Abstract: Described herein are cyclic peptides, nanoparticles bound with cyclic peptides, and methods for using said cyclic peptides and/or said nanoparticles bound with cyclic peptides for intraoperative nerve tissue imaging.
Type:
Grant
Filed:
May 17, 2019
Date of Patent:
March 9, 2021
Assignees:
Cornell University, Memorial Sloan Kettering Cancer Center
Inventors:
Michelle S. Bradbury, Barney Yoo, Ulrich Wiesner, Peiming Chen, Kai Ma, Snehal G. Patel, Daniella Karassawa Zanoni
Abstract: The invention relates to expressing proteins in the axons of mammalian neurons. The invention provides nucleic acids that can be used to express a selected polypeptide in neuronal axons, viruses that can be used deliver nucleic acids of the invention into neuronal axons, as well as methods for doing so. Thus, the invention provides pharmaceutical compositions comprising viruses of the invention, as well as their use in methods of treating injured axons or conditions associated with aberrant axon growth or function.
Abstract: A metal-based battery includes at least one metal electrode immersed within an electrolyte that includes: (1) an aprotic solvent; (2) a simple halogen containing material; and (3) optionally a metal salt that includes a complex halogen containing anion. The simple halogen containing material may include a metal halide salt that includes a metal cation selected from the group including but not limited to lithium and sodium metal cations. The metal halide salt may also include a halide anion selected from the group consisting of fluoride, chloride, bromide and iodide halide anions. The use of the metal halide salt within the metal-based battery provides enhanced cycling ability within the metal-based battery. Also contemplated are additional simple halogen containing material additives that may enhance cycling performance of a metal-based battery.
Type:
Grant
Filed:
March 24, 2015
Date of Patent:
March 2, 2021
Assignee:
Cornell University
Inventors:
Lynden A. Archer, Tomas Arias, Yingying Lu, Zhengyuan Tu, Deniz Gunceler, Snehashis Choudhury
Abstract: Provided herein are small molecule inhibitors for the targeting or IRE1 protein family members. Binding may be direct or indirect. Further provided herein are methods of using IRE1 small molecule inhibitors for use in treating or ameliorating cancer in a subject. Moreover, IRE1 small molecule inhibitors described herein are for the treatment of cancer, where the cancer is a solid or hematologic cancer.
Type:
Grant
Filed:
December 1, 2017
Date of Patent:
March 2, 2021
Assignee:
Cornell University
Inventors:
Joseph P. Vacca, Dansu Li, Sarah Bettigole
Abstract: Hydrogels and hybrid hydrogels, methods of making the hydrogels/hybrid hydrogels, and methods of using the hydrogels/hybrid hydrogels. The hydrogels have polysaccharide moieties (e.g., chitosan or hyaluronic acid moieties). The hybrid hydrogels have polysaccharide moieties (e.g., chitosan or hyaluronic acid moieties) and poly(ester amide) moieties. The poly(ester amide) moieties can have one or more arginine moieties. The hydrogels/hybrid hydrogels can be used, for example, in consumer products and as cargo carrier materials (e.g., as therapeutic agent carriers).
Abstract: A microfluidic device includes a base comprising a chamber configured to receive a microfluidic component. A sealing member includes a body, an inlet reservoir, and an outlet reservoir, where the inlet reservoir and the outlet reservoir communicate with the chamber through fluid passages when the sealing member and base are removably coupled. A microfluidic component removably within the chamber includes microfluidic channels on a surface thereof and a tissue culture chamber coupled to at least one of the microfluidic channels. The microfluidic channels and the tissue culture chamber are in fluid communication with the inlet and outlet reservoirs through the fluid passages to form a fluid circuit for directing fluid from the inlet reservoir, through the tissue culture chamber, to the outlet reservoir, and from the outlet reservoir back to the inlet reservoir upon tilting the microfluidic device to a forward tilted position and to a reverse tilted position, respectively.
Abstract: The present invention relates to a probiotic cell transformed with a construct suitable to overexpress and display on the surface of the probiotic cell a fusion protein comprising at least a portion of a transport protein coupled to at least a portion of one or more antigenic proteins or peptides. Probiotic-derived vesicles displaying this fusion protein as well as methods of inducing an immune response using the probiotic cells or vesicles are also disclosed.
