Patents Assigned to Cornell University
  • Publication number: 20230285499
    Abstract: The disclosure provides methods of preventing or treating heart failure in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to subjects in need thereof.
    Type: Application
    Filed: December 12, 2022
    Publication date: September 14, 2023
    Applicants: Cornell University, University of Washington
    Inventors: Hazel H. Szeto, Peter S. Rabinovitch, Dao-Fu Dai
  • Publication number: 20230285603
    Abstract: The present technology provides compounds, as well as compositions including such compounds, useful for imaging and/or treatment of a glioma, a breast cancer, an adrenal cortical cancer, a cervical carcinoma, a vulvar carcinoma, an endometrial carcinoma, a primary ovarian carcinoma, a metastatic ovarian carcinoma, a non-small cell lung cancer, a small cell lung cancer, a bladder cancer, a colon cancer, a primary, gastric adenocarcinoma, a primary colorectal adenocarcinoma, a renal cell carcinoma, and/or a prostate cancer.
    Type: Application
    Filed: October 11, 2022
    Publication date: September 14, 2023
    Applicant: Cornell University
    Inventors: John W. Babich, James M. Kelly, Alejandro Amor-Coarasa, Shashikanth Ponnala
  • Patent number: 11752175
    Abstract: This invention relates to methods and compositions for detecting, identifying and treating glaucoma diseases. More particularly, this invention discloses compositions and methods for affecting intraocular pressure and increasing ocular outflows in glaucoma. Compositions and methods provided include purified and synthesized extracellular vesicle complexes from glaucoma ocular humor for use in methods and devices for detecting, characterizing and treating glaucoma diseases along with active agents. The presence of extracellular vesicle complexes in glaucoma can also be used as a biomarker.
    Type: Grant
    Filed: September 21, 2019
    Date of Patent: September 12, 2023
    Assignee: Cornell University
    Inventors: John T. G. Pena, James Murray Mitchell, Harmon Lawrence Remmel
  • Patent number: 11744470
    Abstract: The present disclosure may be embodied as methods and/or systems for non-contact measuring of an on-body and/or inside-body motion of an individual. A sensing signal is provided within a near-field coupling range of a motion to be measured. In this way, a measurement signal may be generated as the sensing signal modulated by the motion. The sensing signal may be an ID-modulated signal. In some embodiments, the sensing signal is a backscattered RFID link provided a wireless tag. A downlink signal may be provided to power the wireless tag. The sensing signal may be a harmonic of the downlink signal. The measurement signal is detected. The motion is measured based on the measurement signal. The measurement signal may be detected as far-field radiation after transmission through a source of the motion. The measurement signal may be detected as reflected from a source of the motion as antenna reflection.
    Type: Grant
    Filed: June 18, 2018
    Date of Patent: September 5, 2023
    Assignee: Cornell University
    Inventors: Xiaonan Hui, Edwin C. Kan
  • Patent number: 11728545
    Abstract: Lithium ion batteries, electrodes, nanofibers, and methods for producing same are disclosed herein. Provided herein are batteries having (a) increased energy density; (b) decreased pulverization (structural disruption due to volume expansion during lithiation/de-lithiation processes); and/or (c) increased lifetime. In some embodiments described herein, using high throughput, water-based electrospinning process produces nanofibers of high energy capacity materials (e.g., ceramic) with nanostructures such as discrete crystal domains, mesopores, hollow cores, and the like; and such nanofibers providing reduced pulverization and increased charging rates when they are used in anodic or cathodic materials.
    Type: Grant
    Filed: June 28, 2021
    Date of Patent: August 15, 2023
    Assignee: Cornell University
    Inventors: Yong Lak Joo, Nathaniel S. Hansen, Daehwan Cho, Kyoung Woo Kim
  • Patent number: 11712436
    Abstract: Provided is a method to identify subjects with inflammatory diseases, such as inflammatory bowel disease, for their suitability for treatment with antifungal compounds. The method comprises identification of loss-of-function in the gene CX3CR1.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: August 1, 2023
    Assignee: Cornell University
    Inventors: Iliyan Iliev, Irina Leonardi
  • Patent number: 11715774
    Abstract: A vertical gallium oxide (Ga2O3) device having a substrate, an n-type Ga2O3 drift layer on the substrate, an, n-type semiconducting channel extending from the n-type Ga2O3 drift layer, the channel being one of fin-shaped or nanowire shaped, an n-type source layer disposed on the channel; the source layer has a higher doping concentration than the channel, a first dielectric layer on the n-type Ga2O3 drift layer and on sidewalls of the n-type semiconducting channel, a conductive gate layer deposited on the first dielectric layer and insulated from the n-type source layer, n-type semiconducting channel as well as n-type Ga2O3 drift layer, a second dielectric layer deposited over the conductive gate layer, covering completely the conductive gate layer on channel sidewalls and an ohmic source contact deposited over the n-type source layer and over at least a part of the second dielectric layer; the source contact being configured not to be in electrical contact with the conductive gate layer.
