Abstract: Disclosed are devices, systems and methods for touch, force and/or thermal sensing by an ultrasonic transceiver chip. In some aspects, an ultrasonic transceiver sensor device includes a semiconductor substrate; a CMOS layer attached to the substrate; an array of piezoelectric transducers coupled to the CMOS layer to generate ultrasonic pulses; and a contact layer attached to the substrate on a side opposite the substrate for providing a surface for contact with an object, where an ultrasonic pulse generated by a piezoelectric transducer propagates through the substrate and the contact layer, such that when the object is in contact with the surface of the contact layer, a reflected ultrasonic pulse is produced and propagates through the contact layer and the substrate to be received at the array of piezoelectric transducers, and the CMOS layer receive and process outputs from the piezoelectric transducers produced in response to the received reflected ultrasonic pulses.
Type:
Grant
Filed:
February 4, 2019
Date of Patent:
October 18, 2022
Assignee:
Cornell University
Inventors:
Amit Lal, Mamdouh Abdelmejeed, Justin Kuo
Abstract: Provided are compounds and compositions for prevention and/or elimination of Zika virus infection. Also provided are methods for preventing and treating a subject in need of prevention or treatment of Zika virus.
Type:
Grant
Filed:
March 19, 2018
Date of Patent:
October 11, 2022
Assignees:
Cornell University, The University of North Carolina at Chapel Hill
Inventors:
Shuibing Chen, Ting Zhou, Lei Tan, Qisheng Zhang
Abstract: The present disclosure provides compositions and methods for improving reproductive health of mammals and increasing milk production from female mammals. The methods involve administering an effective amount of IL-8 to a female mammal such that the reproductive health of the mammal is improved, or milk production from the mammal is increased, or the fat content of the milk is increased, or the dry matter intake of the mammal is improved, or a combination thereof occurs. In another aspect the disclosure includes prophylaxis and/or therapy of uterine conditions by administering IL-8 to a female mammal. The disclosure includes but is not necessarily limited to systemic administration of the IL-8. Kits for carrying out the methods are also included.
Abstract: Molecular-beam epitaxy (MBE) and more particularly suboxide MBE (S-MBE) and related structures are disclosed. S-MBE is disclosed that includes the use of a molecular beam of a suboxide that may be subsequently oxidized in a single step reaction to form an oxide film. By way of example, for a gallium oxide (Ga2O3) film, a molecular beam including a suboxide of gallium (Ga2O) may be provided. S-MBE may be performed in adsorption-controlled regimes where there is an excess of source material containing species in order to promote high growth rates for oxide films with improved crystallinity. Source mixtures for providing molecular beams of suboxides are disclosed that include mixtures of a particular element and an oxide of the element in ratios that promote such adsorption-controlled growth regimes. Related structures include oxide films having increased thickness with reduced crystal defects, including single polymorph films of gallium oxide.
Type:
Grant
Filed:
October 21, 2020
Date of Patent:
October 4, 2022
Assignees:
Cornell University, The Penn State Research Foundation
Inventors:
Patrick Vogt, Darrell G. Schlom, Felix V. E. Hensling, Kathy Azizie, Zi-Kui Liu, Brandon J. Bocklund, Shun-Li Shang
Abstract: This invention relates to pharmaceutical compositions and methods for treating (including managing) or preventing metabolic syndrome related conditions using one or more RAR? (e.g., RAR?2) agonists. Such conditions include, but are not limited to, diseases in pancreas, liver, kidney, testes, muscle, or adipose tissue, as well as other organs that are associated with high fat diet and/or vitamin A deficiency, as well as other conditions associated with abnormal level of triglyceride, cholesterol and/or glucose.
Type:
Application
Filed:
November 1, 2021
Publication date:
September 29, 2022
Applicant:
Cornell University
Inventors:
Lorraine J GUDAS, Yannick BENOIT, Ronald PEREZ, Xiao-Han TANG, Steven TRASINO
Abstract: Disclosed are components and systems for cell-free glycoprotein synthesis (CFGpS). In particular, the components and systems include and utilize prokaryotic cell lysates from engineered prokaryotic cell strains that have been engineered to enable cell-free synthesis of glycoproteins.
