Abstract: An inflatable transfer mattress includes a top panel, a bottom panel having a perimeter sealingly coupled to a perimeter of the top panel to define an internal volume therebetween, and a rotational positioning device coupled to the top panel. The internal volume is configured to receive an air flow therein. The rotational positioning device is positioned outside of the internal volume and includes at least one inflatable bladder configured to be inflated from a deflated state to an inflated state. The bladder portion is configured to rotate a patient to a predetermined angle with respect to the top panel in the inflated state.

Abstract: The invention provides a compound of formula (I): or a pharmaceutically-acceptable salt thereof, that is an inhibitor of JAK kinases. The invention also provides pharmaceutical compositions comprising such compound, a crystalline form, methods of using such compound to treat inflammatory skin diseases and other diseases, and processes and intermediates useful for preparing such compound.

Abstract: A method is provided and may include accessing a terminal branch of an ophthalmic artery through a skin of a head of a subject via a first device, positioning at least one of the first device or a second device within the ophthalmic artery of the subject, and performing an atherectomy of the ophthalmic artery or a junction between the ophthalmic artery and an internal carotid artery of the subject, using the at least one of the first device or the second device, so as to treat a blockage, a stenosis, a lesion, plaque, or other physiology in the ophthalmic artery or the junction between the ophthalmic artery and the internal carotid artery of the subject.

Abstract: The present disclosure discloses a support for household appliance and a household appliance. The support for household appliance comprises a fixed part and a moving part, a hollow chamber is formed between the fixed part and the moving part and the hollow chamber is provided with a hydraulic medium. At least two household-appliance-used supports communicate with one another through high-pressure pipes; and the hydraulic medium circulates among the household-appliance-used supports under action of pressure to drive the moving part to extend and retract to achieve automatic leveling. Liquid outlet nozzles communicating with the hollow chamber are arranged on the fixed part, the high-pressure pipes are in sealed connection with the liquid outlet nozzles through snap-in connecting members, and the snap-in connecting members have reinforcing aprons which are fit with the fixed part.

Abstract: Disclosed is a compound of formula (I) in which a, R1-R5 and X1 are as described herein. Also disclosed are a pharmaceutical composition containing the compound and a method of using the compound for treating cancer, such as renal cancer.

Abstract: A mechanical and hydraulic dual-effect expansion device for well drilling with expandable tubular technology includes an anchor having a lower end connected to an upper end of an insertion connection tube via a coupling, a hydraulic cylinder assembly comprising a hydraulic cylinder and a piston tube movably disposed within an inner cavity of the hydraulic cylinder, and a variable-diameter expansion cone assembly comprising a sealing cone portion and a variable-diameter expansion cone portion, wherein the sealing cone portion has an upper end connected to a lower end of the piston tube and a lower end connected to an upper end of the variable-diameter expansion cone portion. The mechanical and hydraulic dual-effect expansion device can facilitate completion of construction operations of an expandable tubular in a casing and an openhole system.

Abstract: The invention relates to a securing element (1; 1a) for a bearing device (50) in a housing (20) of a drive device (10), wherein the plate-like securing element (1; 1a) has two side legs (34, 35) and a base leg (36) which connects the side legs (34, 35), wherein, between the base leg (36) and the side legs (34, 35), there is formed a cutout (38) for receiving a shaft (12) which is mounted rotatably in a bearing (15), wherein the two side legs (34, 35) are designed to interact, by means of a first face side (21), with the bearing (15) and, by means of a second face side (23), with a stop surface (33) in the housing (20).

Abstract: A method and system for determining visual related physical conditions of a user of a display device, determined from the user's responses to a selection of visual-tasks. A dataset is provided for correlating the user's responses with the corresponding scores, so that by measuring the degree of correlation between the user's scores and a predetermined combination of the corresponding scores, the user's visual physical condition can be determined. A system is also provided, including a user device as well as a remote server for providing visual acuity and related testing to detect certain vision deficiencies and visual related physical conditions. In addition, a user device application is provided.

Abstract: Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.

Abstract: The invention relates to processes for preparing 2-(1-(tert-butoxycarbonyl)-piperidine-4-yl)benzoic acid having formula I: Among its various uses, this compound is useful as an intermediate for preparing ampreloxetine and salts thereof.

