Patents Assigned to CorMatrix Cardiovascular, Inc.
  • Patent number: 8771737
    Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.
    Type: Grant
    Filed: January 2, 2013
    Date of Patent: July 8, 2014
    Assignee: CorMatrix Cardiovascular, Inc
    Inventor: Robert G Matheny
  • Patent number: 8758448
    Abstract: The invention is to articles of extracellular matrix. The articles comprise one or more sheets of mammalian extracellular matrix laminated together. A single sheet can be folded over and laminated on 3 sides. Two or more sheets can be laminated to each other at their edges. The sheets can further encase a composition comprising a cell or cells, such as for example, a stem cell. A single sheet can be folded over to encase a composition, or rolled to encase a composition with lamination at either end of the roll, for example. The invention also includes methods of using these articles to regenerate tissue at tissue defects, or heal wounds in damaged tissue.
    Type: Grant
    Filed: February 23, 2011
    Date of Patent: June 24, 2014
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventor: Robert G. Matheny
  • Patent number: 8753885
    Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.
    Type: Grant
    Filed: January 2, 2013
    Date of Patent: June 17, 2014
    Assignee: CorMatrix Cardiovascular, Inc
    Inventor: Robert G Matheny
  • Patent number: 8753886
    Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.
    Type: Grant
    Filed: May 1, 2013
    Date of Patent: June 17, 2014
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventor: Robert G Matheny
  • Patent number: 8734841
    Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.
    Type: Grant
    Filed: January 2, 2013
    Date of Patent: May 27, 2014
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventor: Robert G Matheny
  • Patent number: 8735155
    Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.
    Type: Grant
    Filed: September 27, 2013
    Date of Patent: May 27, 2014
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventor: Robert G Matheny
  • Patent number: 8734842
    Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.
    Type: Grant
    Filed: January 2, 2013
    Date of Patent: May 27, 2014
    Assignee: CorMatrix Cardiovascular, Inc
    Inventor: Robert G Matheny
  • Patent number: 8709076
    Abstract: A two-piece prosthetic valve having first and second members, a first end of the first member being sized and configured to receive a second end of the second member therein, the second end of the second member being attached to the first member at at least one commissure connection point to form at least one leaflet therein.
    Type: Grant
    Filed: March 1, 2013
    Date of Patent: April 29, 2014
    Assignee: Cormatrix Cardiovascular, Inc.
    Inventors: Robert Matheny, Zachary Reinhardt
  • Patent number: 8696744
    Abstract: Methods for forming extracellular matrix valve conduits are disclosed. Extracellular matrix valve conduits produced using the disclosed methods are also disclosed. Methods of sterilizing and decellularizing extracellular matrix materials are also disclosed.
    Type: Grant
    Filed: May 24, 2012
    Date of Patent: April 15, 2014
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventors: Robert G. Matheny, Christian L. Gilbert, William Novick
  • Patent number: 8679176
    Abstract: A prosthetic tissue valve for aortic, pulmonary, mitral or tricuspid valve replacement is described herein. A sewing ring for use with the prosthetic tissue valve is also described. The valve can have a circumference that is a predetermined distance larger than the circumference of an annulus in a defective valve. The valve can be substantially planar in an unstressed position before attachment at the annulus and substantially non-planar upon attachment in a biased position at the annulus. The valve can have a multi-lobal shape in the unstressed position. Methods are provided for placing the valve as described herein in the biased position within the annulus of the defective valve.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: March 25, 2014
    Assignee: CorMatrix Cardiovascular, Inc
    Inventor: Robert G. Matheny
  • Patent number: 8642084
    Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.
    Type: Grant
    Filed: January 2, 2013
    Date of Patent: February 4, 2014
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventor: Robert G Matheny
  • Patent number: 8608796
    Abstract: A prosthetic tissue valve for aortic, pulmonary, mitral or tricuspid valve replacement is described herein. A sewing ring for use with the prosthetic tissue valve is also described. The valve can have a circumference that is a predetermined distance larger than the circumference of an annulus in a defective valve. The valve can be substantially planar in an unstressed position before attachment at the annulus and substantially non-planar upon attachment in a biased position at the annulus. Methods are provided for placing the valve as described herein in the biased position within the annulus of the defective valve.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: December 17, 2013
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventor: Robert Matheny
  • Patent number: 8568761
    Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function. Methods for regenerating defective or absent myocardium apply a composition to a site of myocardium in need of regeneration using a delivery mode appropriate for the particular formulation.