Type:
Grant
Filed:
June 29, 2018
Date of Patent:
September 27, 2022
Assignees:
Northwestern University, Cornell University
Inventors:
Michael Christopher Jewett, Jessica Carol Stark, Matthew P. DeLisa, Thapakorn Jaroentomeechai
Abstract: In general, the presently disclosed technology relates to identification of cancer subtypes. More specifically, the technology relates to methods for determining molecular drivers of cancer and/or progression using a multivariate image data and statistical analysis of in-situ molecular markers and morphological characteristics in the same cells of a biological sample suspected of b cancer. This analysis takes place after a single acquisition that obtains the molecular and anatomic morphology data in parallel. The analysis compares specific morphological and molecular markers to known samples exhibiting particular genetic drivers of the cancer. This method provides statistical information that allows for an increased confidence in the identification of specific molecular drivers of the cancer.
Type:
Grant
Filed:
April 12, 2018
Date of Patent:
September 13, 2022
Assignees:
Ventana Medical Systems, Inc., Cornell University
Inventors:
Francesca Demichelis, Karl Garsha, Phillip C. Miller, Ray B. Nagle, Michael Otter, Gary Anthony Pestano, Mark Rubin
Abstract: Methods, systems, and devices are disclosed for enhancement of spin-orbit torque. In one aspect, a magnetic device includes a magnetic tunneling junction (MTJ), including a free magnetic layer, a pinned magnetic layer and a non-magnetic junction layer between the free magnetic layer and the pinned magnetic layer, and a spin Hall effect metal layer that includes one or more insertion metal layers operable to introduce interfacial scattering of electrons flowing in the spin Hall metal layer to increase the spin current that interacts with and changes the magnetization of the free magnetic layer of the MTJ.
Abstract: Quantitative susceptibility mapping methods, systems and computer-accessible medium include generating images of tissue magnetism property from complex magnetic resonance imaging data using the Bayesian inference approach. The tissue magnetism images is then used to monitor remyelination, such as remyelination in multiple sclerosis patients in response to therapy. Multiple sclerosis lesions defined on magnetic resonance imaging are further characterized on tissue magnetism images into hyperintense, isointense and hypointense parts for measuring remyelination. Thus, magnetic susceptibility information and other tissue properties associated with at least one structure are determined.
Type:
Application
Filed:
March 4, 2022
Publication date:
September 8, 2022
Applicants:
Cornell University, Universität Basel
Inventors:
Cristina Granziera, Reza Rahmanzadeh, Yi Wang, Riccardo Galbusera
Abstract: Methods for repelling Drosophila species (e.g., D. suzukii, D. melanogaster) involving treating an object or area with a composition containing a Drosophila species (e.g., D. suzukii, D. melanogaster) repelling effective amount of 2-pentylfuran and optionally a carrier.
Type:
Grant
Filed:
February 12, 2021
Date of Patent:
September 6, 2022
Assignees:
The United States of America, as represented by the Secretary of Agriculture, Cornell University
Abstract: The present technology provides compounds as well as compositions including such compounds useful in targeted radiotherapy of cancer and/or mammalian tissue overexpressing prostate specific membrane antigen (“PSMA”) where the compounds are represented by the following: or a pharmaceutical y acceptable salt thereof, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable salt thereof, wherein M1 is independently at each occurrence an alpha-emitting radionuclide. Equivalents of such compounds are also disclosed.
Type:
Application
Filed:
February 23, 2022
Publication date:
September 1, 2022
Applicant:
Cornell University
Inventors:
John W. Babich, Justin Wilson, Nikki Thiele, James Kelly, Shashikanth Ponnala
Abstract: A fabric having a base layer with an inside and a face side. The base layer may be hydrophobic and/or omniphobic. The fabric also has a hydrophilic transport layer, a portion of which passes through one or more ducts in the side of the base layer for absorbing liquids. The inner portion may have a shape configured to better absorb and move liquids. The liquids are transported to the face side of the base layer. A covering layer may be disposed on the face side of the base layer such that the outer portion of the transport layer is between the base and covering layers. In some embodiments, an inner layer is disposed on the inside of the base layer such that the inner portion of the transport layer is between the inner layer and the base layer.
