Abstract: An insertion guide facilitates insertion of an endotracheal tube (ETT) into the trachea of a patient instead of the esophagus of the patient. The ETT includes an elongated, somewhat flexible, generally hollow tube and the insertion guide includes an elongated, solid and relatively rigid shaft that is configured to be positioned within the hollow tube of the ETT. The shaft is provided with a radiused portion and/or an angled portion adjacent a distal end of the insertion guide that protrudes outwardly beyond a distal end of the ETT. The radiused portion and/or the angled portion of the shaft facilitate insertion of the distal end of the ETT past the epiglottis and into the trachea of the patient instead of into the esophagus of the patient.

Abstract: The present invention provides compounds represented by formulas (I) to (XVII) or pharmaceutically acceptable salts thereof:

Abstract: Described is a system for monitoring deflection of turbine blades of a wind turbine comprising a tower. The system comprises a position detecting apparatus mounted to the wind turbine, the position detection apparatus comprising position detection components each detecting a presence or absence of a corresponding one of the segments of the turbine blades; and a deflection controller configured to receive the presence or absence detection and to use the presence or absence detection to determine a distance of each of the segments of the turbine blades relative to the tower, whereby the distance of each of the segments of the turbine blades relative to the tower is representative of the deflection of the turbine blades.

Abstract: A pixel circuit for a ultra-low power image sensor, including: an integration node, on which a photodiode current is integrated, a comparator arranged to compare a voltage at the integration node with a reference voltage, a n+1 bits digital memory, a writing pulse signal generator arranged to generate a writing pulse signal, on the basis of the comparator output voltage and on the voltage at a memory node, the start of the pulse triggering the writing of the digital word in the n-bits digital memory part. The comparator includes a switch in series with a current source and arranged to be commanded by the voltage at the memory node so that the switch is open at the end of the pulse, so as to drastically limit the consumption of static power of the pixel circuit during the integration phase.

Abstract: Disclosed is an apparatus for tracking an object based on radar image reconstruction, the apparatus including a two-dimensional image producing unit configured to produce a two-dimensional image by collecting multiple one-dimensional radar signals from which clutter is removed, an object detecting unit configured to determine the presence or absence of an object from the two-dimensional image and estimate a two-dimensional position of the present object, and an object tracking unit configured to track a movement path of the object based on the two-dimensional position estimated by the object detecting unit.

Abstract: A baby carrier system is disclosed herein. The baby carrier system includes a baby carrier and a waist strap. The baby carrier includes a main body, a baby securing system, and shoulder straps. The waist strap may preferably be detachable and adjustable. In some embodiments, the baby carrier system may be a multi-functional baby carrier system that includes a multi-functional baby carrier configured for use as a car seat insert, where the multi-functional baby carrier includes fastener slits that allow for a car seat harness to secure a baby when the fastener slits are unfastened.

Abstract: A plug for use in a cap assembly of a refill capsule is disclosed. The plug (300) generally comprises a hollow tubular body (302) with an open proximal end that is surrounded by a first rim (304) that provides a proximal abutment surface for bearing against a frangible sealing component of a cap assembly. A tubular skirt wall (306) is arranged coaxially with respect to the tubular body, and extends around the skirt wall (306) to form a plug recess (308) between the skirt wall (306) and the tubular body (302). The skirt wall (306) extends from a skirt distal end at which the skirt wall (306) is connected to the tubular body (302), to a free proximal end. The free proximal end of the skirt comprises an outwardly extending flange (310) comprising a distal facing abutment surface (312) for abutting a rim (406) of a refillable vessel (400).

Abstract: The invention relates to a refinement of a spindle drive (1), and to a louvered window or a louvered shutter having a spindle drive for moving louver elements such that applied return forces and return torques can be absorbed better, and in particular without placing a load on the drive motor. For this purpose, the spindle drive (1) has a specially designed return stop mechanism (6) arranged between a drive shaft of a drive motor (3) and a threaded spindle (4).

Abstract: The present invention provides a fortificant composition comprising a sugar derived humectant in the range of 30 to 60 wt %; a solubilizer in the range of 1 to 40 wt %; an encapsulated fat soluble fortificant in the range of 0.001 to 10 wt %; a water soluble fortificant in the range of 0.001 to 10 wt %; and water in the range of 1 to 30 wt %.

