Abstract: An apparatus comprises at least one processing device comprising a processor coupled to a memory. The at least one processing device is configured to obtain a system of nonlinear equations characterizing a physical system, to construct a flexible embedded system from the system of nonlinear equations, wherein the flexible embedded system is configurable with any of a plurality of arbitrary reference states as respective starting points, to utilize the flexible embedded system to generate at least one output providing a solution to the system of nonlinear equations, and to establish one or more operating parameters of the physical system based at least in part on the output generated utilizing the flexible embedded system. The physical system is configured in accordance with the one or more established operating parameters. The physical system in some embodiments illustratively comprises an electric power system, an integrated circuit, or another type of electrical or electronic system or circuit.
Abstract: This invention relates to pharmaceutical compositions and methods for treating (including managing) or preventing metabolic syndrome related conditions using one or more RAR e.g., RAR agonists. Such conditions include, but are not limited to, diseases in pancreas, liver, kidney, testes, muscle, or adipose tissue, as well as other organs that are associated with high fat diet and/or vitamin A deficiency, as well as other conditions associated with abnormal level of triglyceride, cholesterol and/or glucose.
Type:
Grant
Filed:
January 16, 2015
Date of Patent:
November 2, 2021
Assignee:
Cornell University
Inventors:
Lorraine J Gudas, Yannick Benoit, Ronald Perez, Xiao-Han Tang, Steven Trasino
Abstract: The long-missing polarization-induced two-dimensional hole gas is finally observed in undoped Group III nitride semiconductor structures and in undoped Group II or Group III oxide semiconductor structures. Experimental results providing unambiguous proof that a 2D hole gas in GaN grown on AlN does not need acceptor doping, and can be formed entirely by the difference in the internal polarization fields across the semiconductor heterojunction are presented.
Type:
Grant
Filed:
July 19, 2019
Date of Patent:
October 26, 2021
Assignee:
Cornell University
Inventors:
Reet Chaudhuri, Samuel James Bader, Jena Debdeep, Huili Grace Xing
Abstract: A thin-film structure includes a support layer and a dielectric layer on the support layer. The support layer includes a material having a lattice constant. The dielectric layer includes a compound having a Ruddlesden-Popper phase (An+1BnX3n+1). where A and B each independently include a cation, X is an anion, and n is a natural number. The lattice constant of the material of the support layer may be less than a lattice constant of the compound.
Type:
Grant
Filed:
November 27, 2019
Date of Patent:
September 28, 2021
Assignees:
Samsung Electronics Co., Ltd., Cornell University
Inventors:
Kiyoung Lee, Woojin Lee, Myoungho Jeong, Yongsung Kim, Eunsun Kim, Hyosik Mun, Jooho Lee, Changseung Lee, Kyuho Cho, Darrell G. Schlom, Craig J. Fennie, Natalie M. Dawley, Gerhard H. Olsen, Zhe Wang
Abstract: The present disclosure provides collaborative radiofrequency identification (RFID) readers that employ code division multiple access (CDMA) encoding to simultaneously broadcast to and read responses from tags in an overlapping reading zone with improved data synchronization and read yield rates. In some embodiments, a harmonic backscattering scheme is used to enable the system to have a much higher signal-to-noise ratio (SNR) and sensitivity, while the reader CDMA protocol can be integrated with an initial TDMA polling process or alternative tag CDMA scheme.
Abstract: Finite-alphabet beamforming for multi-antenna wideband systems is provided. The combination of massive multi-user multiple-input multiple-output (MU-MIMO) technology and millimeter-wave (mmWave) communication enables unprecedentedly high data rates for radio frequency (RF) communications. In such systems, beamforming must be performed at extremely high rates over hundreds of antennas. For example, spatial equalization applies beamforming in the uplink to mitigate interference among user equipment (UEs) at a base station (BS). Finite-alphabet equalization provides a new paradigm that restricts the entries of a spatial equalization matrix to low-resolution numbers, enabling high-throughput, low-power, and low-cost equalization hardware. Similarly, precoding applies beamforming in the downlink to maximize the reception of a signal transmitted from a BS to a target UE. Finite-alphabet precoding can be applied in the downlink to similarly improve power and cost in precoding hardware.
