Abstract: Sulfur containing nanoparticles that may be used within cathode electrodes within lithium ion batteries include in a first instance porous carbon shape materials (i.e., either nanoparticle shapes or “bulk” shapes that are subsequently ground to nanoparticle shapes) that are infused with a sulfur material. A synthetic route to these carbon and sulfur containing nanoparticles may use a template nanoparticle to form a hollow carbon shape shell, and subsequent dissolution of the template nanoparticle prior to infusion of the hollow carbon shape shell with a sulfur material. Sulfur infusion into other porous carbon shapes that are not hollow is also contemplated. A second type of sulfur containing nanoparticle includes a metal oxide material core upon which is located a shell layer that includes a vulcanized polymultiene polymer material and ion conducting polymer material. The foregoing sulfur containing nanoparticle materials provide the electrodes and lithium ion batteries with enhanced performance.
Type:
Grant
Filed:
January 25, 2018
Date of Patent:
January 5, 2021
Assignee:
Cornell University
Inventors:
Lynden A. Archer, Jayaprakash Navaneedhakrishnan
Abstract: A nucleophilic substitution reaction to crosslink cyclodextrin (CD) polymer with rigid aromatic groups, providing a high surface area, mesoporous CD-containing polymers (P-CDPs). The P-CDPs can be used for removing organic contaminants from water. By encapsulating pollutants to form well-defined host-guest complexes with complementary selectivities to activated carbon (AC) sorbents. The P-CDPs can rapidly sequester pharmaceuticals, pesticides, and other organic micropollutants, achieving equilibrium binding capacity in seconds with adsorption rate constants 15-200 times greater than ACs and nonporous CD sorbents. The CD polymer can be regenerated several times, through a room temperature washing procedure, with no loss in performance.
Type:
Grant
Filed:
August 24, 2018
Date of Patent:
January 5, 2021
Assignee:
Cornell University
Inventors:
William R. Dichtel, Alaaeddin Alsbaiee, Brian J. Smith, Juan Hinestroza, Diego Alzate-Sanchez, Leilei Xiao, Yuhan Ling, Damian Helbling
Abstract: An apparatus in one embodiment comprises at least one processing device. The processing device comprises a processor coupled to a memory, and is configured to obtain energy usage data generated by advanced metering infrastructure of a particular energy usage location of an electrical distribution system, to model a virtual localized energy storage device for the particular energy usage location, and to execute an algorithm to control charging and discharging of the virtual localized energy storage device based at least in part on the energy usage data and associated pricing data of the electrical distribution system. The processing device is further configured to provide an interface through which a user can adjust one or more parameters for controlling energy usage at the particular energy usage location based at least in part on a charge state of the virtual localized energy storage device.
Abstract: A method for preparing a material composition comprising a hollow transition metal oxide nanoparticle supported upon a carbon material support includes a solution impregnation process step, followed by a thermal reduction process step and finally a thermal oxidation process step. The material composition, an electrode and an electrical component such as but not limited to a battery are all predicated at least in-part upon the material composition prepared in accord with the foregoing method. The foregoing material composition, electrode, battery and method may ultimately provide a LIB with enhanced performance.
Type:
Grant
Filed:
July 9, 2018
Date of Patent:
January 5, 2021
Assignees:
Cornell University, Huazhong University of Science and Technology
Inventors:
Yingchao Yu, Héctor D. Abruña, Deli Wang, Weidong Zhou, Hongfang Liu, Shuang Qin
Abstract: By rotationally casting soft robots, no bonding of different material layers is required. Soft robots including one or more integrated enclosed compartments are constructed from fibers that are embedded directly into the mold prior to adding elastomeric precursors.
Type:
Grant
Filed:
October 22, 2014
Date of Patent:
January 5, 2021
Assignee:
Cornell University
Inventors:
Robert Shepherd, Huichan Zhao, Ahmed Elsamadisi
Abstract: The present technology provides compounds, as well as compositions including such compounds, useful for imaging and/or treatment of a glioma, a breast cancer, an adrenal cortical cancer, a cervical carcinoma, a vulvar carcinoma, an endometrial carcinoma, a primary ovarian carcinoma, a metastatic ovarian carcinoma, a non-small cell lung cancer, a small cell lung cancer, a bladder cancer, a colon cancer, a primary, gastric adenocarcinoma, a primary colorectal adenocarcinoma, a renal cell carcinoma, and/or a prostate cancer.
Type:
Application
Filed:
September 9, 2020
Publication date:
December 31, 2020
Applicant:
Cornell University
Inventors:
John W. Babich, James M. Kelly, Alejandro Amor-Coarasa, Shashikanth Ponnala
Abstract: The systems and method described herein can generate guidance images that can indicate the real-time position of a medical device within an anatomical target. For example, the images can be high-resolution, 3D holographic renderings of a catheter (an example medical device) within a patient's heart (an example anatomical target). The guidance system can generate images that include computer generated (CG) images or models of the medical device and target anatomy. The guidance system can generate the CG images of the target anatomy from pre-operative images of a first modality, such as CT images or MR images. The guidance system can determine real-time placement position of the medical device from an intra-operative image of a second modality, such as fluoroscopic images.
