Patents Assigned to Cornell University
  • SYSTEMS AND METHODS FOR EVALUATION OF CHROMOSOMAL INSTABILITY USING MACHINE-LEARNING
    Publication number: 20230117405
    Abstract: The present application provides methods and systems for detecting and quantifying chromosomal instability from histology images with machine learning. Also described herein are methods for selecting treatments for a medical disease, by determining a chromosomal instability pathological metric from histology images. The disclosed methods and systems may also be used to investigate disease progression and prognosis.
    Type: Application
    Filed: September 21, 2022
    Publication date: April 20, 2023
    Applicants: Volastra Therapeutics, Inc., Center for Technology Licensing at Cornell University (CTL)
    Inventors: Akanksha VERMA, Olivier ELEMENTO, Zhuoran XU
  • TAL-effector mediated herbicide tolerance
    Patent number: 11624076
    Abstract: The present disclosure relates to methods of altering expression of a genomic locus of interest or specifically targeting a genomic locus of interest in a plant cell, which may involve contacting the genomic locus with a non-naturally occurring or engineered composition that comprises a DNA binding domain comprising one or more Transcription Activator-Like (TAL) effector monomers specifically ordered to target the genomic locus of interest to improve tolerance of the plant cell to an effective concentration of an inhibitor herbicide.
    Type: Grant
    Filed: April 19, 2017
    Date of Patent: April 11, 2023
    Assignees: BASF Agricultural Solutions Seed US LLC, Cornell University
    Inventors: Manuel Dubald, Alain Sailland, Yueh-Jiang Hwang, Apurva Bhargava, Adam Bogdanove, Fabio Rinaldi
  • Method for removing re-sputtered material from patterned sidewalls
    Patent number: 11615960
    Abstract: The present invention provides a method for removing re-sputtered material on a substrate. A process chamber having a plasma source and a substrate support is provided along with the substrate having an upper surface and a lower surface. A masking material having a patterned sidewall is patterned onto the upper surface of the substrate along with a sacrificial layer between the upper surface of the substrate and the masking material. The lower surface of the substrate is placed onto the substrate support. A plasma is generated using the plasma source. The substrate is processed on the substrate support using the generated plasma. The sacrificial layer is removed after the processing of the substrate.
    Type: Grant
    Filed: December 2, 2020
    Date of Patent: March 28, 2023
    Assignee: Cornell University
    Inventors: David G. Lishan, Kyle Dorsey, Vincent J. Genova
  • Waveguide and sensor based on same
    Patent number: 11614583
    Abstract: A waveguide is provided. The waveguide having a first core, a second core spaced apart from and parallel with the first core, and a cladding surrounding the first core and the second core. An interstitial portion of the cladding is located between the first core and the second core. A first region of the first core adjacent to the cladding or of the cladding adjacent to the first core is color dyed.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: March 28, 2023
    Assignee: Cornell University
    Inventors: Robert Shepherd, Hedan Bai, Shuo Li, Yaqi Tu
  • MITOCHONDRIAL-TARGETED ANTIOXIDANTS PROTECT AGAINST MECHANICAL VENTILATION-INDUCED DIAPHRAGM DYSFUNCTION AND SKELETAL MUSCLE ATROPHY
    Publication number: 20230076067
    Abstract: The present disclosure provides methods and compositions for preventing or treating MV-induced or disuse-induced skeletal muscle infirmities in a mammalian subject. The methods further include administering to the subject an effective amount of an aromatic-cationic peptide.
    Type: Application
    Filed: February 25, 2022
    Publication date: March 9, 2023
    Applicants: Cornell University, University of Florida Research Foundation
    Inventors: Hazel H. Szeto, Scott Kline Powers
  • System for determining reservoir properties from long-term temperature monitoring
    Patent number: 11591901
    Abstract: An apparatus comprises at least one processing device comprising a processor coupled to a memory. The processing device is configured to obtain time-series temperature data from respective temperature sensors arranged at respective different subsurface depths, and for each of a plurality of pairs of the temperature sensors, to compute a cross-correlation of their corresponding time-series temperature data, to compute a time derivative of the cross-correlation, and to generate an estimate of at least one reservoir property based at least in part on the time derivative of the cross-correlation. At least one automated action is performed based at least in part on the generated estimate, such as, for example, controlling an amount of fluid flow into or out of a particular subsurface region. The generated estimates illustratively comprise estimates of subsurface hydraulic diffusivity.
