Abstract: New nicotinic acid glycerol ester compound(s) (NAEs); topical personal care compositions containing NAEs; and methods for modulating or activating cellular AMPK levels; and for increasing skin cellular bioenergetics are described. Use of one or more of the nicotinic acid glycerol ester compounds for modulating or activating cellular AMPK levels; and for increasing skin cellular bioenergetics are described. Use of a skin benefit agent comprising certain nicotinic acid glycerol ester compounds in the manufacture of a topical personal care composition for modulating or activating cellular AMPK levels; and for increasing skin cellular bioenergetics are described.

Abstract: A bone graft delivery system and method for using same to deliver graft material into a surgical site. The system includes an interbody implant having a securing site disposed on a surface of the implant and a holder having an elongated, hollow handle including a distal end. The distal end of the holder is configured to removably engage the securing site of the interbody implant to secure the interbody implant to the distal end of the holder until such time as a user desires to disengage the holder from the interbody implant. The interbody implant may be a cage implant having opposing anterior and posterior surfaces, opposing first and second lateral surfaces, and opposing top and bottom surfaces, wherein the top surface comprises a first aperture and the bottom surface comprises a second aperture, the posterior surface comprising a third aperture, the first, second, and third apertures all linking to a main cavity, the main cavity generally extending between the top surface and the bottom surface.

Abstract: The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

Abstract: A method for measuring, adjusting and maintaining the level of blood volume in a patient is described. A blood volume expander composition includes, in combination, a standard unmodified protein, colloid or crystalloid and a fluorescently-labeled protein, colloid or crystalloid of approximately the same molecular weight. The use of blood volume expanders to measure, adjust and maintain the level of blood volume in a patient also is described.

Abstract: The present invention relates to a topical composition. More particularly the present invention relates to antimicrobial composition for providing benefits against malodor. Accordingly, the present invention provides a topical composition comprising; a. at least one compound selected from a biphenol; and, b. at least one coinage metal compound.

Abstract: The invention relates to aqueous skin cleansing compositions. Specific amounts and chain length of acyl glycinate and acyl glutamate when used in specified ratios, have been found to unexpectedly enhance lather volume and texture, as well as provide superior mildness.

Abstract: Various embodiments of diffusing devices and scent cartridges are described. The diffusing device can include a cover or retaining ring that magnetically attaches to the diffusing device to hold the cartridge in place. The scent cartridge can include a top plate suspended above the cartridge such that a scent depository of the cartridge is hidden or obscured while the top plate can include artwork or a kinetic arrangement that has a change in visual appearance due to an airflow against or through the top plate.

Abstract: The invention relates to a device for wiping and cleaning a glazed surface (S) of an automotive vehicle, comprising at least: —one direct current electric motor (7) rotating in a single direction and capable of moving at least one “wiper arm” unit (BB) formed by a drive arm (1) and a wiper blade (2) by means of a linkage (14), said “wiper arm” unit being moved according to an angular reciprocating movement between a rest position (11) and an end position (12) opposite the rest position (11) in relation to an angular sector (13) on the glazed surface (S), —a device (15) for dispensing an active liquid on the glazed surface (S), the active liquid preferably being a de-icing liquid or an insect-removing liquid, —a control means (10) configured to control, on the one hand, the operation of the motor (7) in order to stop the “wiper arm” unit (BB) for a non-zero duration and, on the other hand, the dispensing of the active liquid by the dispensing device (15).

Abstract: The method of modulating epileptogenicity in a brain of an epileptic patient includes: providing a virtual brain; providing a model of an epileptogenic and of a propagation zones and loading the model in the virtual brain to create a virtual epileptic brain; acquiring data of the brain of the epileptic patient; identifying, in the data, a location of at least one possible epileptogenic zone; fitting the virtual epileptic brain against the data acquired from the epileptic patient and parametrizing the at least one possible epileptogenic zone in the virtual epileptic brain as an epileptogenic zone; and simulating, within the virtual epileptic brain, the effect of a network modulation mimicking a clinical intervention of the brain of the patient.

Abstract: The invention provides substituted pyrazolo[1,5-a]pyrimidinyl carboxamide and related organic compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., Gaucher disease, Parkinson's disease, Lewy body disease, dementia, or multiple system atrophy, in a patient. Exemplary substituted pyrazolo[1,5-a]pyrimidinyl carboxamide compounds described herein include 2-heterocyclyl-4-alkyl-pyrazolo[1,5-a]pyrimidine-3-carboxamide compounds and variants thereof. The invention provides, in part, a compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein the variables are as defined herein.

Abstract: A composite material for sensing a chemical species in a medium is provided. The composite material includes a polymer having a glass transition temperature, a porosity promoter dispersed in the polymer in an amount such that the chemical species is transportable from the medium into the composite material at a temperature below the glass transition temperature, and a chemical indicator dispersed in the composite material, the chemical indicator providing an optical response varying with a concentration of the chemical species in the composite material.

