Abstract: Non-antigenic, bioremodelable tissue prostheses that can be engineered into a variety of shapes and used to repair, augment, reconstruct or replace damaged or diseased biological structures and associated tissue.
    Type: Grant
    Filed: May 3, 2016
    Date of Patent: September 6, 2016
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventor: Robert G Matheny
  • Patent number: 9352070
    Abstract: Non-antigenic, resilient, bioremodelable, biocompatible tissue prostheses that can be engineered into a variety of shapes and used to repair, augment, reconstruct or replace damaged or diseased biological structures and associated tissue.
    Type: Grant
    Filed: March 2, 2015
    Date of Patent: May 31, 2016
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventor: Robert G Matheny
  • Patent number: 9333277
    Abstract: An extracellular matrix (ECM) structure for tissue regeneration, the ECM structure having a a sheet member comprising small intestine submucosa (SIS), the SIS sheet member being folded and laminated proximate the sheet member edge, wherein a folded laminated ECM structure having a cavity therein is formed, the ECM structure further including an ECM composition that is disposed in the ECM structure cavity, the ECM composition including liver basement membrane, urinary bladder submucosa, a mesenchymal stem cell and a growth factor.
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: May 10, 2016
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventor: Robert G Matheny
  • Patent number: 9327055
    Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.
    Type: Grant
    Filed: February 28, 2014
    Date of Patent: May 3, 2016
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventor: Robert G Matheny
  • Patent number: 9327000
    Abstract: Methods for treating a cardiovascular disorder comprising administration of one or more extracellular matrix (ECM) based compositions directly to damaged or diseased cardiovascular tissue associated with the cardiovascular disorder, and provision of ventricular assistance.
    Type: Grant
    Filed: May 13, 2015
    Date of Patent: May 3, 2016
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventor: Robert G Matheny
  • Patent number: D790705
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: June 27, 2017
    Assignee: CORMATRIX CARDIOVASCULAR, INC
    Inventors: Robert G Matheny, Minh X Vo, Carlos C Chang, Selvamuthu k Natarajan
  • Patent number: D790706
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: June 27, 2017
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventors: Robert G Matheny, Minh X Vo, Carlos C Chang, Selvamuthu k Natarajan