Abstract: Disclosed herein, inter alia, is method, kit and systems for detecting a pathogen infection in a bodily sample, the method comprising (i) staining said bodily sample with two or more dyes, comprising at least one dye predominantly staining DNA to thereby provide differential staining between DNA and at least one other cellular component being different from DNA; (ii) identifying at least a first stained area comprising the DNA, if exists in the sample, and at least one other stained area comprising the other cellular component; (iii) extracting structural features for the first stained area and the at least one other stained area, said structural features comprise at least one of (i) size of at least one of the first stained area and one other stained area and (ii) location of said first stained area and said at least one other stained area one with respect to the other; and (iv) determining the presence of a suspected pathogen in the bodily sample if a first stained area was identified and said structural fe

Abstract: A system and method for processing objects having chemical contaminates includes a shredding module arranged to shred the objects to form a plurality of shredded fragments, each having the chemical contaminates, and a separating module arranged to separate the chemical contaminates from the shredded fragments.

Abstract: The present invention provides salts of (E)-N,N-dimethyl-4-((2-((5-((Z)-4,4,4-trifluoro-1-(3-fluoro-1H-indazol-5-yl)-2-phenylbut-1-en-1-yl)pyridin-2-yl)oxy)ethyl)amino)but-2-enamide represented by the formula I and acids, and crystals thereof, possessing a potential to be used as drug substance in pharmaceuticals.

Abstract: A fibrous material, method for making the same, and articles comprising the same are shown and described. The fibrous material is a low density material that exhibits high strength properties. In embodiments, the fibrous material has a density of 0.15 g/cm3 or less and a tensile strength of 10 N/inch or greater. The fibrous material may be in the form of a paperboard and is suitable for use in a variety of applications including as a packaging material.

Abstract: Tamper resistant systems and devices and methods of forming the same are disclosed. A tamper resistant system includes a container having a container body defining a cavity having a threaded opening therein, a threaded closure removably covering the threaded opening, and a frangible component including a length of material having a first end and a second end. The first end is integrated with the container body such that the frangible component and the container body have a single piece construction and the frangible component extends from the container body. The second end is coupled to the threaded closure. Subsequent removal of the threaded closure from the container causes damage to at least one of the frangible component, the threaded closure, and the container body. The frangible component, the threaded closure, and the container body are at least partially constructed of an environmentally friendly material.

Abstract: The positioning signals broadcast by GNSS constellations are affected by significant errors, notably due to the crossing of the ionospheric layer or of the tropospheric layer. Several unwieldy means have been deployed to provide professional users with corrections of said errors. These means, however, all require the knowledge of at least one precise reference point at a given distance. According to the invention, positioning receivers that are not very precise, such as smartphones, present in a geographical zone, of unknown precise position, can contribute to the production of precise atmospheric error corrections if said receivers are sufficiently numerous.

Abstract: A method dispenses and/or aspirates a predetermined volume of fluid from a chamber. The chamber includes a lower portion containing fluid and an upper portion containing gas. The method includes measuring an initial pressure in the upper portion and introducing or evacuating a known quantity of gas into or out of the upper portion. The volume of gas in the upper portion is determined based on the volume of gas introduced or evacuated from the upper portion and a measured change in pressure in the upper portion. An upper portion target pressure that will dispense or aspirate a predetermined volume of fluid is determined. A controllable valve is opened while the pressure in the upper portion of the chamber is monitored. Once the target pressure is reached, the predetermined volume of fluid has been dispensed or aspirated, and the controllable valve is then closed.

Abstract: The invention relates to a process for manufacturing at least one implant for focal electrical stimulation of a nervous structure, said implant being of the type including in a supporting structure a network of cavities at the bottom of which are placed microelectrodes, the cavities being bounded by walls erected and located around the microelectrodes, the supporting structure being produced beforehand by implementing the following steps: deposition and etching, in a planar manner, on an insulating substrate, of electrical contacts, of electrical tracks and of microelectrodes, first tracks electrically connecting the microelectrodes and the electrical contacts, second electrical tracks being electrically connected to a ground.

Abstract: The present invention relates to a method for measuring circulating cells in superficial body fluids by means of high-frequency-based device. The method can be used for detecting circulating cells in the fluids of an individual without the necessity of extracting a sample of the individual, being useful as a diagnostic tool and for monitoring the effectiveness of a treatment administered to an individual suffering from a viral, protozoal, fungal and/or bacterial disease.