Type:
Grant
Filed:
March 5, 2020
Date of Patent:
September 7, 2021
Assignee:
Cornell University
Inventors:
Oscar Fernando CastaƱeda Fernandez, Christoph Emanuel Studer
Abstract: A processing platform in illustrative embodiments comprises one or more processing devices each including at least one processor coupled to a memory. The processing platform is configured to obtain a text document containing at least one claim about data of a relational database. Claim keywords are extracted from the text document, and query fragments are identified based at least in part on indexing of one or more relational data sets of the relational database. The relevance of the claim keywords to the query fragments is determined, and candidate queries are identified based at least in part on probabilistic inferencing from the determined relevance of the claim keywords to the query fragments. The candidate queries are evaluated against the relational database, and consistency of the claim with the data of the relational database is determined based at least in part on results of the evaluation of the candidate queries.
Abstract: Provided herein are compounds (e.g., compounds of Formula (I) and Formula (II), that modulate HCN channels, intermembrane proteins that serve as nonselective voltage-gated cation channels in the plasma membranes of heart and brain cells. Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating HCN-related disorders (e.g., pain) with the compounds in a subject, by administering the compounds and/or compositions described herein.
Type:
Application
Filed:
June 27, 2019
Publication date:
September 2, 2021
Applicant:
Cornell University
Inventors:
Gareth R. Tibbs, Peter A. Goldstein, Anthony A. Sauve, Rajendra Uprety, James David Warren, Rebecca L. Joyce, Dipti N. Barman
Abstract: Methods of treating CMV (cytomegalovirus) retinitis in a human patient in need thereof comprise administering to the human patient a population of allogeneic T cells comprising CMV-specific T cells, wherein the human patient is infected with human immunodeficiency virus (HIV) or has been the recipient of a solid organ transplant.
Type:
Grant
Filed:
May 23, 2019
Date of Patent:
August 31, 2021
Assignees:
Memorial Sloan Kettering Cancer Center, Cornell University
Inventors:
Richard John O'Reilly, Susan Elizabeth Prockop, Ekaterina Doubrovina, Guenther Koehne, Aisha Nasreen Hasan, Szilard Kiss
Abstract: The present disclosure provides aromatic-cationic peptide compositions and methods of using the same. The methods comprise use of the peptides in electron transport, inhibition of cardiolipin peroxidation, and inhibition of apoptosis and necrosis to treat, prevent or ameliorate the symptoms of autoimmune diseases or condition.
Abstract: This patent document provides optical processing and switching of optical channels based on mode-division multiplexing (MDM) and wavelength division multiplexing (WDM).
Abstract: Disclosed is a compound of formula (I): wherein R1, R2, R3, and are as defined herein. Also disclosed are methods for increasing mammalian cell NAD+ production and improving mitochondrial cell densities comprising administering to a cell the compound or a salt thereof.
Type:
Grant
Filed:
August 26, 2019
Date of Patent:
August 24, 2021
Assignee:
Cornell University
Inventors:
Anthony Sauve, Farheen Sultana Mohammed, Yue Yang
Abstract: A device configured for low-energy ultrasonic 2D Fourier transform analysis, comprising: (i) a first layer comprising an array of piezoelectric pixels; (ii) a second layer comprising an array of piezoelectric pixels; (iii) a third layer, positioned between the first and second layers, comprising a bulk ultrasonic transmission medium; wherein the second layer of array of piezoelectric pixels is in the Fourier plane of an input signal of the first layer array of piezoelectric pixels.
Abstract: The long-missing polarization-induced two-dimensional hole gas is finally observed in undoped Group III nitride semiconductor structures and in undoped Group II or Group III oxide semiconductor structures. Experimental results providing unambiguous proof that a 2D hole gas in GaN grown on AlN does not need acceptor doping, and can be formed entirely by the difference in the internal polarization fields across the semiconductor heterojunction are presented.