    Type: Grant
    Filed: September 8, 2020
    Date of Patent: February 28, 2023
    Assignees: Cornell University, The Regents of the University of California
    Inventors: Patrick Fulton, Emily Brodsky
  • BIOABSORBABLE IMPLANT COMBINED WITH TISSUE-ENGINEERED COMPOSITE INTERVERTEBRAL DISC
    Publication number: 20230056877
    Abstract: The present disclosure describes an intervertebral disk replacement system. The system can include a tissue-engineered intervertebral disc that is combined with a bioresorbable stabilization system for structural guidance. The system can prevent or reduce intervertebral disk implant displacement and can increase the stiffness when compared to the implantation of the intervertebral disk implant without the stabilization system.
    Type: Application
    Filed: November 3, 2022
    Publication date: February 23, 2023
    Applicant: Cornell University
    Inventors: Roger Hartl, Lawrence Bonassar, Yu Moriguchi, Gernot Lang, Rodrigo Navarro-Ramirez
  • Peptide-linked drug delivery system
    Patent number: 11571481
    Abstract: The present disclosure relates to a systemically administered peptide delivery platform that biodistributes to the kidney or urinary tract. The disclosure further relates to methods of treating a disease of the kidney or urinary tract in a subject in need thereof.
    Type: Grant
    Filed: December 20, 2021
    Date of Patent: February 7, 2023
    Assignees: Cornell University, Tu Therapeutics Inc.
    Inventors: Shek Hang Benedict Law, Vanessa Bellat, Benjamin Byung-min Choi
  • Superlattice structure including two-dimensional material and device including the superlattice structure
    Patent number: 11575011
    Abstract: Provided are a superlattice structure including a two-dimensional material and a device including the superlattice structure. The superlattice structure may include at least two different two-dimensional (2D) materials bonded to each other in a lateral direction, and an interfacial region of the at least two 2D materials may be strained. The superlattice structure may have a bandgap adjusted by the interfacial region that is strained. The at least two 2D materials may include first and second 2D materials. The first 2D material may have a first bandgap in an intrinsic state thereof. The second 2D material may have a second bandgap in an intrinsic state thereof. An interfacial region of the first and second 2D materials and an adjacent region may have a third bandgap between the first bandgap and the second bandgap.
    Type: Grant
    Filed: November 1, 2021
    Date of Patent: February 7, 2023
    Assignees: Samsung Electronics Co., Ltd., The University of Chicago, Center for Technology Licensing at Cornell University
    Inventors: Minhyun Lee, Jiwoong Park, Saien Xie, Jinseong Heo, Hyeonjin Shin
  • Stabilization of Retromer for the Treatment of Alzheimer's Disease and Other Neurodegenerative Disorders
    Publication number: 20230021959
    Abstract: The present disclosure relates to methods and compositions for elevating and stabilizing retromer for treating and/or preventing Alzheimer's disease and other neurodegenerative disorders. Additionally, the disclosure relates to adenoviral based therapy for treating Alzheimer's disease (AD), and other neurodegenerative conditions such as Parkinson's Disease (PD), neuronal ceroid lipofuscinosis (NCL), and transmissible spongiform encephalopathies (TSEs or prion disease), multiple system atrophy (MSA), Down's syndrome, and hereditary spastic paraplegia, as well as tauopathies such as progressive supranuclear palsy (PSP), frontotemporal lobar dementia linked to chromosome 17q21-22 and its subtypes (FTLD-17/FTLD-Tau), Lewy Body Disease (LBD), amyotrophic lateral sclerosis (ALS), frontal-temporal degeneration (FTD), ALS-FTD, and chronic traumatic encephalopathy (CTE).