Abstract: The present invention provides a fluorescent silica-based nanoparticle that allows for precise detection, characterization, monitoring and treatment of a disease such as cancer. The nanoparticle has a range of diameters including between about 0.1 nm and about 100 nm, between about 0.5 nm and about 50 nm, between about 1 nm and about 25 nm, between about 1 nm and about 15 nm, or between about 1 nm and about 8 nm. The nanoparticle has a fluorescent compound positioned within the nanoparticle, and has greater brightness and fluorescent quantum yield than the free fluorescent compound. The nanoparticle also exhibits high biostability and biocompatibility. To facilitate efficient urinary excretion of the nanoparticle, it may be coated with an organic polymer, such as poly(ethylene glycol) (PEG). The small size of the nanoparticle, the silica base and the organic polymer coating minimizes the toxicity of the nanoparticle when administered in vivo.
Type:
Grant
Filed:
December 13, 2019
Date of Patent:
August 23, 2022
Assignees:
Sloan-Kettering Institute for Cancer Research, Cornell University
Inventors:
Michelle S. Bradbury, Ulrich Wiesner, Oula Penate Medina, Andrew Burns, Jason S. Lewis, Steven M. Larson
Abstract: The present disclosure provides compositions and methods for improving reproductive health of mammals and increasing milk production from female mammals. The methods involve administering an effective amount of IL-8 to a female mammal such that the reproductive health of the mammal is improved, or milk production from the mammal is increased, or the fat content of the milk is increased. In another aspect the disclosure includes prophylaxis and/or therapy of uterine conditions by administering IL-8 to a female mammal.
Abstract: An implant can include a flexible body made of a non-bioresorbable hydrogel material. The implant can also include a radiopaque marker located within the flexible body, where the body and the radiopaque marker can be implanted in a body cavity to mark the cavity in a radiographic image of the cavity.
Abstract: A parallel processor in associative content-addressable memory (PPAC) is provided. Processing in memory (PIM) moves computation into memories with the goal of improving throughput and energy-efficiency compared to traditional von Neumann-based architectures. Most existing PIM architectures are either general-purpose but only support atomistic operations, or are specialized to accelerate a single task. The PPAC described herein provides a novel in-memory accelerator that supports a range of matrix-vector-product (MVP)-like operations that find use in traditional and emerging applications. PPAC is, for example, able to accelerate low-precision neural networks, exact/approximate hash lookups, cryptography, and forward error correction. The fully-digital nature of PPAC enables its implementation with standard-cell-based complementary metal-oxide-semiconductor (CMOS), which facilitates automated design and portability among technology nodes.
Type:
Grant
Filed:
July 15, 2020
Date of Patent:
August 9, 2022
Assignee:
Cornell University
Inventors:
Christoph Emanuel Studer, Oscar Fernando Castañeda Fernandez
Abstract: Exemplary methods for quantitative mapping of physical properties, systems and computer-accessible medium can be provided to generate images of tissue magnetic susceptibility, transport parameters and oxygen consumption from magnetic resonance imaging data using the Bayesian inference approach, which minimizes a data fidelity term under a constraint of a structure prior knowledge. The data fidelity term is constructed directly from the magnetic resonance imaging data. The structure prior knowledge can be characterized from known anatomic images using image feature extraction operation or artificial neural network. Thus, according to the exemplary embodiment, system, method and computer-accessible medium can be provided for determining physical properties associated with at least one structure.
Type:
Application
Filed:
May 28, 2020
Publication date:
July 21, 2022
Applicant:
Cornell University Center for Technology Licensing (CTL)
Abstract: An embodiment of a robotic fabric has a first fabric layer and an actuator that is configured to have a first state and a second state. A property of the first fabric layer is different when the actuator is in the first state as compared to the property of the first fabric layer when the actuator is in the second state.
Abstract: The present disclosure provides a high-power-density power converter topology with a common neutral between its input and output AC ports while having a single DC bus. The topology may also be embodied as an online uninterruptible power supply (UPS). The presently-disclosed topology enables high power density by utilizing half-bridge switch structures suitable for MHz-frequency operation.
Type:
Grant
Filed:
September 6, 2019
Date of Patent:
July 5, 2022
Assignees:
Cornell University, The Regents of the University of Colorado, a body corporate
Abstract: The present disclosure describes approaches to voice restoration using personal devices that detect surface electromyographic (sEMG) signals from articulatory muscles for the recognition of silent speech in a patient (such as a patient with total laryngectomy, on voice rest, etc.). A personal device may comprise a cutaneous sensor unit and a control module that wirelessly transmits signals to a computing device capable of, for example, applying a predictive model to signals to generate text or synthesize speech. Methods and systems for training and applying predictive models, and fabricating personal devices, are disclosed.