Type:
Application
Filed:
July 19, 2019
Publication date:
August 12, 2021
Applicant:
Cornell University
Inventors:
Reet Chaudhuri, Samuel James Bader, Jena Debdeep, Huili Grace Xing
Abstract: The invention relates to compositions of nicotinoyl ribosides and nicotinamide riboside derivatives and their methods of use. In some embodiments, the invention relates to methods of making nicotinoyl ribosides. In some embodiments, the invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinoyl riboside. In further embodiments, the invention relates to methods of using nicotinoyl ribosides and nicotinamide riboside derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival.
Abstract: The present disclosure may be embodied as a method for creating a restriction pattern from a mask material having a strain (?mask) an for mapping elastomeric membrane having a strain (?membrane) into a target 3D shape. The method may include discretizing the target 3D shape into a plurality of radial segments, and a radial strain (?r) is determined for each radial position (r) on each radial segment of the plurality of radial segments. A restriction pattern is determined, wherein the restriction pattern comprises a quantity of mask material for each position r to provide a composite strain (?mask, ?silicone). In some embodiments, the method further includes depositing a first membrane layer into a mold and placing mask material into the first membrane layer according to the determined restriction pattern. The first membrane layer is cured.
Type:
Grant
Filed:
October 15, 2018
Date of Patent:
August 3, 2021
Assignee:
Cornell University
Inventors:
James Pikul, Itai Cohen, Robert Shepherd
Abstract: Apparatus comprising: a sleeve adapted to be slid over the exterior of an endoscope; an aft balloon secured to the sleeve; an inflation/deflation tube carried by the sleeve and in fluid communication with the interior of the aft balloon; a pair of hollow push tubes slidably mounted to the sleeve, the pair of hollow push tubes being connected to one another at their distal ends with a raised push tube bridge, the raised push tube bridge being configured to nest an endoscope therein; and a fore balloon secured to the distal ends of the pair of hollow push tubes, the interior of the fore balloon being in fluid communication with the interiors of the pair of hollow push tubes, wherein the fore balloon is capable of assuming a deflated condition and an inflated condition, and further wherein (i) when the fore balloon is in its deflated condition, an axial opening extends therethrough, the axial opening being sized to receive the endoscope therein, and (ii) when the fore balloon is in its inflated condition, the ax
Type:
Grant
Filed:
December 11, 2018
Date of Patent:
August 3, 2021
Assignees:
Cornell University
Inventors:
John Frederick Cornhill, Jeffrey Milsom, Sameer Sharma, Tuan Anh Nguyen, Christopher Dillon, Gabriel Greeley, Rahul Sathe, Matthew DeNardo, Ashley Whitney, Jeremy Van Hill, Anthony Assal, Stephen Evans, Timothy Robinson, Alan Fortunate, Audrey Bell, Richard Yazbeck, Brian David Chouinard, Phal Kun Chan, William Rebh
Abstract: The present invention relates to compositions and methods for the treatment and prevention of canine influenza virus (CIV) and CIV-related pathology. The present invention is based in part upon the discovery that various mutations in segment 1 and segment 2 of the CIV genome, thereby encoding mutant PB2 and PB1 protein, render the virus to be temperature-sensitive.
Type:
Grant
Filed:
October 1, 2019
Date of Patent:
July 20, 2021
Assignees:
University of Rochester, Cornell University
Inventors:
Luis Martinez-Sobrido, Aitor Nogales-Gonzalez, Colin Parrish
Abstract: The invention provides a compound of formula (I): wherein R is as described herein. The invention also provides a process for the preparation of the compound.
Abstract: The present invention provides dehydroleucodine derivatives. In particular, the present invention provides amine derivatives of dehydroleucodine and methods of using dehydroleucodine and the amine derivatives of dehydroleucodine to inhibit the growth of cancer cells.
Type:
Grant
Filed:
February 22, 2019
Date of Patent:
July 13, 2021
Assignees:
Universidad Tecnica Particular De Loja, Cornell University, BioVentures, LLC
Inventors:
Cesar M. Compadre, Paola E. Ordonez, Monica L. Guzman, Darin E. Jones, Omar Malagon, Giovanni Vidari, Peter Crooks