    Type: Grant
    Filed: July 15, 2005
    Date of Patent: October 29, 2013
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventor: Robert G. Matheny
  • Patent number: 8449607
    Abstract: A prosthetic tissue valve for aortic, pulmonary, mitral or tricuspid valve replacement is described herein. A sewing ring for use with the prosthetic tissue valve is also described. The valve can have a circumference that is a predetermined distance larger than the circumference of an annulus in a defective valve. The valve can be substantially planar in an unstressed position before attachment at the annulus and substantially non-planar upon attachment in a biased position at the annulus. Methods are provided for placing the valve as described herein in the biased position within the annulus of the defective valve.
    Type: Grant
    Filed: July 26, 2012
    Date of Patent: May 28, 2013
    Assignee: Cormatrix Cardiovascular, Inc.
    Inventor: Robert G. Matheny
  • Patent number: 8409275
    Abstract: A prosthetic tissue valve for aortic, pulmonary, mitral or tricuspid valve replacement is described herein. A sewing ring for use with the prosthetic tissue valve is also described. The valve can have a circumference that is a predetermined distance larger than the circumference of an annulus in a defective valve. The valve can be substantially planar in an unstressed position before attachment at the annulus and substantially non-planar upon attachment in a biased position at the annulus. Methods are provided for placing the valve as described herein in the biased position within the annulus of the defective valve.
    Type: Grant
    Filed: July 27, 2012
    Date of Patent: April 2, 2013
    Assignee: Cormatrix Cardiovascular, Inc.
    Inventor: Robert G. Matheny
  • Publication number: 20120251507
    Abstract: Disclosed herein are compositions and methods for treating or preventing a cardiac arrhythmia in a subject.
    Type: Application
    Filed: May 24, 2012
    Publication date: October 4, 2012
    Applicant: CORMATRIX CARDIOVASCULAR, INC.
    Inventors: ROBERT G. MATHENY, Beecher C. Lewis
  • Patent number: 8257434
    Abstract: A prosthetic tissue valve for aortic, pulmonary, mitral or tricuspid valve replacement is described herein. A sewing ring for use with the prosthetic tissue valve is also described. The valve can have a circumference that is a predetermined distance larger than the circumference of an annulus in a defective valve. The valve can be substantially planar in an unstressed position before attachment at the annulus and substantially non-planar upon attachment in a biased position at the annulus. Methods are provided for placing the valve as described herein in the biased position within the annulus of the defective valve.
    Type: Grant
    Filed: September 3, 2010
    Date of Patent: September 4, 2012
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventor: Robert G. Matheny
  • Publication number: 20070014869
    Abstract: The invention is to a composition for reconstruction, replacement or repair of a defect in or dsmage to intracardiac tissue comprising a patch, emulsion, injectable solution or other composition comprising extracellular matrix. As extracellular matrix can assimilate with the intracardiac tissue to help generate healthy functioning tissue, using extracellular matrix to address a defect in intracardiac tissue can obviate the need for second or subsequent open heart surgeries, or if the composition can be delivered in a minimally invasive medical procedure, can obviate the need for open heart surgery altogether. Conduction of the intracardiac tissue may also be restored using extracellular matrix material to reconstruct, replace or repair the damaged intracardiac tissue.
    Type: Application
    Filed: January 18, 2006
    Publication date: January 18, 2007
    Applicant: CorMatrix Cardiovascular, Inc.
    Inventor: Robert Matheny
  • Patent number: D688372
    Type: Grant
    Filed: October 8, 2012
    Date of Patent: August 20, 2013
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventor: Robert G. Matheny
  • Patent number: D694408
    Type: Grant
    Filed: October 8, 2012
    Date of Patent: November 26, 2013
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventor: Robert G. Matheny