Abstract: Compounds of formula (I) that are capable of acting as purine receptor antagonists, pharmaceutical compositions including the compounds, and methods of making the compounds, are disclosed. The compounds and compositions can be used in treating or preventing disorders related to purine receptor hyperfunctioning.

Abstract: A foot for a household appliance includes a hydraulic plate, a sheath connected with the hydraulic plate, an adjustable foot arranged in the sheath and axially moveable relative to the sheath, and a device for communicating the flow of a hydraulic medium between at least two feet of the household appliance. An accommodating chamber is formed by the hydraulic plate, the sheath and the adjustable foot; the hydraulic medium is arranged in the accommodating chamber, and the hydraulic medium is compressed or expanded along with the change of pressure to drive the adjustable foot to move axially in the sheath for leveling. A control device for turning on/off the flow of the hydraulic medium is provided on the communicating device, a better leveling support effect is achieved by controlling the on/off of the communicating device.

Abstract: Method of manufacturing a photovoltaic module comprising at least a first layer and a second layer affixed to each other by means of an encapsulant, said method comprising a lamination step wherein the encapsulant material comprises a silane-modified polyolefin having a melting point below 90° C., pigment particles and an additive comprising a cross-linking catalyst; and wherein in said lamination step heat and pressure are applied to the module, said heat being applied at a temperature between 60° C. and 125° C.

Abstract: A method for exposing a pattern in an area on a surface using a charged particle beam lithography is disclosed and includes inputting an original set of exposure information for the area. A backscatter is calculated for the area of the pattern based on the exposure information. An artificial background dose is determined for the area. The artificial background dose comprises additional exposure information and is combined with the original set of exposure information creating a modified set of exposure information. A system for exposing a pattern in an area on a surface using a charged particle beam lithography is also disclosed.

Abstract: Apparatus and installation methods for sampling ports are disclosed. Sampling ports include a port housing and a lid assembly. The lid assembly is configured to sealably close against the port housing. Additionally, the lid assembly can be secured, such as with a lock, to the port housing. In one aspect, the port housing includes a sample mount arrangement configured to receive a sampling assembly. The sample mount arrangement defines a sampling channel and the port housing defines a sampling opening and a first securing mount. The lid assembly includes a latch arrangement and defines a second securing mount.

Abstract: Method for softening knitted cotton, wherein knitted cotton is treated with an ancillary laundry composition comprising: a. Soil release polymer b. Silicone c. less than 4 w.t.% surfactant; and d. Water wherein the method comprises delivering the ancillary laundry composition into the wash or rise stage and comprises the steps of: a. Pouring a laundry product into a washing receptacle, a washing machine drawer, or a dosing shuttle b. Pouring the ancillary laundry composition on top of the laundry product. Use of the method for softening knitted cotton.

Abstract: The present invention relates to the identification of proteins of the WNT signaling pathway as therapeutic targets of pigmentation disorder and as biomarkers of pigmentation status. The invention in particular relates to products and methods for treating a hypopigmentation disorder. The invention also relates to products and methods for detecting, diagnosing, staging or monitoring the course of hypopigmentation disorder and is particularly suited for human subjects.

Abstract: The present invention relates to an optical system including at least one objective lens (2) for receiving light from an object (1), an array of image forming elements (4) for generating multiple images of the object on an image sensor plane (SP) and a filter (F). The optical system is configured to form a real image of the filter on the array of image forming elements to filter the multiple images of the object, the filter being arranged with respect to the at least one objective lens so that a real image of the filter is formed on the array of image forming elements, and wherein the optical system is configured to be telecentric in the image plane of the filter.

Abstract: The invention provides methods for the synthesis of a halichondrin macrolides or analogs thereof through a cyclization reaction strategy. The strategy of the present invention involves subjecting an intermediate to Prins reaction conditions to afford a macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides or analogs thereof and methods for preparing the same.

Abstract: A telescopic cleaning device is intended for projecting at least one cleaning and/or drying fluid onto a glass surface to be cleaned of a motor vehicle, such as an optical surface of an optical sensor of an optical detection system. The cleaning device includes at least one fluid distribution element, rendered movable, along an axis of elongation (X) and at the end of a movable piston between a retracted first position and an extended second position for cleaning and/or drying. The fluid distribution element comprises a distribution bar (4) inside which a fluid distribution channel (56) extends and the distribution bar is equipped with a heating device (60) integrated at least in part into the distribution bar in order to heat the fluid passing through said distribution channel.