    Type: Grant
    Filed: March 28, 2019
    Date of Patent: August 1, 2023
    Assignee: Cornell University
    Inventors: Zongyang Hu, Kazuki Nomoto, Grace Huili Xing, Debdeep Jena, Wenshen Li
  • Patent number: 11710785
    Abstract: A High Electron Mobility Transistor (HEMT) device can include an AlN buffer layer on a substrate and an epi-GaN channel layer on the AlN buffer layer. An AlN barrier layer can be on the Epi-GaN channel layer to provide a channel region in the epi-GaN channel layer. A GaN drain region can be recessed into the epi-GaN channel layer at a first end of the channel region and a GaN source region can be recessed into the epi-GaN channel layer at a second end of the channel region opposite the first end of the channel region. A gate electrode can include a neck portion with a first width that extends a first distance above the AlN barrier layer between the GaN drain region and the GaN source region to a head portion of the gate electrode having a second width that is greater than the first width.
    Type: Grant
    Filed: June 4, 2020
    Date of Patent: July 25, 2023
    Assignee: Cornell University
    Inventors: Austin Hickman, Reet Chaudhuri, Samuel James Bader, Huili Grace Xing, Debdeep Jena
  • Patent number: 11701245
    Abstract: The present disclosure provides an electrohydraulic device. The device includes a battery having a vessel containing a flowable electrolyte. The battery may be a flow cell battery, such as, for example, a redox flow cell battery. In a flow cell battery, the flowable electrolyte may a catholyte and/or an anolyte. An actuator is in fluidic communication with the vessel of the battery. The actuator is configured to be actuated using the flowable electrolyte. A cation exchange membrane may separate the vessel into an anolyte side and a catholyte side. The actuator may be in fluidic communication with either side (anolyte side or catholyte side) of the vessel.
    Type: Grant
    Filed: April 23, 2020
    Date of Patent: July 18, 2023
    Assignee: Cornell University
    Inventors: Robert F. Shepherd, James Pikul
  • Patent number: 11698368
    Abstract: This disclosure provides a method for determining male fertility status. The method comprises determining GM1 distribution patterns following induced sperm capacitation, identifying the frequency of distribution of various patterns, and determining if the frequency distribution of certain GM1 patterns in response to induced capacitation is altered. Based on the change in the frequency distribution patterns of certain patterns in response to induced capacitation, alone or in combination with other sperm attributes, male fertility status can be identified.
    Type: Grant
    Filed: September 16, 2015
    Date of Patent: July 11, 2023
    Assignee: Cornell University
    Inventors: Alexander J. Travis, Gianpiero Palermo
  • Patent number: 11684590
    Abstract: Provided herein are compounds (e.g., compounds of Formula (I) and Formula (II), that modulate HCN channels, intermembrane proteins that serve as nonselective voltage-gated cation channels in the plasma membranes of heart and brain cells. Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating HCN-related disorders (e.g., pain) with the compounds in a subject, by administering the compounds and/or compositions described herein.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: June 27, 2023
    Assignee: Cornell University
    Inventors: Gareth R. Tibbs, Peter A. Goldstein, Anthony A. Sauve, Rajendra Uprety, James David Warren, Jr., Rebecca L. Joyce, Dipti N. Barman
  • Publication number: 20230197883
    Abstract: A method for achieving voltage-controlled gate-modulated light emission using monolithic integration of fin- and nanowire-n-i-n vertical FETs with bottom-tunnel junction planar InGaN LEDs is described. This method takes advantage of the improved performance of bottom-tunnel junction LEDs over their top-tunnel junction counterparts, while allowing for strong gate control on a low-cross-sectional area fin or wire without sacrificing LED active area as in lateral integration designs. Electrical modulation of 5 orders, and an order of magnitude of optical modulation are achieved in the device.
    Type: Application
    Filed: July 13, 2021
    Publication date: June 22, 2023
    Applicant: Cornell University
    Inventors: Shyam Bharadwaj, Kevin Lee, Kazuki Nomoto, Austin Hickman, Len van Deurzen, Huili Grace Xing, Debdeep Jena, Vladimir Protasenko
  • Patent number: 11680264
    Abstract: The invention is directed to compositions and methods for increasing the pH of a melanosome in a melanocyte, darkening skin or hair pigmentation, or treating a disease associated with decreased melanin comprising administering a soluble adenylyl cyclase (sAC) inhibitor and/or an exchange protein activated by cyclic AMP (EPAC) inhibitor to the melanocyte. The invention also provides compositions and methods for decreasing the pH of a melanosome in a melanocyte, lightening skin or hair pigmentation, or treating a disease associated with increased melanin comprising administering a sAC activator and/or an EPAC activator to the melanocyte.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: June 20, 2023
    Assignee: Cornell University
    Inventor: Jonathan Zippin
  • Patent number: 11681897
    Abstract: Techniques, systems, and devices are described for implementing for implementing computation devices and artificial neurons based on nanoelectromechanical (NEMS) systems. In one aspect, a nanoelectromechanical system (NEMS) based computing element includes: a substrate; two electrodes configured as a first beam structure and a second beam structure positioned in close proximity with each other without contact, wherein the first beam structure is fixed to the substrate and the second beam structure is attached to the substrate while being free to bend under electrostatic force. The first beam structure is kept at a constant voltage while the other voltage varies based on an input signal applied to the NEMS based computing element.