Type:
Grant
Filed:
November 26, 2019
Date of Patent:
February 16, 2021
Assignee:
Cornell University
Inventors:
David A. Putnam, Joseph Rosenthal, Chung-Jr Huang, Matthew DeLisa, Susana Mendez
Abstract: The system and methods described herein determine a subject's indication of attention to a first and a second sensory stimuli. The system determines a sensory evoked response of the subject by calculating the statistical relationship between the subject's neural response to the stimuli and a signal feature of the first and the second sensory stimuli. A magnitude value of the sensory evoked response is extracted to determine whether the subject attended-to or ignored the sensory stimuli. The system will select the stimuli that elicited the greater indication of attention, and then trigger further processing by a computer. Such processing can include selecting future content for improving safety warnings, educational materials, or advertisements or further processing can include controlling and navigating a brain computer user interface.
Type:
Grant
Filed:
March 2, 2018
Date of Patent:
February 16, 2021
Assignee:
Cornell University
Inventors:
Nicholas Schiff, Chananel Braiman, Chagit Reichenbach
Abstract: Solid-state devices including a layer of a superconductor material epitaxially grown on a crystalline high thermal conductivity substrate, the superconductor material being one of TiNx, ZrNx, HfNx, VNx, NbNx, TaNx, MoNx, WNx, or alloys thereof, and one or more layers of a semiconducting or insulating or metallic material epitaxially grown on the layer of superconductor material, the semiconducting or insulating material being one of a Group III N material or alloys thereof or a Group 4b N material or SiC or ScN or alloys thereof.
Type:
Application
Filed:
March 6, 2019
Publication date:
February 11, 2021
Applicants:
Cornell University, The Government of the United States of America, as represented by the Secretary of the Navy
Inventors:
Rusen Yan, Guru Bahadur Singh Khalsa, John Wright, H. Grace Xing, Debdeep Jena, D. Scott Katzer, Neeraj Nepal, Brian P. Downey, David J. Meyer
Abstract: A device that includes a metal(III)-polar III-nitride substrate having a first surface opposite a second surface, a tunnel junction formed on one of the first surface or a buffer layer disposed on the first surface, a p-type III-nitride layer formed directly on the tunnel junction, and a number of material layers; a first material layer formed on the p-type III-nitride layer, each subsequent layer disposed on a preceding layer, where one layer from the number of material layers is patterned into a structure, that one layer being a III-nitride layer. Methods for forming the device are also disclosed.
Type:
Application
Filed:
January 31, 2019
Publication date:
February 11, 2021
Applicant:
Cornell University
Inventors:
Henryk Turski, Debdeep Jena, Huili Grace Xing, Shyam Bharadwaj, Alexander Austin Chaney, Kazuki Nomoto
Abstract: Described herein are silyl monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. Such multimer forming associations of monomers may be promoted by the proximal binding of the monomers to their target biomolecule(s). In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g. in vivo) to form a multimer, (e.g. a dimer). Contemplated monomers may include a ligand moiety, a linker element, and a connector element that joins the ligand moiety and the linker element. In an aqueous media, such contemplated monomers may join together via each linker element and may thus be capable of modulating one or more biomolecules substantially simultaneously, e.g., modulate two or more binding domains on a protein or on different proteins.
Type:
Grant
Filed:
August 25, 2016
Date of Patent:
February 9, 2021
Assignees:
Cornell University, Purdue Research Foundation
Inventors:
Francis Barany, Maneesh Pingle, Donald E. Bergstrom, Sarah F. Giardina, Lee Daniel Arnold
Abstract: A processing platform in illustrative embodiments comprises one or more processing devices each including at least one processor coupled to a memory. The processing platform is configured to extract channel features of a wireless channel of a wireless system from channel state information characterizing a radio geometry of the wireless channel, to generate a forward charting function that maps the extracted channel features to a channel chart characterizing a representational spatial geometry of the wireless channel, and to utilize the channel chart to estimate at least one position-related characteristic of one or more wireless devices in an actual spatial geometry of the wireless channel. Generating the forward charting function illustratively comprises performing an unsupervised learning process to learn the forward charting function from the extracted channel features.
Abstract: A wafer-based charged particle accelerator includes a charged particle source and at least one RF charged particle accelerator wafer sub-assembly and a power supply coupled to the at least one RF charged particle accelerator wafer sub-assembly. The wafer-based charged particle accelerator may further include a beam current-sensor. The wafer-based charged particle accelerator may further include at least a second RF charged particle accelerator wafer sub-assembly and at least one ESQ charged particle focusing wafer. Fabrication methods are disclosed for RF charged particle accelerator wafer sub-assemblies, ESQ charged particle focusing wafers, and the wafer-based charged particle accelerator.