    Type: Application
    Filed: December 7, 2020
    Publication date: January 26, 2023
    Applicants: The Trustees of Columbia University in the City of New York, Cornell University, Meiragtx UK II Limited
    Inventors: Scott A. SMALL, Gregory PETSKO, Rebecca COX, Samuel D. WAKSAL, Alexandria FORBES, Yasir H. QURESHI
  • Ultrasmall nanoparticles labeled with Zirconium-89 and methods thereof
    Patent number: 11559591
    Abstract: Described herein are nanoprobes comprising ultrasmall aminated and cRGDY-conjugated nanoparticles labeled with Zirconium-89 (89Zr) and methods of their use. The provided compositions are renally clearable and possess suitable blood circulation half-time, high tumor active targeting capability, dominant renal clearance, low liver accumulation, and a high tumor-to-background ratio. The described nanoprobes exhibit great potential as “target-or-clear” tracers to human subjects for systemic targeted imaging (or treatment) of cancer.
    Type: Grant
    Filed: May 17, 2018
    Date of Patent: January 24, 2023
    Assignees: Memorial Sloan Kettering Cancer Center, Cornell University
    Inventors: Michelle S. Bradbury, Feng Chen, Ulrich Wiesner, Kai Ma
  • METHODS AND PROCESSES FOR THE USE OF CALCIUM- AND MAGNESIUM-BEARING OXIDES, HYDROXIDES, AND SILICATES; CALCIUM- AND MAGNESIUM-BEARING AQUEOUS STREAMS TO CAPTURE, CONVERT, AND STORE CARBON DIOXIDE AND PRODUCE HYDROGEN
    Publication number: 20230021218
    Abstract: The present disclosure relates to methods for producing hydrogen and calcium- or magnesium-bearing carbonates by capturing, converting, and storing carbon dioxide. The methods may include providing one or more calcium- or magnesium-bearing compounds; providing one or more water-soluble oxygenates; providing a plurality of catalysts; and reacting one or more calcium- or magnesium-bearing compounds and one or more water-soluble oxygenates with plurality of catalysts under conditions to produce hydrogen and calcium- or magnesium-bearing carbonates. The methods may include providing one or more calcium- or magnesium-bearing silicates; providing carbon monoxide; providing water vapor; and reacting one or more calcium- or magnesium-bearing silicates, carbon monoxide, and water vapor.
    Type: Application
    Filed: January 4, 2021
    Publication date: January 19, 2023
    Applicant: Cornell University
    Inventor: Greeshma GADIKOTA
  • Macrocyclic complexes of alpha-emitting radionuclides and their use in targeted radiotherapy of cancer
    Patent number: 11554182
    Abstract: The present technology provides compounds as well as compositions including such compounds useful for the treatment of cancers where the compounds are represented by the following formula (I) or a pharmaceutically acceptable salt thereof, wherein M is an alpha-emitting radionuclide.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: January 17, 2023
    Assignee: Cornell University
    Inventors: Justin Wilson, Nikki Thiele
  • Phase-shift-based amplitude detector for a high-speed atomic force microscope
    Patent number: 11549964
    Abstract: An atomic force microscope includes a cantilever operating in amplitude modulation mode. A controller determines the amplitude of the cantilever oscillation by processing a signal representative of the cantilever motion by square-rooting a signal having a value substantially equal to a sum of a square of the received signal and a squared and phase-shifted version of the received signal. The aforementioned processing, in some implementations is implemented using analog circuit components.
    Type: Grant
    Filed: February 7, 2022
    Date of Patent: January 10, 2023
    Assignee: Cornell University
    Inventors: Atsushi Miyagi, Simon Scheuring
  • System and methods for fabricating actuators and electrically actuated hydraulic solid materials
    Patent number: 11541642
    Abstract: With applications such as soft robotics being severely hindered by the lack of strong soft actuators, the invention provides a new soft-actuator material—Electrically Actuated Hydraulic Solid (EAHS) material—with a stress-density that outperforms any known electrically-actuatable material. One type of actuator is fabricated by making a closed cell that acts as highly paralyzed version of a standard paraffin actuator. Each cell exhibits microscopic expansion, which is summed to produce macroscopic motion. The closed cellular nature of the material allows the system to be cut and punctured and still operate. It can be produced in a lab or industrial scale, and can be formed using molding, 3D printing or cutting.
