Abstract: The invention provides compounds of formula (I): where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds and methods of using such compounds to treat respiratory diseases.

Abstract: Photovoltaic module comprising: a front sheet arranged on a light incident side of said photovoltaic module; a back sheet arranged on an opposite side of said photovoltaic module to said front sheet; a photovoltaic conversion device disposed between said front sheet and said back sheet; at least one front encapsulation layer disposed between said photovoltaic conversion device and said front sheet; wherein said front encapsulation layer comprises pigment particles distributed therein

Abstract: Provided herein are bifunctional compounds that bind tau protein and/or promote targeted ubiquitination for the degradation of tau protein. In particular, provided are compounds that can bind tau protein, a protein whose aggregation is implicated in a variety of neurodegenerative disease (e.g., tauopathies), and can promote its degradation by recruiting an E3 ubiquitin ligase (e.g., Cereblon), which can ubiquitinate tau protein, marking it for proteasomal degradation. Also provided are radiolabeled forms of the bifunctional compounds, pharmaceutical compositions comprising the bifunctional compounds, methods of detecting and/or diagnosing neurological disorders, methods of detecting and/or diagnosing pathological aggregation of tau protein (e.g., in the central nervous system), methods of treating and/or preventing neurological disorders, and methods of promoting the degradation of tau protein by E3 ubiquitin ligase activity in a subject by administering a compound or composition described herein.

Abstract: A method may include accessing an artery in communication with an ophthalmic artery of a subject, and advancing a microcatheter along the accessed artery so as to align a distal end of the microcatheter with an ostium of the ophthalmic artery, wherein the microcatheter includes a lumen having a guidewire positioned therein. In addition, the method includes proximally withdrawing the guidewire relative to the microcatheter so as to enable a distal portion of the microcatheter to assume a curved relaxed configuration, and cannulating the ostium with the distal portion of the microcatheter when the distal portion is in the curved relaxed configuration.

Abstract: Provided is a method for manufacturing a hard carbon-based coating. The method includes: a step A of preparing a film-forming apparatus including a power supply device and a discharge electrode containing a carbon material, and a substrate having a surface on which a coating is to be formed; and a step B of causing the film-forming apparatus to repeatedly generate a discharge between the discharge electrode and the substrate, to form a hard carbon-based coating on the surface.

Abstract: A brushless DC motor (1) comprises a rotor comprising magnetic elements twining poles of the electric motor (1) and a control magnet comprising a number of pole pairs equal to three times that of the electric motor (1), a stator having electromagnetic excitation coils, at least one first and one second Hall-effect sensor (17, 17?) configured to detect predetermined angular positions of the rotor, and a control unit configured to apply a predetermined sequence of excitation signals to the coils, wherein the Hall-effect sensors are spaced apart by an angle greater than or equal to 10°, the first Hall-effect sensor (17) is used to determine the switching times of the excitation signals and the second Hall-effect sensor (17?) is used, in combination with the first Hall-effect sensor (17), to determine the direction of rotation of the rotor when the motor starts up, or vice versa.

Abstract: An alternatively changeable electric circuit comprising a voltage source, an electric load electrically connected with said electric voltage source via a basic electric conductor having a primary branch and a secondary branch, and an alternative conductor connected in parallel to said basic electric conductor, wherein upon fulfillment of a predetermined circumstance, said primary branch is physically interrupted, causing an electric current which initially flowed through said primary branch to be redirected through said alternative conductor. The alternative conductor comprises two electric conductive sections which are aligned with each other and spaced apart at a distance, forming an electrically insulating gap there-between.

Abstract: The present disclosure provides inhibitors of activin receptor-like kinase 5 (ALK5). Also disclosed are methods to modulate the activity of ALK5 and methods of treatment of disorders mediated by ALK5.

Abstract: The present invention relates to a compound of formula (I) wherein: i is 0 or 1; j is 0 or 1; k is 0 or 1; R1 and R2 are in particular H, (C1-C12)alkyl, or a group of formula C(O)R; R is a, linear or branched, alkyl radical, comprising at least 19 carbon atoms; R3 is H and k=0 when j=1; or, when j=0, R3 is —C(O)R or -L-C(O)R; L, U and L? are linkers; wherein, when j=0, at least one of the groups R1; R2 and R3 comprises a radical R.