Type:
Grant
Filed:
August 12, 2019
Date of Patent:
February 2, 2021
Assignee:
Cornell University
Inventors:
Amit Lal, Thomas Schenkel, Arun Persaud, Qing Ji, Peter Seidl, Will Waldron, Serhan Ardanuc, Vinaya Kumar Kadayra Basavarajappa
Abstract: A method for treating one or more symptoms of COPD comprising administering to an in need of treatment a therapeutically effect amount of one or more mitochondrial iron chelators. The mitochondrial iron chelator can be deferiprone. Compostions comprising mitochondrial iron chelators suitable for administration are also disclosed.
Type:
Grant
Filed:
December 1, 2016
Date of Patent:
February 2, 2021
Assignee:
Cornell University
Inventors:
Augustine M. K. Choi, Suzanne M. Cloonan
Abstract: Apparatuses comprising a substrate; a monolayer graphene film disposed on at least a portion of the substrate; and a single-layer transition metal dichalcogenide (TMD) disposed only on the substrate and lateral edges of the monolayer graphene film, methods of making the apparatuses, and devices comprising one or more of the apparatuses. The apparatuses have a one-dimensional ohmic edge contact between the monolayer graphene and monolayer semiconducting TMDs.
Type:
Grant
Filed:
June 13, 2017
Date of Patent:
February 2, 2021
Assignee:
Cornell University
Inventors:
Jiwoong Park, Hui Gao, Marcos H. D. Guimaraes, Daniel C. Ralph, Kibum Kang, Saien Xie
Abstract: The disclosure relates to a method for protecting a kidney from renal injury. For example, acute renal injury may be associated with decreased or blocked blood flow in the subject's kidney or exposure to a nephrotoxic agent, such as a radiocontrast dye. The methods include administering to the subject an effective amount of an aromatic-cationic peptide to a subject in need thereof.
Abstract: A vertical gallium oxide (Ga2O3) device having a substrate, an n-type Ga2O3 drift layer on the substrate, an, n-type semiconducting channel extending from the n-type Ga2O3 drift layer, the channel being one of fin-shaped or nanowire shaped, an n-type source layer disposed on the channel; the source layer has a higher doping concentration than the channel, a first dielectric layer on the n-type Ga2O3 drift layer and on sidewalls of the n-type semiconducting channel, a conductive gate layer deposited on the first dielectric layer and insulated from the n-type source layer, n-type semiconducting channel as well as n-type Ga2O3 drift layer, a second dielectric layer deposited over the conductive gate layer, covering completely the conductive gate layer on channel sidewalls and an ohmic source contact deposited over the n-type source layer and over at least a part of the second dielectric layer; the source contact being configured not to be in electrical contact with the conductive gate layer.
Abstract: The invention relates to methods and kits for detecting thyroid cancer by detecting differences in the expression of genes that are differentially expressed in thyroid cancer cells.
Type:
Grant
Filed:
February 23, 2017
Date of Patent:
January 12, 2021
Assignee:
Cornell University
Inventors:
Thomas J. Fahey, III, Nimmi Kapoor, Theresa Scognamiglio
Abstract: Exemplary quantitative susceptibility mapping methods, systems and computer-accessible medium can be provided to generate images of tissue magnetism property from complex magnetic resonance imaging data using the Bayesian inference approach, which minimizes a cost function consisting of a data fidelity term and two regularization terms. The data fidelity term is constructed directly from the complex magnetic resonance imaging data. The first prior is constructed from matching structures or information content in known morphology. The second prior is constructed from a region having an approximately homogenous and known susceptibility value and a characteristic feature on anatomic images. The quantitative susceptibility map can be determined by minimizing the cost function. Thus, according to the exemplary embodiment, system, method and computer-accessible medium can be provided for determining magnetic susceptibility information associated with at least one structure.
Type:
Grant
Filed:
April 3, 2018
Date of Patent:
January 12, 2021
Assignee:
Cornell University
Inventors:
Yi Wang, Zhe Liu, Youngwook Kee, Alexey Dimov, Yan Wen, Jingwei Zhang, Pascal Spincemaille
Abstract: This invention relates to a new and distinct primocane bearing red raspberry plant designated as ‘Crimson Treasure’ primarily adapted to growing conditions of west central New York and other regions of similar climate. The new plant is primarily characterized by sturdy upright canes, conical fruit that is longer than broad, an extended mid-season to late season primocane production period, open display of fruit and intense red fruit color.