Type:
Application
Filed:
February 26, 2019
Publication date:
December 31, 2020
Applicant:
Cornell University
Inventors:
Jun Liu, Bobak Mosadegh, Gurpreet Singh, Simon Dunham, James K. Min, Subhi Al'Aref
Abstract: The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.
Type:
Grant
Filed:
June 16, 2019
Date of Patent:
December 29, 2020
Assignee:
Cornell University
Inventors:
Lawrence J. Bonassar, Roger Hartl, Robert D. Bowles, Harry H. Gebhard
Abstract: Apparatus comprising: a sleeve adapted to be slid over the exterior of an endoscope; a proximal balloon secured to the sleeve; an inflation/deflation tube carried by the sleeve and in fluid communication with the interior of the proximal balloon; a push tube slidably mounted to the sleeve; and a distal balloon secured to the distal end of the push tube, the interior of the distal balloon being in fluid communication with the push tube, wherein the distal balloon is capable of assuming a deflated condition and an inflated condition, and further wherein when the distal balloon is in its deflated condition, an axial opening extends therethrough, the axial opening being sized to receive the endoscope therein, and when the distal balloon is in its inflated condition, the axial opening is closed down.
Type:
Grant
Filed:
June 5, 2018
Date of Patent:
December 29, 2020
Assignee:
Cornell University
Inventors:
John Frederick Cornhill, Jeffery Milsom, Sameer Sharma, Tuan Anh Nguyen, Christopher Dillon, Gabriel Greeley, Rahul Sathe, Matthew DeNardo, Ashley Whitney, Jeremy Van Hill, Anthony Assal
Abstract: The present invention comprises the provision and use of a novel endoscopic device which is capable of stabilizing, straightening, expanding and/or flattening the side wall of a body lumen and/or body cavity so as to better present the side wall tissue for examination and/or treatment during an endoscopic procedure. The present invention also comprises the provision and use of a novel endoscopic device capable of steadying and/or stabilizing the distal tips and/or working ends of instruments inserted into a body lumen and/or body cavity, whereby to facilitate the use of those instruments.
Type:
Grant
Filed:
March 27, 2018
Date of Patent:
December 29, 2020
Assignee:
Cornell University
Inventors:
Jeffrey Milsom, Howard Riina, J. Frederick Cornhill, Edward Dickinson, Clair Strohl, James J. Mahoney, Jr., Pat Coppola
Abstract: The present disclosure describes a delivery device. The delivery device of the present disclosure can include one or more pullout resistors that can anchor the delivery device to the patient's abdomen. The pullout resistors can reduce feeding tube migration. The delivery device can include pullout resistors that anchor the delivery device with the abdomen rather than inflatable bumpers or balloons that can obstruct the intestine. When implanted, the pullout resistors can lie between the small intestine and intraabdominal wall. The pullout resistors can prevent inadvertent retrograde displacement of the delivery device without obstructing the lumen of the intestine. The pullout resistors can be flexible to enable a healthcare professional to apply an external retraction force to remove the delivery device.
Type:
Application
Filed:
February 14, 2019
Publication date:
December 24, 2020
Applicant:
Cornell University
Inventors:
Rasa Zarnegar, Thomas Ciecierega, Carl Crawford, Brendan Finnerty, Thomas Fahey, III
Abstract: The technology described in this document can be used to implement an optical device including a seed pump laser to produce pump seed laser pulses at a pump wavelength, a pulse stretcher operable to stretch a pulse duration of the pump seed laser pulses to produce stretched pump seed laser pulses, a pump fiber amplifier including one or more fiber gain media to receive the seed pump laser pulses to produce a pump laser beam of pump laser pulses, a signal laser to produce a signal laser beam at a signal wavelength different from the pump wavelength, an optical module coupled to combine the pump laser beam and the signal laser beam, and a fiber optical parametric amplifier (OPA) to cause a nonlinear parametric interaction in the nonlinear fiber medium to produce an output signal beam, an output idler laser beam at an idler wavelength, and an output pump beam.
Abstract: Patterning electronic devices using reactive-ion etching of tin oxides is provided. Reactive-ion etching facilitates patterning of tin oxides, such as barium stannate (BaSnO3), at a consistent and controllable etch rate. The reactive-ion etching approach described herein facilitates photolithographic patterning of tin oxide-based semiconductors to produce electronic devices, such as thin-film transistors (TFTs). This approach further patterns a tin oxide-based semiconductor without adversely affecting its electrical properties (e.g., resistivity, electron or hole mobility), as well as maintaining surface roughness. This approach can be used to produce optically transparent devices with high drain current (ID, drain-to-source current per channel width) and high on-off ratio.