Abstract: The invention provides a detergent composition for the non-oxidative laundering of fabric stains, the composition comprising: (a) from 0.1 to 10% (by weight based on the total weight of the composition) of N,N?-bis(2-hydroxybenzyl)-ethylenediamine-N,N?-diacetic acid (HBED) and/or salts thereof, and (b) from 3 to 80% (by weight based on the total weight of the composition) of one or more detersive surfactants.

Abstract: The present invention relates to a fibre for purification of liquids comprising a matrix of polymer with organosilane impregnated therein and a method for preparing the same. The fibre of the present invention is capable of providing at least 2 log reduction of viruses, bacteria and cysts and flux of 10 to 1000 litre per square meter per hour at 2 psig.

Abstract: System including a vehicle seat comprising a seating portion, a backrest pivotally mounted on the seat by a lockable hinge mechanism, the seat further comprising a motorized adjustment device connected to the backrest independently of the hinge mechanism. An electric control device synchronously controls the hinge mechanism and the motorized adjustment device.

Abstract: The present invention relates to a cross-linkable rubber composition, a cross-linked rubber composition obtained by cross-linking such a rubber composition, a method of preparing a tyre and a tyre. In a cross-linkable rubber composition the cross-linkable rubber composition comprises, per hundred parts by weight of rubber (phr): ?1 phr to ?99 phr of a rubber component selected from the group of styrene-butadiene rubber (SBR), polybutadiene rubber (BR), natural rubber (NR) or a mixture thereof; and ?1 phr to ?120 phr of an aliphatic resin component. The composition further comprises ?1 phr to ?50 phr of a polyisoprene rubber (IR) having ?mol-%, as determined by NMR spectroscopy, of 3,4-linked units derived from isoprene.

Abstract: Cytoablative treatments lead to severe damages on thymic epithelial cells (TECs), which result in delayed de novo thymopoïesis and a prolonged period of T-cell immunodeficiency. Understanding the mechanisms that govern thymic regeneration is of paramount interest for the recovery of a functional immune system notably after bone marrow transplantation (BMT). Here, the inventors show that administration of RANK ligand (RANKL) after total body irradiation and BMT boosts thymic regeneration. Notably, this treatment is also beneficial upon BMT in aged individuals. The inventors show that RANKL can improve thymopoiesis in aged individuals affected by thymic involution. Finally, the inventors show that RANK receptor is conserved in the human thymus. Accordingly, one aspect of the present invention relates to a method of boosting thymic regeneration in a patient suffering from a thymic injury comprising administering to the subject a therapeutically effective amount of a RANKL polypeptide.

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: The present invention relates to the field of chromatography. More closely, the invention relates to a chromatographic method for purification of Factor VIII and von Willebrand factor from a cryoprecipitate of plasma. The chromatographic method is performed on a matrix comprising an inner porous core and outer porous lid surrounding said core.

Abstract: The invention provides substituted pyrrolo[1,2-a]pyrimidines and related organic compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., Gaucher disease, Parkinson's disease, Lewy body disease, dementia, or multiple system atrophy, in a patient. Exemplary substituted pyrrolo[1,2-a]pyrimidines compounds described herein include substituted 2,4-dimethyl-N-phenylpyrrolo[1,2-a]pyrimidine-8-carboxamide compounds and variants thereof.

Abstract: A vehicle seat, comprising: a lower frame, intended to be connected to the floor of a vehicle, having: a base, intended to be connected to the floor of the vehicle, and a seating portion frame, comprising at least two seating places to accommodate at least two users, a first backrest pivotally hinged to the base, a second backrest pivotally hinged to the base, wherein the seat further comprises a connection system connecting the first backrest to the seating portion frame, configured so that the pivoting of the first backrest relative to the base causes the simultaneous movement of the seating portion frame relative to the base in the longitudinal direction and the vertical direction of the seat, in the two pivoting directions of the first backrest relative to the base.

Abstract: A system for placing a label on an object comprising: a scanning module arranged to scan the object for a suitable label placement position based on predefined parameters associated with the label; a robotic controlled apparatus arranged to extract the label from a label substrate and move the label to be adjacent to the suitable label placement position; and, wherein the robotic controlled apparatus is further arranged to apply the label onto the suitable label placement position such that the label is adhere to the object.