Abstract: An audio amplifier includes: a buck controller configured to control an output voltage at a first supply terminal, the output voltage selected from a set including a plurality of output voltages, where the output voltage takes a settling time to settle; a first audio bridge including: a class-AB driver stage coupled to the first supply terminal, and a delay insertion circuit configured to receive a processed digital stream and provide the processed digital stream to the class-AB driver stage a delay time after receiving the processed digital stream, where the delay time is based on the settling time; and an audio amplitude detector configured to detect a first peak amplitude in the first digital audio stream, where the buck controller is configured to select a lowest output voltage from the set that is higher than the first peak amplitude plus a headroom voltage.

Abstract: The present invention relates to a method to improve chromatography beads. More closely, the invention relates to a novel method for production of dextran-containing porous media and chromatography media produced with this method. In the method, the chromatography media is subjected to dextranase-treatment leading to improved pressure-flow properties of the media.

Abstract: Systems and a method are disclosed for improved 3D visualization on a head display unit. Exemplary features include filtering of the volume of interest and viewing the filtered volume of interest via a head display unit with a left eye display and a right eye display. Additional options include zooming and rotating. These features at least improve display of the 3D images to a user.

Abstract: The invention relates to new identified mutations in the epidermal growth factor receptor gene, leading to amino acidic changes which highly correlate with the resistance to a therapy regimen comprising cetuximab. The invention includes peptide sequences and primers to detect the mutations, as well as kits for predicting the response of a subject to a therapy regime comprising cetuximab. In particular, the invention is useful in the therapy regimen applicable to metastasic colorectal cancer.

Abstract: The present invention discloses a coating monitoring system of wind turbines, comprising a monitoring object having at least one coating on the surface. A coating monitoring module is coupled to the monitoring object, and the coating monitoring module comprises a MEMS system including a signal generating device, and a printed circuit board connected to the MEMS system. The coating monitoring module measures a measured coating impedance value of the monitoring object. A potentiostat, calculating an actual coating impedance value of the monitoring object, is connected to the monitoring object. And a computing device coupled to the coating monitoring module, the computing device correcting the measured coating impedance value based on the actual coating impedance value.

Abstract: The invention relates to dipeptidyl peptidase-4 inhibitors, including saxagliptin and sitagliptin, for use in the topical eye treatment and/or prevention of retinal neurodegenerative diseases, in particular diabetic retinopathy and its associated microvascular impairment. The invention also encompasses pharmaceutical topical eye compositions for use in the topical treatment and/or prevention of these diseases.

Abstract: Methods, devices, and systems for determining a job file for a three-dimensional printing machine based on part-to-build data. Embodiments include determining the part-to-build data based on: determining part data from a received computer-aided design (CAD) file, generating orientation data, generating support data, generating feature data, and generating slicing data. In some embodiments, determining the job file may be further based on generating nesting matrix associated with the part-to-build data.

Abstract: The present invention relates to an antimicrobial composition and more particularly to an antimicrobial composition at the pH of skin. The present invention provides an antimicrobial composition comprising: a. 0.5 to 20% by weight of a solvent comprising an alkyl glycol ether, b. 0.1 to 20% by weight of a carboxylic acid selected from an aromatic carboxylic acid having pKa greater than 4 or an aliphatic carboxylic acid having pKa greater than 4.5 or mixtures thereof c. 1 to 80% by weight of an anionic surfactant.

Abstract: Recommendations are provided to users of social network site for a set of audiovisual items; the sequence of recommendations is optimized to increase an overall expected ratings from such users.

Abstract: This microwave component (10) comprises a waveguide (12) comprising an upper layer, a lower layer, and a central layer (18) intermediate between the upper layer and the lower layer, said layers defining a zone (19) of propagation of an electromagnetic wave, the propagation zone (19) extending along a propagation axis, and comprising a cavity (32) bounded by the upper layer, the lower layer, and, laterally, by two opposite lateral edges (36) of the central layer (18). The waveguide (12) comprises at least one dielectric strip (28) placed in the propagation zone (19), the dielectric strip (28) being defined in one of the upper layer and the lower layer or being placed in the cavity (32) away from the lateral edges (36) of the cavity (32).

Abstract: A pluggable state-of-charge (SOC) indicator and methods of use are disclosed. The pluggable SOC indicator includes at least one voltage input jack for connecting to a battery, at least one instance of control electronics, and at least one SOC indicator, such as a 5-bar liquid crystal display (LCD). Embodiments of the pluggable SOC indicator include, but are not limited to, a pluggable single-connector SOC indicator, a pluggable dual-connector SOC indicator, a pluggable tri-connector SOC indicator, and a pluggable quad-connector SOC indicator. Further, the control electronics are programmable for any input voltage range and/or battery discharge characteristics.