Abstract: Provided herein are compounds that inhibit MALT1, a protein whose activity is responsible for constitutive NF-?B signaling in certain cancers (e.g., activated B-cell diffuse large B-cell lymphoma (ABC-DLBCL)). Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating MALT1-related diseases and disorders (e.g., cancer) with the compounds in a subject, by administering the compounds and/or compositions described herein.
Type:
Application
Filed:
March 8, 2018
Publication date:
December 10, 2020
Applicants:
Cornell University, Dana-Farber Cancer Institute, Inc.
Inventors:
Nathanael S. Gray, David A, Scott, John Hatcher, Ari M. Melnick, Lorena Fontan Gabas
Abstract: This disclosure is directed to methods of conducting dynamic single-molecule fluorescence studies such as smFRET on a membrane protein which permits observation and quantification of conformational dynamics of a membrane protein. Also disclosed herein are mutant membrane proteins in which one or more mutations have been introduced for affixing a fluorophore, as well as reagents and kits containing such mutant membrane proteins for conducting dynamic single-molecule fluorescence studies. The methods and compositions disclosed herein can be used in screening for compounds that enhance or reduce the activity of a membrane protein, useful for treating diseases associated with the malfunction of the membrane protein or alterations in membrane protein conformation.
Type:
Grant
Filed:
November 18, 2016
Date of Patent:
December 8, 2020
Assignees:
Cornell University, THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
Inventors:
Scott Blanchard, Harel Weinstein, Jonathan Javitch
Abstract: Techniques, systems, and devices are described for implementing for implementing computation devices and artificial neurons based on nanoelectromechanical (NEMS) systems. In one aspect, a nanoelectromechanical system (NEMS) based computing element includes: a substrate; two electrodes configured as a first beam structure and a second beam structure positioned in close proximity with each other without contact, wherein the first beam structure is fixed to the substrate and the second beam structure is attached to the substrate while being free to bend under electrostatic force. The first beam structure is kept at a constant voltage while the other voltage varies based on an input signal applied to the NEMS based computing element.
Type:
Grant
Filed:
January 25, 2018
Date of Patent:
December 8, 2020
Assignee:
Cornell University
Inventors:
Amit Lal, Serhan Ardanuc, Jason T. Hoople, Justin C. Kuo
Abstract: An apparatus in one embodiment comprises a processing platform having at least one processing device. The processing platform implements a database configured to store bindings between user identity information and respective cryptocurrency addresses for users of an address-based cryptocurrency, and an account-identity service system accessible to at least one cryptocurrency vendor. The account-identity service system is configured to utilize the stored bindings to respond to queries from the cryptocurrency vendor. A given one of the queries from the cryptocurrency vendor identifies a particular one of the users and a corresponding cryptocurrency address for which the particular user has requested to purchase an amount of the address-based cryptocurrency.
Abstract: Devices or circuits based on spin torque transfer (STT) and Spin Hall effect are disclosed by using a spin Hall effect (SHE) metal layer coupled to a magnetic free layer for various applications. The efficiency or strength of the STT effect based on this combination of SHE and STT can be enhanced by an interface modification between the SHE metal layer and the magnetic free layer or by modifying or engineering the SHE metal layer by doping the SHE metal with certain impurities or other means.
Type:
Grant
Filed:
June 25, 2018
Date of Patent:
November 24, 2020
Assignee:
Cornell University
Inventors:
Robert A. Buhrman, Minh-hai Nguyen, Chi-feng Pai, Daniel C. Ralph
Abstract: Disclosed are methods, systems, components, and compositions for cell-free synthesis of glycosylated proteins. The glycosylated proteins may be utilized in vaccines, including anti-bacterial vaccines. The glycosylated proteins may include a bacterial polysaccharide conjugated to a carrier, which may be utilized to generate an immune response in an immunized host against the polysaccharide conjugated to the carrier. The glycosylated proteins may be synthesized in cell-free glycoprotein synthesis (CFGpS) systems using prokaryote cell lysates that are enriched in components for glycoprotein synthesis such as oligosaccharyltransferases (OSTs) and lipid-linked oligosaccharides (LLOs) including OSTs and LLOs associated with synthesis of bacterial O antigens.
Type:
Grant
Filed:
July 14, 2017
Date of Patent:
November 10, 2020
Assignees:
Northwestern University, Cornell University
Inventors:
Michael Christopher Jewett, Jessica Carol Stark, Matthew P. DeLisa, Thapakorn Jaroentomeechai
Abstract: The present invention is directed methods for identifying, in a sample, one or more target nucleotide sequences differing from other nucleotide sequences in the sample by one or more nucleotides, one or more copy numbers, one or more transcript sequences, and/or one or more methylated residues, using ligation detection reactions, polymerase mediated extension reactions, and/or cleavage reactions. The present invention is also directed to methods for identifying, in a sample, one or more nucleotides in a target nucleotide sequence.
Type:
Grant
Filed:
March 23, 2016
Date of Patent:
November 10, 2020
Assignees:
The University of North Carolina at Chapel Hill, Cornell University, Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
Inventors:
Francis Barany, John William Efcavitch, Steven A. Soper, Sunggook Park