Abstract: The present invention relates to the use of coconut water as extraction solvent, to extraction methods using coconut water and extracts obtained by extraction with coconut water.

Abstract: The edged tool storage device set is an edged tool storage device set including a first edged tool storage device and a second edged tool storage device, in which the first edged tool storage device includes a first case that has a first hole storing a blade of an edged tool and a flange-shaped first projection that projects from the first case in a direction crossing the extending direction of the first hole, and the second edged tool storage device includes a second case that has a second hole storing a blade of an edged tool and a groove-shaped first recess that faces a direction crossing the extending direction of the second hole and has a shape allowing fitting with the first projection.

Abstract: Packet of smoke articles, including: a container, which has a parallelepiped shape and has a front wall, a rear wall, a bottom wall and two lateral walls; a parallelepiped-shape inner wrapper that wraps a group of smoke articles, which is housed inside the container and has a front wall, a rear wall, a top wall, a bottom wall and two lateral walls; and a separating element, which is arranged inside the inner wrapper and divides the inner volume of the inner wrapper so as to form several partitions of the group of smoke articles.

Abstract: The present invention is directed to 5-(pyridine-3-yl)oxaxole compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

Abstract: A laser system based on nonlinear pulse compression and a LMA optical fiber therefor are provided. The LMA optical fiber is configured to amplify seed light pulses and promote the onset of nonlinear spectral broadening. The LMA optical fiber includes a first section having constant core and cladding diameters and receiving and supporting propagation of the light pulses in multiple transversal modes. The first section is configured to suppress high order modes propagating therealong. The LMA optical fiber further includes a tapered second section receiving the fundamental mode from the first section, the core and cladding diameters increasing gradually along said second section so as to provide an adiabatic transition of the fundamental mode. The LMA optical fiber further includes an optional third section having constant core and cladding diameters. Dispersive compression of the light pulses outputted by the LMA optical fiber provides excellent beam quality and high peak powers.

Abstract: An integrated circuit, includes: an input configured to receive an induced signal that is modulated according to a protocol belonging to the group including protocols using ASK modulation and protocols using OOK modulation; a detection circuit configured to detect the modulation of the induced signal; a decoding circuit configured to detect the protocol; a configurable limiter configured to limit a level of the induced signal and having a first configuration adapted to protocols using ASK modulation and a second configuration adapted to protocols using OOK modulation; and a control circuit configured to set the limiter in the first configuration until a protocol is detected, and to switch the limiter from the first configuration to the second configuration in response to a protocol using OOK modulation being detected.

Abstract: The invention relates to a recombinant adeno-associated virus (AAV) capsid protein, which is a hybrid between AAV serotype 9 (AAV9) and AAV serotype 74 (AAVrh74) capsid proteins, wherein said recombinant hybrid AAV capsid protein has a reduced liver tropism compared to the parent AAV9 and AAVrh74 capsid proteins. The invention relates also to the derived hybrid AAV serotype vector particles packaging a gene of interest and their use in gene therapy, in particular for treating neuromuscular genetic diseases.

Abstract: The invention relates to a terminal end piece (8) for a wiper blade. The terminal end piece (8) comprises a peripheral wall (20) which separates an external environment of the terminal end piece (8) from an internal space (11) of the terminal end piece (8). The terminal end piece (8) delimits a first housing (21) which is arranged in the internal space (11) and which extends primarily in a first plane (P1). A second housing (22) is interposed between the peripheral wall (20) and the first housing (21). The terminal end piece (8) comprises at least one locking member (37) which is configured to connect the terminal end piece (8) to a flexible support (6) of the wiper blade (1).

Abstract: Methods for decreasing harmful effects of blue light on skin are disclosed that include topically administering to a subject in need thereof a composition of an effective quantity of a purified, enzymatic hydrolysate of Theobroma cacao L. beans comprising peptides and saccharides having a molecular weight between 200 Da and 10 kDa in a physiologically acceptable medium. The hydrolysate of Theobroma cacao L. beans is present in the composition at a concentration from 0.001 to 20% with respect to the total weight of the composition. The composition can be a cosmetic composition.

Abstract: The invention relates to a liquid recovery system for a motor vehicle and to a vehicle including such a recovery system that that includes at least one liquid intake that communicates with a tank and is referred to as the first tank, which is designed to store liquid from the liquid intake and where the liquid intake is arrangeably designed below the vehicle's beltline.