    Type: Grant
    Filed: May 24, 2021
    Date of Patent: January 3, 2023
    Assignee: Cornell University
    Inventor: Jeffrey Lipton
  • Signal processing device, amplifier, and method
    Patent number: 11546012
    Abstract: An active electronic device that enables bidirectional communication over a single antenna or path is disclosed. The device may be characterized by a forward path (from an input to an antenna port) offering high gain, and a reverse path (to a receiver port) that can be configured as an finite impulse response (“FIR”) filter. An amplifier of the device is disclosed, the amplifier allowing for tuning of output resistance using passive mixers.
    Type: Grant
    Filed: January 6, 2020
    Date of Patent: January 3, 2023
    Assignee: Cornell University
    Inventors: Alyssa Apsel, Alyosha Molnar
  • Method for rapid in vitro synthesis of glycoproteins via recombinant production of n-glycosylated proteins in prokaryotic cell lysates
    Patent number: 11542538
    Abstract: Disclosed are methods, systems, components, and compositions for cell-free synthesis of glycosylated proteins. The glycosylated proteins may be utilized in vaccines, including anti-bacterial vaccines. The glycosylated proteins may include a bacterial polysaccharide conjugated to a carrier, which may be utilized to generate an immune response in an immunized host against the polysaccharide conjugated to the carrier. The glycosylated proteins may be synthesized in cell-free glycoprotein synthesis (CFGpS) systems using prokaryote cell lysates that are enriched in components for glycoprotein synthesis such as oligosaccharyltransferases (OSTs) and lipid-linked oligosaccharides (LLOs) including OSTs and LLOs associated with synthesis of bacterial O antigens.
    Type: Grant
    Filed: October 22, 2020
    Date of Patent: January 3, 2023
    Assignees: Cornell University, Northwestern University
    Inventors: Michael Christopher Jewett, Jessica Carol Stark, Matthew P. DeLisa, Thapakorn Jaroentomeechai
  • COMPUTATIONAL SYSTEMS AND METHODS FOR IMPROVING THE ACCURACY OF DRUG TOXICITY PREDICTIONS
    Publication number: 20220415451
    Abstract: In some implementations, the present solution can determine a first structural vector of a first chemical based on a chemical structure of the first chemical. The system can also determine first target vector of the first chemical based on at least one gene target for the first chemical. The system can use the structural vector and the target vector to generate a toxicity predictor score for the first chemical.
    Type: Application
    Filed: August 24, 2022
    Publication date: December 29, 2022
    Applicant: Cornell University
    Inventors: Olivier Elemento, Kaitlyn Gayvert, Neel Madhukar
  • Apple tree rootstock named ‘G.257’
    Patent number: PP35016
    Abstract: A new and distinct variety of apple tree rootstock Malus domestica x Malus robusta hybrid ‘G.257’ is described. The new variety is a semi-dwarfing rootstock that is resistant to fire blight (Erwinia amylovora) and crown rot (Phytophthora cactorum) and tolerant to the replant disease complex. The ‘G.257’ rootstock is useful in that it can be propagated clonally and used as a rootstock or root system for apple trees as well as for interstems of apple trees.
    Type: Grant
    Filed: January 31, 2022
    Date of Patent: March 7, 2023
    Assignees: Cornell University, The United States of America, as Represented by the Secretary of Agriculture
    Inventors: Gennaro Fazio, Terence Lee Robinson, Herbert Sanders Aldwinckle, James N. Cummins
  • Apple tree rootstock named ‘G.484’
    Patent number: PP35046
    Abstract: A new and distinct variety of apple tree rootstock Malus hybrid ‘G.484’ is described herein. The new variety is a dwarfing, precocious and productive rootstock that is resistant to fire blight (Erwinia amylovora) and crown rot (Phytophthora cactorum). The ‘G.484’ rootstock is useful in that it can be propagated clonally and used as a rootstock or root system for apple trees as well as for interstems of apple trees.
    Type: Grant
    Filed: January 31, 2022
    Date of Patent: March 21, 2023
    Assignees: Cornell University, The United States of America, as Represented by the Secretary of Agriculture
    Inventors: Gennaro Fazio, Terence Lee Robinson, Herbert Sanders Aldwinckle, James Cummins