Abstract: Large digital images are classified by analyzing them at a subimage level and assigning classification probabilities to the subimages; these may be combined into a classification probability for the entire image. Classification probabilities may be visualized across the image using probabilities computed for the subimages. This enables ready identification of the image subregions upon which classification is based as well as the classification scores or probabilities associated therewith. For example, a large source image—too large to be analyzed directly by a neural network—may be decomposed into smaller subimages such as square tiles, which are sifted based on a visual criterion. The visual criterion may be image entropy, density, background percentage, or other discriminator. A neural network produces tile-level classifications that are aggregated to classify the source image, and overlapping tiles are used to create a probability map showing subimage probabilities.

Abstract: Transcutaneous, ultrasound-mediated methods for administering compound(s) to subject tissue(s) are provided. Examples involve positioning an occluding device in a vessel such that the blockage is adjacent to target tissue; engaging the device to occlude outflow from a region adjacent to the tissue; administering compound(s) to the vessel such that it is substantially retained adjacent to the target tissue; determining the location of the compound and/or a detectable adjunct compound optionally administered with the compound, using diagnostic ultrasound, radiography, or fluorography; administering therapeutic ultrasound energy transcutaneously to mediate delivery of the compound across the vessel wall and into adjacent target tissue.

Abstract: A method of treatment of a marine surface to improve the resistance of the surface to fouling from a marine organism, the method comprising treatment of a surface prone to fouling from a marine organism with a composition comprising a lactam, wherein the composition comprises from 0.0005 to 5 wt.

Abstract: The invention relates to a method of treatment of a surface to improve the resistance of the surface to fouling from a photosynthetic species, the method comprising treatment of a surface prone to fouling from a photosynthetic organism with a composition comprising a lactam, wherein the composition comprises from 0.0001 to 5 wt. % of a lactam; and, wherein the surface to be treated is selected from metal, plastic or composites; and to the use of the lactam to inhibit growth of a photosynthetic organism on a surface, wherein the surface to be treated is selected from metal, plastic or composites.

Abstract: A method may produce an isoquinoline-6-sulfonamide derivative useful as a medicinal drug; and an intermediate which is used for the method, and more specifically, a 1,4-diazocane compound of formula (8), wherein R4 is an amino protecting group, or a salt thereof.

Abstract: A method for naturally culling mussel population on a mussel-culture rope, comprising the steps of installing a predator guard around the mussel-culture rope; and during the step of installing, adjusting a degree of mussel protection of that predator guard. In one aspect, the step of adjusting comprises the steps of opening and adjusting a size of a breach in the predator guard. In another aspect, the predator guard is made of an elongated hemicylindroidal mesh-like element with an open side. The hemicylindroidal element has flaps bordering the open side. The flaps constitute duck-mobility impediments for limiting without completely precluding predation by diving ducks.

Abstract: A food composition in the form of a dispersion, the composition comprising a water phase with water and modified waxy starch and vegetable oil dispersed in the water, wherein the modified waxy starch is present in an amount of from 4 to 9 wt %, based on the weight of the water in the food composition, wherein the composition does not comprise egg-derived emulsifier, preferably the composition does not contain a surface-active emulsifier, has a viscosity between 800 to 3000 mPa·s (measured at 20° C. with Brookfield viscosimeter DV-II and spindle RV #3 at 50 rpm), has a pH from 2.5 to 5, does not contain a gum or non-modified starch. Process to manufacture a food composition comprising the steps of preparing a) a water phase comprising water and modified waxy starch, b) swelling the starch or allowing the starch to swell, mixing the composition resulting from b) with vegetable oil. The starch is preferably physically modified starch.

Abstract: A kitchen appliance in the form of a multi-purpose frying pan includes a base, a cover with a hot air system, an inner pot, a stirrer and a stirrer drive device. The inner pot can be removed from the base. A pot cavity is formed between the lid cover and the inner pot and the stirrer is located in the pot cavity, and the stirrer drive device is installed in the pan. Covered and on the outside of the hot air system, the stirrer drive device drives the stirrer to rotate. The stirrer drive device is disposed on the lid to prevent water or oil from polluting the motor during the cleaning of the cookware. The stirrer drive device is arranged on the outside of the hot air system to effectively prevent the drive device from blocking the transmission of hot air from the hot air system to the inner pot.

Abstract: A snare unit formed from film material includes a plurality of slots that define segments. The snare unit is attachable relative to a drumhead with a surface of the film flat against a surface of the drumhead. In the attached position, one or more of the segments vibrates against the drumhead when the drumhead is struck to produce a snare-like audible sound. In a drumhead with reduced volume, the snare unit is positioned flat against one or more layers of a porous material to define a drumhead and attached such that a portion of the snare unit vibrates against a surface of the porous material when the drumhead is struck, thereby producing a snare-like sound having a volume reduced relative to a standard drumhead.