    Type: Grant
    Filed: December 7, 2020
    Date of Patent: June 20, 2023
    Assignee: Cornell University
    Inventors: Amit Lal, Serhan Ardanuc, Jason T. Hoople, Justin C. Kuo
  • Patent number: 11678587
    Abstract: A ferroelectric device includes a substrate, a first electrode on the substrate, and a hexagonal ferroelectric material on the first electrode. The first electrode comprises a single crystal epitaxial material. By using a single crystal epitaxial material for an electrode to a hexagonal ferroelectric material, a high-quality material interface may be provided between these layers, thereby improving the performance of the ferroelectric device by allowing for a reduced coercive field.
    Type: Grant
    Filed: October 21, 2020
    Date of Patent: June 13, 2023
    Assignee: Cornell University
    Inventors: Darrell Schlom, Rachel Steinhardt, Megan Holtz
  • Publication number: 20230178585
    Abstract: A dielectric thin film includes a stack structure of a perovskite material layer including at least two Group II elements and a rocksalt layer on the perovskite material layer and including at least two Group II elements. A first content ratio of the at least two Group II elements included in the perovskite material layer may be the same as a second content ratio of the at least two Group II elements included in the rocksalt layer.
    Type: Application
    Filed: December 1, 2022
    Publication date: June 8, 2023
    Applicants: Samsung Electronics Co., Ltd., Cornell University
    Inventors: Kiyoung LEE, Darrell G. Schlom, Matthew R. Barone, Myoungho Jeong
  • Publication number: 20230165979
    Abstract: The present technology provides compounds, as well as compositions including such compounds, useful for imaging and/or treatment of a non-small cell lung cancer, small cell carcinoma of the lung, bladder cancer, colon cancer, gallbladder cancer, pancreatic cancer, esophageal cancer, melanoma, liver cancer, primary gastric adenocarcinoma, primary colorectal adenocarcinoma, renal cell carcinoma, prostate cancer, a neuroendocrine tumor, a pituitary tumor, a vasoactive intestinal peptide-secreting tumor, a glioma, breast cancer, an adrenal cortical cancer, a cervical carcinoma, a vulvar carcinoma, an endometrial carcinoma, a primary ovarian carcinoma, a metastatic ovarian carcinoma, and/or a metastatic cancer.
    Type: Application
    Filed: April 14, 2021
    Publication date: June 1, 2023
    Applicants: Cornell University, The University of Melbourne
    Inventors: John W. BABICH, James M. Kelly, Alejandro Amor-Coarasa, Shashikanth Ponnala, Paul Donnelly
  • Patent number: 11660354
    Abstract: Described herein are novel conjugates containing an inhibitor (e.g., a PSMA inhibitor, e.g., a gastrin-releasing peptide receptor inhibitor) and metal chelator that are covalently attached to a macromolecule (e.g., a nanoparticle, a polymer, a protein). Such conjugates exhibit distinct properties over the free, unbound inhibitor/chelator construct.
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: May 30, 2023
    Assignees: Memorial Sloan Kettering Cancer Center, Cornell University, The Curators of the University of Missouri
    Inventors: Michelle S. Bradbury, Thomas P. Quinn, Barney Yoo, Wolfgang Weber, Karim Touijer, Howard Scher, Kai Ma, Ulrich Wiesner
  • Publication number: 20230158061
    Abstract: The present technology is directed to nanoparticle compositions and methods useful in treating RHAMM-positive cancers.
    Type: Application
    Filed: April 23, 2021
    Publication date: May 25, 2023
    Applicant: Cornell University
    Inventors: Ching-Hsuan Tung, Yi-Chieh Nancy Du, Seung Koo Lee, Xiang Chen
  • Patent number: PP35202
    Abstract: A new and distinct variety of apple tree rootstock Malus domestica x Malus robusta hybrid ‘G.66’ is described herein. The new variety is a productive, yield efficient, semi-dwarfing rootstock that is resistant to fire blight (Erwinia amylovora) and crown rot (Phytophthora cactorum). The ‘G.66’ rootstock is useful in that it can be propagated clonally and used as a rootstock or root system for apple trees as well as for interstems of apple trees.
    Type: Grant
    Filed: January 31, 2022
    Date of Patent: June 6, 2023
    Assignees: Cornell University, The United States of America, as Represented by the Secretary of Agriculture
    Inventors: Gennaro Fazio, Terence Lee Robinson, Herbert Sanders Aldwinckle, James N. Cummins